DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1991-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.88.13.5670PMID 2062845PMCID PMC51939
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A potent GAL4 derivative activates transcription at a distance in vitro.

  1990cited by this paper
• A single DNA‐binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position.

  1990cited by this paper
• DNA-looping and enhancer activity: association between DNA-bound NtrC activator and RNA polymerase at the bacterial glnA promoter.

  1990cited by this paper
• The Hin invertasome: protein-mediated joining of distant recombination sites at the enhancer.

  1990cited by this paper
• GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase.

  1990cited by this paper
• DNA looping and unlooping by AraC protein

  1990cited by this paper
• Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.

  1989cited by this paper
• Single and double loop formation when deoR repressor binds to its natural operator sites.

  1989cited by this paper
• ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication

  1989cited by this paper
• Synergistic activation by the glutamine-rich domains of human transcription factor Sp1.

  1989cited by this paper
• Five intermediate complexes in transcription initiation by RNA polymerase II.

  1989cited by this paper
• Function of a bacterial activator protein that binds to transcriptional enhancers.

  1989cited by this paper
• The structure of interfaces between subunits of dimeric and tetrameric proteins.

  1989cited by this paper
• An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge.

  1989cited by this paper
• Mini-P1 plasmid replication: the autoregulation-sequestration paradox.

  1988cited by this paper
• Surface, subunit interfaces and interior of oligomeric proteins.

  1988cited by this paper
• Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein.

  1988cited by this paper
• Autonomous DNA binding domains of lambda integrase recognize two different sequence families.

  1988cited by this paper
• Distinct regions of Sp1 modulate DNA binding and transcriptional activation.

  1988cited by this paper
• Isolation and characterization of the Tn3 resolvase synaptic intermediate.

  1988cited by this paper
• Factors involved in specific transcription in mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site.

  1987cited by this paper
• Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain.

  1987cited by this paper
• lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

  1987cited by this paper
• Transpososomes: stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA.

  1987cited by this paper
• Three-dimensional structure of flavocytochrome b2 from baker's yeast at 3.0-A resolution.

  1987cited by this paper
• The gene-specific initiation factor USF (upstream stimulatory factor) bound at the adenovirus type 2 major late promoter: mass and three-dimensional structure.

  1987cited by this paper
• Association of DNA-bound progesterone receptors

  1987cited by this paper
• Upstream operators enhance repression of the lac promoter.

  1986cited by this paper
• Gene regulation by proteins acting nearby and at a distance

  1986cited by this paper
• DNA loops induced by cooperative binding of lambda repressor.

  1986cited by this paper
• Heat shock regulatory elements function as an inducible enhancer in the Xenopus hsp70 gene and when linked to a heterologous promoter.

  1986cited by this paper
• Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region.

  1985cited by this paper
• Monomers through trimers of large tumor antigen bind in region I and monomers through tetramers bind in region II of simian virus 40 origin of replication DNA as stable structures in solution.

  1985cited by this paper
• Multiple specific contacts between a mammalian transcription factor and its cognate promoters

  1984cited by this paper
• Demonstration of two operator elements in gal: in vitro repressor binding studies.

  1984cited by this paper
• Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II.

  1983cited by this paper
• A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

  1983cited by this paper
• Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution

  1983cited by this paper
• A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

  1983cited by this paper

• The 2SP Site Mutation in the Bovine Natural Resistance-Associated Macrophage 1 Promoter Exhibits Antituberculosis Potential

  2025cites this paper
• Viral Appropriation of Specificity Protein 1 (Sp1): The Role of Sp1 in Human Retro- and DNA Viruses in Promoter Activation and Beyond

  2025cites this paper
• G-quadruplex-dependent transcriptional regulation by molecular condensation in the Bcl3 promoter

  2025cites this paper
• YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer

  2025cites this paper
• The Functional Impact of the Noncoding SNP rs3741442 on Orofacial Clefting

  2025cites this paper
• Unraveling the role of specificity protein 1 in gliomas: pathophysiology and clinical implications

  2025cites this paper
• ssG4-seq for global profiling of strand-specific G-quadruplex structures in mammalian genomes

  2025cites this paper
• Role of Specificity Protein 1 (SP1) in Cardiovascular Diseases: Pathological Mechanisms and Therapeutic Potentials

  2024cites this paper
• Role of post-translational modifications of Sp1 in cancer: state of the art

  2024cites this paper
• Molecular architecture of enhancer-promoter interaction.

  2022cites this paper
• Enhancer-gene specificity in development and disease.

