Structure, Function, and Modulation of GABAA Receptors*

The GABAA receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA. How many isoforms of the receptor exist is far from clear. GABAA receptors located in the postsynaptic membrane mediate neuronal inhibition that occurs in the millisecond time range; those located in the extrasynaptic membrane respond to ambient GABA and confer long-term inhibition. GABAA receptors are responsive to a wide variety of drugs, e.g. benzodiazepines, which are often used for their sedative/hypnotic and anxiolytic effects.

• Publication year

  2012

• Venue

  Journal of Biological Chemistry

• Publication date

  2012-10-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.R112.386664PMID 23038269PMCID PMC3504738
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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