That's my story, and I'm sticking to it—an update on B. burgdorferi adhesins

Adhesion is the initial event in the establishment of any infection. Borrelia burgdorferi, the etiological agent of Lyme disease, possesses myriad proteins termed adhesins that facilitate contact with its vertebrate hosts. B. burgdorferi adheres to host tissues through interactions with host cells and extracellular matrix, as well as other molecules present in serum and extracellular fluids. These interactions, both general and specific, are critical in the establishment of infection. Modulation of borrelial adhesion to host tissues affects the microorganisms's ability to colonize, disseminate, and persist. In this review, we update the current knowledge on structure, function, and role in pathogenesis of these “sticky” B. burgdorferi infection-associated proteins.

• Publication year

  2014

• Venue

  Frontiers in Cellular and Infection Microbiology

• Publication date

  2014-04-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fcimb.2014.00041PMID 24772392PMCID 3982108
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Extracellular Matrix

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  2014cited by this paper
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  2013cited by this paper
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  2013influential reference
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  2013cited by this paper
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  2013influential reference
• BB0172, a Borrelia burgdorferi Outer Membrane Protein That Binds Integrin α3β1

  2013cited by this paper
• Borrelia burgdorferi BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro

  2013influential reference
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  2013cited by this paper
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  2013influential reference
• The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX

  2013cited by this paper
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  2013influential reference
• BB 0172 , a Borrelia burgdorferi Outer Membrane Protein That Binds

  2013cited by this paper
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  2013influential reference
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  2013cited by this paper
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  2013cited by this paper
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  2013influential reference
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  2012influential reference
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  2012influential reference
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  2012cited by this paper
• Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

  2012influential reference
• Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination

  2012cited by this paper
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  2012cited by this paper
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  2012influential reference
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  2012influential reference
• The Borrelia burgdorferi Integrin Ligand P66 Affects Gene Expression by Human Cells in Culture

  2011influential reference
• A Surface Enolase Participates in Borrelia burgdorferi-Plasminogen Interaction and Contributes to Pathogen Survival within Feeding Ticks

  2011influential reference
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  2011influential reference
• The OspE-Related Proteins Inhibit Complement Deposition and Enhance Serum Resistance of Borrelia burgdorferi, the Lyme Disease Spirochete

  2011cited by this paper
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  2011influential reference
• Adhesion mechanisms of Borrelia burgdorferi.

  2011cited by this paper
• The Enolase of Borrelia burgdorferi Is a Plasminogen Receptor Released in Outer Membrane Vesicles

  2011influential reference
• Decorin binding by DbpA and B of Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi sensu Stricto.

  2011cited by this paper
• Analysis of Borrelia burgdorferi Surface Proteins as Determinants in Establishing Host Cell Interactions

  2011cited by this paper
• Borrelia burgdorferi Enolase Is a Surface-Exposed Plasminogen Binding Protein

  2011influential reference
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Characterization of a novel family of fibronectin-binding proteins with M23 peptidase domains from Treponema denticola.

  2010cited by this paper
• Moonlighting proteins

  2010cited by this paper
• Hidden in plain sight marketing prescription drugs to consumers in the twentieth century.

  2010cited by this paper
• Effect of Borrelia burgdorferi OspC at the Site of Inoculation in Mouse Skin

  2010cited by this paper
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  2010influential reference
• The Borrelial Fibronectin-Binding Protein RevA Is an Early Antigen of Human Lyme Disease

  2010influential reference
• Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen.

  2010influential reference
• Complement Factor H-Related Proteins CFHR2 and CFHR5 Represent Novel Ligands for the Infection-Associated CRASP Proteins of Borrelia burgdorferi

  2010cited by this paper
• Essentials of glycobiology

  2009cited by this paper
• Borrelia burgdorferi BmpA Is a Laminin-Binding Protein

  2009influential reference
• Mechanisms of transendothelial migration of leukocytes.

  2009cited by this paper
• The Borrelia burgdorferi outer-surface protein ErpX binds mammalian laminin.

