Genetics of Proteasome Diseases

The proteasome is a large, multiple subunit complex that is capable of degrading most intracellular proteins. Polymorphisms in proteasome subunits are associated with cardiovascular diseases, diabetes, neurological diseases, and cancer. One polymorphism in the proteasome gene PSMA6 (−8C/G) is associated with three different diseases: type 2 diabetes, myocardial infarction, and coronary artery disease. One type of proteasome, the immunoproteasome, which contains inducible catalytic subunits, is adapted to generate peptides for antigen presentation. It has recently been shown that mutations and polymorphisms in the immunoproteasome catalytic subunit PSMB8 are associated with several inflammatory and autoinflammatory diseases including Nakajo-Nishimura syndrome, CANDLE syndrome, and intestinal M. tuberculosis infection. This comprehensive review describes the disease-related polymorphisms in proteasome genes associated with human diseases and the physiological modulation of proteasome function by these polymorphisms. Given the large number of subunits and the central importance of the proteasome in human physiology as well as the fast pace of detection of proteasome polymorphisms associated with human diseases, it is likely that other polymorphisms in proteasome genes associated with diseases will be detected in the near future. While disease-associated polymorphisms are now readily discovered, the challenge will be to use this genetic information for clinical benefit.

• Publication year

  2013

• Venue

  Scientifica

• Publication date

  2013-12-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2013/637629PMID 24490108PMCID 3892944
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nucleic Acids Research

  2015cited by this paper
• The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.

  2014cited by this paper
• Crude and purified proteasome activity assays are affected by type of microplate.

  2014cited by this paper
• Regulation of proteasome activity in health and disease.

  2014cited by this paper
• The complexity of recognition of ubiquitinated substrates by the 26S proteasome.

  2014cited by this paper
• Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond.

  2014cited by this paper
• Structural biology of the proteasome.

  2013cited by this paper
• Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection

  2013cited by this paper
• Evaluation and management of patients with isolated neutropenia.

  2013cited by this paper
• New therapeutics in systemic lupus erythematosus

  2013cited by this paper
• Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

  2013influential reference
• High-throughput sequencing for biology and medicine

  2013influential reference
• Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies.

  2013influential reference
• The Role and Challenges of Exome Sequencing in Studies of Human Diseases

  2013influential reference
• Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke

  2013cited by this paper
• Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance.

  2013influential reference
• A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

  2013cited by this paper
• The immunoproteasome in antigen processing and other immunological functions.

  2013cited by this paper
• Comparative effectiveness of therapies for Graves' hyperthyroidism: a systematic review and network meta-analysis.

  2013cited by this paper
• Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

  2013cited by this paper
• A mosaic 2q24.2 deletion narrows the critical region to a 0.4 Mb interval that includes TBR1, TANK, and PSMD14

  2013influential reference
• Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form.

  2013cited by this paper
• Molecular architecture and assembly of the eukaryotic proteasome.

  2013cited by this paper
• Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.

  2013cited by this paper
• Imputation of Variants from the 1000 Genomes Project Modestly Improves Known Associations and Can Identify Low-frequency Variant - Phenotype Associations Undetected by HapMap Based Imputation

  2013cited by this paper
• PSMB9 Codon 60 Polymorphisms Have No Impact on the Activity of the Immunoproteasome Catalytic Subunit B1i Expressed in Multiple Types of Solid Cancer

  2013cited by this paper
• Validation of the association between PSMA6 -8 C/G polymorphism and type 2 diabetes mellitus in Chinese Dongxiang and Han populations.

  2012cited by this paper
• Diagnostic exome sequencing in persons with severe intellectual disability.

  2012cited by this paper
• Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity.

  2012cited by this paper
• Introduction to genetic association studies.

  2012cited by this paper
• Cancer vulnerabilities unveiled by genomic loss.

  2012cited by this paper
• Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins.

  2012cited by this paper
• Faculty Opinions recommendation of Mice completely lacking immunoproteasomes show major changes in antigen presentation.

  2012cited by this paper
• The proteasome in health and disease.

  2012cited by this paper
• Immunoproteasomes: structure, function, and antigen presentation.

  2012cited by this paper
• Proteasome inhibitors: a new perspective for treating autoimmune diseases.

  2012cited by this paper
• Upregulation of proteasome activity in muscle RING finger 1‐null mice following denervation

  2012cited by this paper
• The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response

  2012cited by this paper
• Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice

  2012cited by this paper
• Ensembl 2013

  2012cited by this paper
• Quantitative assessment of the influence of PSMA6 variant (rs1048990) on coronary artery disease risk

  2012influential reference
• GenBank

  2012cited by this paper
• Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network

  2012cited by this paper
• LMP2/LMP7 gene variant: A risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population

  2011cited by this paper
• A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.

  2011cited by this paper
• Genome-Wide Association Study of White Blood Cell Count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT)

  2011cited by this paper
• Fine-tuning nucleophosmin in macrophage differentiation and activation.

  2011cited by this paper
• Mice completely lacking immunoproteasomes display major alterations in antigen presentation

  2011cited by this paper
• Initial characterization of the human central proteome

  2011cited by this paper
• Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature Syndrome: A Case Report

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• A new bioinformatics analysis tools framework at EMBL–EBI

  2010cited by this paper
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• The G‐Allele of the PSMA6−8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels

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  2010cited by this paper
• Contrasting Proteome Biology and Functional Heterogeneity of the 20 S Proteasome Complexes in Mammalian Tissues*S

  2009cited by this paper
• The functional variant rs1048990 in PSMA6 is associated with susceptibility to myocardial infarction in a Chinese population.

  2009cited by this paper
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  2009influential reference
• Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver.

  2009cited by this paper
• Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

  2009influential reference
• Haplotypes Encompassing the KIAA0391 and PSMA6 Gene Cluster Confer a Genetic Link for Myocardial Infarction and Coronary Artery Disease

  2009influential reference
• Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations

  2009cited by this paper
• Recognition and processing of ubiquitin-protein conjugates by the proteasome.

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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• Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13.

  2007cited by this paper
• Introducing single-nucleotide polymorphism markers in the diagnosis of Wilson disease.

  2007cited by this paper
• [Studies of association in complex diseases: statistical problems related to the analysis of genetic polymorphisms].

  2007cited by this paper
• Introduction to genetic association studies.

  2007cited by this paper

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