Reactive Oxygen Intermediate-Dependent NF-κB Activation by Interleukin-1β Requires 5-Lipoxygenase or NADPH Oxidase Activity

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecular and Cellular Biology

• Publication date

  1999-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.19.3.1950PMID 10022882PMCID PMC83988
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• KB Site-dependent Induction of Gene Expression by Diverse Inducers of Nuclear Factor KB Requires Raf-l*

  2001cited by this paper
• Sphingomyelinase Activates Proteolytic 1KB-a Degradation in a Cell-free System*

  2001cited by this paper
• Role of the protein kinase C lambda/iota isoform in nuclear factor-kappaB activation by interleukin-1beta or tumor necrosis factor-alpha: cell type specificities.

  1999cited by this paper
• Role of the protein kinase C λ/ι isoform in nuclear factor-κB activation by interleukin-1β or tumor necrosis factor-α: cell type specificities

  1999cited by this paper
• IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.

  1998cited by this paper
• Serum interleukin 1 in ovarian cancer patients.

  1998cited by this paper
• IKK-γ is an essential regulatory subunit of the IκB kinase complex

  1998cited by this paper
• MyD88, an Adapter Protein Involved in Interleukin-1 Signaling*

  1998cited by this paper
• Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

  1998cited by this paper
• Role of the Rho GTPase in bradykinin-stimulated nuclear factor-kappaB activation and IL-1beta gene expression in cultured human epithelial cells.

  1998cited by this paper
• Distinct signal transduction pathways mediate nuclear factor-kappaB induction by IL-1beta in epithelial and lymphoid cells.

  1997influential reference
• A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

  1997cited by this paper
• MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

  1997cited by this paper
• The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.

  1997cited by this paper
• The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

  1997cited by this paper
• Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.

  1997cited by this paper
• MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

  1997cited by this paper
• Rho GTPases and signaling networks.

  1997cited by this paper
• Activation of the I k B a Kinase Complex by MEKK 1 , a Kinase of the JNK Pathway

  1997cited by this paper
• Identification and Characterization of an IκB Kinase

  1997cited by this paper
• Catalysis by a multiprotein IkappaB kinase complex.

  1997cited by this paper
• The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation*

  1997cited by this paper
• A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

  1997cited by this paper
• IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.

  1997cited by this paper
• IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

  1997cited by this paper
• Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.

  1997cited by this paper
• Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

  1997cited by this paper
• Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway.

  1997cited by this paper
• Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.

  1997cited by this paper
• IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

  1997cited by this paper
• Inhibition of 5-lipoxygenase blocks IL-1 beta-induced vascular adhesion molecule-1 gene expression in human endothelial cells.

  1997cited by this paper
• The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)*

  1997cited by this paper
• Identification and characterization of an IkappaB kinase.

  1997cited by this paper
• Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

  1997cited by this paper
• Catalysis by a Multiprotein IκB Kinase Complex

  1997cited by this paper
• IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

  1997cited by this paper
• IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

  1997cited by this paper
• The IkB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKa and IKKb, Necessary for IkB Phosphorylation and NF-kB Activation

  1997cited by this paper
• Interleukin-1 beta induces nuclear factor kappa B in epithelial cells independently of the production of reactive oxygen intermediates.

  1996cited by this paper
• The NF-kappa B and I kappa B proteins: new discoveries and insights.

  1996cited by this paper
• IRAK: A Kinase Associated with the Interleukin-1 Receptor

  1996cited by this paper
• TRAF6 is a signal transducer for interleukin-1

  1996cited by this paper
• Molecular characterization and modular analysis of human MyD88.

  1996cited by this paper
• Biologic basis for interleukin-1 in disease.

  1996cited by this paper
• Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.

  1996cited by this paper
• TRAF6 is a signal transducer for interleukin-1.

