Award Number: W81XWH-05-1-0295 TITLE: Characterization of a SUMO Ligase that is Essential for DNA Damage-Induced NF-Kappa B Activation

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  2007

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• Integrating cell-signalling pathways with NF-kappaB and IKK function.

  2007cited by this paper
• NF-κB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage

  2007cited by this paper
• Autoproteolysis of PIDD marks the bifurcation between pro‐death caspase‐2 and pro‐survival NF‐κB pathway

  2007cited by this paper
• Posttranslational modifications of NEMO and its partners in NF-κB signaling

  2006cited by this paper
• Dimerization of the IκB Kinase-Binding Domain of NEMO Is Required for Tumor Necrosis Factor Alpha-Induced NF-κB Activity

  2006cited by this paper
• An extended consensus motif enhances the specificity of substrate modification by SUMO

  2006cited by this paper
• Mutations in the NF-kappaB signaling pathway: implications for human disease.

  2006cited by this paper
• Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*

  2006cited by this paper
• Ubiquitin and SUMO systems in the regulation of mitotic checkpoints.

  2006cited by this paper
• Introduction to NF-kappaB: players, pathways, perspectives.

  2006cited by this paper
• Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFκB-dependent transcription

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• IκB kinase complexes: gateways to NF-κB activation and transcription

  2006cited by this paper
• Transcriptional regulation via the NF-κB signaling module

  2006cited by this paper
• A Novel Link Between SUMO Modification and Cancer Metastasis

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• Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

  2006cited by this paper
• SUSP1 antagonizes formation of highly SUMO2/3-conjugated species

  2006cited by this paper
• Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates

  2006cited by this paper
• Role of desumoylation in the development of prostate cancer.

  2006cited by this paper
• Signals from within: the DNA-damage-induced NF-kappaB response.

  2006cited by this paper
• PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress

  2006cited by this paper
• Calcium-Dependent Regulation of NEMO Nuclear Export in Response to Genotoxic Stimuli

  2006cited by this paper
• Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

  2006cited by this paper
• The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.

  2006cited by this paper
• The SUMO-Specific Protease SENP5 Is Required for Cell Division

  2006cited by this paper
• Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

  2006cited by this paper
• SUMOsp: a web server for sumoylation site prediction

  2006cited by this paper
• The Interaction of Piasy with Trim32, an E3-Ubiquitin Ligase Mutated in Limb-girdle Muscular Dystrophy Type 2H, Promotes Piasy Degradation and Regulates UVB-induced Keratinocyte Apoptosis through NFκB*

  2006cited by this paper
• Nuclear factor-kappaB in cancer development and progression.

  2006cited by this paper
• The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.

  2005cited by this paper
• dUbc9 negatively regulates the Toll-NF-kappa B pathways in larval hematopoiesis and drosomycin activation in Drosophila.

  2005cited by this paper
• Negative Regulation of NF-κB Signaling by PIAS1

  2005cited by this paper
• SUMO: a history of modification.

  2005cited by this paper
• Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity.

  2005cited by this paper
• Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator.

  2005cited by this paper
• PIDD mediates NF-kappaB activation in response to DNA damage.

  2005cited by this paper
• A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.

  2005cited by this paper
• A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

  2005cited by this paper
• Negative regulation of NF-kappaB signaling by PIAS1.

  2005cited by this paper
• The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.

  2005cited by this paper
• PIDD Mediates NF-k BA ctivation in Response to DNA Damage

  2005cited by this paper
• SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.

  2005cited by this paper
• Enhanced G2-M Arrest by Nuclear Factor-κB-Dependent p21waf1/cip1 Induction

  2005cited by this paper
• Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex

  2005cited by this paper
• PPAR gamma, 10 years later.

  2005cited by this paper
• Mutation of SENP1/SuPr-2 Reveals an Essential Role for Desumoylation in Mouse Development

  2005cited by this paper
• PIASy mediates SUMO‐2 conjugation of Topoisomerase‐II on mitotic chromosomes

  2005cited by this paper
• A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.

  2004cited by this paper
• Regulation of Constitutive p50/c-Rel Activity via Proteasome Inhibitor-Resistant IκBα Degradation in B Cells

  2004cited by this paper
• SUMO: a regulator of gene expression and genome integrity

  2004cited by this paper
• PIASy-Deficient Mice Display Modest Defects in IFN and Wnt Signaling1

  2004cited by this paper
• A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

  2004cited by this paper
• The two NF-kappaB activation pathways and their role in innate and adaptive immunity.

