A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Development

• Publication date

  2012-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.078733PMID 22874919PMCID PMC3424044
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

  2011cited by this paper
• Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

  2011cited by this paper
• Sox9-Haploinsufficiency Causes Glucose Intolerance in Mice

  2011cited by this paper
• Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.

  2011cited by this paper
• Restriction of hepatic competence by Fgf signaling

  2011cited by this paper
• Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development

  2011influential reference
• FGF-receptor signalling controls neural cell diversity in the zebrafish hindbrain by regulating olig2 and sox9

  2010cited by this paper
• Mesenchymal Bone Morphogenetic Protein Signaling Is Required for Normal Pancreas Development

  2010influential reference
• Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung

  2009cited by this paper
• Supplemental Data Sox 17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

  2009cited by this paper
• Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.

  2009cited by this paper
• Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors

  2009influential reference
• Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.

  2008cited by this paper
• Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation.

  2008influential reference
• Sox9 is required for prostate development.

  2008cited by this paper
• Loss of Fgfr2 leads to partial XY sex reversal.

  2008influential reference
• A multipotent progenitor domain guides pancreatic organogenesis.

  2007cited by this paper
• Bmp and Fgf signaling are essential for liver specification in zebrafish

  2007cited by this paper
• Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver

  2007cited by this paper
• Fgf10 regulates hepatopancreatic ductal system patterning and differentiation

  2007cited by this paper
• Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via β‐catenin activation

  2007cited by this paper
• Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells

  2007cited by this paper
• Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation.

  2007cited by this paper
• SOX9 is required for maintenance of the pancreatic progenitor cell pool

  2007cited by this paper
• Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development.

  2006cited by this paper
• An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells.

  2006cited by this paper
• Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

  2006cited by this paper
• Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.

  2006cited by this paper
• A transient cell cycle shift in Drosophila imaginal disc cells precedes multipotency.

  2005cited by this paper
• Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

  2004cited by this paper
• Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

  2004cited by this paper
• Fission of pancreatic islets during postnatal growth of the mouse

  2004influential reference
• Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination

  2004influential reference
• The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells.

  2003cited by this paper
• A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

  2003influential reference
• Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation

  2002cited by this paper
• Conditional inactivation of Sox9: A mouse model for campomelic dysplasia

  2002influential reference
• Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.

  2002influential reference
• The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

  2002influential reference
• A highly efficient ligand‐regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

  2001cited by this paper
• Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.

  2001influential reference
• A bipotential precursor population for pancreas and liver within the embryonic endoderm.

  2001cited by this paper
• Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation.

  2001cited by this paper
• Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor

  2001cited by this paper
• Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4.

  2001cited by this paper
• Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway.

  2000cited by this paper
• Repressive and restrictive mesodermal interactions with gut endoderm: possible relation to Meckel's Diverticulum.

  2000influential reference
• Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre‐mediated excision

  2000influential reference
• Control of endodermal endocrine development by Hes-1

  2000cited by this paper
• Notch signalling controls pancreatic cell differentiation

  1999cited by this paper
• Analysis of pancreatic development using a cell lineage label.

  1999cited by this paper
• Generalized lacZ expression with the ROSA26 Cre reporter strain

  1999cited by this paper
• Attenuation of green fluorescent protein half-life in mammalian cells.

  1999cited by this paper
• Initiation of mammalian liver development from endoderm by fibroblast growth factors.

  1999influential reference
• GATA transcription factors as potentiators of gut endoderm differentiation.

  1998influential reference
• Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

  1998influential reference
• The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.

  1998influential reference
• The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice.

  1996influential reference
• Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors.

  1996influential reference
• PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

  1996cited by this paper
• Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

  1996influential reference
• Receptor Specificity of the Fibroblast Growth Factor Family*

  1996cited by this paper
• THE DEVELOPMENT OF THE DORSAL AND VENTRAL MAMMALIAN PANCREAS IN VIVO AND IN VITRO

  1970cited by this paper
• Early Pancreas Organogenesis: Morphogenesis, Tissue Interactions, and Mass Effects.

  1967cited by this paper
• Epitheliomesenchymal interaction in pancreatic morphogenesis.

