The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Diabetologia

• Publication date

  2001-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s001250100625PMID 11596676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus

  2004cited by this paper
• Apoptosis and disease progression in the spontaneously diabetic BB/S rat

  2001cited by this paper
• Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats

  2000cited by this paper
• Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.

  1999cited by this paper
• Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.

  1999cited by this paper
• Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.

  1998cited by this paper
• Beta-cell behaviour during the prediabetic stage. Part II. Non-insulin-dependent and insulin-dependent diabetes mellitus.

  1997cited by this paper
• Combined Analysis and Single-Step Detection of GAD65 and IA2 Autoantibodies in IDDM Can Replace the Histochemical Islet Cell Antibody Test

  1997cited by this paper
• Beta cell apoptosis in T cell-mediated autoimmune diabetes.

  1997cited by this paper
• Insulin-Dependent Diabetes Mellitus: A Constellation of Autoimmune Diseases

  1997cited by this paper
• Genetic susceptibility to the development of autoimmune disease.

  1997cited by this paper
• Loss of GLUT2 glucose transporter expression in pancreatic beta cells from diabetic Chinese hamsters

  1996cited by this paper
• Autoimmune diabetes: the role of the islets of Langerhans.

  1996cited by this paper
• Diabetic animal models:

  1996cited by this paper
• An imprinted gene(s) for diabetes?

  1995cited by this paper
• A major histocompatibility complex class II restriction for BioBreeding/Worcester diabetes-inducing T cells

  1995cited by this paper
• Insulin-dependent diabetes mellitus as an autoimmune disease.

  1994cited by this paper
• Genetic characterization of inbred strains of the rat (Rattus norvegicus).

  1994cited by this paper
• Corrigendum: Genetic dissection of autoimmune type I diabetes in the BB rat

  1994cited by this paper
• Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes.

  1993cited by this paper
• Prognostically Significant Heterogeneity of Cytoplasmic Islet Cell Antibodies in Relatives of Patients with Type I Diabetes

  1992cited by this paper
• The murine autoimmune diabetes model: NOD and related strains.

  1992cited by this paper
• New Inbred Strain of Long-Evans Tokushima Lean Rats With IDDM Without Lymphopenia

  1991cited by this paper
• Procedural guidelines for performing immunophenotyping by flow cytometry.

  1989cited by this paper
• Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.

  1986cited by this paper
• KI‐M2R, a New Specific Monoclonal Antibody, Discriminates Tissue Macrophages From Reticulum Cells and Monocytes In Vivo and In Vitro

  1985cited by this paper
• Immunology of insulin-dependent diabetes mellitus.

  1985cited by this paper
• Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

  1981cited by this paper
• The BB Diabetic Rat: Profound T-Cell Lymphocytopenia

  1981cited by this paper

• Matching model with mechanism: Appropriate rodent models for studying various aspects of diabetes pathophysiology.

  2025cites this paper
• Animal models in the study of diabetic erectile dysfunction: mechanisms and applications

  2025cites this paper
• Multiple low dose streptozotocin‐induced diabetes as a model for studying autoimmune diabetes in humans

  2025cites this paper
• Animal models for type 1 and type 2 diabetes: advantages and limitations

  2024cites this paper
• Progress in experimental models to investigate the in vivo and in vitro antidiabetic activity of drugs

  2024cites this paper
• Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities

  2023cites this paper
• New Frontiers in Three-Dimensional Culture Platforms to Improve Diabetes Research

  2023cites this paper
• Contribution of animal models to diabetes research: Its history, significance, and translation to humans

  2023cites this paper
• Hearing loss in type 1 diabetes mellitus: a need to understand precise pathological mechanisms and develop novel therapeutic approaches

  2023cites this paper
• Animal Models in Diabetic Research—History, Presence, and Future Perspectives

  2023cites this paper
• Preclinical models for Type 1 Diabetes Mellitus - A practical approach for research

  2023cites this paper
• Current advancement in the preclinical models used for the assessment of diabetic neuropathy

  2023cites this paper
• Experimental diabetic animal models to study diabetes and diabetic complications

  2023cites this paper
• Maternal diabetes negatively impacts fetal health

  2022cites this paper
• Establishment of Zebrafish Models for Diabetes Mellitus and Its Microvascular Complications

  2022cites this paper
• Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-α Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes

  2022cites this paper
• Insulin Structure, Function and Diabetes Models in Animals

  2021cites this paper
• Experimental animal models for diabetes and its related complications—a review

  2021cites this paper
• Animal Models of Diabetes-Associated Renal Injury

  2020cites this paper
• Rat Models of Human Type 1 Diabetes.

  2020cites this paper
• Animal Models of Diabetes: Methods and Protocols

  2020cites this paper
• Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes

  2020cites this paper
• Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes

  2020cites this paper
• Taxonomy and Stocks and Strains

  2020cites this paper
• Future Perspective of Diabetic Animal Models

  2020cites this paper
• Retinal changes in mice spontaneously developing diabetes by Th17-cell deviation.

  2020cites this paper
• Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes

  2020cites this paper
• Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat

  2020cites this paper
• MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity

  2019cites this paper
• 1 Results , meta-analysis and a first evaluation of U NOx R , the urinary nitrate-to-nitrite molar ratio , as a measure of nitrite reabsorption in experimental and clinical settings

  2019cites this paper
• Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy

  2019cites this paper
• Genomic Research in Rat Models of Kidney Disease.

