Tip cells: Master regulators of tubulogenesis?

Highlights • Single tip cells or groups of leading cells develop at the forefront of growing tissues.• Tip cells regulate tubule growth and morphogenesis.• Tip cells develop distinctive patterns of gene expression and specialised characteristics.• Tip cells are required for health and may be involved in the progression of cancer.

• Publication year

  2014

• Venue

  Seminars in Cell and Developmental Biology

• Publication date

  2014-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.semcdb.2014.04.009PMID 24721475PMCID 4071413
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specification of leading and trailing cell features during collective migration in the Drosophila trachea

  2014cited by this paper
• Epidermal Growth Factor Signalling Controls Myosin II Planar Polarity to Orchestrate Convergent Extension Movements during Drosophila Tubulogenesis

  2014cited by this paper
• The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila

  2013cited by this paper
• VEGF and Notch in tip and stalk cell selection.

  2013cited by this paper
• Tip Cells Act as Dynamic Cellular Anchors in the Morphogenesis of Looped Renal Tubules in Drosophila

  2013cited by this paper
• The making of a fusion branch in the Drosophila trachea.

  2012cited by this paper
• Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite

  2012cited by this paper
• Distinct cellular mechanisms of blood vessel fusion in the zebrafish embryo.

  2011cited by this paper
• Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo

  2011cited by this paper
• Hypoxia-induced angiogenesis: good and evil.

  2011cited by this paper
• Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels

  2011cited by this paper
• Control of Mitotic Spindle Angle by the RAS-Regulated ERK1/2 Pathway Determines Lung Tube Shape

  2011cited by this paper
• The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling

  2011cited by this paper
• The developmental, molecular, and transport biology of Malpighian tubules.

  2010cited by this paper
• Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.

  2010cited by this paper
• Tracheal remodelling in response to hypoxia

  2010cited by this paper
• Vascular morphogenesis in the zebrafish embryo.

  2010cited by this paper
• Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

  2010cited by this paper
• Hemocyte-Secreted Type IV Collagen Enhances BMP Signaling to Guide Renal Tubule Morphogenesis in Drosophila

  2010cited by this paper
• Angiogenesis: a team effort coordinated by notch.

  2009cited by this paper
• Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

  2009cited by this paper
• Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis

  2009cited by this paper
• Collective cell migration in morphogenesis, regeneration and cancer

  2009cited by this paper
• Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.

  2009cited by this paper
• Tip-cell migration controls stalk-cell intercalation during Drosophila tracheal tube elongation.

  2008cited by this paper
• Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture

  2008cited by this paper
• Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis.

  2008cited by this paper
• Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase.

  2008cited by this paper
• Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries

  2007cited by this paper
• Reciprocal asymmetry of SYS-1/β-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans

  2007cited by this paper
• Regulation of vascular morphogenesis by Notch signaling.

  2007cited by this paper
• Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration

  2007cited by this paper
• Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans.

  2006cited by this paper
• Renal branching morphogenesis: concepts, questions, and recent advances.

  2006cited by this paper
• GDNF/Ret signaling and the development of the kidney.

  2006cited by this paper
• Faculty Opinions recommendation of A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling.

  2006cited by this paper
• From fate to function: the Drosophila trachea and salivary gland as models for tubulogenesis.

  2006cited by this paper
• Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells.

  2006cited by this paper
• Social interactions among epithelial cells during tracheal branching morphogenesis

  2006cited by this paper
• Organ positioning in Drosophila requires complex tissue-tissue interactions.

  2005cited by this paper
• A-Catenin Identified by Functional Rather Than Sequence Criteria and Its Role in Wnt / MAPK Signaling

  2005cited by this paper
• Renal tubule development in Drosophila: a closer look at the cellular level.

  2005cited by this paper
• Developmental decisions in Dictyostelium discoideum.

  2005cited by this paper
• Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation

  2004cited by this paper
• Pattern and regulation of cell proliferation during murine ureteric bud development

  2004cited by this paper
• Fine structure of the protonephridial system in planaria

  2004cited by this paper
• Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea

  2004cited by this paper
• Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney.

  2004cited by this paper
• The ultrastructure of the protonephridial flame cell of the freshwater planarian Bdellocephala brunnea

  2004cited by this paper
• Fine structure of the protonephridial system in planaria

  2004cited by this paper
• Novel functions and signalling pathways for GDNF

  2003cited by this paper
• Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.

  2003cited by this paper
• POP-1 controls axis formation during early gonadogenesis in C. elegans.

  2002cited by this paper
• In vivo imaging of embryonic vascular development using transgenic zebrafish.

  2002cited by this paper
• Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.