  2022cites this paper
• Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer

  2022cites this paper
• Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

  2021cites this paper
• Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription

  2021cites this paper
• Transcription factor Sp1 is upregulated by PKCι to drive the expression of YAP1 during pancreatic carcinogenesis.

  2020cites this paper
• HIPPIE2: a method for fine-scale identification of physically interacting chromatin regions

  2019cites this paper
• Three‐dimensional genome architecture in health and disease

  2019cites this paper
• Tissue- and stage-specific roles of the ubiquitously expressed transcription factor sp1 in haematopoietic development

  2018cites this paper
• Mitochondrial physiology within myelinated axons in health and disease : an energetic interplay between counterparts

  2018cites this paper
• ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells

  2018cites this paper
• Un'indagine su larga scala dell'interazione Enhancer-Promotore mediata da fattori di trascrizione

  2017influential citation
• Effect of NaeI-L43K mutation on protein dynamics and DNA conformation: Insights from molecular dynamics simulations.

  2017cites this paper
• Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation.

  2017cites this paper
• Global re‐wiring of p53 transcription regulation by the hepatitis B virus X protein

  2016cites this paper
• The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease

  2016cites this paper
• MIR193BHG: a novel hypoxia-inducible long noncoding RNA involved in the fine-tuning of cholesterol metabolism

  2016cites this paper
• Comparative DNA‐Protein Interaction and Epithelial Tight Junctions Modulation Potential of Immunosuppressive Regime

  2016cites this paper
• NF-κB and IRF pathways: cross-regulation on target genes promoter level

  2015cites this paper
• INSIGHTS INTO THE FUNCTIONAL THREE-DIMENSIONAL ORGANIZATION OF PROKARYOTIC AND EUKARYOTIC GENOMES IN RESPONSE TO ENVIRONMENTAL STIMULI AND CELL CYCLE PROGRESSION

  2015cites this paper
• O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.

  2015cites this paper
• Sp1 and the ‘hallmarks of cancer’

  2015cites this paper
• Transcriptional Regulators of Claudins in Epithelial Tight Junctions

  2015cites this paper
• Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation.

  2015cites this paper
• Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy

  2015cites this paper
• 3D imaging of Sox2 enhancer clusters in embryonic stem cells

  2014cites this paper
• Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21Cip1 by modulating the transcription factor Sp1

  2014cites this paper
• Characterization of Biological and Condensed Matter at the Nanoscale

  2014cites this paper
• Mechanisms and proteins involved in long-distance interactions

  2014cites this paper
• Recrudescence Mechanisms and Gene Expression Profile of the Reproductive Tracts from Chickens during the Molting Period

  2013cites this paper
• Correction: Activity of the Upstream Component of Tandem TERT/Survivin Promoters Depends on Features of the Downstream Component

  2013cites this paper
• Differential Responses of Neuronal and Spermatogenic Cells to the Doppel Cytotoxicity

  2013cites this paper
• Sp1 modifies leg-to-wing transdetermination in Drosophila.

  2013cites this paper
• Manganese superoxide dismutase regulation and cancer.

  2012cites this paper
• Activity of the Upstream Component of Tandem TERT/Survivin Promoters Depends on Features of the Downstream Component

  2012cites this paper
• Interaction between isolated transcriptional activation domains of Sp1 revealed by heteronuclear magnetic resonance

  2012cites this paper
• In Vivo Binding of Orc2 to a Region of the Chicken Lysozyme GAS41 Origin Containing Multiple Sp1-Binding Sites

  2012cites this paper
• Skin Diseases-Related Enzymes: Mechanisms and Clinical Applications

  2011cites this paper
• Disruption of the Abdominal-B Promoter Tethering Element Results in a Loss of Long-Range Enhancer-Directed Hox Gene Expression in Drosophila

  2011influential citation
• The Role of Manganese Superoxide Dismutase in Skin Cancer

  2011cites this paper
• The Role of Differential Phosphorylation of the Retinoblastoma Protein in Regulating Cell Proliferation and Elastogenesis

  2011cites this paper
• Spatial and Topological Organization of DNA Chains Induced by Gene Co-localization

  2010cites this paper
• Scaling of Metabolic Enzymes: Transcriptional Basis of Interspecies Variation in Mitochondrial Content

  2010cites this paper
• The GC skew near Pol II start sites and its association with SP1-binding site variants

  2010cites this paper
• The c-MYC NHE III(1): function and regulation.

