Ubiquitin ligases and cell cycle control.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Annual Review of Biochemistry

• Publication date

  2013-06-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/annurev-biochem-060410-105307PMID 23495935
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

  2012cited by this paper
• The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.

  2012cited by this paper
• The ubiquitin code.

  2012cited by this paper
• Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)

  2012cited by this paper
• Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis

  2012cited by this paper
• APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1

  2012cited by this paper
• Structure of the mitotic checkpoint complex

  2012cited by this paper
• The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

  2011cited by this paper
• The F box protein partner of paired regulates stability of Drosophila centromeric histone H3, CenH3(CID).

  2011cited by this paper
• FBXW5 controls centrosome number

  2011cited by this paper
• Regulation of ubiquitin chain initiation to control the timing of substrate degradation.

  2011cited by this paper
• APC15 drives the turnover of MCC-Cdc20 to make the Spindle Assembly Checkpoint responsive to kinetochore attachment

  2011cited by this paper
• Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

  2011cited by this paper
• Quality control in the initiation of eukaryotic DNA replication

  2011cited by this paper
• Constructing and decoding unconventional ubiquitin chains

  2011cited by this paper
• The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

  2011cited by this paper
• Chfr and RNF8 synergistically regulate ATM activation

  2011cited by this paper
• Homeostatic control of mitotic arrest.

  2011cited by this paper
• RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

  2011cited by this paper
• Structural insights into anaphase-promoting complex function and mechanism

  2011cited by this paper
• SCFCyclin F controls centrosome homeostasis and mitotic fidelity via CP110 degradation

  2010cited by this paper
• The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression

  2010cited by this paper
• APC/C-Cdh1

  2010cited by this paper
• Regulated degradation of spindle assembly factors by the anaphase-promoting complex.

  2010cited by this paper
• Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

  2010cited by this paper
• The SUMO protease SENP6 is essential for inner kinetochore assembly

  2010cited by this paper
• Casein Kinase 1 Functions as both Penultimate and Ultimate Kinase in Regulating Cdc25A Destruction

  2010cited by this paper
• Eukaryotic chromosome DNA replication: where, when, and how?

  2010cited by this paper
• Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4.

  2010cited by this paper
• How cyclin A destruction escapes the spindle assembly checkpoint

  2010cited by this paper
• The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation

  2010cited by this paper
• An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain.

  2010cited by this paper
• The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis

  2009cited by this paper
• Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.

  2009cited by this paper
• The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.

  2009cited by this paper
• BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase.

  2009cited by this paper
• Cell cycle, CDKs and cancer: a changing paradigm

  2009cited by this paper
• Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

  2009cited by this paper
• The SCFSlimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

  2009cited by this paper
• Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex

  2009cited by this paper
• Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.

  2009cited by this paper
• The Influence of Catalysis on Mad2 Activation Dynamics

  2009cited by this paper
• Control of cell growth by the SCF and APC/C ubiquitin ligases.

  2009cited by this paper
• RING domain E3 ubiquitin ligases.

  2009cited by this paper
• Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

  2008cited by this paper
• Genome-wide analysis reveals a cell cycle–dependent mechanism controlling centromere propagation

  2008cited by this paper
• Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer

  2008cited by this paper
• The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

  2008cited by this paper
• Regulation of APC/C activators in mitosis and meiosis.

  2008cited by this paper
• The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

  2008cited by this paper
• FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

  2008cited by this paper
• The RanGTP gradient – a GPS for the mitotic spindle

  2008cited by this paper
• Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

  2008cited by this paper
• The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

  2008cited by this paper
• Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

  2008cited by this paper
• Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells.

  2007cited by this paper
• p31comet blocks Mad2 activation through structural mimicry.

  2007cited by this paper
• Sequential E2s drive polyubiquitin chain assembly on APC targets.

  2007cited by this paper
• Inhibition of APCCdh1 Activity by Cdh1/Acm1/Bmh1 Ternary Complex Formation*

  2007cited by this paper
• Multiple levels of cyclin specificity in cell-cycle control

  2007cited by this paper
• Revisiting the Role of the Mother Centriole in Centriole Biogenesis

  2007cited by this paper
• Regulation of cell cycle progression and gene expression by H2A deubiquitination

  2007cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007cited by this paper
• Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.

