Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  International Journal of Biological Macromolecules

• Publication date

  2017-06-01

• Fields of study

  Biology, Medicine, Engineering, Environmental Science

• Identifiers
  DOI 10.1016/j.ijbiomac.2016.10.113PMID 28223135
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP 1 LC 3 B and ATG 5

  2017cited by this paper
• Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export.

  2016cited by this paper
• The role of HIF in immunity and inflammation.

  2016cited by this paper
• Hypoxia in health and disease.

  2016cited by this paper
• The tumour hypoxia induced non-coding transcriptome.

  2016cited by this paper
• Methotrexate-conjugated quantum dots: synthesis, characterisation and cytotoxicity in drug resistant cancer cells

  2016cited by this paper
• Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells.

  2015cited by this paper
• Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells

  2015cited by this paper
• LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells

  2015cited by this paper
• Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: synthesis, anti-invasive and anti-angiogenic properties.

  2015cited by this paper
• Surface modified multifunctional nanomedicines for simultaneous imaging and therapy of cancer

  2014cited by this paper
• Interaction, Controlled Release, and Antitumor Activity of Doxorubicin Hydrochloride From pH-Sensitive P(NIPAAm-MAA-VP) Nanofibrous Scaffolds Prepared by Green Electrospinning

  2014cited by this paper
• Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer

  2014cited by this paper
• Development and applications of CRISPR-Cas9 for genome engineering.

  2014cited by this paper
• Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors

  2014cited by this paper
• The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition

  2014cited by this paper
• Overexpression of Hypoxia-Inducible Factor-1&agr; Is a Predictor of Poor Prognosis in Cervical Cancer: A Clinicopathologic Study and a Meta-analysis

  2014cited by this paper
• Hypoxia-mediated metastasis.

  2014cited by this paper
• NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction

  2014cited by this paper
• Development and Applications of CRISPR-Cas 9 for Genome Engineering

  2014cited by this paper
• Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells

  2014cited by this paper
• Self-reporter shikonin-Act-loaded solid lipid nanoparticle: formulation, physicochemical characterization and geno/cytotoxicity evaluation.

  2014cited by this paper
• Targeting tumor microenvironment: crossing tumor interstitial fluid by multifunctional nanomedicines

  2014influential reference
• Development of dual responsive nanocomposite for simultaneous delivery of anticancer drugs

  2014cited by this paper
• Regulation of erythropoiesis by hypoxia-inducible factors.

  2013cited by this paper
• Tamoxifen loaded folic acid armed PEGylated magnetic nanoparticles for targeted imaging and therapy of cancer.

  2013cited by this paper
• Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy.

  2013cited by this paper
• Specific targeting of cancer cells by multifunctional mitoxantrone-conjugated magnetic nanoparticles

  2013cited by this paper
• Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy.

  2013influential reference
• Erythrocytosis: the HIF pathway in control.

  2013cited by this paper
• Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity

  2013cited by this paper
• Targeted fluoromagnetic nanoparticles for imaging of breast cancer mcf-7 cells.

  2013cited by this paper
• Stimuli-responsive nanofibers prepared from poly(N-isopropylacrylamide-acrylamide-vinylpyrrolidone) by electrospinning as an anticancer drug delivery

  2013cited by this paper
• New strategies for targeting the hypoxic tumour microenvironment in breast cancer.

  2013cited by this paper
• MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA through Decreasing Nuclear–Cytoplasmic Translocation of RNA-Binding Protein HuR

  2013cited by this paper
• Hypoxia-inducible factor-1α overexpression indicates poor clinical outcomes in tongue squamous cell carcinoma

  2012cited by this paper
• Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment

  2012cited by this paper
• Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia

  2012cited by this paper
• Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis.

  2011cited by this paper
• Oxygen sensing, homeostasis, and disease.

  2011cited by this paper
• Targeting hypoxia in cancer therapy

  2011influential reference
• The HIF pathway and erythrocytosis.

  2011cited by this paper
• Regulation of cancer cell metabolism

  2011cited by this paper
• Hypoxia and inflammation.

  2011influential reference
• Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo

  2011cited by this paper
• Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway.

  2011cited by this paper
• Cytotoxic impacts of linear and branched polyethylenimine nanostructures in a431 cells.

  2011cited by this paper
• Hypoxia and inflammation.

  2011cited by this paper
• A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells

  2011cited by this paper
• Adenosine A₂a receptors and O₂ sensing in development.

  2011cited by this paper
• Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer.

  2011cited by this paper
• Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

  2011cited by this paper
• Overexpression of the natural antisense hypoxia-inducible factor-1alpha transcript is associated with malignant pheochromocytoma/paraganglioma.

