Intestinal barrier in inflammatory bowel disease.

A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we provide an overview about the major components of this protective system as for example an intact epithelium, the synthesis of various antimicrobial peptides (AMPs) and the formation of the mucus layer. We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease. Barrier disturbances including a defective production of AMPs, alterations in thickness or composition of the intestinal mucus layer, alterations of pattern-recognition receptors, defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn's disease and ulcerative colitis.

• Publication year

  2014

• Venue

  World Journal of Gastroenterology

• Publication date

  2014-02-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3748/wjg.v20.i5.1165PMID 24574793PMCID PMC3921501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human colonic mucus is a reservoir for antimicrobial peptides.

  2013cited by this paper
• Mucosal Protection by Phosphatidylcholine

  2013cited by this paper
• Toll-Like Receptors Promote Mutually Beneficial Commensal-Host Interactions

  2012cited by this paper
• Intestinal Barrier Dysfunction: The Primary Driver of IBD?

  2012cited by this paper
• Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

  2012cited by this paper
• Perspectives on mucus properties and formation--lessons from the biochemical world.

  2012cited by this paper
• Epithelial barrier: an interface for the cross‐communication between gut flora and immune system

  2012cited by this paper
• Role of mucus layers in gut infection and inflammation.

  2012cited by this paper
• Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

  2012cited by this paper
• Innate immune signaling in defense against intestinal microbes

  2012cited by this paper
• The Antibacterial Lectin RegIII-Gamma Promotes the Spatial Segregation of Microbiota and Host in the Intestine

  2012cited by this paper
• Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

  2012cited by this paper
• Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease.

  2012cited by this paper
• From intestinal stem cells to inflammatory bowel diseases.

  2011cited by this paper
• Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract

  2011cited by this paper
• The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

  2011cited by this paper
• Altered O‐glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

  2011cited by this paper
• Mucin dynamics and enteric pathogens

  2011cited by this paper
• Importance of disrupted intestinal barrier in inflammatory bowel diseases

  2011cited by this paper
• Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

  2011cited by this paper
• Nod2 is essential for temporal development of intestinal microbial communities

  2011cited by this paper
• Roadblocks in the gut: barriers to enteric infection

  2011cited by this paper
• The Nlrp3 inflammasome: contributions to intestinal homeostasis.

  2011cited by this paper
• NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

  2011cited by this paper
• Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

  2011cited by this paper
• Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel

  2011cited by this paper
• Antimicrobial peptides important in innate immunity

  2011cited by this paper
• Paneth cell α-defensins in enteric innate immunity

  2011cited by this paper
• Defensins in innate immunity

  2010cited by this paper
• Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

  2010cited by this paper
• Paneth's disease.

  2010cited by this paper
• Antimicrobial peptides: general overview and clinical implications in human health and disease.

  2010cited by this paper
• Advances of endomicroscopy for gastrointestinal physiology and diseases.

  2010cited by this paper
• Antimicrobial peptides present in mammalian skin and gut are multifunctional defence molecules.

  2010cited by this paper
• The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

  2010cited by this paper
• Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

  2010cited by this paper
• Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

  2010cited by this paper
• The Interaction of Large Bowel Microflora with the Colonic Mucus Barrier

  2010cited by this paper
• Intestinal epithelial cells in inflammatory bowel diseases.

  2010cited by this paper
• Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion

  2010cited by this paper
• Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

  2010cited by this paper
• Epithelial crosstalk at the microbiota–mucosal interface

  2010cited by this paper
• Innate antimicrobial host defense in small intestinal Crohn's disease.

  2010cited by this paper
• Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.

  2010cited by this paper
• The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.

  2010cited by this paper
• Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

  2009cited by this paper
• Mucosal flora in Crohn's disease and ulcerative colitis - an overview.

  2009cited by this paper
• Intestinal barrier function: molecular regulation and disease pathogenesis.

  2009cited by this paper
• Epithelial Tight Junctions in Intestinal Inflammation

  2009cited by this paper
• Nod2 is required for the regulation of commensal microbiota in the intestine

  2009cited by this paper
• Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

  2009cited by this paper
• Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.

  2009cited by this paper
• Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity

  2009cited by this paper
• The role of infection in inflammatory bowel disease: initiation, exacerbation and protection.