  2007cited by this paper
• Cdc20: a WD40 activator for a cell cycle degradation machine.

  2007cited by this paper
• Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

  2007cited by this paper
• Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates

  2007cited by this paper
• Human Kid is Degraded by the APC/CCdh1 but Not by the APC/CCdc20

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007cited by this paper
• Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

  2007cited by this paper
• Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

  2007cited by this paper
• A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.

  2007cited by this paper
• Finishing mitosis, one step at a time

  2007cited by this paper
• Plk4-induced centriole biogenesis in human cells.

  2007cited by this paper
• MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

  2006cited by this paper
• The ubiquitin-proteasome pathway in cell cycle control.

  2006cited by this paper
• SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

  2006cited by this paper
• Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.

  2006cited by this paper
• Acm1 Is a Negative Regulator of the Cdh1-Dependent Anaphase-Promoting Complex/Cyclosome in Budding Yeast

  2006cited by this paper
• PCNA Is a Cofactor for Cdt1 Degradation by CUL4/DDB1-mediated N-terminal Ubiquitination*

  2006cited by this paper
• The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

  2006cited by this paper
• Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

  2006cited by this paper
• Ubiquitin ligases: cell-cycle control and cancer

  2006cited by this paper
• Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

  2006cited by this paper
• Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.

  2006cited by this paper
• Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

  2006cited by this paper
• The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.

  2006cited by this paper
• The anaphase promoting complex/cyclosome: a machine designed to destroy

  2006cited by this paper
• PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

  2006cited by this paper
• The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.

  2005cited by this paper
• Centrosomal Microtubule Nucleation Activity Is Inhibited by BRCA1-Dependent Ubiquitination

  2005cited by this paper
• The APC subunit Doc1 promotes recognition of the substrate destruction box.

  2005cited by this paper
• CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.

  2005cited by this paper
• Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.

  2005cited by this paper
• Preventing re-replication of chromosomal DNA

  2005cited by this paper
• Mechanism of Aurora-B Degradation and Its Dependency on Intact KEN and A-Boxes: Identification of an Aneuploidy-Promoting Property

  2005cited by this paper
• Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.

  2005cited by this paper
• Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.

  2005cited by this paper
• Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase

  2005cited by this paper

• Roles of E3 ubiquitin ligases and deubiquitinating enzymes in renal cell carcinoma

  2026cites this paper
• E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

  2025cites this paper
• Transcriptome analysis of testis in response to silencing of Piwi2 sheds light on spermatogenesis in the mud crab Scylla paramamosain

  2025cites this paper
• Multilayered Regulatory Dynamics of p53 Mutations and Platinum Resistance in Ovarian Cancer.

  2025cites this paper
• Targeting the E1 ubiquitin‐activating enzyme Uba1 impairs male fertility in Bactrocera dorsalis

  2025cites this paper
• Deuterium labeling enables proteome-wide turnover kinetics analysis in cell culture

  2025cites this paper
• Protein modification by a eukaryotic-like ubiquitin-related modifier in the hyperthermophilic archaeon Saccharolobus islandicus

  2025cites this paper
• Deubiquitinating Enzymes in Osteoarthritis: From Mechanisms to Therapeutic.

  2025cites this paper
• 19S proteasome loss causes monopolar spindles through ubiquitin-independent KIF11 degradation

  2025cites this paper
• Deubiquitinase dynamics: methodologies for understanding substrate interactions

  2025cites this paper
• Elevated FBXO45 promotes TFG ubiquitination and drives lung metastasis of hepatocellular carcinoma

  2025cites this paper
• 19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism

  2025cites this paper
• Deuterium labeling enables proteome wide turnover kinetics analysis in cell culture

  2025cites this paper
• β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

  2025cites this paper
• Ubiquitination-Binding Enzyme 2C is Associated with Cancer Development and Prognosis and is a Potential Therapeutic Target

  2024cites this paper
• Prediction of Protein Half-lives from Amino Acid Sequences by Protein Language Models

  2024cites this paper
• Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1‐Mediated Proteolysis of CENP‐A

  2024cites this paper
• Identification of E3 ubiquitin ligase-associated prognostic genes and construction of a prediction model for uterine cervical cancer based on bioinformatics analysis

  2024cites this paper
• Protein degradation is required for normal proliferation of Drosophila intestinal stem cells

  2024influential citation
• Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells

  2024cites this paper
• Molecular mechanisms of ubiquitination in wound healing.