  2004cited by this paper
• PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.

  2004cited by this paper
• Protein Inhibitor of Activated STAT Y (PIASy) and a Splice Variant Lacking Exon 6 Enhance Sumoylation but Are Not Essential for Embryogenesis and Adult Life

  2004cited by this paper
• Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis

  2004cited by this paper
• PIAS3 Suppresses NF-κB-mediated Transcription by Interacting with the p65/RelA Subunit*

  2004cited by this paper
• SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

  2004cited by this paper
• PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity

  2004cited by this paper
• The Trimerization Domain of Nemo Is Composed of the Interacting C-terminal CC2 and LZ Coiled-coil Subdomains*

  2004cited by this paper
• PIASy-mediated repression of the androgen receptor is independent of sumoylation

  2004cited by this paper
• Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression.

  2004cited by this paper
• Signaling to NF-kappaB.

  2004cited by this paper
• Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.

  2003cited by this paper
• Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.

  2003cited by this paper
• The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation.

  2003cited by this paper
• P300 transcriptional repression is mediated by SUMO modification.

  2003cited by this paper
• At the crossroads of SUMO and NF-κB

  2003cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy

  2003cited by this paper
• Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

  2003cited by this paper
• Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

  2003cited by this paper
• A Synergy Control Motif within the Attenuator Domain of CCAAT/Enhancer-binding Protein α Inhibits Transcriptional Synergy through Its PIASy-enhanced Modification by SUMO-1 or SUMO-3*

  2003cited by this paper
• SUMO: ligases, isopeptidases and nuclear pores.

  2003cited by this paper
• Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.

  2002cited by this paper
• The Zinc Finger Domain of NEMO Is Selectively Required for NF-κB Activation by UV Radiation and Topoisomerase Inhibitors

  2002cited by this paper
• Versatile protein tag, SUMO: Its enzymology and biological function

  2002cited by this paper
• The nucleoporin RanBP2 has SUMO1 E3 ligase activity.

  2002cited by this paper
• Identification of a Substrate Recognition Site on Ubc9*

  2002cited by this paper
• Association of the Human SUMO-1 Protease SENP2 with the Nuclear Pore*

  2002cited by this paper
• TNF-R1 Signaling: A Beautiful Pathway

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• Conjugation of Smt3 to Dorsal May Potentiate the Drosophila Immune Response

  2002cited by this paper
• Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex

  2002cited by this paper
• The Small Ubiquitin-like Modifier-1 (SUMO-1) Consensus Sequence Mediates Ubc9 Binding and Is Essential for SUMO-1 Modification*

  2001cited by this paper
• Mechanisms underlying ubiquitination.

  2001cited by this paper
• Human mitochondrial topoisomerase I

  2001cited by this paper
• Regulation of Heat Shock Transcription Factor 1 by Stress-induced SUMO-1 Modification*

  2001cited by this paper
• Respiratory chain-generated oxidative stress following treatment of leukemic blasts with DNA-damaging agents.

  2001cited by this paper
• SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting*

  2001cited by this paper
• SUMO-1 Modification Regulates the DNA Binding Activity of Heat Shock Transcription Factor 2, a Promyelocytic Leukemia Nuclear Body Associated Transcription Factor*

  2001cited by this paper
• A Common Motif within the Negative Regulatory Regions of Multiple Factors Inhibits Their Transcriptional Synergy

  2000cited by this paper
• ATM Is Required for IκB Kinase (IKK) Activation in Response to DNA Double Strand Breaks*

  2000cited by this paper
• A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes.

  2000cited by this paper
• A New SUMO-1-specific Protease, SUSP1, That Is Highly Expressed in Reproductive Organs*

  2000cited by this paper
• Mammalian Smt3a, b-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus

  2000cited by this paper
• A Functional Interaction between Dorsal and Components of the Smt3 Conjugation Machinery*

  2000cited by this paper
• Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B.

  2000cited by this paper
• Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.

  2000cited by this paper
• Differential Regulation of Sentrinized Proteins by a Novel Sentrin-specific Protease*

  2000cited by this paper
• NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events.

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• Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export

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