Tissue engineering and regenerative medicine –where do we stand?

Introduction Intrinsic and extrinsic vascularization of TE constructs – the AV‐loop model Gene Transfer Techniques Combining mesenchymal stem cells with the AV‐loop model of intrinsic vascularization TE and RM in the context of Cancer Research Newly discovered cells of potential benefit for RM Summary

• Publication year

  2012

• Venue

  Journal of Cellular and Molecular Medicine

• Publication date

  2012-05-28

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1111/j.1582-4934.2012.01564.xPMID 22436120PMCID 3823070
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Journal of Cellular and Molecular Medicine

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• Identification of telocytes in the upper lamina propria of the human urinary tract

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• New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies

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• Cardiac telocytes — their junctions and functional implications

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• Regenerative medicine strategies.

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• Osteoinduction and survival of osteoblasts and bone-marrow stromal cells in 3D biphasic calcium phosphate scaffolds under static and dynamic culture conditions

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• Tracheal telocytes

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• Telocyte morphologies and potential roles in diseases

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• Nanofibrous Collagen Nerve Conduits for Spinal Cord Repair

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• Human embryonic stem cells: early hints on safety and efficacy.

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• Telocytes in parotid glands.

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  2012influential reference
• Mesenchymal stem cells: application for solid-organ transplantation

  2012cited by this paper
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  2010influential reference
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  2007influential reference
• The history of tissue engineering

  2006cited by this paper
• History of Tissue Engineering and A Glimpse Into Its Future

  2006cited by this paper
• Intrinsic versus extrinsic vascularization in tissue engineering.

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  2006cited by this paper
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  2006cited by this paper
• [Prevascularisation strategies in tissue engineering].

  2006influential reference
• Impact of Expansion and Redifferentiation Conditions on Chondrogenic Capacity of Cultured Chondrocytes

  2006cited by this paper
• Highly efficient regulation of gene expression by tetracycline in a replication-defective herpes simplex viral vector.

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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation.

  2000cited by this paper
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  2000cited by this paper
• The science of tissue engineering.

  2000cited by this paper
• Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering.

  2000cited by this paper
• VEGF gene delivery to myocardium: deleterious effects of unregulated expression.

  2000cited by this paper
• Viral vector delivery in solid-state vehicles: gene expression in a murine prostate cancer model.

  2000cited by this paper
• Virus treatment questioned after gene therapy death

  1999cited by this paper
• Flap prefabrication in the head and neck: a 10-year experience.

  1999cited by this paper
• Binding of Basic Fibroblast Growth Factor to Fibrinogen and Fibrin*

  1998cited by this paper
• Tissue engineering.

  1998cited by this paper
• The effect of recombinant basic fibroblast growth factor (bFGF) in fibrin adhesive vehicle on the healing of ischaemic and normal incisional skin wounds.

  1998cited by this paper
• Fibrin sealant: current and potential clinical applications.

  1996cited by this paper
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  1996cited by this paper
• About the authors

  1995cited by this paper

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  2016cites this paper
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