Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Mechanisms of Ageing and Development

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mad.2010.01.006PMID 20117128PMCID PMC2846990
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

  2009influential reference
• Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

  2009cited by this paper
• SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

  2009cited by this paper
• SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

  2009cited by this paper
• Sirtuin modulators: targets for metabolic diseases and beyond.

  2008cited by this paper
• Sirtuins — novel therapeutic targets to treat age-associated diseases

  2008cited by this paper
• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

  2008cited by this paper
• SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress.

  2007influential reference
• Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.

  2007cited by this paper
• Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis

  2007influential reference
• A therapeutic role for sirtuins in diseases of aging?

  2007cited by this paper
• Mitotic Regulation of SIRT2 by Cyclin-dependent Kinase 1-dependent Phosphorylation*

  2007cited by this paper
• Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1*

  2007influential reference
• ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

  2006cited by this paper
• SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

  2006cited by this paper
• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

  2006cited by this paper
• Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

  2005cited by this paper
• Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase*

  2005cited by this paper
• The macro domain is an ADP‐ribose binding module

  2004cited by this paper
• Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases.

  2003cited by this paper
• Structure and autoregulation of the yeast Hst2 homolog of Sir2

  2003influential reference
• Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation

  2002cited by this paper
• SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

  2002influential reference
• Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae.

  2002cited by this paper
• The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase

  2002influential reference
• Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

  2000cited by this paper
• Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.

  2000cited by this paper
• Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

  2000cited by this paper
• Locus specificity determinants in the multifunctional yeast silencing protein Sir2

  2000cited by this paper
• The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.

  2000cited by this paper
• Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae.

  2000cited by this paper
• A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

  2000cited by this paper
• Analysis of sir2p domains required for rDNA and telomeric silencing in saccharomyces cerevisiae

  2000cited by this paper
• Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.

  1999cited by this paper
• Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast.

  1995cited by this paper

• Integrative computational simulations and functional assays decode allosteric dysregulation in a pathogenic SIRT6 variant.

  2026cites this paper
• Therapeutic Perspectives of SIRT6 Regulation: Computational Analysis of Activation and Inhibition by Bioactive Molecules

  2025cites this paper
• SIRT6 in health and diseases: from molecular mechanisms to therapeutic prospects.

  2025cites this paper
• Sirtuins in Parkinson's Disease: Molecular Mechanisms and Pathophysiological Roles.

  2025cites this paper
• COMP Is a Biomarker of Cartilage Destruction, Extracellular Matrix and Vascular Remodeling and Tissue Repair

  2025cites this paper
• Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions.

  2025cites this paper
• The multi-dimensional regulatory mechanism of Sirt6 in heart health: From cell death pathways to targeted therapy for cardiovascular diseases.

  2025cites this paper
• DNA stimulates the deacetylase SIRT6 to mono-ADP-ribosylate proteins with histidine repeats

  2025cites this paper
• Potential roles of the sirtuins in promoting longevity for larger Argopecten scallops

  2025influential citation
• A new mechanism involved in cardiovascular senescence induced by environmentally relevant dose of 16 priority-controlled PAHs.

  2025cites this paper
• Research Progress on SIRT6 in Pulmonary Diseases: A Comprehensive Review from Bench to Bedside

  2025cites this paper
• The nitration of SIRT6 aggravates neuronal damage during cerebral ischemia-reperfusion in rat.

  2024cites this paper
• Caloric restriction mimetics: pinostilbene versus resveratrol regarding SIRT1 and SIRT6 interaction.

  2024cites this paper
• SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

  2024cites this paper
• Activation of SIRT6 Deacetylation by DNA Strand Breaks

  2023cites this paper
• Lipid Profile Altered in Phenanthrene Exposed Zebrafish Embryos with Implications for Neurological Development and Early Life Nutritional Status

  2023cites this paper
• Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling

  2023influential citation
• SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats

  2023cites this paper
• MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC.

  2023cites this paper
• The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitus

  2023cites this paper
• Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein

  2023cites this paper
• Sirtuin 6—A Key Regulator of Hepatic Lipid Metabolism and Liver Health

  2023cites this paper
• Implications of altered sirtuins in metabolic regulation and oral cancer

  2023cites this paper
• SIRT6 mediates multidimensional modulation to maintain organism homeostasis

  2022influential citation
• Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review

  2022cites this paper
• Protein intrinsic disorder on a dynamic nucleosomal landscape.

  2021cites this paper
• Post-translational lysine ac(et)ylation in health, ageing and disease

  2021cites this paper
• Roles of SIRT6 in kidney disease: a novel therapeutic target

  2021cites this paper
• Structural alterations in the catalytic core of hSIRT2 enzyme predict therapeutic benefits of Garcinia mangostana derivatives in Alzheimer's disease: molecular dynamics simulation study

  2021cites this paper
• Structural alterations in the catalytic core of hSIRT2 enzyme predict therapeutic bene fi ts of Garcinia mangostana derivatives in Alzheimer's disease: molecular dynamics simulation study † RSC Advances PAPER

  2021cites this paper
• Sirtuin 6: linking longevity with genome and epigenome stability.

