Role of the host genetic variability in the influenza A virus susceptibility.

The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.

• Publication year

  2014

• Venue

  Acta Biochimica Polonica

• Publication date

  2014-09-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.18388/ABP.2014_1858arXiv 1409.2031PMID 25184407
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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