New concepts on the pathogenesis of fever.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Reviews of Infectious Diseases

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/CLINIDS/10.1.168PMID 2451266
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Concentrations of Immunoreactive Human Tumor Necrosis Factor Alpha Produced by Human Mononuclear Cells In Vitro

  1988cited by this paper
• Effects of pyrogens on prostaglandin E2 and thromboxane A2 synthesis in brain: implications for the pathogenesis of fever.

  1987cited by this paper
• C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma.

  1987cited by this paper
• Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells.

  1987cited by this paper
• Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

  1987cited by this paper
• Development and use of a radioimmunoassay for human interleukin-1 beta.

  1987cited by this paper
• Expression of mRNA homologous to interleukin 1 in human epidermal cells.

  1987cited by this paper
• Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells

  1987cited by this paper
• Modulation of endothelial cell functions by different molecular species of interleukin 1.

  1987cited by this paper
• Phase I evaluation of recombinant interleukin-2 in patients with advanced malignant disease.

  1986cited by this paper
• Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s).

  1986cited by this paper
• There is more than one interleukin 1.

  1986cited by this paper
• Prostaglandin E as the neural mediator of the febrile response.

  1986cited by this paper
• Interleukin 1 of the central nervous system is produced by ameboid microglia

  1986cited by this paper
• Prostaglandin E2 and fever: a continuing debate.

  1986cited by this paper
• Multiple biological activities of human recombinant interleukin 1.

  1986cited by this paper
• Cachectin and tumour necrosis factor as two sides of the same biological coin

  1986cited by this paper
• Interleukin 1 production by human polymorphonuclear neutrophils.

  1986cited by this paper
• Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages.

  1986cited by this paper
• Extreme pyrexia.

  1986cited by this paper
• Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.

  1986influential reference
• Neurotransmitters in temperature control.

  1986cited by this paper
• In vitro enhanced thromboxane B2 release by polymorphonuclear leukocytes and macrophages after treatment with human recombinant interleukin 1.

  1986cited by this paper
• Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1

  1986cited by this paper
• Inducible interleukin-1 gene expression in human vascular smooth muscle cells.

  1986cited by this paper
• Complete nucleotide sequence of the gene for human interleukin 1 alpha.

  1986cited by this paper
• Immune interferon enhances the production of interleukin 1 by human endothelial cells stimulated with lipopolysaccharide.

  1986cited by this paper
• Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

  1986cited by this paper
• The work of the Leeds Malignant Hyperpyrexia Unit, 1971–84

  1986cited by this paper
• Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

  1986cited by this paper
• Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.

  1986cited by this paper
• Recombinant human interleukin 1 alpha: purification and biological characterization.

  1986cited by this paper
• Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate.

  1986cited by this paper
• Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor

  1986cited by this paper
• Purification and characterization of a unique human interleukin 1 from the tumor cell line U937.

  1986influential reference
• Pyrogenic and haematological effects of the interferon-inducing 22K factor (interleukin 1 beta) from human leukocytes.

  1986cited by this paper
• Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1.

  1986cited by this paper
• Clinical effects and toxicity of interleukin‐2 in patients with cancer

  1986cited by this paper
• Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters.

  1986cited by this paper
• Phase I study of i.v. administered recombinant gamma interferon in cancer patients.

  1986cited by this paper
• Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin).

  1986cited by this paper
• Purification of human interleukin 1 from human monocyte culture supernatants and identity of thymocyte comitogenic factor, fibroblast-proliferation factor, acute-phase protein-inducing factor, and endogenous pyrogen.

  1985cited by this paper
• Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

  1985cited by this paper
• Effect of protein synthesis inhibitors on leukocytic pyrogen-induced in vitro hypothalamic prostaglandin production.

  1985cited by this paper
• Production of an endogenous pyrogen by glomerular mesangial cells.

  1985cited by this paper
• Multiple Interleukin-1 Activities in Luteal Phase Human Plasma

  1985cited by this paper
• Dissimilarities between purified human interleukin-1 and recombinant human interleukin-2 in the induction of fever, brain prostaglandin, and acute-phase protein synthesis.

