Central administration of resveratrol improves diet-induced diabetes.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Endocrinology

• Publication date

  2009-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/en.2009-0528PMID 19819963PMCID PMC2795706
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

  2009cited by this paper
• Sirt1 protects against high-fat diet-induced metabolic damage

  2008cited by this paper
• Hypomorphic Mutation in PGC1 β causes mitochondrial dysfunction and liver insulin resistance

  2008cited by this paper
• Negative regulation of the deacetylase SIRT1 by DBC1

  2008cited by this paper
• DBC1 is a negative regulator of SIRT1

  2008cited by this paper
• SirT1 gain of function increases energy efficiency and prevents diabetes in mice.

  2008influential reference
• Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

  2008cited by this paper
• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.

  2008cited by this paper
• Resveratrol stimulates AMP kinase activity in neurons

  2007cited by this paper
• Sirtuins in mammals: insights into their biological function.

  2007cited by this paper
• Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

  2007cited by this paper
• Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.

  2007cited by this paper
• Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

  2007cited by this paper
• Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

  2007cited by this paper
• SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.

  2007cited by this paper
• Hindbrain catecholamine neurons control multiple glucoregulatory responses.

  2006cited by this paper
• Resveratrol improves health and survival of mice on a high-calorie diet

  2006influential reference
• Central nervous system control of food intake and body weight

  2006cited by this paper
• Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.

  2006cited by this paper
• Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats.

  2006cited by this paper
• Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

  2006cited by this paper
• Distribution of [3H]trans-resveratrol in rat tissues following oral administration

  2006cited by this paper
• Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

  2005cited by this paper
• Hypothalamic KATP channels control hepatic glucose production

  2005cited by this paper
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

  2005cited by this paper
• Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism

  2005cited by this paper
• A brain-liver circuit regulates glucose homeostasis.

  2005cited by this paper
• Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

  2005cited by this paper
• Genetic Factors in Type 2 Diabetes: The End of the Beginning?

  2005cited by this paper
• Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

  2005cited by this paper
• The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

  2005cited by this paper
• Central leptin acutely reverses diet-induced hepatic insulin resistance.

  2005cited by this paper
• Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

  2004cited by this paper
• Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

  2004cited by this paper
• Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

  2004cited by this paper
• AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

  2004cited by this paper
• Hepatic glucose metabolism in humans--its role in health and disease.

  2003influential reference
• Effect of exercise intensity on skeletal muscle AMPK signaling in humans.

  2003cited by this paper
• Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

  2003cited by this paper
• Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

  2003cited by this paper
• Rethinking the central causes of diabetes

  2003cited by this paper
• Central administration of oleic acid inhibits glucose production and food intake.

  2002cited by this paper
• Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence

  2002cited by this paper
• Hypothalamic insulin signaling is required for inhibition of glucose production

  2002influential reference
• Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

  2002cited by this paper
• ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis

  2001cited by this paper
• Negative control of p53 by Sir2alpha promotes cell survival under stress.

  2001cited by this paper
• Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.

  2001cited by this paper
• hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.

  2001cited by this paper
• Negative Control of p53 by Sir2 Promotes Cell Survival under Stress

  2001cited by this paper
• Central melanocortin receptors regulate insulin action.

  2001cited by this paper
• Diet-Induced Type II Diabetes in C57BL/6J Mice

  1988cited by this paper

• Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet‐Induced Obese Rats

  2025cites this paper
• Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus

  2024cites this paper
• Cellular Stress Response (Hormesis) in Response to Bioactive Nutraceuticals with Relevance to Alzheimer Disease

  2023cites this paper
• The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

  2022cites this paper
• Diet-Induced Metabolic Dysfunction of Hypothalamic Nutrient Sensing in Rodents

  2022cites this paper
• Resveratrol in Treating Diabetes and Its Cardiovascular Complications: A Review of Its Mechanisms of Action

  2022cites this paper
• Differential Effects of Resveratrol on HECa10 and ARPE-19 Cells

  2022cites this paper
• Inflammatory Stress Induced by Intraperitoneal Injection of LPS Increases Phoenixin Expression and Activity in Distinct Rat Brain Nuclei

  2022cites this paper
• Epigenetics in toxicology and drug development

  2021cites this paper
• Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

  2021cites this paper
• Unravelling the involvement of gut microbiota in type 2 diabetes mellitus.

