Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Brain Structure and Function

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1007/s00429-014-0729-5PMID 24756342
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood.

  2014cited by this paper
• Childhood trauma, personality disorders symptoms and current major depressive disorder in Togo

  2013cited by this paper
• Modulation of amygdala response and connectivity in depression by serotonin transporter polymorphism and diagnosis.

  2013cited by this paper
• FKBP5 and attention bias for threat: associations with hippocampal function and shape.

  2013cited by this paper
• Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: findings from a longitudinal study.

  2013cited by this paper
• Functional Connectivity from the Amygdala to the Hippocampus Grows Stronger after Stress

  2013cited by this paper
• A magnetic resonance imaging study of hippocampal, amygdala and subgenual prefrontal cortex volumes in major depression subtypes: melancholic versus psychotic depression.

  2013cited by this paper
• Amygdala activation and its functional connectivity during perception of emotional faces in social phobia and panic disorder.

  2013cited by this paper
• Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy.

  2013cited by this paper
• Neural traces of stress: cortisol related sustained enhancement of amygdala-hippocampal functional connectivity

  2013cited by this paper
• Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy.

  2012cited by this paper
• Brain connectivity in psychiatric imaging genetics

  2012cited by this paper
• Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients.

  2012cited by this paper
• Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.

  2012cited by this paper
• FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity

  2012cited by this paper
• Endogenous cortisol is associated with functional connectivity between the amygdala and medial prefrontal cortex.

  2012cited by this paper
• Amygdala volume in combat-exposed veterans with and without posttraumatic stress disorder: a cross-sectional study.

  2012cited by this paper
• Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems

  2012cited by this paper
• Expression and Regulation of the Fkbp5 Gene in the Adult Mouse Brain

  2011cited by this paper
• How to regulate emotion? Neural networks for reappraisal and distraction.

  2011cited by this paper
• The size and burden of mental disorders and other disorders of the brain in Europe 2010.

  2011cited by this paper
• Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population

  2011cited by this paper
• Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth

  2011cited by this paper
• Functional connectivity of emotional processing in depression.

  2011cited by this paper
• The glucocorticoid receptor: pivot of depression and of antidepressant treatment?

  2011cited by this paper
• The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety.

  2011cited by this paper
• Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

  2010cited by this paper
• Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.

  2010cited by this paper
• Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype

  2010cited by this paper
• DNA sequence variants of the FKBP5 gene are associated with unipolar depression.

  2010cited by this paper
• [The German version of the Childhood Trauma Questionnaire (CTQ): preliminary psychometric properties].

  2010cited by this paper
• Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation.

  2010cited by this paper
• Imaging genetics of cognitive functions: Focus on episodic memory

  2010cited by this paper
• Time-Dependent Effects of Corticosteroids on Human Amygdala Processing

  2010cited by this paper
• Die deutsche Version des Childhood Trauma Questionnaire (CTQ): Erste Befunde zu den psychometrischen Kennwerten

  2010cited by this paper
• Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis

  2010cited by this paper
• Amygdala volumes in a sample of current depressed and remitted depressed patients and healthy controls.

  2010cited by this paper
• Memory for emotional faces in naturally occurring dysphoria and induced sadness.

  2009cited by this paper
• Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension.

  2009cited by this paper
• Amygdala volume marks the acute state in the early course of depression.

  2009cited by this paper
• Frontolimbic function and cortisol reactivity in response to emotional stimuli

  2009cited by this paper
• Emotion circuits in the brain.

  2009cited by this paper
• Glucocorticoids and the regulation of memory in health and disease.

  2009cited by this paper
• The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders.

  2009influential reference
• The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.

  2008cited by this paper
• Impulsivity, compulsivity, and habit: the role of orbitofrontal cortex revisited.

  2008cited by this paper
• Neural bases of moderation of cortisol stress responses by psychosocial resources.

  2008cited by this paper
• Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.

  2008influential reference
• Interaction of endogenous cortisol and noradrenaline in the human amygdala.