  1985cited by this paper
• Effects of Purified Human Interleukin-1 on the Release of Prostaglandin E2 from Fibroblasts

  1985cited by this paper
• Perfusion of vasopressin within the rat brain suppresses prostaglandin E-hyperthermia.

  1985cited by this paper
• Fever: Historical Perspectives and Evolution of Modern Views

  1985cited by this paper
• Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor.

  1985cited by this paper
• The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities.

  1985cited by this paper
• Prostacyclin synthesis induced in vascular cells by interleukin-1.

  1985cited by this paper
• Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits.

  1985cited by this paper
• Biologic properties of epidermal cell thymocyte-activating factor (ETAF).

  1985cited by this paper
• Current concepts. Neuroleptic malignant syndrome.

  1985cited by this paper
• Increased plasma interleukin-1 activity in women after ovulation.

  1985cited by this paper
• Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor.

  1985cited by this paper
• Human and murine interleukin 1 possess sequence and structural similarities.

  1985cited by this paper
• Temperature sensitivity of interleukin-dependent murine T cell proliferation: Q2 mapping of the responses of peanut agglutinin-negative thymocytes.

  1985cited by this paper
• Suppression of Ag-induced release of EP (IL 1) by spleen cells of specifically desensitized donors: evidence for the role of a suppressor cell.

  1985cited by this paper
• The effects of variations in pH and temperature on the activation of mouse thymocytes by both forms of rabbit interleukin-1.

  1985cited by this paper
• Evidence for the involvement of the organum vasculosum laminae terminalis in the febrile response of rabbits and rats.

  1985cited by this paper
• Chemical characterization of an interleukin-1-inducing substance derived from human mixed leukocyte reactions: IL-1-inducing substance is not gamma interferon.

  1985cited by this paper
• Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1

  1985cited by this paper
• Pig interleukin 1. Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever

  1985cited by this paper
• Immunologic reconstitution in the acquired immunodeficiency syndrome.

  1985cited by this paper
• Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.

  1985cited by this paper
• Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1.

  1985cited by this paper
• Interleukin 1 activity in normal human urine.

  1984cited by this paper
• Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?

  1984cited by this paper
• Mechanisms of fever induced by recombinant human interferon.

  1984influential reference
• Human large granular lymphocytes are potent producers of interleukin-1

  1984cited by this paper
• Neurochemistry of thermoregulation.

  1984cited by this paper
• Interleukin-1 and the pathogenesis of the acute-phase response.

  1984cited by this paper
• Inhibition of brain protein synthesis suppresses the release of prostaglandin E2 in febrile rabbits.

  1984cited by this paper
• Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

  1984cited by this paper
• Fever: the old and the new.

  1984cited by this paper
• Demonstration of interleukin 1 activity in apparently homogeneous specimens of the pI 5 form of rabbit endogenous pyrogen

  1984cited by this paper
• Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

  1984cited by this paper
• Production of intra- and extracellular interleukin-1 (IL-1) by human monocytes.

  1984cited by this paper
• Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

  1984cited by this paper
• Cleavage of human interleukin 1: isolation of a peptide fragment from plasma of febrile humans and activated monocytes.

  1984cited by this paper
• Accessory cell function of human B cells. I. Production of both interleukin 1-like activity and an interleukin 1 inhibitory factor by an EBV-transformed human B cell line

  1984cited by this paper
• Interferons as macrophage‐activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide‐stimulated human monocytes

  1983cited by this paper
• The pyrogenic and mitogenic actions of interleukin-1 are related

  1983cited by this paper
• Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein.

  1983cited by this paper
• Human interleukin 1: purification and properties.

  1983cited by this paper
• The effect of temperature on the activation of thymocytes by interleukins I and II.

  1983cited by this paper
• Rabbit polymorphonuclear leukocytes do not secrete endogenous pyrogens or interleukin 1 when stimulated by endotoxin, polyinosine:polycytosine, or muramyl dipeptide

  1983cited by this paper
• Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat.