  2010cites this paper
• The role of the kidney in diabetic thiamine deficiency

  2010cites this paper
• Sp1 and Sp3 regulate transcription of the chicken GAS41 gene.

  2010cites this paper
• Dissecting protein-induced DNA looping dynamics in real time

  2009cites this paper
• transcriptome and genome analyses Next-generation DNA sequencing of paired-end tags ( PET ) for

  2009cites this paper
• Expression and developmental requirement for transcription factor Sp2

  2009cites this paper
• Role of altered pH homeostasis and hypoxia in the phenotypic changes of cancer cells

  2009cites this paper
• Chapter 3 History of the STEM at Brookhaven National Laboratory

  2009cites this paper
• Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses.

  2009cites this paper
• Regulation of superoxide dismutase genes: implications in disease.

  2009cites this paper
• Transcriptional regulation of Kv4.2 gene by Iroquois family proteins

  2009cites this paper
• Overexpression of Transcription Factor Sp1 Leads to Gene Expression Perturbations and Cell Cycle Inhibition

  2009cites this paper
• Epigenetic modulation of the protein kinase A RIIα (PRKAR2A) gene by histone deacetylases 1 and 2 in human smooth muscle cells

  2009cites this paper
• Sp1: emerging roles--beyond constitutive activation of TATA-less housekeeping genes.

  2008cites this paper
• Nuclear organization and chromatin dynamics--Sp1, Sp3 and histone deacetylases.

  2008cites this paper
• A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice.

  2008cites this paper
• Beta-globin regulation and long-range interactions.

  2008cites this paper
• Study of the role of pax transcription factors and SP-related factors in C. Elegans organ development

  2008cites this paper
• Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter region

  2008cites this paper
• HIV evades RNA interference directed at TAR by an indirect compensatory mechanism.

  2008cites this paper
• The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein.

  2007cites this paper
• Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1.

  2007cites this paper
• Down-regulation of human topoisomerase IIα expression correlates with relative amounts of specificity factors Sp1 and Sp3 bound at proximal and distal promoter regions

  2007influential citation
• Cleaving, Condensing and Manipulating Single DNA Molecules

  2007cites this paper
• A novel promoter-tethering element regulates enhancer-driven gene expression at the bithorax complex in the Drosophila embryo

  2007cites this paper
• Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression

  2007cites this paper
• The Role of a Single-stranded Nucleotide Loop in Transcriptional Regulation of the Human sod2 Gene*

  2007cites this paper
• Inhibition of histone deacetylation promotes abnormal epidermal differentiation and specifically suppresses the expression of the late differentiation marker profilaggrin.

  2007cites this paper
• Susceptibility to late onset hearing loss: an investigation into genetic variation at the Brn-3c locus.

  2006cites this paper
• Estimating the Prevalence and Regulatory Potential of the Telomere Looping Effect in Yeast Transcription Regulation

  2006cites this paper
• CONTROL TRANSCRIPCIONAL I AL·LOSTÈRIC DEL GEN CARNITINA PALMITOÏLTRANSFERASA 1B (CPT1B)

  2006cites this paper
• Genetic etiology of hereditary colorectal cancer: new mechanisms and advanced mutation detection techniques

  2006cites this paper
• The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter.

  2006cites this paper
• Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity.

  2006cites this paper
• Genotyp-Phänotyp Korrelation bei Dichromasie und anomaler Trichromasie

  2006cites this paper
• Transcription factor binding aites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity

  2006cites this paper
• Real-time observation of DNA looping dynamics of Type IIE restriction enzymes NaeI and NarI

  2006cites this paper
• Gene expression and differentiation

  2005cites this paper
• Estrogen regulation of trefoil factor 1 expression by estrogen receptor alpha and Sp proteins.

  2005cites this paper
• Logic Functions of the Genomic Cis-regulatory Code

  2005cites this paper
• A point mutation affecting an SP1 binding site in the promoter of the ferrochelatase gene impairs gene transcription and causes erythropoietic protoporphyria.

  2005cites this paper
• Sp1‐like transcription factors are regulators of embryonic development in vertebrates

  2005cites this paper
• Estrogen regulation of trefoil factor 1 expression by estrogen receptor α and Sp proteins

  2005cites this paper
• Regulation of Sp2 DNA-Binding Activity and trans-Activation

  2005cites this paper
• Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1.

  2005cites this paper
• THE REGULATION OF GROWTH FACTOR RECEPTORS EGFR AND IGF-IR AND THE GROWTH FACTOR VEGF BY THIOREDOXIN-1

  2005cites this paper
• Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity

  2005cites this paper