  1996cited by this paper
• Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta- converting enzyme-mediated apoptosis

  1996cited by this paper
• rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

  1996cited by this paper
• THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

  1996cited by this paper
• Isoleukotrienes Are Biologically Active Free Radical Products of Lipid Peroxidation (*)

  1995cited by this paper
• Phosphorylation of human I kappa B‐alpha on serines 32 and 36 controls I kappa B‐alpha proteolysis and NF‐kappa B activation in response to diverse stimuli.

  1995cited by this paper
• Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

  1995cited by this paper
• Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals.

  1995cited by this paper
• IL‐2 gene expression and NF‐kappa B activation through CD28 requires reactive oxygen production by 5‐lipoxygenase.

  1995cited by this paper
• The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway.

  1995cited by this paper
• Regulation of the phagocyte respiratory burst by small GTP-binding proteins.

  1995cited by this paper
• Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system.

  1994cited by this paper
• The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling.

  1994cited by this paper
• STRUCTURE, REGULATION AND FUNCTION OF NF-1d3

  1994cited by this paper
• A proteasome inhibitor prevents activation of NF‐kappa B and stabilizes a newly phosphorylated form of I kappa B‐alpha that is still bound to NF‐kappa B.

  1994cited by this paper
• Structure, regulation and function of NF-kappa B.

  1994cited by this paper
• Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity.

  1994cited by this paper
• A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation

  1993cited by this paper
• Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes

  1993cited by this paper
• Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

  1993cited by this paper
• Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

  1993cited by this paper
• Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

  1993cited by this paper
• 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

  1993cited by this paper
• The biochemical basis of the NADPH oxidase of phagocytes.

  1993cited by this paper
• A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site

  1992cited by this paper
• Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

  1992cited by this paper
• TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown.

  1992cited by this paper
• 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors.

  1992cited by this paper
• Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review).

  1992cited by this paper
• Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

  1992cited by this paper
• The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition.

  1992cited by this paper
• Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

  1992cited by this paper
• The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

  1992cited by this paper
• Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

  1991cited by this paper
• Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.

  1990cited by this paper
• Activation of Human Immunodeficiency Virus Type 1 by Oxidative Stress

  1990cited by this paper
• Identification and isolation of a membrane protein necessary for leukotriene production

  1990cited by this paper
• Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.

  1990cited by this paper
• Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

  1990cited by this paper
• Mutual regulation of the transcriptional activator NF-cB and its inhibitor, I1cB-a

  year unknowncited by this paper
• A Novel Mitogen-Inducible Gene Product Related to p50/p105-NF-KB Participates in Transactivation through a KB Site

  year unknowncited by this paper

• Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis.

  2025cites this paper
• Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition

  2024cites this paper
• Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses

  2023cites this paper
• Selenium metabolism and regulation of immune cells in immune‐associated diseases

  2022cites this paper
• Characterization of Peritoneal Reactive Ascites Collected from Acute Appendicitis and Small Bowel Obstruction Patients.

  2022cites this paper
• The Interaction of Central Nervous System and Acute Kidney Injury: Pathophysiology and Clinical Perspectives

  2022cites this paper
• Rheumatoid arthritis: From synovium biology to cell-based therapy.

  2022cites this paper
• Anti-inflammatory and anti-COVID-19 effect of a novel polyherbal formulation (Imusil) via modulating oxidative stress, inflammatory mediators and cytokine storm

  2022cites this paper
• Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation

  2022cites this paper
• Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits.

  2022cites this paper
• Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress and causes impaired neuroprotection

  2021cites this paper
• Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury

  2021cites this paper
• Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress, and causes impairment of neuroprotection

  2021cites this paper
• The effects of pharmacologic inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2 -induced mouse islet or clonal pancreatic beta cell dysfunction

  2020cites this paper
• Knockdown of Dual Oxidase 1 (DUOX1) Promotes Wound Healing by Regulating Reactive Oxygen Species (ROS) by Activation of Nuclear Factor kappa B (NF-κB) Signaling

  2020cites this paper
• A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease.