  2009cited by this paper
• Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease

  2009cited by this paper
• Molecular basis of canonical and bactericidal autophagy.

  2009cited by this paper
• Gut Microbiota and Probiotics in Modulation of Epithelium and Gut-Associated Lymphoid Tissue Function

  2009cited by this paper
• A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn.

  2009cited by this paper
• The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

  2009cited by this paper
• Insights into IBD pathogenesis

  2009cited by this paper
• Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: A clue to pathogenesis

  2009cited by this paper
• Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis.

  2009cited by this paper
• Intestinal barrier dysfunction in inflammatory bowel diseases.

  2009cited by this paper
• XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.

  2008cited by this paper
• The role of the multifunctional peptide LL-37 in host defense.

  2008cited by this paper
• Potential roles of histones in host defense as antimicrobial agents.

  2008cited by this paper
• Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease

  2008cited by this paper
• Secreted enteric antimicrobial activity localises to the mucus surface layer

  2008cited by this paper
• Role of Intestinal Mucins in Innate Host Defense Mechanisms against Pathogens

  2008cited by this paper
• The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

  2008cited by this paper
• Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

  2008cited by this paper
• Microbial influences in inflammatory bowel diseases.

  2008cited by this paper
• Crohn's disease--defect in innate defence.

  2008cited by this paper
• Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

  2008cited by this paper
• Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease.

  2008cited by this paper
• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

  2008cited by this paper
• Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population

  2008cited by this paper
• Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13.

  2008cited by this paper
• A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

  2008cited by this paper
• Clinical significance of NOD 2 / CARD 15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

  2008cited by this paper
• The c.1-260C>T Promoter Variant of CD14 but Not the c.896A>G (p.D299G) Variant of Toll-Like Receptor 4 (TLR4) Genes Is Associated with Inflammatory Bowel Disease

  2007cited by this paper
• The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.

  2007cited by this paper
• Adherent‐invasive Escherichia coli in inflammatory bowel disease

  2007cited by this paper
• Editor's quiz: Sigmoid stricture in a 39-year-old female.

  2007cited by this paper
• Innate immune defenses in the intestinal tract

  2007cited by this paper
• The role of microbes in Crohn's disease.

  2007cited by this paper
• Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells.

  2007cited by this paper
• Human defensins: synthesis and structural properties.

  2007cited by this paper
• Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy.

  2007cited by this paper
• Review: Human antimicrobial proteins — effectors of innate immunity

  2007cited by this paper
• Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn’s disease

  2007cited by this paper
• CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease.

  2007cited by this paper
• A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

  2007cited by this paper
• The prevalence of genetic and serologic markers in an unselected European population‐based cohort of IBD patients

  2007cited by this paper
• Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

  2007cited by this paper
• Peptide Antimicrobial Agents

  2006cited by this paper
• Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

  2006cited by this paper
• Defensins in innate antiviral immunity

  2006cited by this paper
• Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease

  2006cited by this paper
• Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease

  2006cited by this paper

• Small Interfering Ribonucleic Acid (siRNA)-Based Therapeutics in Inflammatory Bowel Disease: Crosstalk between Immune Modulation and Epithelial Barrier Restoration

  2026cites this paper
• HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier.

  2026cites this paper
• Advances and prospects of microenvironment-targeted nanotherapeutics for ulcerative colitis: evolving paradigms in the precision gut microenvironment.

  2026cites this paper
• Lanatoside C ameliorates DSS-induced colitis with improved intestinal barrier integrity and reduced M1 macrophage polarization

  2026cites this paper
• Flos sophorae immaturus exosome-like nanovesicles alleviate ulcerative colitis by attenuating intestinal oxidative stress and inflammation through activating Aryl hydrocarbon receptor via gut microbiota and tryptophan metabolism regulation

  2026cites this paper
• Targeting IBD treatment: smart drug delivery systems for oral administration

  2026cites this paper
• HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella Typhimurium infection.

  2025cites this paper
• Risk factors for Clostridioides difficile infection among patients diagnosed with inflammatory intestinal and rheumatological diseases in the biologic era

  2025cites this paper
• ROS-triggered transformation of microgels to bioadhesive patch for orally administrated treatment of inflammatory bowel disease.

