A GABAA receptor of defined subunit composition and positioning: Concatenation of five subunits

No abstract is available for this paper.

• Publication year

  2006

• Venue

  FEBS Letters

• Publication date

  2006-03-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2006.02.002PMID 16494876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Constraining the Expression of Nicotinic Acetylcholine Receptors by Using Pentameric Constructs

  2006cited by this paper
• Novel Plant Substances Acting as β Subunit Isoform-Selective Positive Allosteric Modulators of GABAA Receptors

  2005cited by this paper
• Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.

  2005cited by this paper
• Benzodiazepines Affect Channel Opening of GABAA Receptors Induced by Either Agonist Binding Site

  2005cited by this paper
• Consequence of the presence of two different β subunit isoforms in a GABAA receptor

  2005cited by this paper
• Positioning of the α-subunit isoforms confers a functional signature to γ-aminobutyric acid type A receptors

  2004cited by this paper
• The Juvenile Myoclonic Epilepsy GABAA Receptor α1 Subunit Mutation A322D Produces Asymmetrical, Subunit Position-Dependent Reduction of Heterozygous Receptor Currents and α1 Subunit Protein Expression

  2004cited by this paper
• Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.

  2004cited by this paper
• Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

  2004cited by this paper
• Individual Properties of the Two Functional Agonist Sites in GABAA Receptors

  2003cited by this paper
• Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement.

  2002cited by this paper
• The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes.

  2002cited by this paper
• Forced subunit assembly in α1β2γ2 GABAA receptors: insight into the absolute arrangement

  2002cited by this paper
• Subunit composition, distribution and function of GABA(A) receptor subtypes.

  2002cited by this paper
• Subunit Arrangement of γ-Aminobutyric Acid Type A Receptors*

  2001cited by this paper
• Stoichiometry of a Ligand-gated Ion Channel Determined by Fluorescence Energy Transfer*

  1999cited by this paper
• International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

  1998cited by this paper
• Stoichiometry and Assembly of a Recombinant GABAA Receptor Subtype

  1997cited by this paper
• Stoichiometry of a Recombinant GABAA Receptor

  1996cited by this paper
• Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

  1995cited by this paper
• GABAA receptor channels.

  1994cited by this paper
• Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification.

  1993cited by this paper
• Subunit selectivity and epitope characterization of mAbs directed against the GABAA/benzodiazepine receptor

  1990cited by this paper
• High-efficiency transformation of mammalian cells by plasmid DNA.

  1987cited by this paper
• Properties of single sodium channels translated by Xenopus oocytes after injection with messenger ribonucleic acid.

  1987cited by this paper
• Monoclonal antibodies reveal structural homogeneity of gamma-aminobutyric acid/benzodiazepine receptors in different brain areas.

  1985cited by this paper
• Inositol lipid breakdown and muscarinic mechanisms

  1984cited by this paper

• Decoding the structural and functional diversity of GABAA receptors: from ensemble logic to therapeutic opportunities

  2025cites this paper
• Detection of Flunitrazepam in Biological Fluids and Beverages:A Review

  2023cites this paper
• Altered GABAA Receptor Expression in the Primary Somatosensory Cortex of a Mouse Model of Genetic Absence Epilepsy

  2022cites this paper
• GABAA receptors: structure, function, pharmacology, and related disorders

  2021cites this paper
• The influence of anesthetics on neurotransmitters in the nervous system of Sepia pharaonis

  2021cites this paper
• High-Dose Benzodiazepines Positively Modulate GABAA Receptors via a Flumazenil-Insensitive Mechanism

  2021cites this paper
• Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs

  2020cites this paper
• Modification de l'expression de gènes impliqués dans le métabolisme cérébral du cholestérol par l'exposition à l'alcool et à la cocaïne

  2019cites this paper
• Molecular docking and ADME studies of natural compounds of Centella asiatica for antiepileptic activity

  2019cites this paper
• Efectos del consumo de alcohol sobre la memoria de trabajo: estudio de caso único

  2019cites this paper
• Efectos del consumo de alcohol sobre la memoria de trabajo: estudio de caso único

  2019cites this paper
• Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic

  2019cites this paper
• Molecular constituents and localization of the ionotropic GABA receptor complex in vivo.

  2019cites this paper
• Flumazenil-insensitive benzodiazepine binding sites in GABAA receptors contribute to benzodiazepine-induced immobility in zebrafish larvae.