  2019cites this paper
• The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFκB-Dependent Manner

  2019cites this paper
• The Effects of Aronia melanocarpa ‘Viking’ Extracts in Attenuating RANKL-Induced Osteoclastic Differentiation by Inhibiting ROS Generation and c-FOS/NFATc1 Signaling

  2018cites this paper
• Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming

  2018influential citation
• Tuberculosis: Smart manipulation of a lethal host

  2018influential citation
• Immunity and Redox Signaling

  2018cites this paper
• Cardioprotection by Bioactive Polyphenols: A Strategic View

  2018cites this paper
• The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide

  2018cites this paper
• Cardioprotection by Bioactive Polyphenols: A Strategic View

  2018cites this paper
• Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets

  2018cites this paper
• Neural Stem Cell Plasticity: Advantages in Therapy for the Injured Central Nervous System

  2017influential citation
• IL-1 Inhibition and Vascular Function in CKD.

  2017cites this paper
• Transflammation: Innate immune signaling in nuclear reprogramming.

  2017cites this paper
• Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes

  2017cites this paper
• Investigation of resolvin E1 as a metabolite of eicosapentaenoic acid with anti-colorectal cancer activity

  2016cites this paper
• Optimal ROS Signaling Is Critical for Nuclear Reprogramming.

  2016cites this paper
• Effets préventifs et thérapeutiques des polyphénols dans un modèle in vitro et in vivo de maladie inflammatoire de l’intestin : caractérisation des polyphénols de la pelure de pomme et de la canneberge par spectrométrie de masse

  2016cites this paper
• Transcription Factor NF-κB: An Update on Intervention Strategies

  2016cites this paper
• Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction

  2016cites this paper
• Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB

  2015cites this paper
• Effects of inflammation on stem cells: together they strive?

  2015cites this paper
• Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats

  2015cites this paper
• Expressions of angiotensin and cytokine receptors in the paracrine signaling of the carotid body in hypoxia and sleep apnea.

  2015cites this paper
• Activation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: Oxidant- and Non-Oxidant-Mediated Triggering Mechanisms

  2015cites this paper
• Pathogenic Roles of the Carotid Body Inflammation in Sleep Apnea

  2014cites this paper
• Practical strategies for modulating foam cell formation and behavior.

  2014cites this paper
• Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT.

  2014cites this paper
• The role of small non-coding RNAs in human T-cell leukemia virus type 1 (HTLV-1) infection and transformation

  2014cites this paper
• 5-Lypoxygenase Products Are Involved in Renal Tubulointerstitial Injury Induced by Albumin Overload in Proximal Tubules in Mice

  2014cites this paper
• Antinociceptive and Anti-Inflammatory Activity of Bovine Milk-Derived -Lactoglobulin: Study of Combined Effect with Tramadol or Indomethacin

  2014cites this paper
• Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

  2014cites this paper
• Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium

  2014cites this paper
• RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells

  2014cites this paper
• Forsythiaside attenuates lipopolysaccharide-induced inflammatory responses in the bursa of Fabricius of chickens by downregulating the NF-κB signaling pathway

  2013cites this paper
• Genetic Component of Oxidative Stress in Rheumatoid Arthritis

  2013cites this paper
• B Activation by Blocking I κMetal Compounds Inhibit NF

  2013cites this paper
• PhagosomesRadicals to Mycobacterial the Synthesis and Delivery of Reactive Macrophages Is Associated with Defects in Complement C5-Deficient Murine The Reduced Bactericidal Function of

  2013cites this paper
• Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation

  2013cites this paper
• Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension

  2013cites this paper
• Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I

  2013cites this paper
• Redox signaling and histone acetylation in acute pancreatitis.