  2024cites this paper
• BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation

  2024cites this paper
• Is Disrupted Mitophagy a Central Player to Parkinson’s Disease Pathology?

  2023cites this paper
• Morphological and transcriptional effects of crude oil and dispersant exposure on the marine sponge Cinachyrella alloclada.

  2023cites this paper
• Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer

  2023cites this paper
• SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.

  2023cites this paper
• The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

  2023cites this paper
• Analysis and prediction of protein stability based on interaction network, gene ontology, and KEGG pathway enrichment scores.

  2023cites this paper
• BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma

  2023cites this paper
• Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble

  2023influential citation
• Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.

  2023cites this paper
• Identification, characterization and expression profiles of E2 and E3 gene superfamilies during the development of tetrasporophytes in Gracilariopsis lemaneiformis (Rhodophyta)

  2023cites this paper
• Role of microRNAs in regulation of doxorubicin and paclitaxel responses in lung tumor cells

  2023cites this paper
• Efficient terminal erythroid differentiation requires the APC/C cofactor Cdh1 to limit replicative stress in erythroblasts

  2022cites this paper
• Role of USP13 in physiology and diseases

  2022cites this paper
• Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia

  2022cites this paper
• FBXO17 Inhibits the Wnt/β-Catenin Pathway and Proliferation of Ishikawa Cells

  2022cites this paper
• Phosphoregulation of the ATP synthase beta subunit stimulates mitochondrial activity for G2/M progression.

  2022cites this paper
• Assembly checkpoint of the proteasome regulatory particle is activated by coordinated actions of proteasomal ATPase chaperones

  2022cites this paper
• Identification of Microproteins in Hep3B Cells at Different Cell Cycle Stages.

  2022cites this paper
• Functions of CDK/cyclin Complexes in Endoreplication Regulation by the CDK Inhibitor SIAMESE

  2022influential citation
• Stabilization of AURKA by the E3 ubiquitin ligase CBLC in lung adenocarcinoma

  2022cites this paper
• Identification of Proteases and Protease Inhibitors in Seeds of the Recalcitrant Forest Tree Species Quercus ilex

  2022cites this paper
• Ubiquitin ligases: Proteolytic signaling, protein turnover, and disease

  2022cites this paper
• Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis

  2022cites this paper
• Targeting the mitochondrial RNA methyltransferase TRMT61B reveals new therapeutic opportunities in aneuploid cancer cells

  2021cites this paper
• Bioinformatic identification of hub genes and related transcription factors in low shear stress treated endothelial cells

  2021cites this paper
• The Roles of Cullins E3 Ubiquitin Ligases in the Lipid Biosynthesis of the Green Microalgae Chlamydomonas reinhardtii

  2021cites this paper
• Molecular insight into somaclonal variation phenomena from transcriptome profiling of cucumber (Cucumis sativus L.) lines

  2021cites this paper
• The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction

  2021cites this paper
• E1 Enzymes as Therapeutic Targets in Cancer

  2021cites this paper
• Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance

  2021cites this paper
• Integration of Transcriptome and Methylome Highlights the Roles of Cell Cycle and Hippo Signaling Pathway in Flatfish Sexual Size Dimorphism

  2021cites this paper
• The importance of CDC27 in cancer: molecular pathology and clinical aspects

  2021cites this paper
• Damsel in distress calling on her knights: Illuminating the pioneering role of E3 ubiquitin ligases in guarding the genome integrity.