  1983influential reference
• Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs.

  1983cited by this paper
• Molecular mechanisms in endotoxin fever

  1983cited by this paper
• Interleukin 1 and T cell activation.

  1982cited by this paper
• Clinical and immunologic effects of recombinant leukocyte A interferon in eight patients with advanced cancer.

  1982cited by this paper
• Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors

  1982cited by this paper
• The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production.

  1982cited by this paper
• Studies on the active site of human leukocytic pyrogen

  1982cited by this paper
• Molecular basis of fever in humans.

  1982cited by this paper
• Chemical characterization of a rabbit leukocytic pyrogen.

  1982cited by this paper

• Exploring the antipyretic efficacy of Merremia vitifolia (Burm. fil.): from traditional use to molecular docking insights

  2025cites this paper
• The GLP-1 Analog Liraglutide Reduces Fever Through Sex-Dependent Neuroinflammatory Modulation

  2025cites this paper
• Prompt treatment of fever and its associated factors among under-five children in sub-Saharan Africa: A multilevel analysis of evidence from 36 countries

  2024cites this paper
• Society of Critical Care Medicine and the Infectious Diseases Society of America Guidelines for Evaluating New Fever in Adult Patients in the ICU

  2023cites this paper
• Integrating in vivo and in silico approaches to investigate the potential of Zingiber roseum rhizome extract against pyrexia, inflammation and pain

  2023cites this paper
• Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection.

  2022cites this paper
• Inflammatory Blood Biomarker Kynurenine Is Linked With Elevated Neuroinflammation and Neurodegeneration in Older Adults: Evidence From Two 1H-MRS Post-Processing Analysis Methods

  2022cites this paper
• Abnormalities of Thermal Regulation and the Nervous System

  2021cites this paper
• Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide

  2021cites this paper
• Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica.

  2021cites this paper
• reply

  2020cites this paper
• Qualitative phytochemical screening and antipyretic activity of methanolic stem bark extract of Mangifera indica in wistar rats

  2020cites this paper
• Evaluation of Postoperative Fever in General Surgery Patients in Rajah Muthiah Medical College and Hospital, Chidambaram, Cuddalore, India

  2020cites this paper
• Immune-mediated febrile response in female rats: Role of central hypothalamic mediators

  2020cites this paper
• Anti-inflammatory, anti-nociceptive and antipyretic activity of young and old leaves of Vernonia amygdalina.

  2019cites this paper
• Prevalence , and etiology of fever in patients attending tertiary care hospitals – a prospective study

  2019cites this paper
• Periodic fever associated with intermittent rhythmic delta activity: a syndrome of hypothalamic origin?

  2019cites this paper
• Progression in migraine: Role of mast cells and pro‐inflammatory and anti‐inflammatory cytokines☆

  2019cites this paper
• Periodic fever associated with intermittent rhythmic delta activity: a syndrome of hypothalamic origin?

  2018cites this paper
• Fever

  2018cites this paper
• Title Both Glycolipid and Protein Components are Required for Plasmodium falciparum induced TNF-α and IL-1 β Production in Human Monocytic Cells

  2018cites this paper
• Childhood Fever Knowledge and Management: A Case of Mothers with Children under Five Years

  2018cites this paper
• Evaluation of postoperative pyrexia in general surgery patients in Medicity Institute of Medical Sciences, Ghanpur, Medchal, India

  2018cites this paper
• Potential diagnostic methods and nutritional changes to combat bovine respiratory disease in receiving cattle

  2017influential citation
• Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses.

  2017cites this paper
• The Effects of Thai Herbal Ha-Rak Formula on COX Isoform Expression in Human Umbilical Vein Endothelial Cells Induced by IL-1β

  2017cites this paper
• The Effect of Antipyretic Temperature Reduction on Heart Rate in Febrile Infants: a Pilot Study

  2017cites this paper
• Fever Phobia as a Reason for Pediatric Emergency Department Visits: Does the Primary Care Physician Make a Difference?