  2002cited by this paper
• Short Stop provides an essential link between F-actin and microtubules during axon extension.

  2002cited by this paper
• In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis.

  2002cited by this paper
• A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila.

  2002cited by this paper
• JCB Article

  2001cited by this paper
• Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney.

  2001cited by this paper
• Cell migration in invertebrates: clues from border and distal tip cells.

  2001cited by this paper
• Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis.

  2001cited by this paper
• An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.

  2000cited by this paper
• Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.

  2000cited by this paper
• CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans

  2000cited by this paper
• Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules.

  2000cited by this paper
• Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.

  2000cited by this paper
• Cell fate choices in Drosophila tracheal morphogenesis

  2000cited by this paper
• A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.

  2000cited by this paper
• Coordinating cell fate and morphogenesis in Drosophila renal tubules.

  2000cited by this paper
• Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line

  1999cited by this paper
• Fgf10 is essential for limb and lung formation

  1999cited by this paper
• Fibroblast growth factor interactions in the developing lung.

  1999cited by this paper
• Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis.

  1999cited by this paper
• Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans

  1999cited by this paper
• The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.

  1999cited by this paper
• Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF.

  1999cited by this paper
• Regulated nuclear import of Rel proteins in the Drosophila immune response

  1998cited by this paper
• The RET–Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells

  1998cited by this paper
• Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.

  1998cited by this paper
• Activation of Rac1 by a Crk SH3-binding protein, DOCK180.

  1998cited by this paper
• Activation of Rac 1 by a Crk SH 3-binding protein , DOCK 180

  1998cited by this paper
• C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

  1998cited by this paper
• Fibroblast Growth Factor 10 ( FGF 10 ) and branching morphogenesis in the embryonic mouse lung

  1997cited by this paper
• Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.

  1997cited by this paper
• The tip-top branching ureter.

  1997cited by this paper
• Genetic control of epithelial tube fusion during Drosophila tracheal development.

  1996cited by this paper
• branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.

  1996cited by this paper
• Symmetry breakage in the development of one-armed gonads in nematodes.

  1996cited by this paper
• Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.

  1996cited by this paper
• Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in Dictyostelium.

  1995cited by this paper
• Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila.

  1994influential reference
• The Drosophila EGF receptor homologue (DER) is required for Malpighian tubule development.

  1993cited by this paper
• breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

  1992cited by this paper
• Whole-embryo culture of Drosophila : development of embryonic tissues in vitro

  1992cited by this paper
• Cell proliferation and rearrangement in the development of the malpighian tubules of the hemipteran, Rhodnius prolixus.

  1992cited by this paper
• Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.

  1991cited by this paper
• The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans.

  1990cited by this paper
• Cell division in Malpighian tubule development in D. melanogaster is regulated by a single tip cell

  1989cited by this paper
• Excretion in the house cricket (Acheta domesticus): fine structure of the Malpighian tubules.

  1988cited by this paper

• P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis

  2025cites this paper
• Akt/PKB Functions in Cell Migration and Invasion.

  2025cites this paper
• The role of oligodendrocyte progenitor cells in the spatiotemporal vascularization of the human and mouse neocortex

  2024cites this paper
• Exploring vasculogenesis in the normal human kidney and clear cell renal cell carcinoma: insights from development to tumor progression and biomarkers for therapy response

  2024cites this paper
• G protein subunit alpha i2's pivotal role in angiogenesis

  2024cites this paper
• Lung patterning: Is a distal‐to‐proximal gradient of cell allocation and fate decision a general paradigm?

  2023cites this paper
• Anatomy, Endocrine Regulation and Embryonic Development of the Rete Testis.

  2021cites this paper
• Physiology, Development, and Disease Modeling in the Drosophila Excretory System

  2020cites this paper
• The apical cell - An enigmatic somatic cell in leech ovaries - Structure and putative functions.

  2020cites this paper
• The endothelial tip-stalk cell selection and shuffling during angiogenesis

  2019cites this paper
• Cell-based simulations of biased epithelial lung growth

  2019cites this paper
• Making Heads or Tails of It: Cell-Cell Adhesion in Cellular and Supracellular Polarity in Collective Migration.

  2017cites this paper
• Morphofunctional basis of the different types of angiogenesis and formation of postnatal angiogenesis-related secondary structures.

  2017cites this paper
• 3D biomimetic model for cellular invasion in angiogenesis and cancer

  2016cites this paper
• Extracellular Matrix Remodeling and the Control of Branching Morphogenetic Programs.

  2016cites this paper
• A new paradigm for animal symmetry

  2015cites this paper
• Collective cell migration: guidance principles and hierarchies.

  2015cites this paper