  2021cites this paper
• Cell Cycle and Cancer

  2021cites this paper
• Functional heterogeneity of immune defenses in molluscan oysters Crassostrea hongkongensis revealed by high-throughput single-cell transcriptome.

  2021cites this paper
• Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

  2021cites this paper
• Analysis of SI-Related BoGAPDH Family Genes and Response of BoGAPC to SI Signal in Brassica oleracea L.

  2021cites this paper
• Proteome-wide mapping of short-lived proteins in human cells.

  2021cites this paper
• SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors

  2021cites this paper
• Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells.

  2021cites this paper
• Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer

  2021cites this paper
• CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies

  2021cites this paper
• Cell Cycle Control: A System of Interlinking Oscillators.

  2021cites this paper
• LZTR1: A promising adaptor of the CUL3 family

  2021cites this paper
• The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression

  2021cites this paper
• Cell cycle regulation by complex nanomachines

  2021cites this paper
• Cullin 3 and Its Role in Tumorigenesis.

  2020cites this paper
• LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

  2020cites this paper
• Photo Cross‐Linking Probes Containing ϵ‐N‐Thioacyllysine and ϵ‐N‐Acyl‐(δ‐aza)lysine Residues†

  2020cites this paper
• Toxoplasma gondii UBL‐UBA shuttle proteins contribute to the degradation of ubiquitinylated proteins and are important for synchronous cell division and virulence

  2020cites this paper
• Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications

  2020cites this paper
• The COP9 Signalosome: A Multi-DUB Complex

  2020cites this paper
• The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest

  2020cites this paper
• CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma

  2020cites this paper
• Chromokinesin KIF4A teams up with stathmin 1 to regulate abscission in a SUMO-dependent manner

  2020cites this paper
• The Role of Ubiquitination and SUMOylation in DNA Replication.

  2020cites this paper
• Chk1-mediated phosphorylation of Cdh1 promotes the SCFβTRCP-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression

  2020cites this paper
• Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

  2020cites this paper
• Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner.

  2020cites this paper
• Proteomics and posttranslational protein modifications in Toxoplasma gondii

  2020cites this paper
• Deep sequencing of small RNAs reveals the repertoire of miRNAs and piRNAs in Biomphalaria glabrata

  2020cites this paper
• Radiation-induced mitotic catastrophe is associated with down-regulated ribosomal biosynthesis and mitosis genes

  2020cites this paper
• Comparative Transcriptomics of Flammulina filiformis Suggests a High CO2 Concentration Inhibits Early Pileus Expansion by Decreasing Cell Division Control Pathways

  2019cites this paper
• The functions and regulations of Smurfs in cancers.

  2019cites this paper
• Important roles of C-terminal residues in degradation of capsid protein of classical swine fever virus

  2019cites this paper
• Spatiotemporal dissection of the cell cycle with single-cell proteogenomics

  2019cites this paper
• Signs of adaptation to trace metal contamination in a common urban bird.

  2019cites this paper
• PARK2 Suppresses Proliferation and Tumorigenicity in Non-small Cell Lung Cancer

  2019cites this paper
• Planarians recruit piRNAs for mRNA turnover in adult stem cells

  2019cites this paper
• Inhibition of neddylation causes meiotic arrest in mouse oocyte

  2019cites this paper
• Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer

  2019cites this paper
• Mitotic functions of poly(ADP-ribose) polymerases

  2019influential citation
• Molecular Mechanisms in Signaling by Target of Rapamycin Complex 2 in Saccharomyces cerevisiae

  2019cites this paper
• Aflatoxin B1 induces S phase arrest by upregulating the expression of p21 via MYC, PLK1 and PLD1.

  2019cites this paper
• Sequence and structure‐based characterization of ubiquitination sites in human and yeast proteins using Chou's sample formulation

  2019cites this paper
• USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP

  2019cites this paper
• The Methods Employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein-Protein Interactions (PPIs).

  2019cites this paper
• Protein turnover of the cytosolic ribosome and proteasome and their biochemical changes in cells in response to oxidative stress

  2019cites this paper