  2008cited by this paper
• Mentalizing about emotion and its relationship to empathy.

  2008cited by this paper
• The role of the amygdala in emotional processing: a quantitative meta-analysis of functional neuroimaging studies.

  2008cited by this paper
• Neural substrates of increased memory sensitivity for negative stimuli in major depression.

  2008cited by this paper
• Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality

  2008cited by this paper
• The orbitofrontal cortex and beyond: from affect to decision-making.

  2008cited by this paper
• Risk indicators and psychopathology in traumatised children and adolescents with a history of sexual abuse

  2008cited by this paper
• Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

  2008cited by this paper
• Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

  2008cited by this paper
• A fast diffeomorphic image registration algorithm

  2007cited by this paper
• Putting Feelings Into Words

  2007cited by this paper
• Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features.

  2007cited by this paper
• Childhood trauma and suicide attempts in patients with unipolar depression

  2007cited by this paper
• Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.

  2007cited by this paper
• Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.

  2006cited by this paper
• Neural mechanisms of genetic risk for impulsivity and violence in humans.

  2006cited by this paper
• Cognitive neuroscience of emotional memory

  2006cited by this paper
• Intermediate phenotypes and genetic mechanisms of psychiatric disorders

  2006cited by this paper
• Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study.

  2005cited by this paper
• Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects.

  2005cited by this paper
• FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells*

  2005cited by this paper
• 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

  2005cited by this paper
• Remembering one year later: role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories.

  2005cited by this paper
• Neural correlates of genetically abnormal social cognition in Williams syndrome

  2005cited by this paper
• Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala.

  2005cited by this paper
• Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

  2004cited by this paper
• For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion

  2004cited by this paper
• Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study

  2004cited by this paper
• Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression

  2004cited by this paper
• Lateralization of amygdala activation: a systematic review of functional neuroimaging studies.

  2004cited by this paper
• Human emotion and memory: interactions of the amygdala and hippocampal complex.

  2004cited by this paper
• Enlarged amygdala volume and reduced hippocampal volume in young women with major depression

  2004cited by this paper
• Inhibition and the right inferior frontal cortex.

  2004cited by this paper
• Neural circuitry underlying voluntary suppression of sadness.

  2003cited by this paper
• The endophenotype concept in psychiatry: etymology and strategic intentions.

  2003cited by this paper
• Development and validation of a brief screening version of the Childhood Trauma Questionnaire.

  2003cited by this paper
• An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets

  2003cited by this paper
• The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes

  2002cited by this paper
• The amygdala: vigilance and emotion

  2001cited by this paper
• 1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidation.

  2000cited by this paper
• Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study.

  2000cited by this paper
• The anatomical connections of the macaque monkey orbitofrontal cortex. A review.

  2000cited by this paper
• Event-Related Activation in the Human Amygdala Associates with Later Memory for Individual Emotional Experience

  2000cited by this paper
• Changes in Functional Connectivity in Orbitofrontal Cortex and Basolateral Amygdala during Learning and Reversal Training

  2000cited by this paper
• Glucocorticoids and the regulation of memory consolidation

  2000cited by this paper
• A volumetric study of hippocampus and amygdala in depressed patients with subjective memory problems.

  2000cited by this paper
• Behavioral sequelae of perinatal insults and early family adversity at 8 years of age.

  2000cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Squirrel Monkey Immunophilin FKBP51 Is a Potent Inhibitor of Glucocorticoid Receptor Binding*

  2000cited by this paper
• Hippocampal volume reduction in major depression.

  2000cited by this paper
• Amygdala enlargement in dysthymia--a volumetric study of patients with temporal lobe epilepsy.

  1999cited by this paper
• Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI.

  1999cited by this paper
• Amygdala activity related to enhanced memory for pleasant and aversive stimuli

  1999cited by this paper

• Central amygdala Fkbp5 expression correlates with faster submission and ethanol self-administration reacquisition: Benztropine reduces ethanol relapse-like reacquisition in stressed rats

  2025cites this paper
• The extraordinary "ordinary magic" of resilience.

