The SUMO protease SENP6 is essential for inner kinetochore assembly

Kinetochore protein CENP-I is regulated by SUMO protease SENP6 and RNF4, a ubiquitin ligase which targets polysumoylated proteins for degradation during mitosis.

• Publication year

  2010

• Venue

  Journal of Cell Biology

• Publication date

  2010-03-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.200909008PMID 20212317PMCID 2835930
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification and Developmental Expression of Xenopus laevis SUMO Proteases

  2009cited by this paper
• Characterization of SENP7, a SUMO-2/3-specific isopeptidase.

  2009cited by this paper
• Regulation of p53 family members by the ubiquitin-like SUMO system.

  2009cited by this paper
• Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.

  2009cited by this paper
• An additional role for SUMO in ubiquitin-mediated proteolysis

  2009influential reference
• Kinetochore-microtubule interactions: the means to the end.

  2008cited by this paper
• Emerging roles of the SUMO pathway in mitosis

  2008cited by this paper
• SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.

  2008influential reference
• RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

  2008cited by this paper
• Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7*

  2008cited by this paper
• Crosstalk between the SUMO and ubiquitin pathways.

  2008cited by this paper
• Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

  2008cited by this paper
• Centromeres: Old tales and new tools

  2008cited by this paper
• Dynamics of inner kinetochore assembly and maintenance in living cells

  2008cited by this paper
• Molecular architecture of the kinetochore–microtubule interface

  2008cited by this paper
• Propagation of centromeric chromatin requires exit from mitosis

  2007cited by this paper
• Modification in reverse: the SUMO proteases.

  2007cited by this paper
• KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.

  2007influential reference
• Mammary development, carcinomas and progesterone: role of Wnt signalling.

  2007cited by this paper
• SUMO-specific proteases: a twist in the tail.

  2007cited by this paper
• The spindle-assembly checkpoint in space and time

  2007influential reference
• Formation and Nuclear Export of Preribosomes Are Functionally Linked to the Small‐Ubiquitin‐Related Modifier Pathway

  2006cited by this paper
• Cenp-F (mitosin) is more than a mitotic marker

  2006cited by this paper
• The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres

  2006influential reference
• SUSP1 antagonizes formation of highly SUMO2/3-conjugated species

  2006cited by this paper
• Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation

  2006cited by this paper
• The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.

  2006cited by this paper
• “HURP on” we're off to the kinetochore!

  2006cited by this paper
• The human CENP-A centromeric nucleosome-associated complex

  2006influential reference
• Crm1 is a mitotic effector of Ran-GTP in somatic cells

  2005cited by this paper
• Kinetochore structure and function.

  2005cited by this paper
• Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma

  2004cited by this paper
• The dynamic kinetochore-microtubule interface

  2004cited by this paper
• Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.

  2004cited by this paper
• Protein modification by SUMO.

  2004cited by this paper
• Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells

  2003cited by this paper
• SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

  2002cited by this paper
• Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores.

  2001cited by this paper
• Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5

  2000cited by this paper
• Visualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells

  2000cited by this paper

• SUMOylation is destined for regulatory T cell-related immune dysregulation

  2026cites this paper
• A genome-wide RNAi screen for novel CIN genes using human artificial chromosome.

  2025cites this paper
• The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms

  2025cites this paper
• The C-terminal SUMOylation-dependent regulation of αKNL2 governs its centromere targeting and interaction with CENH3

  2025cites this paper
• The fission yeast SUMO-targeted ubiquitin ligase Slx8 functionally associates with clustered centromeres and the silent mating-type region at the nuclear periphery

  2024cites this paper
• Multifaceted roles of SUMO in DNA metabolism

  2024cites this paper
• DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity

  2024cites this paper
• SUMO‐specific proteases: SENPs in oxidative stress‐related signaling and diseases

  2024cites this paper
• The role of SUMOylation in biomolecular condensate dynamics and protein localization

  2024cites this paper
• SUMO proteases: from cellular functions to disease.

  2024cites this paper
• Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia

  2023cites this paper
• Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases

  2023cites this paper
• SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations.

  2023cites this paper
• SUMOylation is enriched in the nuclear matrix and required for chromosome segregation

  2023cites this paper
• p97/VCP drives turnover of SUMOylated centromeric CCAN proteins and CENP-A

  2023cites this paper
• SUMO control of centromere homeostasis

  2023influential citation
• Insights in Post-Translational Modifications: Ubiquitin and SUMO

  2022cites this paper
• Stress combined with loss of the Candida albicans SUMO protease Ulp2 triggers selection of aneuploidy via a two-step process

  2022cites this paper
• Kinetochore Architecture Employs Diverse Linker Strategies Across Evolution

  2022cites this paper
• E3 Ligase for CENP-A (Part 1)

  2022cites this paper
• SUMOylation regulates Lem2 function in centromere clustering and silencing

  2022cites this paper
• SUMO paralogue–specific functions revealed through systematic analysis of human knockout cell lines and gene expression data

  2021cites this paper
• Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore

  2021influential citation
• Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis

  2021cites this paper
• SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.

  2021cites this paper
• SUMO-Targeted Ubiquitin Ligases and Their Functions in Maintaining Genome Stability

  2021cites this paper
• SENP Proteases as Potential Targets for Cancer Therapy

  2021cites this paper
• Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis

  2021cites this paper
• The structural basis for Ulp2 recruitment to the kinetochore

  2021influential citation
• Characterization of SNPs in RNF4 and their Implication In Cancer

  2021cites this paper
• SUMOylation Is Associated with Aggressive Behavior in Chondrosarcoma of Bone

  2021cites this paper
• RNF4 Regulates the BLM Helicase in Recovery From Replication Fork Collapse

  2021cites this paper
• A Chain of Events: Regulating Target Proteins by SUMO Polymers.

