Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Molecular Aspects of Medicine

• Publication date

  2016-02-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.mam.2015.12.001PMID 26724171
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Disrupting Na+,HCO3–-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development

  2016cited by this paper
• Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

  2015cited by this paper
• Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

  2015cited by this paper
• Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

  2015cited by this paper
• Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation.

  2015cited by this paper
• Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

  2015cited by this paper
• Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

  2015cited by this paper
• HCO 3 −-cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane

  2015cited by this paper
• MYC, Metabolism, and Cancer.

  2015cited by this paper
• The Na+/HCO3− Co‐Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

  2015cited by this paper
• A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

  2015cited by this paper
• Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.

  2015cited by this paper
• InVivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors

  2015cited by this paper
• Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

  2015cited by this paper
• LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

  2015cited by this paper
• Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival

  2015cited by this paper
• Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes.

  2015cited by this paper
• Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

  2015cited by this paper
• Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.

  2015cited by this paper
• Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.

  2015cited by this paper
• Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

  2015cited by this paper
• A three‐gene panel that distinguishes benign from malignant thyroid nodules

  2015cited by this paper
• Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells

  2015cited by this paper
• Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859.

  2015cited by this paper
• Nutrient-sensing mechanisms and pathways

  2015cited by this paper
• Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

  2015cited by this paper
• Evidence from simultaneous intracellular- and surface-pH transients that carbonic anhydrase II enhances CO2 fluxes across Xenopus oocyte plasma membranes.

  2014cited by this paper
• Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells

  2014cited by this paper
• Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome.

  2014cited by this paper
• Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner

  2014cited by this paper
• Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

  2014cited by this paper
• Intracellular Carbonic Anhydrase Activity Sensitizes Cancer Cell pH Signaling to Dynamic Changes in CO2 Partial Pressure*

  2014cited by this paper
• MCT4 defines a glycolytic subtype of pancreatic cancer with poor prognosis and unique metabolic dependencies.

  2014cited by this paper
• JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells.

  2014cited by this paper
• The chemistry, physiology and pathology of pH in cancer

  2014cited by this paper
• L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

  2014cited by this paper
• Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

  2014cited by this paper
• Evidence from simultaneous intracellular- and surface-pH transients that carbonic anhydrase IV enhances CO2 fluxes across Xenopus oocyte plasma membranes.

  2014cited by this paper
• Evidence from mathematical modeling that carbonic anhydrase II and IV enhance CO2 fluxes across Xenopus oocyte plasma membranes.

  2014cited by this paper
• ErbB2 upregulates the Na+,HCO3‐‐cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Krüppel‐like factor 4

  2014cited by this paper
• Transport of amino acids in the kidney.

  2014cited by this paper
• SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1

  2014cited by this paper
• Monocarboxylic acid transport.

  2013cited by this paper
• Antitumor efficacy of a monoclonal antibody that inhibits the activity of cancer-associated carbonic anhydrase XII.

  2013cited by this paper
• Peroxisome Proliferator Activated Receptor-α/Hypoxia Inducible Factor-1α Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells

  2013cited by this paper
• Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

  2013cited by this paper
• Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

  2013cited by this paper
• The SLC3 and SLC7 families of amino acid transporters.

  2013cited by this paper
• Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

  2013cited by this paper
• Disrupting proton dynamics and energy metabolism for cancer therapy

  2013cited by this paper
• Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma

  2013cited by this paper
• The SLC26 gene family of anion transporters and channels.

  2013cited by this paper
• Acidity generated by the tumor microenvironment drives local invasion.

  2013cited by this paper
• Nutrient transporters: the Achilles' heel of anabolism.

  2013cited by this paper
• Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

  2013cited by this paper
• Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

  2013cited by this paper
• Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

  2013cited by this paper
• Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

  2013cited by this paper
• Contribution of Na+,HCO3−‐cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7)

  2013cited by this paper
• HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.

  2013cited by this paper
• The SLC4 family of bicarbonate (HCO₃⁻) transporters.

  2013cited by this paper
• Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia

  2013cited by this paper
• Expression of glucose transporters in cancers.

  2013cited by this paper
• Using the “reverse Warburg effect” to identify high-risk breast cancer patients

  2012cited by this paper
• The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2.

