BAFF controls B cell metabolic fitness through a PKCβ- and Akt-dependent mechanism

B cell life depends critically on the cytokine B cell–activating factor of the tumor necrosis factor family (BAFF). Lack of BAFF signaling leads to B cell death and immunodeficiency. Excessive BAFF signaling promotes lupus-like autoimmunity. Despite the great importance of BAFF to B cell biology, its signaling mechanism is not well characterized. We show that BAFF initiates signaling and transcriptional programs, which support B cell survival, metabolic fitness, and readiness for antigen-induced proliferation. We further identify a BAFF-specific protein kinase C β–Akt signaling axis, which provides a connection between BAFF and generic growth factor–induced cellular responses.

• Publication year

  2006

• Venue

  Journal of Experimental Medicine

• Publication date

  2006-10-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20060990PMID 17060474PMCID 2118121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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