  2019cites this paper
• Concatenated γ-aminobutyric acid type A receptors revisited: Finding order in chaos

  2019cites this paper
• Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2 heterotrimeric GABAA receptor in complex with GABA illuminates mechanism of receptor assembly and agonist binding

  2018influential citation
• Structure of a human synaptic GABA-A receptor

  2018cites this paper
• Concatenated nicotinic acetylcholine receptors: A gift or a curse?

  2018cites this paper
• Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors

  2018cites this paper
• Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

  2018cites this paper
• The Benzodiazepine Binding Sites of GABAA Receptors.

  2018cites this paper
• GABA type a receptor trafficking and the architecture of synaptic inhibition

  2018cites this paper
• Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches

  2018cites this paper
• Low Expression in Xenopus Oocytes and Unusual Functional Properties of α1β2γ2 GABAA Receptors with Non-Conventional Subunit Arrangement

  2017cites this paper
• Title Page Title : GABA type A receptor trafficking and the architecture of synaptic inhibition Running title : GABA A R trafficking and synapses

  2017cites this paper
• Assembly rules for GABAA receptor complexes in the brain

  2017cites this paper
• α subunits in GABAA receptors are dispensable for GABA and diazepam action

  2017cites this paper
• Real-Time AFMs Combined with Inverted Optical Microscopes for Wet Cell/Tissue Imaging

  2016cites this paper
• Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors*

  2016cites this paper
• Novel positive allosteric modulators of GABAA receptors with anesthetic activity

  2016cites this paper
• A new chromanone derivative isolated from Hypericum lissophloeus (Hypericaceae) potentiates GABAA receptor currents in a subunit specific fashion.

  2016cites this paper
• Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital.

  2016cites this paper
• A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes

  2016cites this paper
• Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.

  2015cites this paper
• Functional Characterization of the 1,5-Benzodiazepine Clobazam and Its Major Active Metabolite N-Desmethylclobazam at Human GABAA Receptors Expressed in Xenopus laevis Oocytes

  2015cites this paper
• Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site‐directed mutagenesis

  2015cites this paper
• The Direct Actions of GABA, 2’-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries

  2015cites this paper
• Alcohol and violence: neuropeptidergic modulation of monoamine systems

  2015cites this paper
• Translation of ligand binding to activation in olfactory cyclic nucleotide-gated (CNG) channels

  2015cites this paper
• Functional properties of 4-PIOL at synaptic and extrasynaptic GABA-A receptors

  2015cites this paper
• Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors.

  2015cites this paper
• A novel open channel blocker of GABA-A receptors

  2014influential citation
• Two Human Epilepsy Mutations Cause Developmentally Dependant Changes in Seizure Phenotype and GABAA Receptor Expression in Genetically Modified Mice

  2014cites this paper
• A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels

  2014cites this paper
• Accelerated discovery of novel benzodiazepine ligands by experiment-guided virtual screening.

  2014cites this paper
• Stoichiometry of δ subunit containing GABAA receptors

  2014cites this paper
• Determination of the Architecture of Multisubunit Proteins Using AFM Imaging

  2014cites this paper
• Neurobiological alterations in alcohol addiction: a review Alteraciones neurobiológicas en el alcoholismo: revisión

  2014cites this paper
• Neurobiological alterations in alcohol addiction: a review.

  2014cites this paper
• Treatment of Essential Tremor with Long-Chain Alcohols: Still Experimental or Ready for Prime Time?

  2014cites this paper
• Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.

  2014cites this paper
• Relative positioning of classical benzodiazepines to the γ2-subunit of GABAA receptors.

  2014cites this paper
• Biophysical Properties of Recombinant γ2- and δ-subunit Containing GABAA Receptors

  2014cites this paper
• GABAA Receptors of Cerebellar Granule Cells in Culture: Interaction with Benzodiazepines

  2013cites this paper
• Assessment of Homology Templates and an Anesthetic Binding Site within the &ggr;-Aminobutyric Acid Receptor

  2013cites this paper
• Molecular analysis of the site for 2‐arachidonylglycerol (2‐AG) on the β2 subunit of GABAA receptors

  2013cites this paper
• Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors?