  2017cites this paper
• Interferon-7 and urine neopterin in attacks of the hyperimmunoglobulinaemia D and periodic fever syndrome

  2017cites this paper
• Virtual screening and biological evaluation of novel antipyretic compounds

  2017cites this paper
• Synergism between IL-ip and TNF-ot on the activity of the pituitary-adrenal axis and on food intake of rats

  2017cites this paper
• Evidence of substance P autocrine circuitry that involves TNF-α, IL-6, and PGE2 in endogenous pyrogen-induced fever.

  2016cites this paper
• Clinical assessment of fever with thrombocytopenia - A prospective study

  2016cites this paper
• Determinants of Fever in Acute Stroke Patients

  2016cites this paper
• Do Peripheral Thermometers Accurately Correlate to Core Body Temperature?

  2016cites this paper
• Pyrexia: aetiology in the ICU

  2016cites this paper
• Female Sex Hormones Influence the Febrile Response Induced by Lipopolysaccharide, Cytokines and Prostaglandins but not by Interleukin‐1β in Rats

  2016cites this paper
• Neuroinflammation in the normal aging hippocampus.

  2015cites this paper
• Talking to the Brain at the Blood-Brain Barrier through Inflammation-Induced Prostaglandin E2

  2015cites this paper
• Central mediators involved in the febrile response: effects of antipyretic drugs

  2015cites this paper
• BETWEEN THE PERIPHERAL IMMUNE SYSTEM AND THE BRAIN

  2015cites this paper
• circumventricular organs during fever in rats nuclear STAT3 translocation in sensory Selected Contribution: Role of IL-6 in LPS-induced

  2015cites this paper
• Accuracy of Peripheral Thermometers for Estimating Temperature

  2015cites this paper
• Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats.

  2015cites this paper
• Alleviative Effects of a Kampo (a Japanese Herbal) Medicine “Maoto (Ma-Huang-Tang)” on the Early Phase of Influenza Virus Infection and Its Possible Mode of Action

  2014cites this paper
• Körpertemperatur und Outcome bei schwerer Sepsis

  2014cites this paper
• Mechanisms of fever production and lysis: lessons from experimental LPS fever.

  2014cites this paper
• Arsenic reduces the antipyretic activity of paracetamol in rats: modulation of brain COX-2 activity and CB₁ receptor expression.

  2014cites this paper
• Kinderen met koorts

  2014cites this paper
• Analysis of IL-1β Release from Cryopreserved Pooled Lymphocytes in Response to Lipopolysaccharide and Lipoteichoic Acid

  2013cites this paper
• Efeito de inibidores de proteínas quinases sobre a resposta febril e a expressão de proteínas em ratos

  2013cites this paper
• The reliability and diagnostic validity of clinical manifestations of catheter-associated urinary tract infection in hospitalized adults: A pilot study

  2013cites this paper
• Thermoregulation: Cytokines Involved in Fever and Exercise

  2013cites this paper
• Chemokine ligand (CCL)-3 promotes an integrated febrile response when injected within pre-optic area (POA) of rats and induces calcium signaling in cells of POA microcultures but not TNF-α or IL-6 synthesis.

  2013cites this paper
• Serum amyloid-A protein and serum rheumatoid factor as serological surrogate markers for smoking risk factor in Saudi population.

  2013cites this paper
• An in vitro method for evaluating endotoxic activity using prostaglandin E(2) induction in bovine peripheral blood.

  2013cites this paper
• Avaliação da via sinalizadora do fator de transcrição NFκB ativada pelo TNF-α em um modelo de carência protéica

  2013cites this paper
• A crucial role for IL-6 in the CNS of rats during fever induced by the injection of live E. coli

  2012cites this paper
• Proinflammatory Cytokines in the Treatment of Bacterial and Fungal Infections

  2012cites this paper
• Detection of interleukin -1β from isolated human lymphocyte in response to lipopolysaccharide and lipoteichoic acid

  2012cites this paper
• Immunomodulators in Bacterial and Fungal Infections

  2012cites this paper
• Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats.

