The OspE-Related Proteins Inhibit Complement Deposition and Enhance Serum Resistance of Borrelia burgdorferi, the Lyme Disease Spirochete

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Infection and Immunity

• Publication date

  2011-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.01274-10PMID 21282413PMCID PMC3067540
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• What Is Lyme Disease?

  2025cited by this paper
• Borrelia burgdorferi (Lyme Disease, Lyme Borreliosis)

  2010cited by this paper
• Borrelia burgdorferi locus BB0795 encodes a BamA orthologue required for growth and efficient localization of outer membrane proteins

  2010cited by this paper
• CspA-Mediated Binding of Human Factor H Inhibits Complement Deposition and Confers Serum Resistance in Borrelia burgdorferi

  2009influential reference
• Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 2 Does Not Contribute to Complement Resistance or Host Infectivity

  2008cited by this paper
• Borrelia burgdorferi Infection-Associated Surface Proteins ErpP, ErpA, and ErpC Bind Human Plasminogen

  2008cited by this paper
• Coordinated Expression of Borrelia burgdorferi Complement Regulator-Acquiring Surface Proteins during the Lyme Disease Spirochete's Mammal-Tick Infection Cycle

  2007cited by this paper
• Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin

  2006cited by this paper
• Evidence that the BBA68 Protein (BbCRASP-1) of the Lyme Disease Spirochetes Does Not Contribute to Factor H-Mediated Immune Evasion in Humans and Other Animals

  2006cited by this paper
• Functional characterization of BbCRASP‐2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL‐1

  2006influential reference
• Complement Regulator-Acquiring Surface Protein 1 Imparts Resistance to Human Serum in Borrelia burgdorferi1

  2005influential reference
• Essential Role for OspA/B in the Life Cycle of the Lyme Disease Spirochete

  2004cited by this paper
• Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins*

  2004influential reference
• The emergence of Lyme disease.

  2004cited by this paper
• Quantitative analysis of Borrelia burgdorferi gene expression in naturally (tick) infected mouse strains

  2004cited by this paper
• Combined Effects of Blood and Temperature Shift on Borrelia burgdorferi Gene Expression as Determined by Whole Genome DNA Array

  2004cited by this paper
• Immunological characterization of the complement regulator factor H-binding CRASP and Erp proteins of Borrelia burgdorferi.

  2004influential reference
• Global Analysis of Borrelia burgdorferi Genes Regulated by Mammalian Host-Specific Signals

  2003influential reference
• Linear and Circular Plasmid Content in Borrelia burgdorferi Clinical Isolates

  2003cited by this paper
• Analysis of the OspE Determinants Involved in Binding of Factor H and OspE-Targeting Antibodies Elicited during Borreliaburgdorferi Infection in Mice

  2003cited by this paper
• Temporal Analysis of Borrelia burgdorferiErp Protein Expression throughout the Mammal-Tick InfectiousCycle

  2003cited by this paper
• Comprehensive Analysis of the Factor H Binding Capabilities of Borrelia Species Associated with Lyme Disease: Delineation of Two Distinct Classes of Factor H Binding Proteins

  2003cited by this paper
• Intra- and Interbacterial Genetic Exchange of Lyme Disease Spirochete erp Genes Generates Sequence Identity Amidst Diversity

  2003cited by this paper
• Changes in Temporal and Spatial Patterns of Outer Surface Lipoprotein Expression Generate Population Heterogeneity and Antigenic Diversity in the Lyme Disease Spirochete, Borrelia burgdorferi

  2002cited by this paper
• Differential Binding of Host Complement Inhibitor Factor H by Borrelia burgdorferi Erp Surface Proteins: a Possible Mechanism Underlying the Expansive Host Range of Lyme Disease Spirochetes

  2002cited by this paper
• Complement Inhibitor Factor H Binding to Lyme Disease Spirochetes Is Mediated by Inducible Expression of Multiple Plasmid-Encoded Outer Surface Protein E Paralogs1

  2002cited by this paper
• Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32‐based shuttle vector for the expression of fluorescent reporters in the Lyme disease spirochaete

  2002cited by this paper
• OspE-Related, OspF-Related, and Elp Lipoproteins Are Immunogenic in Baboons Experimentally Infected with Borrelia burgdorferi and in Human Lyme Disease Patients

  2002cited by this paper
• Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi

  2001cited by this paper
• Complement Evasion by Borrelia burgdorferi: Serum-Resistant Strains Promote C3b Inactivation

  2001cited by this paper
• Regulation of OspE-Related, OspF-Related, and Elp Lipoproteins of Borrelia burgdorferi Strain 297 by Mammalian Host-Specific Signals

  2001cited by this paper
• The Complement Regulator Factor H Binds to the Surface Protein OspE of Borrelia burgdorferi *

  2001influential reference
• Surface exposure and protease insensitivity of Borrelia burgdorferi Erp (OspEF-related) lipoproteins.

  2001cited by this paper
• A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi

  2000cited by this paper
• Repetition, conservation, and variation: the multiple cp32 plasmids of Borrelia species.

  2000cited by this paper
• Molecular and Evolutionary Analysis ofBorrelia burgdorferi 297 Circular Plasmid-Encoded Lipoproteins with OspE- and OspF-Like Leader Peptides

  1999cited by this paper
• Borrelia burgdorferi Erp Proteins Are Immunogenic in Mammals Infected by Tick Bite, and Their Synthesis Is Inducible in Cultured Bacteria

  1998cited by this paper
• Heterogeneity in the complement-dependent bacteriolysis within the species of Borrelia burgdorferi

  1997cited by this paper
• Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes

  1997cited by this paper
• Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.

