Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways, where abnormal UPS function has been observed in cancer and neurological diseases. Many neurodegenerative diseases share a common pathological feature, namely intracellular ubiquitin-positive inclusions formed by aggregate-prone neurotoxic proteins. This suggests that dysfunction of the UPS in neurodegenerative diseases contributes to the accumulation of neurotoxic proteins and to instigate neurodegeneration. Here, we review recent findings describing various aspects of UPS dysregulation in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

• Publication year

  2016

• Venue

  Frontiers in Aging Neuroscience

• Publication date

  2016-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fnagi.2016.00303PMID 28018215PMCID 5156861
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

  2016cited by this paper
• Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration*

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• Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

  2016cited by this paper
• Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons

  2016cited by this paper
• Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

  2016cited by this paper
• Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson’s Disease

  2016cited by this paper
• Types of Ubiquitin Ligases.

  2016cited by this paper
• Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

  2016cited by this paper
• Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

  2015cited by this paper
• Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction

  2015cited by this paper
• Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies

  2015cited by this paper
• Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection

  2015cited by this paper
• Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer’s disease

  2015cited by this paper
• The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function

  2015cited by this paper
• Synaptotagmins interact with APP and promote Aβ generation

  2015cited by this paper
• α-synuclein interacts with SOD1 and promotes its oligomerization

  2015cited by this paper
• Mutations in LRRK2 potentiate age-related impairment of autophagic flux

  2015cited by this paper
• Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

  2015cited by this paper
• Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease

  2015cited by this paper
• Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease

  2015cited by this paper
• Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

  2015influential reference
• Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

  2015cited by this paper
• Making (anti-) sense out of huntingtin levels in Huntington disease

  2015cited by this paper
• Analysis of in vivo turnover of tau in a mouse model of tauopathy

  2015cited by this paper
• Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

  2015cited by this paper
• Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity

  2015cited by this paper
• STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

  2015cited by this paper
• The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment

  2014cited by this paper
• Ubiquitination in disease pathogenesis and treatment

  2014influential reference
• The Histone H 2 A Deubiquitinase USP 16 Interacts with HERC 2 and Fine-tunes Cellular Response to DNA Damage *

  2014cited by this paper
• Direct cellular delivery of human proteasomes to delay tau aggregation

  2014cited by this paper
• The Histone H2A Deubiquitinase USP16 Interacts with HERC2 and Fine-tunes Cellular Response to DNA Damage*

  2014cited by this paper
• Ubiquitin pathways in neurodegenerative disease

  2014cited by this paper
• Parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an Alzheimer's disease mouse model.

  2014influential reference
• RBR E3 ubiquitin ligases: new structures, new insights, new questions

  2014cited by this paper
• Usp16 contributes to somatic stem cell defects in Down syndrome

  2013cited by this paper
• SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria

  2013cited by this paper
• Linear ubiquitination: a newly discovered regulator of cell signalling.

  2013cited by this paper
• Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity

  2013influential reference
• Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

  2012cited by this paper
• Negative regulation of IL-17-mediated signaling and inflammation by ubiquitin-specific protease 25

  2012cited by this paper
• The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.

  2012influential reference
• Control of BACE1 degradation and APP processing by ubiquitin carboxyl‐terminal hydrolase L1

  2012cited by this paper
• Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems.

  2012cited by this paper
• APP processing in Alzheimer's disease

  2011cited by this paper
• The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.

  2011cited by this paper
• Emerging roles for Lys11-linked polyubiquitin in cellular regulation.

  2011cited by this paper
• Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)

  2011influential reference
• Balancing act: deubiquitinating enzymes in the nervous system

  2011influential reference
• The spatial and temporal organization of ubiquitin networks

  2011cited by this paper
• PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

  2010cited by this paper
• Enhancement of Proteasome Activity by a Small-Molecule Inhibitor of Usp14

  2010cited by this paper
• Parkin reverses intracellular β‐amyloid accumulation and its negative effects on proteasome function

  2010influential reference
• Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

  2010cited by this paper
• TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.

  2010cited by this paper
• Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-β Generation

  2010influential reference
• TRAF 6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson ’ s disease brains

  2010cited by this paper
• Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes*

  2010cited by this paper
• The Proteasome-Associated Deubiquitinating Enzyme Usp14 Is Essential for the Maintenance of Synaptic Ubiquitin Levels and the Development of Neuromuscular Junctions

  2009influential reference
• Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

  2009cited by this paper
• Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

  2009cited by this paper
• Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

  2009cited by this paper
• Parkinson's disease: from monogenic forms to genetic susceptibility factors.

  2009cited by this paper
• Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

  2009cited by this paper
• Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant α-Synuclein

  2009cited by this paper
• NEMO specifically recognizes K63‐linked poly‐ubiquitin chains through a new bipartite ubiquitin‐binding domain

  2009cited by this paper
• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

  2009cited by this paper
• The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63 Linkages in Mixed Linkage Ubiquitin Chains*

  2008cited by this paper
• Diversity of degradation signals in the ubiquitin–proteasome system

  2008cited by this paper
• Proteasome subunit Rpn13 is a novel ubiquitin receptor

  2008cited by this paper
• Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities

  2007cited by this paper
• Regulation of cell cycle progression and gene expression by H2A deubiquitination

  2007cited by this paper
• CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.

  2007cited by this paper
• The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

  2007influential reference
• CHIP and HSPs interact with β-APP in a proteasome-dependent manner and influence Aβ metabolism

  2007cited by this paper
• Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.

  2007cited by this paper
• Parkin: a multifaceted ubiquitin ligase.

  2006cited by this paper
• The roles of intracellular protein-degradation pathways in neurodegeneration

  2006cited by this paper
• Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.

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• Alzheimer Disease-specific Conformation of Hyperphosphorylated Paired Helical Filament-Tau Is Polyubiquitinated through Lys-48, Lys-11, and Lys-6 Ubiquitin Conjugation*

  2006cited by this paper
• Faculty Opinions recommendation of Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory.

  2006influential reference
• Amyloid peptide attenuates the proteasome activity in neuronal cells.

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• Argonaute—a database for gene regulation by mammalian microRNAs

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• Ubiquitin C‐terminal hydrolase L3 (Uchl3) is involved in working memory

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• Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

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• CHIP Suppresses Polyglutamine Aggregation and Toxicity In Vitro and In Vivo

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• In vivo evidence of CHIP up‐regulation attenuating tau aggregation

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• Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.

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• Mechanism and function of deubiquitinating enzymes.

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• UCHL1 is a Parkinson's disease susceptibility gene

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• UCHL1 is a Parkinson's disease susceptibility gene.

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• CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

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• Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases*

  2004cited by this paper
• CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival*

  2004cited by this paper
• Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

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• Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

  2004cited by this paper
• Parkinson's Disease Mechanisms and Models

  2003cited by this paper

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