  2011cited by this paper
• KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.

  2011cited by this paper
• Abstract 4461: MPT0B098, a novel microtubule inhibitor, displays potent anti-angiogenic activity via destabilizing hypoxia-inducible factor-1alpha mRNA

  2011cited by this paper
• Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.

  2011cited by this paper
• mechanisms of disease Oxygen Sensing , Homeostasis , and Disease

  2011cited by this paper
• Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

  2010cited by this paper
• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

  2010cited by this paper
• Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.

  2010cited by this paper
• IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer

  2010cited by this paper
• 1,2,3,4,6-Penta-O-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells.

  2010cited by this paper
• HIF pathway mutations and erythrocytosis

  2010cited by this paper
• Target gene therapy of glioma: overexpression of BAX gene under the control of both tissue-specific promoter and hypoxia-inducible element.

  2010cited by this paper
• Hypoxic tumors and their effect on immune cells and cancer therapy.

  2010cited by this paper
• HIF-1: upstream and downstream of cancer metabolism.

  2010cited by this paper
• Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

  2010cited by this paper
• The role of HIF in immunity.

  2010influential reference
• Cancer stem cells, hypoxia and metastasis.

  2009cited by this paper
• The basics of epithelial-mesenchymal transition.

  2009cited by this paper
• Targeting the hypoxia-inducible factor (HIF) pathway in cancer

  2009influential reference
• Hypoxia response element‐driven cytosine deaminase/5‐fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro

  2009cited by this paper
• Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

  2009cited by this paper
• Induction of Human Alveolar Epithelial Cell Growth Factor Receptors by Dendrimeric Nanostructures

  2009cited by this paper
• Cellular Toxicity of Nanogenomedicine in MCF-7 Cell Line: MTT assay

  2009cited by this paper
• Oxygen Toxicity and Reactive Oxygen Species: The Devil Is in the Details

  2009cited by this paper
• Oxygen in Health and Disease: Regulation of Oxygen Homeostasis-Clinical Implications

  2009cited by this paper
• Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α

  2008cited by this paper
• Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability

  2008cited by this paper
• Regulation of gene expression by hypoxia: integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element.

  2008influential reference
• Divergent effects of hypoxia on dendritic cell functions.

  2008cited by this paper
• Microarray Analysis of the Toxicogenomics and the Genotoxic Potential of a Cationic Lipid-Based Gene Delivery Nanosystem in Human Alveolar Epithelial A549 Cells

  2008cited by this paper
• Therapeutic Nanoparticles for Drug Delivery in Cancer

  2008cited by this paper
• Preliminary results of a Cancer Research UK phase I trial combining the dinitrobenzamide prodrug CB1954 (tretazicar) and the NQO2 substrate EP-0152R (caricotamide) intravenously (IV) every 3 weeks

  2008cited by this paper
• Gene Therapy: Some History, Applications, Problems, and Prospects

  2008cited by this paper
• Hypoxia, HIF1 and glucose metabolism in the solid tumour

  2008cited by this paper
• Regulation of hypoxia-inducible factor-1α by NF-κB

  2008cited by this paper
• HIF-1 regulation: not so easy come, easy go.

  2008cited by this paper
• Regulation of gene expression by hypoxia.

  2008cited by this paper
• NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

  2008cited by this paper
• Apoptosis: A Review of Programmed Cell Death

  2007cited by this paper
• Differential regulation of hypoxia-inducible factor-1 through receptor tyrosine kinase transactivation in vascular smooth muscle cells.

  2007cited by this paper
• Discovery of TH-302: An achiral hypoxia-activated cytotoxic prodrug

  2007cited by this paper
• Targeting hypoxia cell signaling for cancer therapy

  2007cited by this paper
• Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.

  2007cited by this paper
• Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

  2007cited by this paper
• Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells.

  2007cited by this paper
• Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site.

  2007cited by this paper
• Reactive Oxygen Species Activate the HIF-1&agr; Promoter Via a Functional NF&kgr;B Site

  2007cited by this paper
• Overexpression of hypoxia-inducible factor-1alpha in human osteosarcoma: correlation with clinicopathological parameters and survival outcome.

  2007cited by this paper

• A Nasal Taxifolin Hydrogel Targets the TLR4/NF-κB/HIF-1α Axis to Suppress Ferroptosis in Alzheimer’s Disease

  2026cites this paper
• Hypoxia signaling in cancer: HIF-1α stimulated by COVID-19 can lead to cancer progression and chemo-resistance in oral squamous cell carcinoma (OSCC)

  2025cites this paper
• A novel pH-sensitive drug carrier system based on 18-crown ether-6/sodium alginate for curcumin/nido-carborane encapsulation: Studies of release properties, cell imaging and bioactivity evaluation

  2024cites this paper
• Chitosan nanoparticles loaded with metformin and digoxin synergistically inhibit MCF-7 breast cancer cells through suppression of NOTCH-1 and HIF-1α gene expression.