  2024cites this paper
• A systematic review of childhood maltreatment and resting state functional connectivity

  2023cites this paper
• Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures

  2023cites this paper
• Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex

  2023cites this paper
• FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents

  2022cites this paper
• Early adversity as the prototype gene × environment interaction in mental disorders?

  2022cites this paper
• Journal Pre-proof Early social altered brain functional connectivity and mental health

  2022cites this paper
• Associations of autistic traits, executive dysfunction and the FKBP5 gene with emotion regulation in Chinese college students

  2022cites this paper
• Early Social Adversity, Altered Brain Functional Connectivity, and Mental Health.

  2022cites this paper
• Influence of FKBP5 Variants and Childhood Trauma on Brain Volume in Non-clinical Individuals

  2021influential citation
• Corticolimbic Circuitry and Genomic Risk for Stress-Related Psychopathology

  2021cites this paper
• Genetic placebo effect on psychological resilience: the moderating role of self-compassion

  2021cites this paper
• FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin

  2021cites this paper
• The role of childhood trauma, HPA axis reactivity and FKBP5 genotype on cognition in healthy individuals.

  2021cites this paper
• Impacts of FKBP5 variants on large-scale brain network connectivity in healthy adults.

  2020cites this paper
• Kohortenstudien in der Kinder- und Jugendpsychiatrie

  2020cites this paper
• [Cohort studies in child and adolescent psychiatry].

  2020cites this paper
• The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting‐state functional connectivity in young adults

  2020cites this paper
• Adverse childhood experiences, posttraumatic stress, and FKBP5 methylation patterns in postpartum women and their newborn infants.

  2020cites this paper
• The moderating effect of FKBP5 and 5-HTTLPR polymorphisms on the day-level association between drinking to cope motivation and negative affect.

  2020cites this paper
• FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals

  2020cites this paper
• Hypothalamic-pituitary-adrenal axis-related genes and cognition in major mood disorders and schizophrenia: a systematic review.

  2020cites this paper
• Interaction between hypothalamic-pituitary-adrenal axis genetic variation and maternal behavior in the prediction of amygdala connectivity in children

  2019cites this paper
• Built by scientists , for scientists 12 . 2 % 116 , 000 125 M TOP 1 % 154 4 , 300

  2019cites this paper
• rs1360780 of the FKBP5 gene modulates the association between maternal acceptance and regional gray matter volume in the thalamus in children and adolescents

  2019cites this paper
• Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

  2019cites this paper
• FKBP5 gene variants and borderline personality disorder.

  2019cites this paper
• Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience.

  2019cites this paper
• FKBP5 Gene Variants May Modulate Depressive Features in Bipolar Disorder

  2019cites this paper
• Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression

  2019cites this paper
• FKBP5 methylation predicts functional network architecture of the rostral anterior cingulate cortex

  2019cites this paper
• Resilience and the brain: a key role for regulatory circuits linked to social stress and support

  2019cites this paper
• Interaction of HPA axis genetics and early life stress shapes emotion recognition in healthy adults.

  2019cites this paper
• Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model.

  2018cites this paper
• Early life stress and trauma: developmental neuroendocrine aspects of prolonged stress system dysregulation

  2018cites this paper
• Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women

  2018cites this paper
• Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man

  2018cites this paper
• The roles of early-life adversity and rumination in neural response to emotional faces amongst anxious and depressed adults

  2018cites this paper
• FKBP5 Moderates the Association between Antenatal Maternal Depressive Symptoms and Neonatal Brain Morphology

  2018cites this paper
• The juvenile antisocial brain : brain imaging studies in clinically antisocial youth with nascent phychopathic traits

  2018cites this paper
• Hpa Axis Genetic Variation and Life Stress Influences on Functional Connectivity in Resting State Networks

  2018cites this paper
• Dissecting the molecular mechanisms of gene x environment interactions: implications for diagnosis and treatment of stress-related psychiatric disorders

  2017cites this paper
• FKBP5 polymorphisms influence pre‐learning stress‐induced alterations of learning and memory

  2017influential citation
• The genetics of anxiety‐related negative valence system traits

  2017cites this paper
• Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.

