Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Molecular Oncology

• Publication date

  2016-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molonc.2016.01.008PMID 26887594PMCID PMC5423166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013influential reference
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  2013influential reference
• Pancreatic cancer.

  2013cited by this paper
• Induction of epithelial-mesenchymal transition by transforming growth factor β.

  2012cited by this paper
• Cancer stem cells: impact, heterogeneity, and uncertainty.

  2012cited by this paper
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  2012influential reference
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• KOMA: ELISA-microarray calibration and data analysis based on kinetic signal amplification.

  2012influential reference
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• Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.

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  2009influential reference
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  2009influential reference
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  2002influential reference
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  1997cited by this paper
• The genetic basis of cancer.

  1995influential reference
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  1994cited by this paper
• Cancer statistics

  1989cited by this paper

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