Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Circulation

• Publication date

  2001-03-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.103.12.1618PMID 11273987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

  1999cited by this paper
• l-Ascorbic Acid Potentiates Nitric Oxide Synthesis in Endothelial Cells*

  1999cited by this paper
• Diabetes, oxidative stress, and platelet activation.

  1999cited by this paper
• In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation.

  1999cited by this paper
• Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery.

  1999cited by this paper
• High glucose concentrations inhibit glucose phosphorylation, but not glucose transport, in human endothelial cells.

  1999cited by this paper
• In Vivo Formation of 8-Iso-Prostaglandin F2α and Platelet Activation in Diabetes Mellitus

  1999cited by this paper
• In Situ Flow Activates Endothelial Nitric Oxide Synthase in Luminal Caveolae of Endothelium with Rapid Caveolin Dissociation and Calmodulin Association*

  1998cited by this paper
• Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (Review).

  1998cited by this paper
• Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

  1998cited by this paper
• Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo.

  1998cited by this paper
• Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations.

  1998cited by this paper
• Endothelium-dependent vasodilatation is impaired in both microcirculation and macrocirculation during acute hyperglycemia.

  1998cited by this paper
• Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro.

  1997cited by this paper
• Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin.

  1997cited by this paper
• High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells.

  1997cited by this paper
• Interaction between adenosine and flow-induced dilation in coronary microvascular network.

  1997cited by this paper
• Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus.

  1996cited by this paper
• Glucose-induced down-regulation of NO production and inducible NOS expression in cultured rat aortic vascular smooth muscle cells: role of protein kinase C.

  1996cited by this paper
• Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

  1996cited by this paper
• Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion.

  1995cited by this paper
• Somatostatin enhances insulin-stimulated glucose uptake in the perfused human forearm.

  1995cited by this paper
• Inhibition of endothelial nitric oxide synthase activity by protein kinase C.

  1995cited by this paper
• Regulation of endothelial constitutive nitric oxide synthase by protein kinase C.

  1995cited by this paper
• Nitric oxide release accounts for insulin's vascular effects in humans.

  1994cited by this paper
• Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

  1994cited by this paper
• Free radicals in diabetic endothelial cell dysfunction.

  1994cited by this paper
• Shear Stress Elevates Endothelial cGMP. Role of a Potassium Channel and G Protein Coupling

  1993cited by this paper
• Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles.

  1993cited by this paper
• Impaired Endothelium‐Dependent Vasodilation in Patients With Insulin‐Dependent Diabetes Mellitus

  1993cited by this paper
• Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

  1992cited by this paper
• Generation of superoxide by purified brain nitric oxide synthase.

  1992cited by this paper
• Endothelial regulation of wall shear stress and blood flow in skeletal muscle microcirculation.

  1991cited by this paper
• Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

  1991cited by this paper
• Regulatory functions of the vascular endothelium.

  1990cited by this paper
• Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

  1990cited by this paper
• Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

  1990cited by this paper
• Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta.

  1988cited by this paper
• Endothelium-Dependent Relaxation in Aorta of BB Rat

  1987cited by this paper
• Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle.

  1986cited by this paper
• Inhibition of sugar uptake by ascorbic acid in Escherichia coli.

  1983cited by this paper

• Metabolic dysregulation in cerebral small vessel disease: pathogenesis and therapeutic targets.

  2026cites this paper
• The Role of Serum Free Fatty Acids in Endothelium‐Dependent Microvascular Function

  2025cites this paper
• Prognostic significance of stress hyperglycemia ratio in patients with type 2 diabetes mellitus and acute coronary syndromes

  2025cites this paper
• Regional and systemic adipose mass and peripheral conduit artery function.

  2025cites this paper
• Anthocyanin-Rich Berries and Their Bioactive Compounds in Ocular Health: Mechanisms and Therapeutic Potential.

  2025cites this paper
• Sexual dysfunction in patients with diabetes: association between remnant cholesterol and erectile dysfunction

  2024cites this paper
• PURIFIED GAMBIR (UNCARIA GAMBIR (HUNTER) ROXB.) ATTENUATE RENAL FUNCTION IN ALLOXAN-INDUCED DIABETIC MALE RATS

  2024cites this paper
• The positive implication of natural antioxidants on oxidative stress-mediated diabetes mellitus complications

  2024cites this paper
• Role of Epigenetics and Metabolomics in Predicting Endothelial Dysfunction in Type 2 Diabetes

  2023cites this paper
• Vitamin C supplementation for diabetes management: A comprehensive narrative review.

  2023cites this paper
• Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats

  2022cites this paper
• Comparative effects of weight loss and incretin‐based therapies on vascular endothelial function, fibrinolysis and inflammation in individuals with obesity and prediabetes: A randomized controlled trial

  2022cites this paper
• Altered Doppler Velocimetry of Fetal Middle Cerebral Artery in Singleton Pregnancies Complicated by Mild Well-Controlled Gestational Diabetes

  2022cites this paper
• Acute hyperglycaemia enhances both vascular endothelial function and cardiac and skeletal muscle microvascular function in healthy humans

  2021cites this paper
• The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study

  2021cites this paper
• Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: A randomized four-arm study

  2021cites this paper
• Introduction.