  2012cited by this paper
• Evolutionary dynamics of carcinogenesis and why targeted therapy does not work

  2012cited by this paper
• Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.

  2012cited by this paper
• Role of monocarboxylate transporters in human cancers: state of the art

  2012cited by this paper
• Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas

  2012cited by this paper
• Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4.

  2012cited by this paper
• Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

  2012cited by this paper
• Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis.

  2012cited by this paper
• Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

  2012cited by this paper
• Leucyl-tRNA synthetase controls TORC1 via the EGO complex.

  2012cited by this paper
• Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target

  2012cited by this paper
• Role of ion channels and transporters in cell migration.

  2012cited by this paper
• HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.

  2012cited by this paper
• The monocarboxylate transporter family—Structure and functional characterization

  2012cited by this paper
• In vivo pH in metabolic‐defective Ras‐transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH

  2012cited by this paper
• Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

  2011cited by this paper
• Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes

  2011cited by this paper
• Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.

  2011cited by this paper
• Overexpression of carbonic anhydrase XII in tissues from resectable non‐small cell lung cancers is a biomarker of good prognosis

  2011cited by this paper
• Lactate: a metabolic key player in cancer.

  2011cited by this paper
• Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.

  2011cited by this paper
• Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4

  2011cited by this paper
• Evidence for a stromal-epithelial “lactate shuttle” in human tumors

  2011cited by this paper
• Interfering with pH regulation in tumours as a therapeutic strategy

  2011cited by this paper
• Dysregulated pH: a perfect storm for cancer progression

  2011cited by this paper
• Differentiation and upregulation of heat shock protein 70 induced by a subset of histone deacetylase inhibitors in mouse and human embryonic stem cells.

  2011cited by this paper
• Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.

  2011cited by this paper
• Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain*

  2011cited by this paper
• CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

  2011cited by this paper
• Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

  2011cited by this paper
• Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.

  2011cited by this paper
• pH control mechanisms of tumor survival and growth

  2011cited by this paper
• Ketones and lactate “fuel” tumor growth and metastasis

  2010cited by this paper
• Nonenzymatic Augmentation of Lactate Transport via Monocarboxylate Transporter Isoform 4 by Carbonic Anhydrase II

  2010cited by this paper
• Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration.

  2010cited by this paper
• NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance.

  2010cited by this paper

• Exploring metabolic biomarkers in primary and chemoreduced retinoblastoma with patient outcome

  2025cites this paper
• PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer

  2024cites this paper
• Tumor perfusion enhancement by microbubbles ultrasonic cavitation reduces tumor glycolysis metabolism and alleviate tumor acidosis

  2024cites this paper
• Hypoxia-associated markers in the prognosis of oral canine melanoma

  2024cites this paper
• HIF: a master regulator of nutrient availability and metabolic cross‐talk in the tumor microenvironment

  2023cites this paper
• HIF-2 Regulation of Amino Acid Transporter Expression in Hepatocellular Carcinoma Cells

  2023cites this paper
• Association of Smoking and Respiratory Disease History with Pancreatic Pathologies Requiring Surgical Resection

  2023cites this paper
• Hypercapnic Tissue Gene Expression and Survival in Early-Stage Pancreatic Ductal Adenocarcinoma.

  2023cites this paper
• Modulating Tumor Physical Microenvironment for Fueling CAR-T Cell Therapy.

  2022cites this paper
• Metabolism heterogeneity in melanoma fuels deactivation of immunotherapy: Predict before protect

  2022cites this paper
• The effect of HIF-1α inhibition in breast cancer cells prior to doxorubicin treatment under conditions of normoxia and hypoxia.

  2022cites this paper
• How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity

  2022cites this paper
• The Key Network of mRNAs and miRNAs Regulated by HIF1A in Hypoxic Hepatocellular Carcinoma Cells

  2022cites this paper
• Arracacia xanthorrhiza Bancr compounds decrease β-actin, hypoxia-inducible factor-1 and nitric oxide production in HeLa cells

  2022cites this paper
• pH regulators of the tumoral microenvironment: A general overview

  2021cites this paper
• Hypoxia boosts aerobic glycolysis of carcinoma：a complex process for tumor development.

