Research Advance in Intestinal Mucosal Barrier and Pathogenesis of Crohn's Disease

To date, the etiology and pathogenesis of Crohn's disease (CD) have not been fully elucidated. It is widely accepted that genetic, immune, and environment factors are closely related to the development of CD. As an important defensive line for human body against the environment, intestinal mucosa is able to protect the homeostasis of gut bacteria and alleviate the intestinal inflammatory and immune response. It is evident that the dysfunction of intestinal mucosa barriers plays a crucial role in CD initiation and development. Yet researches are insufficient on intestinal mucosal barrier's action in the prevention of CD onset. This article summarizes the research advances about the correlations between the disorders of intestinal mucosal barriers and CD.

• Publication year

  2016

• Venue

  Gastroenterology Research and Practice

• Publication date

  2016-08-29

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2016/9686238PMID 27651792PMCID 5019909
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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