Promoter-proximal pausing of RNA polymerase II: an opportunity to regulate gene transcription

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Receptor and Signal Transduction Research

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3109/10799890903517921PMID 20170405
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcription Factors

  2010cited by this paper
• The transcription elongation factors NELF, DSIF and P‐TEFb control constitutive transcription in a gene‐specific manner

  2009cited by this paper
• Paused Pol II captures enhancer activity and acts as a potent insulator.

  2009cited by this paper
• Negative elongation factor NELF controls transcription of immediate early genes in a stimulus-specific manner.

  2009cited by this paper
• A functional NF-kappaB enhancer element in the first intron contributes to the control of c-fos transcription.

  2009cited by this paper
• NELF and GAGA Factor Are Linked to Promoter-Proximal Pausing at Many Genes in Drosophila

  2008cited by this paper
• Divergent Transcription from Active Promoters

  2008cited by this paper
• Promoter elements associated with RNA Pol II stalling in the Drosophila embryo

  2008influential reference
• Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

  2008cited by this paper
• Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

  2008cited by this paper
• Gene Expression--Where to Start?

  2008cited by this paper
• The Antisense Transcriptomes of Human Cells

  2008cited by this paper
• RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters

  2008cited by this paper
• NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly.

  2008cited by this paper
• RNA‐driven cyclin‐dependent kinase regulation: When CDK9/cyclin T subunits of P‐TEFb meet their ribonucleoprotein partners

  2008cited by this paper
• Poised polymerases: on your mark...get set...go!

  2008cited by this paper
• The transition from transcriptional initiation to elongation.

  2008cited by this paper
• Identification of Spt5 Target Genes in Zebrafish Development Reveals Its Dual Activity In Vivo

  2008cited by this paper
• MicroRNA-133 controls cardiac hypertrophy

  2007cited by this paper
• HEXIM1 and the Control of Transcription Elongation: From Cancer and Inflammation to AIDS and Cardiac Hypertrophy

  2007cited by this paper
• The Diverse Biological Roles of MYST Histone Acetyltransferase Family Proteins

  2007cited by this paper
• Gene-specific recruitment of positive and negative elongation factors during stimulated transcription of the MKP-1 gene in neuroendocrine cells

  2007cited by this paper
• RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo

  2007cited by this paper
• P-TEFb Is Critical for the Maturation of RNA Polymerase II into Productive Elongation In Vivo

  2007cited by this paper
• Up-Regulation of P-TEFb by the MEK1-Extracellular Signal-Regulated Kinase Signaling Pathway Contributes to Stimulated Transcription Elongation of Immediate Early Genes in Neuroendocrine Cells

  2007influential reference
• RNA polymerase is poised for activation across the genome

  2007cited by this paper
• Characterization of hampin/MSL1 as a node in the nuclear interactome.

  2007cited by this paper
• Properties of RNA Polymerase II Elongation Complexes Before and After the P-TEFb-mediated Transition into Productive Elongation*

  2007cited by this paper
• A chromatin landmark and transcription initiation at most promoters in human cells.

  2007cited by this paper
• The Rate of c-fos Transcription in Vivo Is Continuously Regulated at the Level of Elongation by Dynamic Stimulus-coupled Recruitment of Positive Transcription Elongation Factor b*

  2007influential reference
• NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.

  2007cited by this paper
• Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells

  2007cited by this paper
• P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.

  2006cited by this paper
• The Spt4p Subunit of Yeast DSIF Stimulates Association of the Paf1 Complex with Elongating RNA Polymerase II

  2006cited by this paper
• Transcriptional Pausing Caused by NELF Plays a Dual Role in Regulating Immediate-Early Expression of the junB Gene

  2006cited by this paper
• The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation

  2006influential reference
• Controlling the elongation phase of transcription with P-TEFb.

  2006influential reference
• A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS.

  2005cited by this paper
• A high-resolution map of active promoters in the human genome

  2005cited by this paper
• Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS.

  2005cited by this paper
• The etiology of Wolf-Hirschhorn syndrome.

  2005cited by this paper
• Zebrafish foggy/spt5 is required for migration of facial branchiomotor neurons but not for their survival

  2005cited by this paper
• Elongation by RNA polymerase II: the short and long of it.

  2004cited by this paper
• Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.

  2004cited by this paper
• Pituitary cell lines and their endocrine applications.

  2004cited by this paper
• Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II.

  2004cited by this paper
• Dynamics of Human Immunodeficiency Virus Transcription: P-TEFb Phosphorylates RD and Dissociates Negative Effectors from the Transactivation Response Element

  2004cited by this paper
• The link between mRNA processing and transcription: communication works both ways.

  2004cited by this paper
• Activation of cardiac Cdk9 represses PGC‐1 and confers a predisposition to heart failure

  2004influential reference
• Cyclin-Dependent Kinase-9 An RNAPII Kinase at the Nexus of Cardiac Growth and Death Cascades

  2004influential reference
• Facts about FACT and transcript elongation through chromatin.

  2004cited by this paper
• Biological control through regulated transcriptional coactivators.

  2004cited by this paper
• Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex

  2003influential reference
• Cyclins That Don’t Cycle : Cyclin T/Cyclin-Dependent Kinase-9 Determines Cardiac Muscle Cell Size

  2003cited by this paper
• Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.

  2003cited by this paper
• In Vivo Evidence that Defects in the Transcriptional Elongation Factors RPB2, TFIIS, and SPT5 Enhance Upstream Poly(A) Site Utilization

  2003cited by this paper
• NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila.

  2003cited by this paper
• Transcriptional control during mammalian anterior pituitary development.