  2021cites this paper
• The Protective Effects of Ropivacaine Against High Glucose-induced Brain Microvascular Endothelial Injury by Reducing MMPs and Alleviating Oxidative Stress

  2021cites this paper
• Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes

  2021cites this paper
• Title: The acute effect of magnesium supplementation on endothelial function: a randomised cross-over pilot study

  2021cites this paper
• Type 2 diabetes mellitus increases risk of erectile dysfunction independent of obesity and dyslipidemia: A Mendelian randomization study

  2021cites this paper
• Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice

  2021cites this paper
• Adenosine Monophosphate-Activated Protein Kinase, Oxidative Stress, and Diabetic Endothelial Dysfunction

  2021cites this paper
• Correlation Between Oxidative Stress Generation, Reticular Fiber Density and Testicular Histomorphometric Parameters Of Streptozotocin-Induced Diabetic Wistar Rat

  2021cites this paper
• Pharmacology and perspectives in erectile dysfunction in man.

  2020cites this paper
• Flow-Mediated Vasodilation

  2020cites this paper
• Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

  2020cites this paper
• Hyperglycemia does not Inhibit Insulin's Effects on Microvascular Perfusion in Healthy Humans: A Randomized Crossover Study.

  2020cites this paper
• Insulin Increases Central Aortic Stiffness in Response To Hyperglycemia in Healthy Humans: A Randomized Four-Way Crossover Study

  2020influential citation
• Insulin Increases The Central-To-Peripheral Arterial Stiffness Gradient in Response To Hyperglycemia in Healthy Humans: A Randomized Four-Way Crossover Study

  2020cites this paper
• Prior exercise enhances skeletal muscle microvascular blood flow and mitigates microvascular flow impairments induced by a high‐glucose mixed meal in healthy young men

  2020cites this paper
• Auricularia polytricha restores altered reproductive parameters in streptozotocin-induced diabetic Wistar rat

  2020cites this paper
• Antioxidant cocktail following a high-sodium meal does not affect vascular function in young, healthy adult humans: a randomized controlled crossover trial.

  2020cites this paper
• Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers

  2019cites this paper
• Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses

  2019cites this paper
• The correlation between erectile dysfunction and metabolic syndrome in an Indian population: A cross-sectional observational study

  2019cites this paper
• Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients

  2019cites this paper
• Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation

  2019cites this paper
• An appropriately sized soft polyester external stent prevents enlargement and neointimal hyperplasia of a saphenous vein graft in a canine model.

  2019cites this paper
• Co-ingestion of antioxidant drinks with an unhealthy challenge meal fails to prevent post-prandial endothelial dysfunction: an open-label, crossover study in healthy older adults

  2019cites this paper
• Role of naturopathy on physical and biochemical parameters in patients with Type 2 diabetes mellitus

  2019cites this paper
• Neutrophil-Lymphocyte Ratio , as a Novel Systematic Biomarker : Predicting IntraceRebral Hemorrhage in Type 2 Diabetes Mellitus

  2019cites this paper
• Effect of phosphodiesterase inhibitors on renal functions and oxidant/antioxidant parameters in streptozocin-induced diabetic rats

  2018cites this paper
• Effects of l-Carnitine on the Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Testicular Tissue Oxidative Stress Levels in Streptozotocin-Induced Diabetic Rats

  2018cites this paper
• Ameliorative effect of Citrus aurantifolia and Cinnamomum burmannii extracts on diabetic complications in a hyperglycemic rat model

  2018cites this paper
• The Effect of the Oral Administration of Leucine on Endothelial Function, Glucose and Insulin Concentrations in Healthy Subjects.

  2018cites this paper
• PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus manihot L. Medik) TERHADAP RADIKAL BEBAS DPPH DAN AKTIVITAS ENZIM GLUTATION PEROKSIDASE PADA TIKUS DIABETES

  2018cites this paper
• Regular Aerobic, Resistance, and Cross-Training Exercise Prevents Reduced Vascular Function Following a High Sugar or High Fat Mixed Meal in Young Healthy Adults

  2018influential citation
• Effect of Intermittent Energy Restriction on Flow Mediated Dilatation, a Measure of Endothelial Function: A Short Report

  2018cites this paper
• Antioxidants in Health and Disease

  2017cites this paper
• Vitamin C in Health and Disease

  2017cites this paper
• Neuroendocrine System Regulatory Mechanisms: Acute Coronary Syndrome and Stress Hyperglycaemia.

  2017cites this paper
• Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?

  2017cites this paper
• Moderate, Short-Term, Local Hyperglycemia Attenuates Forearm Endothelium-Dependent Vasodilation After Transient Ischemia-Reperfusion in Human Volunteers.

  2017cites this paper
• The Role of Statins in the Activation of Heme Oxygenase-1 in Cardiovascular Diseases.

  2017cites this paper
• Conflicting effects of atazanavir therapy on atherosclerotic risk factors in stable HIV patients: A randomized trial of regimen switch to atazanavir

  2017cites this paper
• The Relationship between Neutrophil-to-Lymphocyte Ratio and Intracerebral Hemorrhage in Type 2 Diabetes Mellitus.