  2021cites this paper
• Moroccan antidiabetic medicinal plants: Ethnobotanical studies, phytochemical bioactive compounds, preclinical investigations, toxicological validations and clinical evidences; challenges, guidance and perspectives for future management of diabetes worldwide

  2021cites this paper
• Bioactive natural products for the prevention and treatment of diabetes mellitus

  2020cites this paper
• Resveratrol Modulates the Gut-Brain Axis: Focus on Glucagon-Like Peptide-1, 5-HT, and Gut Microbiota

  2020cites this paper
• From role of gut microbiota to microbial-based therapies in type 2-diabetes.

  2020cites this paper
• The Effect of Resveratrol Supplementation on Improving Non-Alcoholic Fatty Liver: A Review on Randomized Clinical Trials

  2020cites this paper
• Resveratrol increase the proportion of oxidative muscle fiber through the AdipoR1-AMPK-PGC-1α pathway in pigs

  2020cites this paper
• Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain

  2020cites this paper
• Dietary phytonutrients in prevention of diabetes related complications.

  2019cites this paper
• Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway.

  2019cites this paper
• Red Wine Consumption and Cardiovascular Health

  2019cites this paper
• Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4

  2019cites this paper
• High-glucose treatment regulates biological functions of human umbilical vein endothelial cells via Sirt1/FOXO3 pathway.

  2019cites this paper
• Natural Products for the Management of Diabetes

  2018cites this paper
• Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Dovepress

  2018cites this paper
• Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia.

  2018cites this paper
• Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection

  2018cites this paper
• Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

  2017cites this paper
• Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis

  2017cites this paper
• Fermented Foods, Microbiota and Human Health

  2017cites this paper
• Epigenetic Regulatory Mechanisms Induced by Resveratrol

  2017cites this paper
• Antihyperglycemic effect of short term resveratrol supplementation in type II diabetes patients

  2017cites this paper
• Introduction in Soft Chemistry and Food Fermentation

  2017cites this paper
• Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus

  2017cites this paper
• Significance of Resveratrol in Clinical Management of Chronic Diseases

  2017cites this paper
• Urolithins, pomegranate ellagitannin microbial metabolites, as potential modulators of cell and molecular events associated with colorectal cancer: in vitro vs.: human studies= Potencial de las urolitinas, metabolitos microbianos derivados de los elagitaninos de la granada, como moduladores de proce

  2016cites this paper
• Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

  2016cites this paper
• The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials

  2016cites this paper
• Toxicology and Epigenetics

  2016cites this paper
• Emerging Potential of Natural Products as an Alternative Strategy to Pharmacological Agents Used Against Metabolic Disorders.

  2016cites this paper
• Functional Properties of Microorganisms in Fermented Foods

  2016cites this paper
• Resveratrol treatment rescues hyperleptinemia and improves hypothalamic leptin signaling programmed by maternal high-fat diet in rats

  2016cites this paper
• Oleuropein induces mitochondrial biogenesis and decreases reactive oxygen species generation in cultured avian muscle cells, possibly via an up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α.

  2016cites this paper
• Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1

  2016cites this paper
• Resveratrol supplementation: Where are we now and where should we go?

  2015cites this paper
• Functionality and Therapeutic Values of Fermented Foods

  2015cites this paper
• Resveratrol and Cancer

  2015cites this paper
• Wine: A Therapeutic Drink

  2015cites this paper
• Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

  2015cites this paper
• Phytochemical analyses and activity of herbal medicinal plants of North- East India for anti-diabetic, anti-cancer and anti-tuberculosis and their docking studies.

  2015cites this paper
• Histone Deacetylases and Cardiometabolic Diseases.

  2015cites this paper
• Application of resveratrol in diabetes: rationale, strategies and challenges.

  2015cites this paper
• The pharmacology of resveratrol in animals and humans.