  1997cited by this paper
• Electrotransformation of the spirochete Borrelia burgdorferi.

  1995cited by this paper
• Binding of human plasminogen to Borrelia burgdorferi

  1995cited by this paper
• Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers

  1995cited by this paper
• Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi

  1995cited by this paper
• Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease

  1994cited by this paper
• Lyme disease.

  1989cited by this paper
• Medical progress. Lyme disease

  1989cited by this paper
• Isolation and cultivation of Lyme disease spirochetes.

  1984cited by this paper
• Principles and practice of infectious diseases. Vols 1 and 2.

  1979cited by this paper
• Biostatistics: A Foundation for Analysis in the Health Sciences

  1975cited by this paper

• The life-and-death struggle between the complement system and pathogens: Mechanisms of elimination, evasion tactics, and translational potential

  2025cites this paper
• Borrelia surface proteins: new horizons in Lyme disease diagnosis

  2025cites this paper
• Erp and Rev Adhesins of the Lyme Disease Spirochete’s Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection

  2023cites this paper
• Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing

  2022cites this paper
• A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes

  2021cites this paper
• Metabolic reprogramming in crustaceans: A vital immune and environmental response strategy

  2021cites this paper
• Lipoproteome screening of the Lyme disease agent identifies novel inhibitors of antibody-mediated complement killing

  2021cites this paper
• Complement Evasion by Lyme Disease Spirochetes.

  2020cites this paper
• New Insights Into CRASP-Mediated Complement Evasion in the Lyme Disease Enzootic Cycle

  2020cites this paper
• LYME DISEASE AND RELAPSING FEVER SPIROCHETES

  2020cites this paper
• Multipartite Genome of Lyme Disease Borrelia: Structure, Variation and Prophages.

  2020cites this paper
• Blood treatment of Lyme borreliae demonstrates the mechanism of CspZ‐mediated complement evasion to promote systemic infection in vertebrate hosts

  2019cites this paper
• Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

  2019cites this paper
• Complement Evasion in Borrelia spirochetes: Mechanisms and Opportunities for Intervention

  2019cites this paper
• Borrelia burgdorferi cp 32 BpaB Modulates Expression of the Prophage NucP Nuclease and SsbP Single-Stranded DNA-Binding Protein

  2019cites this paper
• Edwardsiella tarda Tunes Tricarboxylic Acid Cycle to Evade Complement-Mediated Killing

  2017cites this paper
• Complement Factor H related proteins and their biological role during bacterial infection

  2017cites this paper
• Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin

  2017cites this paper
• Pathogens' toolbox to manipulate human complement.

  2017cites this paper
• Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival

  2017cites this paper
• Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion

  2016cites this paper
• GC-MS-Based Metabolome and Metabolite Regulation in Serum-Resistant Streptococcus agalactiae.

  2016cites this paper
• Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex

  2016cites this paper
• Travelling between Two Worlds: Complement as a Gatekeeper for an Expanded Host Range of Lyme Disease Spirochetes

  2016cites this paper
• Outer Membrane Proteins BB0405 and BB0406 Are Immunogenic, but Only BB0405 Is Required for Borrelia burgdorferi Infection

  2016cites this paper
• The effects of key motility and chemotaxis genes on Borrelia burgdorferi dissemination and evasion of immune clearance in murine tissues

  2015cites this paper
• Host cell heparan sulfate glycosaminoglycans are ligands for OspF‐related proteins of the Lyme disease spirochete

  2015cites this paper
• That's my story, and I'm sticking to it—an update on B. burgdorferi adhesins

  2014cites this paper
• The Cross-Talk between Spirochetal Lipoproteins and Immunity

  2014cites this paper
• Innate immunity networks during infection with Borrelia burgdorferi

  2014cites this paper
• Novel Immunological Markers of Lyme Borreliosis

  2014cites this paper
• Outer Membrane-Barrel in the Borrelia burgdorferi β Forms a Characterization Provide Evidence that P 66 Structural Modeling and Physicochemical

  2014cites this paper
• Innate immunity in host defense against Borrelia

  2013cites this paper
• Distribution of cp32 Prophages among Lyme Disease-Causing Spirochetes and Natural Diversity of Their Lipoprotein-Encoding erp Loci

  2013cites this paper
• Structural Modeling and Physicochemical Characterization Provide Evidence that P66 Forms a β-Barrel in the Borrelia burgdorferi Outer Membrane

  2013cites this paper
• Bpur, the Lyme Disease Spirochete's PUR Domain Protein

  2013cites this paper
• Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression.

  2013cites this paper
• Complement evasion by Borrelia burgdorferi: it takes three to tango.

  2013cites this paper
• ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family

  2013cites this paper
• Molecular mechanisms regulating Complement Receptor 3-mediated phagocytosis of Borrelia burgdorferi

  2012cites this paper
• Changes in Bacterial Growth Rate Govern Expression of the Borrelia burgdorferi OspC and Erp Infection-Associated Surface Proteins

  2012cites this paper
• Borrelial Complement-Binding Proteins

  2012cites this paper
• Comparative molecular analyses of Borrelia burgdorferi sensu stricto strains B31 and N40D10/E9 and determination of their pathogenicity

  2012cites this paper
• Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance of Borrelia burgdorferi

  2012influential citation
• Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

  2012cites this paper
• Borrelia burgdorferi cp32 BpaB Modulates Expression of the Prophage NucP Nuclease and SsbP Single-Stranded DNA-Binding Protein

  2012cites this paper
• BpaB and EbfC DNA-Binding Proteins Regulate Production of the Lyme Disease Spirochete's Infection-Associated Erp Surface Proteins

  2011cites this paper