  2017cites this paper
• Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial.

  2016cites this paper
• Atypical Hemolytic–Uremic Syndrome: A Clinical Review

  2016cites this paper
• Early screening and diagnosis of diabetic retinopathy

  2016cites this paper
• Profile of peroxidative injury and antioxidant indicators in singleton, twins and multiple bearing goats throughout pregnancy

  2016cites this paper
• response in healthy individuals Effects of an oral glucose tolerance test on the myogenic

  2016cites this paper
• Effects of high glucose with or without other metabolic substrates on alpha-adrenergic contractions in rat mesenteric and femoral arteries

  2016cites this paper
• [Hyperglycaemia is associated with worse outcomes in Latin-American individuals with acute myocardial infarction].

  2016cites this paper
• Male Sexual Dysfunction, Leptin, Pituitary and Gonadal Hormones in Nigerian Males with Metabolic Syndrome and Type 2 Diabetes Mellitus

  2016cites this paper
• Vitamin C physiology: the known and the unknown andGoldilocks

  2016cites this paper
• Molecular Links Between Diabetes and Osteoarthritis: The Role of Physical Activity.

  2016cites this paper
• Vitamin C: the known and the unknown and Goldilocks.

  2016cites this paper
• Ascorbic acid repletion: A possible therapy for diabetic macular edema?

  2016cites this paper
• Pemberian Ekstrak Biji Kakao (Theobroma cacao L) Menghambat Penurunan Kadar Nitric Oxide (No) dan Jumlah Sel Endotel Korpus Kavernosa Tikus (Rattus norvegicus) Jantan Wistar Diabetes

  2016cites this paper
• Hiperglucemia se asocia a mayor número de desenlaces adversos en individuos latinoamericanos con infarto agudo de miocardio

  2016cites this paper
• Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load.

  2016influential citation
• Contribution of Musa paradisiaca in the inhibition of α-amylase, α-glucosidase and Angiotensin-I converting enzyme in streptozotocin induced rats.

  2015cites this paper
• Protective Effects of Vitamin C (Ascorbic Acid) in Lead Acetate Exposed Diabetic Male Rats: Evaluation of Blood Biochemical Parameters and Testicular Histopathology

  2015cites this paper
• Hypoglycemic property of cocoa products: potential underlying mechanisms

  2015cites this paper
• Haemolytic Uremic Syndrome in Children (1955-2015): A 60 Years Journey

  2015cites this paper
• Metabolic syndrome: An independent risk factor for erectile dysfunction

  2015cites this paper
• Penile Doppler Ultrasound Predicting Cardiovascular Disease in Men with Erectile Dysfunction

  2015cites this paper
• Antioxidants in Cardiovascular Therapy: Panacea or False Hope?

  2015cites this paper
• HISTORY OF HAEMOLYT IC UREMIC SYNDROME

  2015cites this paper
• Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice

  2015cites this paper
• Diabetes Mellitus and the Cardiovascular System

  2015cites this paper
• A Diagnostic Instrument, or an Experimental Tool?

  2015cites this paper
• Atazanavir improves cardiometabolic measures but not vascular function in patients with long-standing type 1 diabetes mellitus

  2015cites this paper
• Is the present cut-point to define type 2 diabetes appropriate in Latin-Americans?

  2014cites this paper
• Dietary supplements in the management of hypertension and diabetes - a review.

  2014cites this paper
• Post transplant thrombotic microangiopathy

  2014cites this paper
• Luminance flicker-induced retinal vasodilation in humans with and without type 1 diabetes

  2014cites this paper
• Cerebral blood flow control in small vessel disease

  2014cites this paper
• Effects of Diabetes-Induced Hyperglycemia in the Heart: Biochemical and Structural Alterations

  2014cites this paper
• Rutin and quercetin show greater efficacy than nifedipin in ameliorating hemodynamic, redox, and metabolite imbalances in sodium chloride-induced hypertensive rats

  2014cites this paper
• Ca(2+) handling alterations and vascular dysfunction in diabetes.

  2014cites this paper
• Oxidative Stress in Diabetes Mellitus and Possible Interventions

  2014cites this paper
• Fluvastatin-induced reduction of oxidative stress ameliorates diabetic cardiomyopathy in association with improving coronary microvasculature

  2014cites this paper
• Nerve Blood Flow Control in Health & Disease:The Effects of Type 1 Diabetes and Exercise Training

  2014cites this paper
• Diabetic retinopathy: current and future methods for early screening from a retinal hemodynamic and geometric approach

  2014cites this paper
• The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report

  2014cites this paper
• Simvastatin Combined with Antioxidant Attenuates the Cerebral Vascular Endothelial Inflammatory Response in a Rat Traumatic Brain Injury

  2014cites this paper
• Diabetes status differentiates endothelial function and plasma nitrite response to exercise stress in peripheral arterial disease following supervised training.

  2014cites this paper
• Intraluminal hyperglycaemia causes conduit and resistance artery dilatation and inhibits vascular autoregulation in the anaesthetised pig.

  2013cites this paper