MYC, Metabolism, and Cancer.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cancer Discovery

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/2159-8290.CD-15-0507PMID 26382145PMCID PMC4592441
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondria and Cancer.

  2016cited by this paper
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  2015influential reference
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• Reduced expression of MYC increases longevity and enhances healthspan.

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• Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

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• Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming.

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• A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

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• Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.

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• Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

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• Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control

  2014cited by this paper
• Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

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• Synthetic lethal screens as a means to understand and treat MYC-driven cancers.

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• Socializing with MYC: cell competition in development and as a model for premalignant cancer.

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• Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

  2014influential reference
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• Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

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• Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.

  2013cited by this paper
• Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.

  2013cited by this paper
• Cellular MYCro economics: Balancing MYC function with MYC expression.

  2013cited by this paper
• BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.

  2013cited by this paper
• Pan-cancer patterns of somatic copy-number alteration

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• MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

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• Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels

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• Modulation of oxidative stress as an anticancer strategy

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• Dysregulation of the basal RNA polymerase transcription apparatus in cancer

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  2012influential reference
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