  2020cites this paper
• The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.

  2020cites this paper
• Stable inheritance of CENP-A chromatin: Inner strength versus dynamic control

  2020cites this paper
• Targeting SUMO Signaling to Wrestle Cancer.

  2020cites this paper
• Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin

  2020cites this paper
• SUMO Chains Rule on Chromatin Occupancy

  2020cites this paper
• Revised annotation and extended characterizations of components of the Chlamydomonas reinhardtii SUMOylation system

  2020cites this paper
• Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation

  2019influential citation
• The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics.

  2019cites this paper
• PICH promotes SUMOylated TopoisomeraseIIα dissociation from mitotic centromeres for proper chromosome segregation

  2019cites this paper
• How Does SUMO Participate in Spindle Organization?

  2019influential citation
• Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin and the associated centromere complex

  2019influential citation
• Localization Analysis of Seven De-sumoylation Enzymes (SENPs) in Ocular Cell Lines.

  2019cites this paper
• Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance in saccharomyces cerevisiae

  2019cites this paper
• SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization

  2019cites this paper
• Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans

  2018cites this paper
• Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases

  2018cites this paper
• Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway

  2018cites this paper
• CENP-B dynamics at centromeres is regulated by a SUMOylation/ubiquitination and proteasomal-dependent degradation mechanism involving the SUMO-targeted ubiquitin E3 ligase RNF4

  2018cites this paper
• Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.

  2018cites this paper
• Guiding Mitotic Progression by Crosstalk between Post-translational Modifications.

  2018cites this paper
• Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases

  2018cites this paper
• RNF4 regulates zebrafish granulopoiesis through the DNMT1‐C/EBPα axis

  2018cites this paper
• Functional and Structural Characterization Reveals Novel FBXW7 Biology

  2018cites this paper
• Sumoylation promotes optimal APC/C activation and timely anaphase

  2018cites this paper
• Reversible regulation of ORC2 SUMOylation by PIAS4 and SENP2

  2017cites this paper
• The Molecular Interface Between the SUMO and Ubiquitin Systems.

  2017cites this paper
• Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity

  2017cites this paper
• Converging Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Signaling: Improved Methodology Identifies Co-modified Target Proteins*

  2017cites this paper
• Maternal SENP7 programs meiosis architecture and embryo survival in mouse.

  2017cites this paper
• Temporal and SUMO-specific SUMOylation contribute to the dynamics of Polo-like kinase 1 (PLK1) and spindle integrity during mouse oocyte meiosis.

  2017cites this paper
• Probing the Molecular Interactions of ATRX

  2017cites this paper
• USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication

  2016cites this paper
• RETRACTED ARTICLE: Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells

  2016cites this paper
• Regulation of a Spindle Positioning Factor at Kinetochores by SUMO-Targeted Ubiquitin Ligases.

  2016cites this paper
• Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements*

  2016cites this paper
• SUMOylation Regulation of Retina Development and Functions.

  2016cites this paper
• Regulation of Chromosome Segregation and Cohesion by the deubiquitinase USP37

  2016cites this paper
• The Effects of SUMO modification of the Tumour Suppressor p53

  2016cites this paper
• Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression.

  2016cites this paper
• Targeting of SUMO substrates to a Cdc48–Ufd1–Npl4 segregase and STUbL pathway in fission yeast

  2015cites this paper
• RETRACTED ARTICLE: SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1

  2015influential citation
• SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation

  2015influential citation
• DeSUMOylation: An Important Therapeutic Target and Protein Regulatory Event

  2015cites this paper
• SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer.

  2015cites this paper
• System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability*

  2015cites this paper
• Identification of SUMO‐2/3‐modified proteins associated with mitotic chromosomes

  2015cites this paper
• SUMO-targeted ubiquitin ligases.

  2014cites this paper
• The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function

  2014cites this paper
• A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1

  2014cites this paper
• Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.

  2014cites this paper
• SUMO Chain-Induced Dimerization Activates RNF4

  2014influential citation
• Exploring the RING-Catalyzed Ubiquitin Transfer Mechanism by MD and QM/MM Calculations

  2014cites this paper
• SUMO-specific proteases/isopeptidases: SENPs and beyond

  2014cites this paper
• A conserved SUMOylation signaling for cell cycle control in a holocentric species Bombyx mori.

  2014cites this paper
• University of Dundee SUMO chain-induced dimerization activates RNF 4

  2014influential citation
• Interplays between Sumoylation, SUMO-Targeted Ubiquitin Ligases, and the Ubiquitin-Adaptor Protein Ufd1 in Fission Yeast

  2014cites this paper
• Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

  2014cites this paper
• SUMO: a multifaceted modifier of chromatin structure and function.

  2013cites this paper
• Role of RNF4 in the Ubiquitination of Rta of Epstein-Barr Virus*

  2013cites this paper
• Role of RNF 4 in the ubiquitination of Rta of Epstein-Barr virus

  2013cites this paper
• SENP6 and SENP7 Peptidases

  2013cites this paper
• Inhibition of SENP6-Induced Radiosensitization of Human Hepatocellular Carcinoma Cells by Blocking Radiation-Induced NF-κB Activation

  2013cites this paper
• STUbLs in chromatin and genome stability.

  2013cites this paper
• Structural and functional characterization of the SUMO proteases SENP6 and SENP7

  2013cites this paper
• Ubiquitin ligases and cell cycle control.

  2013cites this paper
• SUMO Rules: Regulatory Concepts and Their Implication in Neurologic Functions

  2013cites this paper
• Centromere Binding and a Conserved Role in Chromosome Stability for SUMO-Dependent Ubiquitin Ligases

  2013cites this paper