  2021cites this paper
• Biochemical analysis of deacetylase activity of rice sirtuin OsSRT1, a class IV member in plants

  2021cites this paper
• Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators

  2020influential citation
• Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing

  2020cites this paper
• Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis

  2020cites this paper
• Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins

  2020cites this paper
• Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair

  2020influential citation
• Emerging roles of SIRT6 in human diseases and its modulators

  2020cites this paper
• Nitro-fatty acids as activators of hSIRT6 deacetylase activity

  2020cites this paper
• Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6

  2020cites this paper
• The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.

  2020cites this paper
• Implications of NAD+ boosters in translational medicine

  2020cites this paper
• Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cells

  2020cites this paper
• SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair

  2020cites this paper
• Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

  2020influential citation
• Histone H3 lysine 56 acetylation enhances AP endonuclease 1-mediated repair of AP sites in nucleosome core particles.

  2019cites this paper
• Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy

  2019cites this paper
• SIRT6 as a transcriptional coactivator of GATA4 prevents doxorubicin cardiotoxicity independently of its deacylase activity

  2019cites this paper
• SIRT6, a Mammalian deacylase with multitasking abilities.

  2019cites this paper
• SIRT6 Activities in DNA Damage Repair and Premature Aging: Functions of SIRT6

  2019cites this paper
• Results-I. Lamin A is an Endogenous Activator of SIRT6 in DNA Damage Repair Process

  2019cites this paper
• SIRT6 is a DNA double-strand break sensor

  2019cites this paper
• Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives

  2019cites this paper
• Biochemical characterization of mono ADP ribosyl transferase activity of human sirtuin SIRT7 and its regulation.

  2019cites this paper
• Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6.

  2018cites this paper
• HiPLA: High-throughput imaging Proximity Ligation Assay

  2018cites this paper
• Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development.

  2018cites this paper
• Sirtuin activators and inhibitors: Promises, achievements, and challenges.

  2018cites this paper
• A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets

  2018cites this paper
• Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy.

  2018cites this paper
• The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.

  2017cites this paper
• Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

  2017cites this paper
• Role of Sirtuins in Linking Metabolic Syndrome with Depression

  2016cites this paper
• Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk

  2016cites this paper
• Function of Sirtuins in Cancer Stem Cells

  2016cites this paper
• The Role of Sirtuin 6 in Maintaining Vascular Integrity

  2016cites this paper
• The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair

  2016cites this paper
• Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Histone/Protein Deacylases.

  2016cites this paper
• A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

  2016cites this paper
• A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.

  2016cites this paper
• SURVEY AND SUMMARY The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair

  2016cites this paper
• Using mitochondrial sirtuins as drug targets: disease implications and available compounds

  2016cites this paper
• Identifying the functional contribution of the defatty-acylase activity of SIRT6

  2016cites this paper
• Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic Opportunities

  2015cites this paper
• Sirtuin-dependent clock control: new advances in metabolism, aging and cancer

  2015cites this paper
• Role of sirtuins in chronic obstructive pulmonary disease

  2015cites this paper
• Applications in High-throughput Sequencing Technologies: From Compression Algorithms and Data Warehousing to Understanding Gene Regulation and Diseases at Scale

  2015cites this paper
• Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development

  2015cites this paper
• Targeting aberrant cancer metabolism — The role of sirtuins

  2015cites this paper
• A dynamic interface between ubiquitylation and cAMP signaling

  2015cites this paper
• Role of SIRT6 in Chromatin

  2015cites this paper
• Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

  2015cites this paper
• SIRT6/NF-κB signaling axis in ginsenoside Rg1-delayed hematopoietic stem/progenitor cell senescence.

  2015cites this paper
• Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.

  2015influential citation
• Posttranslational modification of Sirt6 activity by peroxynitrite.

  2015cites this paper
• Studying sirtuin inhibitors with in silico and in vitro approaches

  2015cites this paper
• Exploring the Roles of the Histone Deacetylase and Longevity Factor SIRT6 in Cancer.

  2014cites this paper
• Sirtuins and the circadian clock: Bridging chromatin and metabolism

  2014cites this paper
• Molecular Pathways Molecular Pathways : Emerging Roles of Mammalian Sirtuin SIRT 7 in Cancer

  2014cites this paper
• SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor‐κB Signaling Pathway

  2014cites this paper
• Changes in human sirtuin 6 gene promoter methylation during aging.

  2014cites this paper
• Chromatin and beyond: the multitasking roles for SIRT6.

  2014cites this paper
• MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

  2014cites this paper
• Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

  2014cites this paper
• A proteomics view of SIRT6 functions and the anti-viral roles of sirtuin proteins

  2014influential citation
• Optical Control of Mammalian Endogenous Transcription and Epigenetic States

  2013cites this paper
• SIRT6 exhibits nucleosome-dependent deacetylase activity

  2013cites this paper
• The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals

  2013influential citation
• SIRT6, a protein with many faces

  2013cites this paper
• Human sirtuins: an overview of an emerging drug target in age-related diseases and cancer.

  2013cites this paper