Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

No abstract is available for this paper.

• Publication year

  2001

• Venue

  The FASEB Journal

• Publication date

  2001-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.01-0009revPMID 11641236
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The common Arg972 polymorphism in insulin receptor substrate‐1 causes apoptosis of human pancreatic islets

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• Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling

  2001cited by this paper
• The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.

  2001influential reference
• Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes

  2001cited by this paper
• IRS-2 pathways integrate female reproduction and energy homeostasis

  2000cited by this paper
• Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

  2000cited by this paper
• The common Arg 972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets

  2000cited by this paper
• Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls.

  2000cited by this paper
• Characterization of insulin receptor substrate 3 in rat liver derived cells.

  2000cited by this paper
• Variability of the Insulin Receptor Substrate-1, Hepatocyte Nuclear Factor-1α (HNF-1α), HNF-4α, and HNF-6 Genes and Size at Birth in a Population-Based Sample of Young Danish Subjects1

  2000cited by this paper
• Roles of Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, and Release of Intracellular Ca2+ Stores in Insulin-stimulated Insulin Secretion in β-Cells*

  2000cited by this paper
• Variability of the insulin receptor substrate-1, hepatocyte nuclear factor-1alpha (HNF-1alpha), HNF-4alpha, and HNF-6 genes and size at birth in a population-based sample of young Danish subjects.

  2000cited by this paper
• Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

  2000cited by this paper
• Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

  2000cited by this paper
• Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo *

  2000influential reference
• The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.

  2000cited by this paper
• Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.

  2000cited by this paper
• Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes.

  2000cited by this paper
• Regulation of proteins involved in insulin signaling pathways in differentiating human adipocytes.

  2000influential reference
• IRS-4 Mediates Protein Kinase B Signaling during Insulin Stimulation without Promoting Antiapoptosis

  2000cited by this paper
• Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

  2000cited by this paper
• Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice.

  1999influential reference
• The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.

  1999cited by this paper
• Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.

  1999influential reference
• Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle*

  1999cited by this paper
• Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells.

  1999cited by this paper
• Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells.

  1999cited by this paper
• Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity

  1999influential reference
• Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.

  1999cited by this paper
• A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease.

  1999influential reference
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  1999cited by this paper
• Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Let sleeping dogs lie?

  1999cited by this paper
• Insulin receptor substrate-2 is not necessary for insulin-and exercise-stimulated glucose transport in skeletal muscle

  1999cited by this paper
• Insulin Receptor Substrate 1-induced Inhibition of Endoplasmic Reticulum Ca2+ Uptake in β-Cells

  1999cited by this paper
• Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study.

  1999cited by this paper
• Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

  1999cited by this paper
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  1999cited by this paper
• Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins*

  1999cited by this paper
• Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM

  1999cited by this paper
• Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.

  1999cited by this paper
• Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis*

  1999cited by this paper
• Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

  1999cited by this paper
• Insulin receptor substrate 1-induced inhibition of endoplasmic reticulum Ca2+ uptake in beta-cells. Autocrine regulation of intracellular ca2+ homeostasis and insulin secretion.

  1999cited by this paper
• Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.

  1999cited by this paper
• A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

  1998cited by this paper
• Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians.

  1998cited by this paper
• Disruption of IRS-2 causes type 2 diabetes in mice

  1998cited by this paper
• Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

  1998cited by this paper
• Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance

  1998influential reference
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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• PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

  1997cited by this paper
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  1997cited by this paper
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  1997influential reference
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997influential reference
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  1997influential reference
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  1996cited by this paper
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  1996influential reference
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  1994influential reference
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  1994influential reference

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