  2017cites this paper
• Examining FKBP5 mRNA expression in human iPSC-derived neural cells.

  2017cites this paper
• The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies

  2017cites this paper
• The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease

  2017cites this paper
• Constitutive differences in glucocorticoid responsiveness to stress are related to variation in aggression and anxiety-related behaviors.

  2017cites this paper
• FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants

  2017cites this paper
• The Role of Chronic Stress in Anxious Depression

  2017cites this paper
• Development of Psychopathy from Childhood

  2017cites this paper
• FKBP 5 polymorphisms influence pre-learning stress-induced alterations of learning and memory

  2017influential citation
• Folgen früher Traumatisierung aus neurobiologischer Sicht

  2017cites this paper
• Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity.

  2017cites this paper
• Gene × Environment Interactions: From Molecular Mechanisms to Behavior

  2017cites this paper
• Reproducibility in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity

  2017influential citation
• Effects of Early Life Stress on Anhedonia and Striatal Dopamine Concentration Depends on Variation in catechol-O-methyltransferase (COMT) Genotype

  2016cites this paper
• Genetic aetiology of anxiety disorders

  2016cites this paper
• Evidence for a Sex-Dependent MAOA× Childhood Stress Interaction in the Neural Circuitry of Aggression.

  2016cites this paper
• Effect of the interaction between childhood abuse and rs1360780 of the FKBP5 gene on gray matter volume in a general population sample

  2016cites this paper
• The Role of Genetics and Epigenetics in the Pathogenesis of Posttraumatic Stress Disorder

  2016cites this paper
• FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students

  2016influential citation
• Gene–Stress–Epigenetic Regulation of FKBP5: Clinical and Translational Implications

  2016cites this paper
• Genetic Moderation of Stress Effects on Corticolimbic Circuitry

  2016influential citation
• Alcohol Consumption: A Study of Genetic and Environmental Correlates with Focus on the Stress System

  2016cites this paper
• Childhood trauma and emotion processing neurocircuitry

  2016cites this paper
• FKBP5 is associated with amygdala volume in the human brain and mood state: A voxel-based morphometry (VBM) study

  2016cites this paper
• Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders

  2016cites this paper
• The age-dependent plasticity highlights the conceptual interface between borderline personality disorder and PTSD

  2016cites this paper
• Gene x environment interactions in conduct disorder: Implications for future treatments.

  2016cites this paper
• Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project

  2016cites this paper
• Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression

  2016cites this paper
• A Prospective Cohort Study of Influences on Externalizing Behaviors Across Childhood: Results From a Nurse Home Visiting Randomized Controlled Trial.

  2016cites this paper
• The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

  2016cites this paper
• Abnormal functional architecture of amygdala‐centered networks in adolescent posttraumatic stress disorder

  2016cites this paper
• Alcohol Consumption : A Study of Genetic and Environmental Correlates with Focus on the Stress System

  2016cites this paper
• Western High-Fat Diet Consumption during Adolescence Increases Susceptibility to Traumatic Stress while Selectively Disrupting Hippocampal and Ventricular Volumes

  2016cites this paper
• Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans

  2016cites this paper
• Joint influence of early life stress and intranasal oxytocin on stress reactivity: Insights from brain connectivity

  2015cites this paper
• The effects of early life stress on the epigenome: From the womb to adulthood and even before.

  2015cites this paper
• Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties

  2015cites this paper
• Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example.

  2015cites this paper
• Amygdala–Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin

  2015cites this paper
• Psychotrauma als Risiko für spätere psychische Störungen

  2014cites this paper
• [Psychological trauma as risk for delayed psychiatric disorders: epigenetic mechanisms].

  2014cites this paper
• Association between the common functional FKBP5 variant (rs1360780) and brain structure in a non-clinical population.

  2014cites this paper
• Epigenetics in posttraumatic stress disorder.

  2014cites this paper