Newly recognized cytotoxic effect of conjugated trienoic fatty acids on cultured human tumor cells.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cancer Letters

• Publication date

  2000-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0304-3835(99)00332-8PMID 10695994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes.

  1999cited by this paper
• Trans‐geometrical and positional isomers of linoleic acid including conjugated linoleic acid (CLA) in German milk and vegetable fats

  1997cited by this paper
• The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system.

  1997cited by this paper
• Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation.

  1995cited by this paper
• The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation.

  1995cited by this paper
• An improved MTT assay.

  1993cited by this paper
• Research reportAn improved MIT assay

  1993cited by this paper
• Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells.

  1992cited by this paper
• Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens

  1992cited by this paper
• Mammary cancer prevention by conjugated dienoic derivative of linoleic acid.

  1991cited by this paper
• Dietary n‐3 (ω‐3) polyunsaturated fatty acid effects on animal tumorigenesis

  1991cited by this paper
• Cytotoxic effect of cis-parinaric acid in cultured malignant cells.

  1991cited by this paper
• Official methods of analysis of the Association of Official Analytical Chemists

  1990cited by this paper
• Gamma-linolenic acid, arachidonic acid, and eicosapentaenoic acid as potential anticancer drugs.

  1990cited by this paper
• Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses

  1989cited by this paper
• Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation.

  1988cited by this paper
• Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid.

  1987cited by this paper
• The biosynthesis of calendic acid, octadeca-(8E,10E, 12Z)-trienoic, acid, by developing marigold seeds: origins of (E,E,Z) and (Z,E,Z) conjugated triene acids in higher plants

  1985cited by this paper
• The characteristics of domestic tung oils

  1954cited by this paper

• Discovery and Synthesis of Conjugated Fatty Acids from Natural Products.

  2025cites this paper
• Conjugated Linoleic Acid in Colorectal Cancer: Examining the Evidence for Its Preventive and Therapeutic Effects, Mechanisms, and Clinical Translatability

  2025cites this paper
• Trans Fats in Spanish Pastries and Their Influence on Mesenchymal Stem Cell Behavior In Vitro and Related Health Risks

  2025cites this paper
• The Combination of Resveratrol and Conjugated Linoleic Acid Dienes Enhances the Individual Effects of These Molecules on De Novo Fatty Acid Biosynthesis in 3T3-L1 Adipocytes

  2024cites this paper
• Green Solid Lipid Nanoparticles by Fatty Acid Coacervation: An Innovative Nasal Delivery Tool for Drugs Targeting Cerebrovascular and Neurological Diseases

  2024cites this paper
• Enzyme from Padina arborescens Holmes Synthesizes Parinaric Acid, a Conjugated Tetraenoic Fatty Acid, from α-Linolenic Acid.

  2024cites this paper
• Conjugated Linoleic Acid strengthens the apoptotic effect of low-dose cisplatin in A549 cells by inducing Bcl-2 downregulation.

  2023cites this paper
• Study on the production of Sophorolipid by Starmerella bombicola yeast using fried waste oil fermentation

  2023cites this paper
• Metabolic, structure-activity characteristics of conjugated linolenic acids and their mediated health benefits

  2023cites this paper
• Recent advances in the development of bitter gourd seed oil: from chemical composition to potential applications

  2022influential citation
• Phytoconstituent analysis of Alpinia galanga and Zingiber officinale plant lipids – A comparative approach

  2022cites this paper
• Comprehensive profiling of conjugated fatty acid isomers and their lipid oxidation products by two-dimensional chiral RP×RP liquid chromatography hyphenated to UV- and SWATH-MS-detection.

  2022cites this paper
• A review of potential anti-cancer properties of some selected medicinal plants grown in Iran

  2022cites this paper
• Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues.

  2021cites this paper
• Evaluating the effect of a mixture of two main conjugated linoleic acid isomers on hepatic steatosis in HepG2 cellular model

  2021cites this paper
• Potential applications of food industrial by-products in the dairy industry

  2021cites this paper
• DFT Calculations of 1H NMR Chemical Shifts of Geometric Isomers of Conjugated Linolenic Acids, Hexadecatrienyl Pheromones, and Model Triene-Containing Compounds: Structures in Solution and Revision of NMR Assignments

  2021cites this paper
• General and genetic toxicology studies of Aleurites moluccana (L.) Willd. Seeds in vitro and in vivo assays.

  2021cites this paper
• Nutritional evaluation, fatty acid analysis and anticancer properties investigation of seeds from kan-zaw, a potential diet oil and medicinal plant

  2021cites this paper
• Goat’s Milk as a Potential Anti-proliferative against Colon Cancer Cell Lines

  2021cites this paper
• Vegetable Fats and Oils

  2020cites this paper
• Development and Application of a Peroxyl Radical Clock Approach for Measuring Both Hydrogen-Atom Transfer and Peroxyl Radical Addition Rate Constants.

