Mitochondrial regulation of oxygen sensing.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Mitochondrion (Amsterdam. Print)

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.mito.2005.06.005PMID 16146708
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling

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• Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.

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• Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

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• Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.

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• Targeting HIF-1 for cancer therapy

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• HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma

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• HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma.

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• Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

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• Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor*

  2003cited by this paper
• Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.

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• Differential regulation of cell motility and invasion by FAK

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• Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways.

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• Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

  2002cited by this paper
• Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α*

  2002cited by this paper
• Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.

  2002cited by this paper
• Exposure of Yeast Cells to Anoxia Induces Transient Oxidative Stress

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• FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

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• Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

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• How oxygen makes its presence felt.

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• Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells.

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• Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing

  2002cited by this paper
• Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain.

  2001cited by this paper
• Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite.

  2001cited by this paper
• HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

  2001cited by this paper
• HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.

  2001cited by this paper
• A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

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• Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene

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• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

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• Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1*

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• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

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• Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension*

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• Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

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• Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

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  1999cited by this paper
• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

  1999cited by this paper
• Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation.

  1999cited by this paper
• Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.

  1999cited by this paper
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  1998cited by this paper
• Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein. Implications for oxygen sensing.

  1998cited by this paper
• Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes*

  1998cited by this paper
• Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

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• Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit*

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• Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

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• Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.

  1996cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996cited by this paper
• Oxygen sensing and molecular adaptation to hypoxia.

  1996cited by this paper
• Molecular Oxygen Modulates Cytochrome c Oxidase Function*

  1996cited by this paper
• Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

  1996cited by this paper
• Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing.

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