  1962influential reference

• Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes

  2025cites this paper
• Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice

  2025cites this paper
• Combinatorial regulatory states define cell fate diversity during embryogenesis

  2024cites this paper
• Directed differentiation of pancreatic δ cells from human pluripotent stem cells

  2024influential citation
• Resolution of acinar dedifferentiation regulates tissue remodeling in pancreatic injury and cancer initiation.

  2024cites this paper
• Cell of Origin of Pancreatic cancer

  2024cites this paper
• SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys

  2024cites this paper
• Integrating Prior Knowledge Using Transformer for Gene Regulatory Network Inference

  2024cites this paper
• Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.

  2023cites this paper
• Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions

  2023cites this paper
• Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective.

  2023cites this paper
• Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association

  2023cites this paper
• Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases

  2023cites this paper
• The role of noncoding RNAs in pancreatic birth defects

  2023cites this paper
• Pax4-Ghrelin mediates the conversion of pancreatic ɛ-cells to β-cells after extreme β-cell loss in zebrafish.

  2023cites this paper
• Clinical significance of pancreatic ductal metaplasia

  2022cites this paper
• Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis

  2022cites this paper
• SOX9 in organogenesis: shared and unique transcriptional functions

  2022cites this paper
• Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges

  2022cites this paper
• Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors

  2022cites this paper
• Comparing development and regeneration in the submandibular gland highlights distinct mechanisms

  2021cites this paper
• Genomic Understanding Reveals the Important Role of FGFR2 as Paeoniflorin Target for Circumventing Breast Cancer Resistance to Tamoxifen

  2021cites this paper
• Deregulation of Transcription Factor Networks Driving Cell Plasticity and Metastasis in Pancreatic Cancer

  2021cites this paper
• Differentiation of Stem Cells into Pancreatic Lineage: In vitro Cell Culture, in vivo Transplantation in Animal Models

  2021cites this paper
• Recapitulating pancreatic cell–cell interactions through bioengineering approaches: the momentous role of non-epithelial cells for diabetes cell therapy

  2021cites this paper
• New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells

  2021cites this paper
• A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish

  2021cites this paper
• Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells

  2021cites this paper
• Shaping the thyroid: from peninsula to de novo lumen formation.

  2021cites this paper
• Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer

  2021cites this paper
• Pancreas morphogenesis: Branching in and then out.

  2021cites this paper
• Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.

  2020cites this paper
• Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ system

  2020cites this paper
• Nuclear receptor tyrosine kinase transport and functions in cancer.

  2020cites this paper
• Cutting the edge between cancerogenesis and organogenesis of the pancreatic endocrine lineage allocation—comprehensive review of the genes Synaptotagmin 13 and 533041C22 Rik in epithelial-to-mesenchymal transition

  2020cites this paper
• Transcriptional Patterning of the Ventricular Cardiac Conduction System

  2020cites this paper
• Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas

  2020cites this paper
• Mesodermal induction of pancreatic fate commitment.

  2019cites this paper
• Pancreas organogenesis: Approaches to elucidate the role of epithelial-mesenchymal interactions.

  2019cites this paper
• Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling

  2019cites this paper
• Antibodies to a CA 19-9 Related Antigen Complex Identify SOX9 Expressing Progenitor Cells In Human Foetal Pancreas and Pancreatic Adenocarcinoma

  2019cites this paper
• Pancreas organogenesis: The interplay between surrounding microenvironment(s) and epithelium-intrinsic factors.

  2019cites this paper
• Title Loss of Pancreas upon Activated Wnt Signaling IsConcomitant with Emergence of Gastrointestinal Identity

  2019cites this paper
• FGF Signaling Directs the Cell Fate Switch from Neurons to Astrocytes in the Developing Mouse Cerebral Cortex

  2019cites this paper
• SOX9+/PTF1A+ Cells Define the Tip Progenitor Cells of the Human Fetal Pancreas of the Second Trimester

  2019cites this paper
• Human stem cell models: lessons for pancreatic development and disease

  2019cites this paper
• Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas.