  2021cites this paper
• SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress

  2021cites this paper
• Targeting hypoxia and hypoxia‐inducible factor‐1 in the tumor microenvironment for optimal cancer immunotherapy

  2021cites this paper
• Modulating hypoxia inducible factor-1 by nanomaterials for effective cancer therapy.

  2021cites this paper
• Transport Metabolons and Acid/Base Balance in Tumor Cells

  2020cites this paper
• Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells

  2020cites this paper
• Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice.

  2020cites this paper
• Overcoming Hypoxia-Induced Chemoresistance in Cancer Using a Novel Glycoconjugate of Methotrexate

  2020cites this paper
• Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance

  2020influential citation
• Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.

  2020cites this paper
• Clinical significance and in vitro cellular regulation of hypoxia mimicry on HIF-1α and downstream genes in canine appendicular osteosarcoma.

  2020cites this paper
• Immunity, Hypoxia and Metabolism - the ménage à trois of cancer: implications for immunotherapy.

  2019cites this paper
• MCT1, MCT4 and CD147 expression and 3-bromopyruvate toxicity in colorectal cancer cells are modulated by the extracellular conditions

  2019cites this paper
• Carbonic anhydrase inhibitors for the treatment of tumors

  2019cites this paper
• Investigation of the Role of Glucose Decorated Chitosan and PLGA Nanoparticles as Blocking Agents to Glucose Transporters of Tumor Cells

  2019cites this paper
• Carbonic anhydrase IX and acid transport in cancer

  2019cites this paper
• Heterogeneous impact of hypoxia on cellular radiation sensitivity of three squamous cell carcinoma lines

  2018cites this paper
• Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

  2018cites this paper
• The role of hypoxia-inducible factors in leukemias.

  2018cites this paper
• Minimal models of invasion and clonal selection in cancer

  2018cites this paper
• Non-dye cell viability monitoring by using pH-responsive inverse opal hydrogels.

  2018cites this paper
• Potentiation of paclitaxel effect by resveratrol in human breast cancer cells by counteracting the 17β‐estradiol/estrogen receptor α/neuroglobin pathway

  2018cites this paper
• Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

  2018cites this paper
• Hypoxic microenvironment promotes proliferation and invasion of non-small cell lung cancer A549 Cells through Wnt/β-catenin signaling pathway

  2018cites this paper
• The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

  2018cites this paper
• In vitro studies on the biological effects of cerium oxide nanoparticles

  2017cites this paper
• Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia.

  2017cites this paper
• Targeting pH regulating proteins for cancer therapy-Progress and limitations.

  2017cites this paper
• Beyond just hemoglobin: Red blood cell potentiation of hemoglobin-oxygen unloading in fish.

  2017cites this paper
• NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion

  2017cites this paper
• Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies.

  2017cites this paper
• Proteus mirabilis inhibits cancer growth and pulmonary metastasis in a mouse breast cancer model

  2017cites this paper
• Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells.

  2017cites this paper
• Hypoxia and cellular metabolism in tumour pathophysiology

  2017cites this paper
• Value of pH regulators in the diagnosis, prognosis and treatment of cancer.

  2017cites this paper
• Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy

  2017cites this paper
• Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer.

  2017cites this paper
• Hypoxia-Inducible Factors and Cancer

  2017cites this paper
• Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes

  2017cites this paper
• Neuroglobin: From structure to function in health and disease.

  2016cites this paper
• CD98 signals controlling tumorigenesis.

  2016cites this paper
• Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

  2016cites this paper
• Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

  2016cites this paper
• Acides aminés et cancer : LAT1, un transporteur essentiel à l’activité mTORC1 et la croissance tumorale

  2016cites this paper
• Notch1 is associated with the multidrug resistance of hypoxic osteosarcoma by regulating MRP1 gene expression.

  2016cites this paper
• Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.

  2016cites this paper
• Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia

  2016cites this paper
• Selection of antitumor displayed peptides for the specific delivery of the anticancer drug lactaptin

  2016cites this paper
• Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

  2016cites this paper
• An exactly solvable, spatial model of mutation accumulation in cancer

  2016cites this paper