Astrocytes’ Contribution to Adult Neurogenesis in Physiology and Alzheimer’s Disease

Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there is a growing body of evidence showing that, in the hippocampus, this process contributes to mechanisms of memory as well as depression. Interestingly, adult neurogenesis is tightly regulated by the neurogenic niche, which provides a structural and molecular scaffold for stem cell proliferation and the differentiation and functional integration of new neurons. In this review, we highlight the role of astrocytes in the regulation of adult neurogenesis in the context of cognitive function. We also discuss how the changes in astrocytes function may dysregulate adult neurogenesis and contribute to cognitive impairment in the context of Alzheimer’s disease.

• Publication year

  2018

• Venue

  Frontiers in Cellular Neuroscience

• Publication date

  2018-11-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fncel.2018.00432PMID 30538622PMCID 6277517
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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