SUMO-specific proteases/isopeptidases: SENPs and beyond

We summarize the evolutionary relationship, structure and subcellular distribution of SUMO proteases (or SUMO isopeptidases). We also discuss their functions and allude to their involvement in human disease.

• Publication year

  2014

• Venue

  Genome Biology

• Publication date

  2014-07-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/s13059-014-0422-2PMID 25315341PMCID 4281951
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• SUMO-specific proteases/isopeptidases: SENPs and beyond

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  2013cited by this paper
• Inhibition of SENP1 induces radiosensitization in lung cancer cells

  2013cited by this paper
• Control of nuclear activities by substrate-selective and protein-group SUMOylation.

  2013cited by this paper
• The SUMO system: a master organizer of nuclear protein assemblies

  2013cited by this paper
• Sumoylation: a regulatory protein modification in health and disease.

  2013cited by this paper
• Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6

  2013cited by this paper
• Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo.

  2013cited by this paper
• SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

  2013cited by this paper
• Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation

  2013cited by this paper
• The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

  2013cited by this paper
• SUMO-specific protease 1 promotes prostate cancer progression and metastasis

  2013cited by this paper
• Ubiquitin‐specific protease‐like 1 (USPL1) is a SUMO isopeptidase with essential, non‐catalytic functions

  2012influential reference
• The SUMO Protease Verloren Regulates Dendrite and Axon Targeting in Olfactory Projection Neurons

  2012cited by this paper
• The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress

  2012cited by this paper
• Differential expression of SUMO-specific protease 7 variants regulates epithelial–mesenchymal transition

  2012cited by this paper
• LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

  2012cited by this paper
• SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.

  2012cited by this paper
• DeSUMOylating isopeptidase: a second class of SUMO protease

  2012influential reference
• Function and regulation of SUMO proteases

  2012cited by this paper
• The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation

  2012cited by this paper
• Coordinated Regulation of Transcription Factor Bcl11b Activity in Thymocytes by the Mitogen-activated Protein Kinase (MAPK) Pathways and Protein Sumoylation*

  2012cited by this paper
• Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells.

  2012cited by this paper
• Crystal structure of DeSI‐1, a novel deSUMOylase belonging to a putative isopeptidase superfamily

  2012cited by this paper
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  2011cited by this paper
• The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

  2011cited by this paper
• The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex

  2011cited by this paper
• The Dynamics and Mechanism of SUMO Chain Deconjugation by SUMO-specific Proteases*

  2011cited by this paper
• SUMO routes ribosome maturation

  2011cited by this paper
• The SUMO protease SENP6 is essential for inner kinetochore assembly

  2010cited by this paper
• SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.

  2010cited by this paper
• The fate of metaphase kinetochores is weighed in the balance of SUMOylation during S phase

  2010cited by this paper
• SENP1 Induces Prostatic Intraepithelial Neoplasia through Multiple Mechanisms*

  2010cited by this paper
• SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression.

  2010cited by this paper
• Distribution and paralogue specificity of mammalian deSUMOylating enzymes.

  2010influential reference
• Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.

  2010cited by this paper
• The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

  2010cited by this paper
• Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

  2010cited by this paper
• RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.

  2009cited by this paper
• Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis*

  2009cited by this paper
• SENP3 is responsible for HIF‐1 transactivation under mild oxidative stress via p300 de‐SUMOylation

  2009cited by this paper
• Characterization of SENP7, a SUMO-2/3-specific isopeptidase.

  2009influential reference
• Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

  2008cited by this paper
• Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases

  2008influential reference
• Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7*

  2008influential reference
• The nucleolar SUMO‐specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

  2008cited by this paper
• Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.

  2007influential reference
• The SUMO protease SENP5 is required to maintain mitochondrial morphology and function

  2007cited by this paper
• Small Ubiquitin-related Modifier (SUMO)-specific Proteases

  2007cited by this paper
• Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*

  2006influential reference
• Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates

  2006influential reference
• SUMO protease SENP1 induces isomerization of the scissile peptide bond

  2006cited by this paper
• Nucleocytoplasmic Shuttling Modulates Activity and Ubiquitination-Dependent Turnover of SUMO-Specific Protease 2

  2006cited by this paper
• The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.

