The Balancing Act of Autoimmunity: Central and Peripheral Tolerance Versus Infection Control

No abstract is available for this paper.

• Publication year

  2010

• Venue

  International Reviews of Immunology

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3109/08830180903434219PMID 20367141
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• REL, a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

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• Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases

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• Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

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• Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

  2009cited by this paper
• Serious infections during anti-TNFalpha treatment in rheumatoid arthritis patients.

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• Antigen-Specific Suppression of Inflammatory Arthritis Using Liposomes1

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• Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

  2009cited by this paper
• Disease remission state in patients treated with the combination of tumor necrosis factor blockade and methotrexate or with disease-modifying antirheumatic drugs: A clinical and imaging comparative study.

  2009cited by this paper
• DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes.

  2009cited by this paper
• Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study.

  2008cited by this paper
• DC activated via dectin-1 convert Treg into IL-17 producers

  2008cited by this paper
• Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus Using Serum and Functional Genomics1

  2008cited by this paper
• Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state.

  2008cited by this paper
• Does social–economical transformation influence the incidence of type 1 diabetes mellitus? A Polish example

  2008cited by this paper
• Dendritic cells in the thymus contribute to T-regulatory cell induction

  2008cited by this paper
• Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

  2008cited by this paper
• Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

  2008cited by this paper
• Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).

  2008cited by this paper
• Abnormal NF-κB Function Characterizes Human Type 1 Diabetes Dendritic Cells and Monocytes1

  2008cited by this paper
• Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes.

  2008influential reference
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  2007cited by this paper
• Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

  2007cited by this paper
• A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

  2007cited by this paper
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

  2007cited by this paper
• Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

  2007influential reference
• Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

  2007cited by this paper
• A decade of AIRE

  2007cited by this paper
• Genetic Variation in PTPN22 Corresponds to Altered Function of T and B Lymphocytes1

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• All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

  2007cited by this paper
• Immune Modulation and Tolerance Induction by RelB-Silenced Dendritic Cells through RNA Interference1

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  2007cited by this paper
• Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

  2007cited by this paper
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  2007cited by this paper
• Allergic sensitization and microbial load − a comparison between Finland and Russian Karelia

  2007cited by this paper
• T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

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• The burden of rheumatoid arthritis and access to treatment: health burden and costs

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• Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

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• Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD.

  2007cited by this paper
• Noncanonical NF-κB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation

  2007cited by this paper
• Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Epidemiological and immunological evidence for the hygiene hypothesis.

  2007cited by this paper
• Cognate CD4+ Help Elicited by Resting Dendritic Cells Does Not Impair the Induction of Peripheral Tolerance in CD8+ T Cells1

  2007cited by this paper
• TCRζdimlymphocytes define populations of circulating effector cells that migrate to inflamed tissues

  2007cited by this paper
• C-Type Lectin DC-SIGN Modulates Toll-like Receptor Signaling via Raf-1 Kinase-Dependent Acetylation of Transcription Factor NF-κB

  2007cited by this paper
• Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

  2007cited by this paper
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  2006cited by this paper
• Proinsulin: a unique autoantigen triggering autoimmune diabetes.

  2006cited by this paper
• Induction of RelB Participates in Endotoxin Tolerance1

  2006cited by this paper
• LAT-mediated signaling in CD4+CD25+ regulatory T cell development

  2006cited by this paper
• U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.

  2006cited by this paper
• IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

  2006cited by this paper
• Circuitry of nuclear factor kappaB signaling.

  2006cited by this paper
• A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

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  2006cited by this paper
• Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus

  2006cited by this paper
• Extreme genetic risk for type 1A diabetes

  2006cited by this paper
• Role of PTPN22 in type 1 diabetes and other autoimmune diseases.

  2006cited by this paper
• Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

  2005cited by this paper
• Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

  2005cited by this paper
• New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility.

  2005cited by this paper
• Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis

  2005cited by this paper
• Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

  2005cited by this paper
• MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction

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• Modifier loci condition autoimmunity provoked by Aire deficiency

  2005cited by this paper
• Selective inhibition of NF‐κB in dendritic cells by the NEMO‐binding domain peptide blocks maturation and prevents T cell proliferation and polarization

  2005cited by this paper
• CD8α+ Dendritic Cells Selectively Present MHC Class I-Restricted Noncytolytic Viral and Intracellular Bacterial Antigens In Vivo1

  2005cited by this paper
• RelA repression of RelB activity induces selective gene activation downstream of TNF receptors.

  2005cited by this paper
• A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

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• A six‐fold gradient in the incidence of type 1 diabetes at the eastern border of Finland

  2005cited by this paper
• Central tolerance: learning self-control in the thymus

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• Cellular and genetic mechanisms of self tolerance and autoimmunity

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• Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

  2005cited by this paper
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  2005cited by this paper
• A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.

  2004cited by this paper
• Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis.

  2004cited by this paper
• IκB kinases: key regulators of the NF-κB pathway

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• Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

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• Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

  2004cited by this paper
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  2003cited by this paper
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• Modulation of NF-κB Activity by Exchange of Dimers

  2003cited by this paper
• Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

  2003cited by this paper
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  2003cited by this paper
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  2003influential reference
• Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

  2003cited by this paper
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  2002cited by this paper
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• Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

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• Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment.

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• High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors.

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