  2020cites this paper
• Conjugated Fatty Acids in Muscle Food Products and Their Potential Health Benefits: A Review.

  2020cites this paper
• Conjugated Lipids and Health

  2020cites this paper
• Drug–Lipid Conjugates for Enhanced Oral Drug Delivery

  2019cites this paper
• New Fatty Acids from the Leaves of Vernicia fordii

  2019cites this paper
• Production of conjugated fatty acids: A review of recent advances.

  2019cites this paper
• Molecular platforms for targeted drug delivery.

  2019cites this paper
• Conjugated Linolenic Acids: Implication in Cancer.

  2019cites this paper
• Comparative study of pomegranate and jacaranda seeds as functional components for the conjugated linolenic acid enrichment of yogurt

  2019cites this paper
• Preparation of β-CD-LA aggregate and its application as drug carriers

  2019cites this paper
• Potential high value conjugated linolenic acids (CLnA) in melon seed waste.

  2019cites this paper
• Cytotoxic effect of punisic acid of pomegranate seed oil on the cellular line of blood cancer (K652)

  2018cites this paper
• Punicic acid was metabolised and incorporated in the form of conjugated linoleic acid in different rat tissues

  2018cites this paper
• Fordin: A novel type I ribosome inactivating protein from Vernicia fordii modulates multiple signaling cascades leading to anti-invasive and pro-apoptotic effects in cancer cells in vitro

  2018cites this paper
• Mitigation of Particulate Matter-Induced Inflammation and Vasoactivity in Human Vascular Endothelial Cells by Omega-3 Polyunsaturated Fatty Acids

  2018cites this paper
• Production of Other Bioproducts from Plant Oils

  2018cites this paper
• Practical applications of agricultural wastes in poultry feeding in Mediterranean and Middle East regions. Part 1: citrus, grape, pomegranate and apple wastes

  2018cites this paper
• EFFECT OF HEPATOPROTECTIVE ROLE EVALUATION OF Hibiscus rosa-sinensis LEAVES AND POMEGRANATE (Punica granatum) PEELS AQ UEOUS EXTRACTS ON MALE ALBINO RATS

  2018cites this paper
• Antioxidant and cytotoxic activity of fatty oil isolated by supercritical fluid extraction from microwave pretreated seeds of wild growing Punica granatum L.

  2018cites this paper
• Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health-Promoting Properties

  2018cites this paper
• Evaluation of Various Biological Activities of the Aerial Parts of Scrophularia frigida Growing in Iran.

  2017cites this paper
• Chemotherapy agent‐unsaturated fatty acid prodrugs and prodrug‐nanoplatforms for cancer chemotherapy

  2017cites this paper
• Fatty and amino acid compositions of Vernicia fordii : a source of α-eleostearic acid and methionine

  2017cites this paper
• Milk fat components with potential anticancer activity—a review

  2017cites this paper
• In-vitro Bioactivity and Phytochemical Screening of Extracts from Rhizomes of Eremostachys azerbaijanica rech. f. Growing in Iran

  2017cites this paper
• Antioxidant status of dairy goats fed diets containing pomegranate seed oil or linseed oil

  2017cites this paper
• Fatty acid profile of Manketti (Schinziophyton rautanenii) nut oil: Influence of extraction method and experimental evidence on the existence of -eleostearic acid

  2017cites this paper
• Sources and Bioactive Properties of Conjugated Dietary Fatty Acids

  2016cites this paper
• Health Benefits of Punicic Acid: A Review.

  2016cites this paper
• POMEGRANATE SEED OIL: A COMPREHENSIVE REVIEW ON ITS THERAPEUTIC EFFECTS

  2016cites this paper
• Metabolism of α-linolenic acid during incubations with strained bovine rumen contents: products and mechanisms.

  2016cites this paper
• Anti-cancer properties of bioactive compounds isolated from Momordica charantia: A mini review

  2016influential citation
• Effect of pomegranate seed oil as a source of conjugated linolenic acid on performance and milk fatty acid profile of dairy goats

  2016cites this paper
• Incorporation and effects of punicic acid on muscle and adipose tissues of rats

  2016cites this paper
• Physico-Chemical Characterization of Oils Extracted from Noni, Spinach, Lady’s Finger, Bitter Gourd and Mustard Seeds, and Copra

  2015cites this paper
• Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR‐/‐ mice

  2015cites this paper
• Dietary pomegranate seed pulp increases conjugated-linoleic and -linolenic acids in muscle and adipose tissues of kid

  2015cites this paper
• Production of conjugated dienoic and trienoic fatty acids by lactic acid bacteria and bifidobacteria

  2015cites this paper
• Jacaric acid inhibits the growth of murine macrophage-like leukemia PU5-1.8 cells by inducing cell cycle arrest and apoptosis

  2015cites this paper
• Conjugated linolenic acids and their bioactivities: a review.