  2003cited by this paper
• Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation.

  2003cited by this paper
• Tracking FACT and the RNA Polymerase II Elongation Complex Through Chromatin in Vivo

  2003cited by this paper
• Dual Roles for Spt5 in Pre-mRNA Processing and Transcription Elongation Revealed by Identification of Spt5-Associated Proteins

  2003cited by this paper
• The mediator coactivator complex: functional and physical roles in transcriptional regulation

  2003cited by this paper
• Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat Shock

  2003cited by this paper
• Review a Unified Theory of Gene Expression of Metabolic Enzymes Are Often Regulated Directly by Metabolites. Once Activated, Transcription Factors Bind Syngenta Central Toxicology Laboratory to Gene Regulatory Elements And, through Interactions Alderley Park with Other Components of the Transcriptio

  2002influential reference
• Evidence that Negative Elongation Factor Represses Transcription Elongation through Binding to a DRB Sensitivity-Inducing Factor/RNA Polymerase II Complex and RNA

  2002influential reference
• The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

  2002cited by this paper
• The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.

  2002cited by this paper
• Rho-dependent termination and ATPases in transcript termination.

  2002cited by this paper
• Interactions between Fission Yeast mRNA Capping Enzymes and Elongation Factor Spt5*

  2002cited by this paper
• Activation and function of cyclin T–Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy

  2002cited by this paper
• Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences

  2002cited by this paper
• Genetic interactions of Spt4-Spt5 and TFIIS with the RNA polymerase II CTD and CTD modifying enzymes in Saccharomyces cerevisiae.

  2001cited by this paper
• Positive Transcription Elongation Factor b Phosphorylates hSPT5 and RNA Polymerase II Carboxyl-terminal Domain Independently of Cyclin-dependent Kinase-activating Kinase*

  2001cited by this paper
• MAP Kinase Phosphatase-1 Gene Transcription in Rat Neuroendocrine Cells Is Modulated by a Calcium-sensitive Block to Elongation in the First Exon*

  2001cited by this paper
• New Roles for Introns: Sites of Combinatorial Regulation of Ca2+- and Cyclic AMP-Dependent Gene Transcription

  2001cited by this paper
• A Highly Purified RNA Polymerase II Elongation Control System*

  2001cited by this paper
• RNA polymerase II and the integration of nuclear events.

  2000influential reference
• Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation.

  2000influential reference
• Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties

  2000cited by this paper
• Essentiality of intron control in the induction of c‐fos by glucose and glucoincretin peptides in INS‐1 β‐cells

  2000cited by this paper
• Transcription elongation factor SII

  2000cited by this paper
• Essential Contribution of Intron Sequences to Ca2+-Dependent Activation of c-fos Transcription in Pituitary Cells

  2000cited by this paper
• FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

  2000cited by this paper
• Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation.

  2000cited by this paper
• A regulator of transcriptional elongation controls vertebrate neuronal development

  2000influential reference
• Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster.

  2000cited by this paper
• High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation.

  2000cited by this paper
• Transcription elongation factor hSPT5 stimulates mRNA capping.

  1999cited by this paper
• A Novel Calcium Signaling Pathway Targets the c-fosIntragenic Transcriptional Pausing Site*

  1999cited by this paper
• NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

  1999cited by this paper
• Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region.

  1999influential reference
• Calcium signalling and gene expression.

  1999cited by this paper
• Structure and Function of the Human Transcription Elongation Factor DSIF*

  1999cited by this paper
• Evidence that P‐TEFb alleviates the negative effect of DSIF on RNA polymerase II‐dependent transcription in vitro

  1998cited by this paper
• Transcription factors and asthma.

  1998cited by this paper
• DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.

  1998cited by this paper
• Regulation of c-fos expression by RNA polymerase elongation competence.

  1998cited by this paper
• Factors regulating the transcriptional elongation activity of RNA polymerase II

  1998cited by this paper
• Basic mechanisms of transcript elongation and its regulation.

  1997influential reference
• Mutations in the SPT4, SPT5, and SPT6 genes alter transcription of a subset of histone genes in Saccharomyces cerevisiae.

  1996cited by this paper

• NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression

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• Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis in Drosophila eye

  2023cites this paper
• Defining the divergent enzymatic properties of RNA polymerases I and II

  2020cites this paper
• Enhancers predominantly regulate gene expression in vivo via transcription initiation

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• Acute Stress Enhances Epigenetic Modifications But Does Not Affect the Constitutive Binding of pCREB to Immediate-Early Gene Promoters in the Rat Hippocampus

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• Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation

  2015cites this paper
• The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription.

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• Histone Cross-talk Connects Protein Phosphatase 1α (PP1α) and Histone Deacetylase (HDAC) Pathways to Regulate the Functional Transition of Bromodomain-containing 4 (BRD4) for Inducible Gene Expression*

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• The effect of histone deacetylase inhibitors on SRC and BCL2L1 gene expression and a potential role for phosphatases in their transcriptional repression

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• Caenorhabditis elegans Dosage Compensation Directs Chromatin and Transcriptional Regulation on Hermaphrodite X Chromosomes.

  2012cites this paper
• Function and regulation of the Super Elongation Complexes in HIV-1 transcription

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• The gene-specific codon counting database: a genome-based catalog of one-, two-, three-, four- and five-codon combinations present in Saccharomyces cerevisiae genes

  2012cites this paper
• Interaction of RNA Polymerase II Fork Loop 2 with Downstream Non-template DNA Regulates Transcription Elongation*

  2011cites this paper
• Transcription elongation factors are involved in programming hormone production in pituitary neuroendocrine GH4C1 cells.

  2010cites this paper