  2009influential reference
• Comparative Analysis of the Properties and Ligand Binding Characteristics of CspZ, a Factor H Binding Protein, Derived from Borrelia burgdorferi Isolates of Human Origin

  2009cited by this paper
• Functional Characterization of Borrelia spielmanii Outer Surface Proteins That Interact with Distinct Members of the Human Factor H Protein Family and with Plasminogen

  2009cited by this paper
• Borrelia burgdorferi RevA Antigen Binds Host Fibronectin

  2009influential reference
• CspA-Mediated Binding of Human Factor H Inhibits Complement Deposition and Confers Serum Resistance in Borrelia burgdorferi

  2009cited by this paper
• Borrelia burgdorferi complement regulator-acquiring surface proteins (BbCRASPs): Expression patterns during the mammal-tick infection cycle.

  2008cited by this paper
• Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences

  2008cited by this paper
• A Novel Treponema pallidum Antigen, TP0136, Is an Outer Membrane Protein That Binds Human Fibronectin

  2008cited by this paper
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  2008influential reference
• Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety.

  2008cited by this paper
• Borrelia burgdorferi Lacking DbpBA Exhibits an Early Survival Defect during Experimental Infection

  2008cited by this paper
• Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection

  2008cited by this paper
• Molecular Mechanisms Involved in Vascular Interactions of the Lyme Disease Pathogen in a Living Host

  2008cited by this paper
• Common and Unique Contributions of Decorin-Binding Proteins A and B to the Overall Virulence of Borrelia burgdorferi

  2008cited by this paper
• In LipL32, the Major Leptospiral Lipoprotein, the C Terminus Is the Primary Immunogenic Domain and Mediates Interaction with Collagen IV and Plasma Fibronectin

  2008cited by this paper
• Borrelia burgdorferi BBB07 interaction with integrin alpha3beta1 stimulates production of pro-inflammatory mediators in primary human chondrocytes.

  2008cited by this paper
• Lsa21, a novel leptospiral protein binding adhesive matrix molecules and present during human infection

  2008cited by this paper
• Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis

  2008cited by this paper
• Both Decorin-Binding Proteins A and B Are Critical for the Overall Virulence of Borrelia burgdorferi

  2008cited by this paper
• Borrelia burgdorferi BBB07 interaction with integrin α3β1 stimulates production of pro‐inflammatory mediators in primary human chondrocytes

  2007influential reference
• Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 2 (CspZ) as a Serological Marker of Human Lyme Disease

  2007cited by this paper
• Identification of a fibronectin-binding protein of Treponema lecithinolyticum by two-dimensional gel electrophoresis and ligand binding assay.

  2007cited by this paper
• Coordinated Expression of Borrelia burgdorferi Complement Regulator-Acquiring Surface Proteins during the Lyme Disease Spirochete's Mammal-Tick Infection Cycle

  2007cited by this paper
• Physiological Osmotic Induction of Leptospira interrogans Adhesion: LigA and LigB Bind Extracellular Matrix Proteins and Fibrinogen

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• The integrins

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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
• Fibronectin-binding proteins of gram-positive cocci.

  2006cited by this paper
• Inactivation of the fibronectin‐binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi

  2006cited by this paper
• Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development

  2006cited by this paper
• Borrelia burgdorferi OspC Protein Required Exclusively in a Crucial Early Stage of Mammalian Infection

  2006cited by this paper
• Fibronectin Binding Protein BBK32 of the Lyme Disease Spirochete Promotes Bacterial Attachment to Glycosaminoglycans

  2006cited by this paper
• Detection of Borrelia burgdorferi gene expression during mammalian infection using transcriptional fusions that produce green fluorescent protein.

  2006cited by this paper
• Modulation of cell-fibronectin matrix interactions during tissue repair.