  2012cites this paper
• The role of Rac1-modulated gene transcription in tumorigenesis

  2012influential citation
• ANTINOCICEPTIVE EFFECT OF WHEY PROTEIN AND ITS FRACTIONS IN SWISS

  2012cites this paper
• An Overview of Oxidative Stress and Antioxidant Defensive System

  2012cites this paper
• 7 Inflammation , Immunity and Redox Signaling

  2012cites this paper
• 5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity

  2012cites this paper
• (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione protects rats from carbon tetrachloride-induced liver injury and fibrogenesis.

  2012cites this paper
• The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

  2012cites this paper
• The involvement of oxidants and NF-κB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells

  2012cites this paper
• An Overview of Oxidative Stress and Antioxidant Defensive System

  2012cites this paper
• Inflammation, Immunity and Redox Signaling

  2012cites this paper
• Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression.

  2011cites this paper
• Basic concepts of inflammation and its role in carcinogenesis.

  2011cites this paper
• A Leaf Methanolic Extract of Wercklea insignis Attenuates the Lipopolysaccharide-Induced Inflammatory Response by Blocking the NF-κB Signaling Pathway in RAW 264.7 Macrophages

  2011cites this paper
• Role of IRAK-1 in the Dynamic Regulation of Reactive Oxygen Species

  2011influential citation
• The role of free radical generation in increasing cerebrovascular permeability.

  2011cites this paper
• 15‐lipoxygenase‐1 exerts its tumor suppressive role by inhibiting nuclear factor‐kappa B via activation of PPAR gamma

  2011cites this paper
• Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes.

  2011cites this paper
• Novel Functions for mda-7/IL-24 and IL-24 delE5: Regulation of Differentiation of Acute Myeloid Leukemic Cells

  2011cites this paper
• Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

  2011cites this paper
• PAF effects on MCP-1 and IL-6 secretion in U-937 monocytes in comparison with oxLDL and IL-1β effects.

  2011cites this paper
• The Role of Macrophages in Regulating Inflammation by Oxidative Burst

  2011cites this paper
• Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK

  2011cites this paper
• Inhibition of Leukotriene Receptors Boosts Neural Progenitor Proliferation

  2011cites this paper
• NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling

  2011cites this paper
• Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways

  2011cites this paper
• Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species

  2011cites this paper
• Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction.

  2010cites this paper
• TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators.

  2010cites this paper
• Oxidative stress in subsynovial connective tissue of idiopathic carpal tunnel syndrome

  2010cites this paper
• Mécanisme de leucémogénèse par les oncogènes SCL et LMO1

  2010cites this paper
• Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARα

  2010cites this paper
• Orchestrating redox signaling networks through regulatory cysteine switches.

  2010cites this paper
• Modification in Oxidative Stress, Inflammation, and Lipoprotein Assembly in Response to Hepatocyte Nuclear Factor 4α Knockdown in Intestinal Epithelial Cells*

  2010cites this paper
• Reactive Oxygen Species-mediated Regulation of Mitochondrial Biogenesis in the Yeast

  2010cites this paper
• Glutamate receptor-mediated taurine release from the hippocampus during oxidative stress

  2010cites this paper
• Zileuton Reduces Inflammatory Reaction and Brain Damage Following Permanent Cerebral Ischemia in Rats

  2010cites this paper
• Expression in Human Chondrocytes Regulate IL-1-Induced ADAMTS-4 Adaptor Proteins and Ras Synergistically

  2009cites this paper
• Peroxynitrite and opiate antinociceptive tolerance: a painful reality.

  2009cites this paper
• Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control.

  2009cites this paper
• Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

  2009influential citation
• Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: the role of reducing oxidative stress in its protective property.

  2009cites this paper
• Role of 5-lipoxygenase and its production of leukotriene B4 in innate host defense and diseases

  2009cites this paper
• Alpinia katsumadai hayata prevents mouse sepsis induced by cecal ligation and puncture through promoting bacterial clearance and downregulating systemic inflammation

  2009cites this paper
• Proinflammatory cytokines provoke oxidative damage to actin in neuronal cells mediated by Rac1 and NADPH oxidase.

  2009cites this paper