  2014cites this paper
• Characterization of white Mahlab (Prunus mahaleb L.) seed oil: a rich source of α-eleostearic acid.

  2014cites this paper
• Pomegranate Seed Oil ( Punica Granatum L . ) : A Source of Punicic Acid ( Conjugated α-Linolenic Acid )

  2014influential citation
• Apoptosis- and differentiation-inducing activities of jacaric acid, a conjugated linolenic acid isomer, on human eosinophilic leukemia EoL-1 cells.

  2014cites this paper
• Hepatoprotective Role of the Pomegranate ( Punica Granatum ) Juice on Carbon Tetrachloride-Induced Oxidative Stress in Rats

  2013cites this paper
• Triterpenes with cytotoxicity from the leaves of Vernicia fordii.

  2013cites this paper
• Facile synthesis and newly found biological activity of aminolyzed tung oil components with conjugated double bonds

  2013cites this paper
• CHAPTER 8 – Omega-3 (n-3) fatty acids

  2012cites this paper
• Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo.

  2012cites this paper
• Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA).

  2012cites this paper
• Conjugated Linoleic and Linolenic Acid Production by Bacteria: Development of Functional Foods

  2012cites this paper
• Uptake of conjugated linolenic acids and conversion to cis-9, trans-11-or trans-9, trans-11-conjugated linoleic acids in Caco-2 cells

  2012cites this paper
• Sistemas Conjugados: Importância na ação e potenciação de fármacos.

  2012cites this paper
• Effect of high hydrostatic pressure on the production of conjugated fatty acids and trans fatty acids by Bifidobacterium breve LMC520.

  2012cites this paper
• Wheat bran lipophilic compounds with in vitro anticancer effects

  2012cites this paper
• In vitro antioxidant study of vegetable oils containing conjugated linolenic acid isomers

  2012cites this paper
• The Production of Conjugated α-Linolenic, γ-Linolenic and Stearidonic Acids by Strains of Bifidobacteria and Propionibacteria

  2012cites this paper
• Enzymatic synthesis of structured lipids containing conjugated linolenic acids extracted from pomegranate seed oil and their physicochemical characteristics

  2012cites this paper
• Original article Production of structured lipids containing conjugated linolenic acid: optimisation by response surface methodology

  2011cites this paper
• Anticancer prodrugs: an overview of major strategies and recent developments.

  2011cites this paper
• Improvement of oxidative stability of conjugated linolenic acid by complexation with Β-cyclodextrin

  2011cites this paper
• Growth inhibition and apoptotic effect of alpha-eleostearic acid on human breast cancer cells

  2011cites this paper
• Antioxidant effect of vegetable oils containing conjugated linolenic acid isomers against induced tissue lipid peroxidation and inflammation in rat model.

  2011cites this paper
• Investigations of the health benefits of buttermilk fat globule membrane lipid components

  2011cites this paper
• Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA.

  2011cites this paper
• In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.

  2011cites this paper
• A method of concentration estimation of trienes, tetraenes, and pentaenes in evening primrose oil

  2011cites this paper
• The Health Promoting Properties of the Conjugated Isomers of α-Linolenic Acid

  2011cites this paper
• Preparation of Conjugated Linolenic Acid from Urea Fractionated Perilla Seed Oil Hydrolysate

  2011cites this paper
• Production of structured lipids containing conjugated linolenic acid: optimisation by response surface methodology

  2011cites this paper
• [Mineral elements analysis of Momordica charantiap seeds by ICP-AES and fatty acid profile identification of seed oil by GC-MS].

  2010cites this paper
• Poly(ADP-ribose) Polymerase (PARP)-1-independent Apoptosis-inducing Factor (AIF) Release and Cell Death Are Induced by Eleostearic Acid and Blocked by α-Tocopherol and MEK Inhibition*

  2010cites this paper
• Chemical and physiological aspects of isomers of conjugated fatty acids

  2010cites this paper
• Alpha‐eleostearic acid suppresses proliferation of MCF‐7 breast cancer cells via activation of PPARγ and inhibition of ERK 1 / 2

  2010cites this paper
• Microbial production of conjugated γ‐linolenic acid from γ‐linolenic acid by Lactobacillus plantarum AKU 1009a

  2010cites this paper
• Pomegranate (Punica granatum) Seed Linolenic Acid Isomers: Concentration-Dependent Modulation of Estrogen Receptor Activity

  2010cites this paper
• Role of fatty acids in malignancy and visual impairment: epidemiological evidence and experimental studies.

  2009cites this paper
• Metabolic diversity in biohydrogenation of polyunsaturated fatty acids by lactic acid bacteria involving conjugated fatty acid production

  2009cites this paper
• Evaluation and Characterization of Bacterial Metabolic Dynamics with a Novel Profiling Technique, Real-Time Metabolotyping

  2009cites this paper
• Eleostearic Acid Inhibits Breast Cancer Proliferation by Means of an Oxidation-Dependent Mechanism

  2009cites this paper