  2012cites this paper
• The influence of cytokines on wakefulness regulation: clinical relevance, mechanisms and methodological problems.

  2012cites this paper
• Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition.

  2012cites this paper
• Anti-inflarnrnatory and antipyretic effects of boldine

  2012cites this paper
• Role of nitric oxide in the central interferon-alpha-induced inhibition of gastric acid secretion in rats.

  2012cites this paper
• Cytokines and sudden infant death

  2012cites this paper
• CHAPTER 4 – Developmental Immunology and Role of Host Defenses in Fetal and Neonatal Susceptibility to Infection

  2011cites this paper
• Drotrecogin Alfa Activated (Recombinant Human Activated Protein C, Xigris)

  2011cites this paper
• Effects of Administration with BQ 788 on Heat Stroke in Rats

  2011cites this paper
• A comparison of methods to reduce fever in young children

  2011cites this paper
• Inflammatory response to pyrogens determined by a novel ELISA method using human whole blood.

  2011cites this paper
• Evaluation of Interleukin 1β levels from human lymphocytes in response to pyrogens

  2011cites this paper
• M29 NHG Clinical Practice Guideline Feverish illness in Children

  2011cites this paper
• Fiebre en pediatría

  2010cites this paper
• Boundary Layer Microclimate and Angolosaurus skoog ; ( Sauria : Cordylidae ) Activity on a Northern Namib Dune

  2010cites this paper
• Time interval from cigarette smoke exposure to blood donation and markers of inflammation: should a smoking cut-off be designated?

  2010cites this paper
• Prevention of Postoperative Surgical Site Gynecologic Infections

  2010cites this paper
• SERUM AMYLOID A IN RUMINANTS: DIAGNOSTIC VALUE AND FOOD CONTAMINATION ASSESSMENT

  2010cites this paper
• Evaluation of analgesic, Antipyretic and anti-inflammatory activities of the ethanol and dichloromenthane extract from scaphium lychnophorum fruit in experiment animals

  2010cites this paper
• Memory impairments in healthy aging: Role of aging-induced microglial sensitization.

  2010cites this paper
• The role of laboratory confirmations and molecular epidemiology in global eradication of measles

  2009cites this paper
• Parents and Fever: What do they Believe, and What do They Do?

  2009cites this paper
• A reutilização de coelhos submetidos ao Teste de Pirogênio no controle da qualidade de produtos biológicos com enfoque na Vacina Antimeningocócica AC

  2009cites this paper
• Analgesia Accompanying Food Consumption Requires Ingestion of Hedonic Foods

  2009cites this paper
• NHG-Standaard Kinderen met koorts

  2009cites this paper
• Fever, sweats and hot flashes

  2009cites this paper
• Antimicrobial activity of non-steroidal anti-inflammatory drugs with respect to immunological response: Diclofenac sodium as a case study

  2009cites this paper
• Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America

  2008cites this paper
• Thyroid storm in a polytrauma patient

  2008cites this paper
• Cytokines and pathological sleep.

  2008cites this paper
• Effect of bovine lactoferrin feeding on lipopolysaccharide‐induced metabolic and hormonal disturbances in preruminant calves

  2008cites this paper
• Endogenous opioids: role in prostaglandin-dependent and -independent fever.

  2008cites this paper
• Fever: to treat or not to treat?

  2008cites this paper
• Temperature management in acute neurologic disorders.

  2008cites this paper
• [When and how should a fever be reduced?].

  2008cites this paper
• CORRELACIÓN DE LOS NIVELES DE PROTEÍNA C-REACTIVA, INTERLEUQUINA 6 Y CREATIN-QUINASA CON LA CLASIFICACIÓN DE GUSTILO Y CON LA PREDICCIÓN DE RESULTADOS.

  2008cites this paper
• Koorts bij kinderen

  2007cites this paper
• Febrile seizures

  2007cites this paper
• Cardiovascular effects of omega-3 free Fatty acids.

  2007cites this paper