  2019cites this paper
• Chronic pancreatitis fibrogenesis : the role of TGFB pathway inhibitor Smad7 in the fibrosis development

  2019cites this paper
• Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury

  2019cites this paper
• SOX9 as One of the Central Units of Regulation Axis of Pancreas Embryogenesis and Cancer Progression

  2019cites this paper
• Cell-based simulations of Notch-dependent cell differentiation on growing domains

  2019cites this paper
• SOX9 как одно из центральных звеньев оси регуляции эмбрионального развития и прогрессии рака поджелудочной железы

  2019cites this paper
• Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification

  2018cites this paper
• sox9b is required in cardiomyocytes for cardiac morphogenesis and function

  2018cites this paper
• A branching morphogenesis program governs embryonic growth of the thyroid gland

  2018influential citation
• Developmental molecular biology of the pancreas

  2018cites this paper
• Dll1 and Jag1 are Differentially Required to Specify Proximal and Distal Pancreatic Duct Compartments

  2018cites this paper
• Growth regulation in thyroid development

  2018cites this paper
• Fibroblast Growth Factor 10 in Pancreas Development and Pancreatic Cancer

  2018cites this paper
• Pathways governing development of stem cell‐derived pancreatic β cells: lessons from embryogenesis

  2018influential citation
• The cell cycle regulates mouse and human pancreas development

  2017cites this paper
• Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development

  2017influential citation
• Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme

  2017cites this paper
• Fgf10-Sox9 are essential for establishment of distal progenitor cells during salivary gland development

  2017influential citation
• The molecular and morphogenetic basis of pancreas organogenesis.

  2017cites this paper
• Therapeutic Potential for FGFR Inhibitors in SOX9-FGFR2 Coexpressing Pancreatic Cancer.

  2017cites this paper
• Cellular and molecular mechanisms coordinating pancreas development

  2017cites this paper
• Molecular mechanisms of Sox transcription factors during the development of liver, bile duct, and pancreas.

  2017cites this paper
• In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

  2017cites this paper
• Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

  2017cites this paper
• Development of the Pancreas

  2017cites this paper
• Unraveling the Myth of Foxa2 in Endocrine Formation of the Pancreatic Lineages

  2017cites this paper
• An in vitro study of mesenchyme–islet cell interactions in islet neogenesis: A model for tissue replacement therapy in diabetes mellitus

  2017cites this paper
• Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity

  2016influential citation
• Epicardial cell engraftment and signaling promote cardiac repair after myocardial infarction

  2016cites this paper
• Identification and analysis of a novel nuclear role of Fibroblast Growth Factor 10 (FGF10)

  2016cites this paper
• The roles of SOX4 and MED15 in the development and maintenance of pancreatic β-cells

  2016cites this paper
• Screen to identify the novel pancreatic gene Synaptotagmin 13 (Syt13)

  2016cites this paper
• Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

  2016cites this paper
• Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling.

  2016cites this paper
• Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology

  2016cites this paper
• Recent advance in diabetes therapy: pancreatic beta cell regeneration approaches

  2016cites this paper
• Transcription factor regulation of pancreatic organogenesis, differentiation and maturation

  2016cites this paper
• ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis.

  2016influential citation
• The untapped potential of the GENSAT mice—A valuable resource for developmental biology

  2016cites this paper
• Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells

  2015cites this paper
• Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors

  2015cites this paper
• Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells.

  2015cites this paper
• Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9

  2015cites this paper
• An expandable donor-free supply of functional hepatocytes for toxicology

  2015cites this paper
• Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice

  2015cites this paper
• A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.

  2015influential citation
• PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

  2015cites this paper
• Notch Signaling in Pancreatic Development

  2015influential citation
• Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

  2015cites this paper
• DIABETIC STUDIES The Review of Sox 9 : A Master Regulator of the Pancreatic Program

  2014influential citation
• TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human Embryonic Stem Cells towards Endoderm

  2014cites this paper
• NGN3 Expression in Definitive Endoderm Progenitors Specifies Pancreatic Endocrine Precursors

  2014cites this paper
• Construction and analysis of microRNA-transcription factor regulation network in Arabidopsis.

  2014cites this paper
• Characterization of ALDH Positive Cells in the Human Fetal Pancreas

  2014cites this paper