  2006cited by this paper
• Mutation of SENP1/SuPr-2 Reveals an Essential Role for Desumoylation in Mouse Development

  2005cited by this paper
• A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.

  2004cited by this paper
• NEDP1, a Highly Conserved Cysteine Protease That deNEDDylates Cullins*

  2003cited by this paper
• Identification and Characterization of DEN1, a Deneddylase of the ULP Family*

  2003cited by this paper
• Conjugation of Smt3 to Dorsal May Potentiate the Drosophila Immune Response

  2002cited by this paper
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  2002cited by this paper
• Association of the Human SUMO-1 Protease SENP2 with the Nuclear Pore*

  2002cited by this paper
• Ubiquitin-like proteins: new wines in new bottles.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast.

  2000cited by this paper
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  2000cited by this paper
• A new protease required for cell-cycle progression in yeast

  1999cited by this paper

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  2025cites this paper
• Targeting small ubiquitin‐related modifier‐specific protease 2 attenuates tumour progression and orchestrates the tumour immune microenvironment in diffuse large B‐cell lymphoma

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• Aging impairs the antiviral defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7

  2025influential citation
• Non-Invasive Assessment of Neurogenesis Dysfunction in Fetuses with Early-Onset Growth Restriction Using Fetal Neuronal Exosomes Isolating from Maternal Blood: A Pilot Study

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• Cysteine proteases and how YabG fits into clan CD of the MEROPS database

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• The emerging roles of ubiquitin-like modifications in regulating HIV replication and host defense

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• Ubiquitin-like Proteins in Autoimmune Diseases: Current Evidence and Therapeutic Opportunities

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• Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell lines

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• SENP5 Attenuates LPS-Induced Acute Lung Injury by Inhibiting Apoptosis of Lung Epithelial Cells Through SLC7A5/mTOR Signaling Pathway.

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• SUMOylation at the crossroads of gut health: insights into physiology and pathology

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• SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy

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• Emerging role of SENP1 in tumorigenesis and cancer therapy

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• The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy

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• SUMOylation of Warts kinase promotes neural stem cell reactivation

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• Targeted inhibition of SUMOylation: treatment of tumors

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• The crosstalk between SUMOylation and immune system in host-pathogen interactions

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• PIAS family in cancer: from basic mechanisms to clinical applications

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• SUMO‐specific proteases: SENPs in oxidative stress‐related signaling and diseases

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• SUMO proteases: from cellular functions to disease.

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• The role of SUMOylation in biomolecular condensate dynamics and protein localization

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• Thymoquinone Nanoparticle Induces Apoptosis and Cell Migration Retardation through Modulating of SUMOylation Process Genes in Breast Cancer Cell Line

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• The role and mechanism of SUMO modification in liver disease.

  2024cites this paper
• In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases

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• SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5

  2024cites this paper
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• TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity

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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective

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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
• Protein–Protein Interactions Facilitate E4orf6-Dependent Regulation of E1B-55K SUMOylation in HAdV-C5 Infection

  2022cites this paper
• SUMO conjugation regulates the activity of the Integrator complex

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• Epigenetic remodelling in human hepatocellular carcinoma

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• SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases

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• Characterizing the differential distribution and targets of Sumo paralogs in the mouse brain

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• SUMOylation in Skeletal Development, Homeostasis, and Disease

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  2022influential citation
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• Maintenance of local adaptation despite gene flow in a coastal songbird

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• Structural basis for the SUMO2 isoform specificity of SENP7.

  2022cites this paper
• Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors

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  2022cites this paper
• SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth

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• SUMOylation in Phytopathogen Interactions: Balancing Invasion and Resistance

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• Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort

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• Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition

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• Functions of Nuclear Receptors SUMOylation.

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