  2015cites this paper
• Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

  2015cites this paper
• Hypothalamic Neurones Governing Glucose Homeostasis

  2015cites this paper
• SIRTUINS AND OBESITY RELATED METABOLIC DYSFUNCTION

  2015cites this paper
• Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients.

  2014cites this paper
• Resveratrol and cardiovascular health--promising therapeutic or hopeless illusion?

  2014cites this paper
• High-fructose diet enhances cerebral neurodegenerative process; preventive effect of resveratrol. A nuclear magnetic resonance imaging and spectroscopy study on rat nutritional models

  2014cites this paper
• Resveratrol as a protective molecule for neuroinflammation: a review of mechanisms.

  2014cites this paper
• Influence of Dietary Polyphenols on Carbohydrate Metabolism

  2014cites this paper
• Resveratrol Action in the Duodenum and the Regulation of Insulin Sensitivity

  2014cites this paper
• Role of SIRT1 in Vascular Complications of Diabetes

  2014cites this paper
• Resveratrol and cancer: focus on in vivo evidence

  2014cites this paper
• The role of polyphenols on sugar release from carbohydrate rich foods, and the consequent impact on metabolic risk factors associated with type 2 diabetes

  2014cites this paper
• The many roles of PGC-1α in muscle--recent developments.

  2014cites this paper
• Metabolic reprogramming of human cells in response to oxidative stress: implications in the pathophysiology and therapy of mitochondrial diseases.

  2014cites this paper
• Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1

  2014cites this paper
• Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.

  2014cites this paper
• Maternal Obesity, Inflammation, and Developmental Programming

  2014cites this paper
• Antiobesity and Vasoprotective Effects of Resveratrol in ApoE-Deficient Mice

  2014cites this paper
• Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

  2014cites this paper
• Resveratrol : a polyphenol with multiple health benefits

  2014cites this paper
• Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System

  2014cites this paper
• Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice

  2014cites this paper
• Diabetic complications in pregnancy: is resveratrol a solution?

  2013cites this paper
• Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

  2013cites this paper
• Resveratrol : A Potent Antidiabetic Nutraceutical

  2013cites this paper
• Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds

  2013cites this paper
• Pharmacometrics of 3-Methoxypterostilbene: A Component of Traditional Chinese Medicinal Plants

  2013cites this paper
• Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients

  2013cites this paper
• Targeting sirtuins for the treatment of diabetes.

  2013cites this paper
• Resveratrol Suppresses PAI-1 Gene Expression in a Human In Vitro Model of Inflamed Adipose Tissue

  2013cites this paper
• Evidence for the analgesic activity of resveratrol in acute models of nociception in mice.

  2013cites this paper
• 29 GHRELIN , LIPID METABOLISM , AND METABOLIC SYNDROME

  2013cites this paper
• Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials.

  2013cites this paper
• SIRT1 and energy metabolism.

  2013cites this paper
• Resveratrol: Effects on Lipids and Cardiovascular Risk

  2013cites this paper
• Ghrelin, Lipid Metabolism, and Metabolic Syndrome

  2013cites this paper
• Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction

  2013cites this paper
• POLYCHLORINATED BIPHENYL LIGANDS OF THE ARYL HYDROCARBON RECEPTOR PROMOTE ADIPOCYTE-MEDIATED DIABETES

  2013cites this paper
• Effects of dietary polyphenols on neuroregulatory factors and pathways that mediate food intake and energy regulation in obesity.

  2013cites this paper
• The Effects of Resveratrol on Diabetes and Obesity

  2012cites this paper
• Sirtuin modulators: mechanisms and potential clinical implications.

  2012cites this paper
• Molecular Mechanisms Involved in the Regulation of Circadian Clock Gene and Neuropeptide Transcription: Influence of Palmitate

  2012cites this paper
• The central nervous system as a promising target to treat diabetes mellitus.

  2012cites this paper
• Title From small to big molecules : how do we prevent and delay theprogression of age-related neurodegeneration ?

  2012cites this paper
• Sirtuin biology and relevance to diabetes treatment.

  2012cites this paper
• Drugs, nutrients, and phytoactive principles improving the health span of rodent models of human age-related diseases.

  2012cites this paper
• SIRT 1 and energy metabolism

  2012cites this paper