  2019cites this paper
• Pathogenesis of Type 1 Diabetes Mellitus and Rodent Experimental Models

  2018cites this paper
• Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

  2018cites this paper
• Effect of Empagliflozin on insulin sensitivity in the lean and obese Zucker rat: a model of metabolic syndrome

  2018cites this paper
• Drosophila melanogaster as a Model for Diabetes Type 2 Progression

  2018cites this paper
• Anti-Diabetic Effect of Fruits on Different Animal Model System

  2018cites this paper
• A Novel Approach for Therapeutic Delivery to the Rodent Pancreas Via Its Arterial Blood Supply

  2018cites this paper
• β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes

  2018cites this paper
• Pathogenesis of Type 1 Diabetes Mellitus and Rodent Experimental Models.

  2018cites this paper
• Animal Models of Type 1 and Type 2 Diabetes Mellitus

  2017cites this paper
• Diabetic aggravation of stroke and animal models

  2017influential citation
• Unravelling the stromal‐nerve interactions in the human diabetic cornea

  2017cites this paper
• Animal models of human type 1 diabetes for evaluating combination therapies and successful translation to the patient with type 1 diabetes

  2017cites this paper
• Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes

  2017cites this paper
• Animal models for diabetes: Understanding the pathogenesis and finding new treatments.

  2016cites this paper
• Experimental Diabetes Mellitus in Different Animal Models

  2016cites this paper
• Type 1 Diabetes

  2016cites this paper
• Rodent Models of Diabetes

  2016cites this paper
• Suppression and Regulation of Immune Responses

  2016cites this paper
• Fat metabolism in type 1 diabetes

  2016cites this paper
• Autoimmune Diabetes: An Overview of Experimental Models and Novel Therapeutics.

  2016cites this paper
• Corneal Diabetes: Where to Next?

  2015influential citation
• Effects of exercise on brain functions in diabetic animal models.

  2015cites this paper
• Diabetes reversal via gene transfer: building on successes in animal models

  2015cites this paper
• A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes

  2015cites this paper
• Current status and patent prospective of animal models in diabetic research

  2015cites this paper
• TNF-α Antibody Therapy in Combination With the T-Cell–Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat

  2015influential citation
• The Transplantation of Insulin Producing Tissue

  2015cites this paper
• Gut immune deficits in LEW.1AR1‐iddm rats partially overcome by feeding a diabetes‐protective diet

  2015cites this paper
• Elucidation of genetic factors in diabetes based on studies of animal models

  2015cites this paper
• Genetically Diabetic Animals

  2015cites this paper
• Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes

  2014cites this paper
• Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes

  2014cites this paper
• Variable immune cell frequencies in peripheral blood of LEW.1AR1‐iddm rats over time compared to other congenic LEW strains

  2014cites this paper
• Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes

  2013cites this paper
• Viruses and Autoimmune Diabetes in Rats

  2013cites this paper
• Comment on Binhai Ren et al. (2013; 15: 28–41): long‐term reversal of diabetes in non‐obese diabetic mice by liver‐directed gene therapy

  2013cites this paper
• Clock Gene Expression in the Liver of Streptozotocin-induced and Spontaneous Type 1 Diabetic Rats

  2013cites this paper
• A Variable CD3+ T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat

  2013cites this paper
• CANDIDATE GENES IN THE GUT AND PANCREAS OF DIABETES-PRONE RATS

  2013influential citation
• Catecholamines are the key for explaining the biological relevance of insulin–melatonin antagonisms in type 1 and type 2 diabetes

  2012cites this paper
• The use of animal models in diabetes research

  2012cites this paper
• Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction.

  2012cites this paper
• GLUT4 in the Endocrine Pancreas – Indicating an Impact in Pancreatic Islet Cell Physiology?

  2012cites this paper
• The insulin–melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus)

  2011cites this paper
• Diabetes in Danish Bank Voles (M. glareolus): Survivorship, Influence on Weight, and Evaluation of Polydipsia as a Screening Tool for Hyperglycaemia

  2011cites this paper
• Physiological studies on the effect of a bradykinin potentiating factor (BPF) isolated from scorpion venom on the burnt skin of alloxan-induced diabetic Guinea pigs.

  2011cites this paper
• Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation.

  2010cites this paper
• Characterization of a mouse model of hyperglycemia and retinal neovascularization.

  2010cites this paper
• Genomic research in rat models of kidney disease.

  2010cites this paper
• Cryopreservation and orthotopic transplantation of rat ovaries.

  2010cites this paper
• Rat Genomics

  2010influential citation
• Coxsackievirus B4 and type 1 diabetes pathogenesis: contribution of animal models

  2009cites this paper
• Genetic Loci Contributing to Spontaneous Autoimmune Diabetes

  2009cites this paper
• The use of animal models in the study of diabetes mellitus.

  2009cites this paper
• Pancreas Biology, Pathology, and Tissue Engineering

  2009cites this paper
• Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus

  2009cites this paper
• Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats

  2009cites this paper
• Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene.

  2009cites this paper
• Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes

  2009influential citation
• The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1

  2008cites this paper
• Klebsiella oxytoca: opportunistic infections in laboratory rodents

  2008cites this paper
• Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.

  2008cites this paper
• Hereditary hyperglycaemia and pancreatic degeneration in Guinea pigs

  2007cites this paper
• Animal Models of Type 1 Diabetes Mellitus

  2007cites this paper
• Induction of dominant tolerance using monoclonal antibodies.

  2007cites this paper
• Cellular and molecular pathogenesis of type 1A diabetes

  2007cites this paper
• Genetic Reconstitution of Autoimmune Type 1 Diabetes With Two Major Susceptibility Genes in the Rat

  2007cites this paper
• Beta cell death in hyperglycaemic Psammomys obesus is not cytokine-mediated

  2006cites this paper