  2024cites this paper
• Hybrid polymer-grafted graphene scaffolds for microvascular tissue engineering and regeneration

  2023cites this paper
• MUC1 aptamer-conjugated niclosamide-loaded PLGA-PEG nanoparticle attenuates HIF-1 stabilization upon hypoxia in MCF7 breast cancer cells

  2023cites this paper
• Repurposing alagebrium for diabetic foot ulcer healing: Impact on AGEs/NFκB/NOX1 signaling.

  2023cites this paper
• A Dual-Crosslinked Hydrogel Based on Gelatin Methacryloyl and Sulfhydrylated Chitosan for Promoting Wound Healing

  2023cites this paper
• The role of keratinocyte function on the defected diabetic wound healing.

  2022cites this paper
• Molecular characterisation of coding regions of HIF-1a gene in Vechur cattle by cDNA sequencing

  2022cites this paper
• The Impact of Different Oxygen Delivery Methods on Corneal Epithelial Repair after Injury

  2022cites this paper
• High-Throughput Screening and Molecular Dynamics Simulation of Natural Products for the Identification of Anticancer Agents against MCM7 Protein

  2022cites this paper
• Pharmacoinformatics-based phytochemical screening for anticancer impacts of yellow sweet clover, Melilotus officinalis (Linn.) Pall

  2021cites this paper
• New Advances in the Research of Resistance to Neoadjuvant Chemotherapy in Breast Cancer

  2021cites this paper
• Adipose-Derived Stem Cells Based on Electrospun Biomimetic Scaffold Mediated Endothelial Differentiation Facilitating Regeneration and Repair of Abdominal Wall Defects via HIF-1α/VEGF Pathway

  2021cites this paper
• Sclareol Inhibits Hypoxia-Inducible Factor-1α Accumulation and Induces Apoptosis in Hypoxic Cancer Cells

  2021cites this paper
• The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and Therapy of Central Nervous System Diseases

  2021cites this paper
• Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway

  2020cites this paper
• Role of HIF-1α in Cold Ischemia Injury of Rat Donor Heart Via the miR-21/PDCD4 Pathway.

  2020cites this paper
• LncRNA TMPO-AS1 up-regulates the expression of HIF-1α and promotes the malignant phenotypes of retinoblastoma cells via sponging miR-199a-5p.

  2020cites this paper
• Preservation of alveolar ridge after tooth extraction with hypoxia-inducible factor-1α protein in a dog model

  2019cites this paper
• Triterpenoid corosolic acid attenuates HIF-1 stabilization upon cobalt (II) chloride-induced hypoxia in A549 human lung epithelial cancer cells.

  2019cites this paper
• Renewed interests in carbonic anhydrase IX in relevance to breast cancer treatment

  2019cites this paper
• Antisense LNA-loaded nanoparticles of star-shaped glucose-core PCL-PEG copolymer for enhanced inhibition of oncomiR-214 and nucleolin-mediated therapy of cisplatin-resistant ovarian cancer cells.

  2019cites this paper
• Mechanism and Consequences of The Impaired Hif-1α Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose

  2019cites this paper
• Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis

  2019cites this paper
• Enhanced penetration and cytotoxicity of metformin and collagenase conjugated gold nanoparticles in breast cancer spheroids.

  2019cites this paper
• Modern aspects of regulatory, pathophysiological and toxic effects of cobalt ions during oral intake in the human body

  2019cites this paper
• The Hypoxia-Mimetic Agent Cobalt Chloride Differently Affects Human Mesenchymal Stem Cells in Their Chondrogenic Potential

  2018cites this paper
• Propyl gallate (PG) and tert-butylhydroquinone (TBHQ) may alter the potential anti-cancer behavior of probiotics

  2018cites this paper
• Anti-proliferative activity-guided isolation of clerodermic acid from Salvia nemorosa L.: Geno/cytotoxicity and hypoxia-mediated mechanism of action.

  2018cites this paper
• Hypoxic microenvironment promotes proliferation and invasion of non-small cell lung cancer A549 Cells through Wnt/β-catenin signaling pathway

  2018cites this paper
• HIF1α protein and mRNA expression as a new marker for post mortem interval estimation in human gingival tissue

  2018influential citation
• Stimuli-responsive chitosan-based nanocarriers for cancer therapy

  2017cites this paper
• Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy

  2017cites this paper