  2006cited by this paper
• Identification of a TLR-Independent Pathway for Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases and Inflammatory Mediators through Binding to Integrin α3β11

  2006cited by this paper
• The dbpBA Locus of Borrelia burgdorferi Is Not Essential for Infection of Mice

  2006cited by this paper
• Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin

  2006cited by this paper

• Machine Learning-Driven Identification of Virulence Determinants in Borrelia burgdorferi Associated with Human Dissemination

  2025cites this paper
• Temporal Dynamic Interplay of Mouse Proteome during Protozoan Infection Alone or with Coinfection

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• Borrelia surface proteins: new horizons in Lyme disease diagnosis

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• Moonlighting enzymes of Borrelia burgdorferi

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• ХВОРОБА ЛАЙМА: ВІД ІСТОРІЇ ВІДКРИТТЯ ДО СУЧАСНИХ ВИКЛИКІВ І ПЕРСПЕКТИВИ ПОДОЛАННЯ

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  2024cites this paper
• The plasmid-encoded members of paralogous gene family 52 are dispensable to the enzootic cycle of Borrelia burgdorferi

  2024cites this paper
• Male C57BL/6J mice have higher presence and abundance of Borrelia burgdorferi in their ventral skin compared to female mice.

  2024cites this paper
• Effects of outer surface lipoproteins on the nanomechanical properties of Lyme borrelia

  2023cites this paper
• Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape

  2023cites this paper
• Tick-to-host transmission differs between Borrelia afzelii strains

  2023cites this paper
• Erp and Rev Adhesins of the Lyme Disease Spirochete’s Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection

  2023cites this paper
• Identification of amino acid domains of Borrelia burgdorferi P66 that are surface exposed and important for localization, oligomerization, and porin function of the protein

  2022cites this paper
• Cas9-mediated endogenous plasmid loss in Borrelia burgdorferi

  2022cites this paper
• VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force

  2022cites this paper
• Conserved lysine residues in decorin binding proteins of Borrelia garinii are critical in adhesion to human brain microvascular endothelial cells

  2021cites this paper
• Borrelia burgdorferi Surface Exposed GroEL Is a Multifunctional Protein

  2021cites this paper
• Lyme Disease in Humans.

  2020cites this paper
• Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C

  2020cites this paper
• Molecular interactions during Borrelia burgdorferi migration from the vector to the mammalian nervous system.

  2020cites this paper
• Spirochetes and Immune Evasion: Infection, Persistence and Clearance

  2020cites this paper
• LYME DISEASE AND RELAPSING FEVER SPIROCHETES

  2020cites this paper
• Lyme Disease Pathogenesis.

  2020cites this paper
• Antigen Engineering Approaches for Lyme Disease Vaccines.

  2019cites this paper
• Inter- and intraspecies-specific adhesion of Lyme borreliae to human keratinocytes.

  2019cites this paper
• Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria

  2019cites this paper
• Studies on the pathogenesis and laboratory diagnosis of Lyme borreliosis

  2019cites this paper
• The prevalence of Lyme disease and associated co-infections in people with a chronic post-concussive syndrome.

  2019cites this paper
• Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

  2019cites this paper
• Borrelia burgdorferi protein interactions critical for microbial persistence in mammals

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion

  2017cites this paper
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  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
• Lyme borreliosis

  2016cites this paper
• Evolutionary Aspects of Emerging Lyme Disease in Canada

  2015cites this paper
• The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation

  2015cites this paper
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  2015cites this paper
• Lyme disease: recent advances and perspectives

  2015cites this paper
• Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

  2015cites this paper
• The effects of key motility and chemotaxis genes on Borrelia burgdorferi dissemination and evasion of immune clearance in murine tissues

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• Increased DNA Yield Following Enzymatic Release of Borrelia from a Collagen Matrix in Culture

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• The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis

  2015cites this paper
• Differentiation of Borrelia Microbes from Collagen Debris and Collagen Fibrils in Blood Cultures

  2015cites this paper
• Structural mechanisms underlying sequence-dependent variations in GAG affinities of decorin binding protein A, a Borrelia burgdorferi adhesin.

  2015cites this paper
• A Short-Term Borrelia burgdorferi Infection Model Identifies Tissue Tropisms and Bloodstream Survival Conferred by Adhesion Proteins

  2015cites this paper
• Structure of decorin binding protein B from Borrelia burgdorferi and its interactions with glycosaminoglycans.

  2015cites this paper