  2013cites this paper
• Photoperiod Dependent Plasticity of GABA-mediated Effects on Neuronal Activity in the Pond Snail Lymnaea stagnalis

  2013cites this paper
• On the stoichiometry of resting and activated CRAC channels.

  2013cites this paper
• ETHANOL REGULATION OF GLUCOCORTICOID RESPONSIVE GENES

  2013cites this paper
• Charakterisierung der Interaktion von Gephyrin mit verschiedenen Untereinheiten des GABAA-Rezeptors

  2012cites this paper
• Structure, Function, and Modulation of GABAA Receptors*

  2012cites this paper
• Benzodiazepines Modulate GABAA Receptors by Regulating the Preactivation Step after GABA Binding

  2012cites this paper
• Influence of GABAA Receptor α Subunit Isoforms on the Benzodiazepine Binding Site

  2012cites this paper
• Effect of progesterone on the expression of GABAA receptor subunits in the prefrontal cortex of rats: implications of sex differences and brain hemisphere

  2012cites this paper
• Modulation of neuronal network activity in the primary motor cortex

  2012cites this paper
• GABAA receptor trafficking-mediated plasticity of inhibitory synapses.

  2011cites this paper
• Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.

  2011cites this paper
• The major central endocannabinoid directly acts at GABAA receptors

  2011cites this paper
• Frog Oocytes to Unveil the Structure and Supramolecular Organization of Human Transport Proteins

  2011cites this paper
• Mutational-kinetic Analysis Reveals the Roles of Arginines and Aromatics in the Core of the GABAA Receptor Ligand-binding Pocket

  2011cites this paper
• A closer look at the high affinity benzodiazepine binding site on GABAA receptors.

  2011cites this paper
• Diversity of Structure and Function of α1α6β3δ GABAA Receptors

  2010cites this paper
• Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze‐fracture replica immunolabelling

  2010cites this paper
• A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained

  2010cites this paper
• The Short Splice Variant of the γ2 Subunit Acts as an External Modulator of GABAA Receptor Function

  2010cites this paper
• Unanticipated Structural and Functional Properties of δ-Subunit-containing GABAA Receptors*

  2009cites this paper
• Use of concatamers to study GABAA receptor architecture and function: application to delta-subunit-containing receptors and possible pitfalls.

  2009cites this paper
• Pentameric concatenated (α4)2(β2)3 and (α4)3(β2)2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression

  2009influential citation
• Relative positioning of diazepam in the benzodiazepine‐binding‐pocket of GABAA receptors

  2009cites this paper
• Activation and Modulation of Concatemeric GABA-A Receptors Expressed in Human Embryonic Kidney Cells

  2009cites this paper
• Structure of α6β3δ GABAA receptors and their lack of ethanol sensitivity

  2009cites this paper
• The molecular architecture of the arachidonate‐regulated Ca2+‐selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits

  2009cites this paper
• The promiscuous role of the epsilon subunit in GABAA receptor biogenesis.

  2008cites this paper
• How to Validate a Heteromeric Ion Channel Drug Target: Assessing Proper Expression of Concatenated Subunits

  2008cites this paper
• Estimating the efficiency of benzodiazepines on GABAA receptors comprising γ1 or γ2 subunits

  2008cites this paper
• Determination of the architecture of ionotropic receptors using AFM imaging

  2008cites this paper
• Atomic Force Microscopy Reveals the Stoichiometry and Subunit Arrangement of the α4β3δ GABAA Receptor

  2008cites this paper
• Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor.

  2008cites this paper
• The subunit arrangement and assembly of ionotropic receptors.

  2008cites this paper
• The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels.

  2007cites this paper
• Tandem couture

  2007influential citation
• Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.

  2007cites this paper
• Differential activation of GABA A receptor subtypes

  2007cites this paper
• Tandem couture: Cys-loop receptor concatamer insights and caveats.

  2007cites this paper
• Two neighboring residues of loop A of the a1 subunit point towards the benzodiazepine binding site of GABAA receptors

  2007cites this paper
• The cellular, molecular and ionic basis of GABA(A) receptor signalling.

  2007cites this paper
• GABAA receptor subtypes: the "one glass of wine" receptors.

  2007cites this paper
• Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators.

  2007cites this paper
• Stoichiometry of a pore mutation that abolishes picrotoxin‐mediated antagonism of the GABAA receptor

  2006cites this paper