  2025cites this paper
• The Spatiotemporal Development of Mesenteric Lymphatic Changes in the TNFΔARE/+ Mouse Model of Terminal Ileitis.

  2025cites this paper
• Remdesivir alleviates inflammation and tissue damage in experimental colitis via AnxA5 Signaling.

  2025cites this paper
• Confocal Endomicroscopy Intestinal Epithelial Barrier Abnormalities in Individuals Without Documented Gastro‐Intestinal Disease

  2025influential citation
• Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution

  2025cites this paper
• Phellodendrine ameliorates intestinal inflammation and protects mucosal barrier via modulating COL1A1, VCAM1 and IL-17 a.

  2025cites this paper
• Improvement of chronic metabolic inflammation and regulation of gut homeostasis: Tea as a potential therapy.

  2025cites this paper
• Pseudomonas aeruginosa Activates the NOD-like Receptor Signaling Pathway by Targeting Nasopharyngeal Cells throughout the Whole Respiratory Tract

  2025cites this paper
• Histamine Metabolism in IBD: Towards Precision Nutrition

  2025cites this paper
• Precision Medicine in Surgery

  2025cites this paper
• Mesenchymal stem/stromal cells-derived exosomes: possible therapeutic mechanism in inflammatory bowel disease

  2025cites this paper
• NFE2L3 regulates inflammation and oxidative stress-related genes in the colon.

  2025cites this paper
• Identification of hub necroptosis-related targets and discovery of potential natural inhibitors in ulcerative colitis based on bioinformatics and computer-aided drug design

  2025cites this paper
• Oral delivery of Clostridium butyricum using selective antibacterial lipids for enhanced treatment of Fusobacterium nucleatum-associated intestinal diseases

  2025cites this paper
• Enterogenic dementia: defining the gut–brain axis and the role of inflammatory bowel disease in cognitive impairment

  2025cites this paper
• SOD mimics delivered to the gut using lactic acid bacteria mitigate the colitis symptoms in a mouse model of inflammatory bowel diseases

  2025cites this paper
• Advancements in therapeutic strategies and drug development for inflammatory bowel diseases

  2025cites this paper
• Oral administration of Folium Artemisiae Argyi-derived exosome-like nanovesicles can improve ulcerative colitis by regulating intestinal microorganisms.

  2025cites this paper
• The Interplay Between Immunological Status and Gut Microbial Dysbiosis in the Development of the Symptoms of Irritable Bowel Syndrome: A Systematic Review with Meta-Analysis

  2025cites this paper
• Targeted therapeutics for IBD unraveling the potential of stimulus-responsive nanoparticles.

  2025cites this paper
• Visiting MASLD through the lens of sex, immunity, and microbial interactions

  2025cites this paper
• Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn’s disease: insights from a systems biology and artificial intelligence-based approach

  2025cites this paper
• Characterizing zonulin and par2 Expression in Zonulin Transgenic and Zonulin Inhibition Mouse Models of Motility and Inflammation

  2025cites this paper
• Advanced adhesion and targeting strategies to prolong gut residence time and improve eLBP efficacy in colonic diseases.

  2025cites this paper
• Regulation of Epithelial HIF by Probiotic Escherichia coli

  2025cites this paper
• Serum biomarkers of intestinal barrier dysfunction predict postoperative endoscopic recurrence in Crohn’s disease patients

  2025cites this paper
• Ex Vivo Modeling and Pharmacological Modulation of Tissue Immune Responses in Inflammatory Bowel Disease Using Precision‐Cut Intestinal Slices

  2025cites this paper
• Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis

  2025cites this paper
• Restoration of the Mucosal Barrier by Lactobacillus gasseri HDS0266 and Enterococcus faecium HDS0288 in Dextran Sodium Sulfate and Clostridioides difficile-Induced Colitis Mice.

  2025cites this paper
• Butylchlorogenate from Chaenomeles speciosa alleviates ulcerative colitis via suppressing NLRP3 inflammasome activation and remodeling intestinal homeostasis.

  2025cites this paper
• Establishment of γ-secretase-deficient goblet-like cells: A novel in vitro platform to dissect regulatory mechanisms of mucus production in the intestinal epithelium.

  2025cites this paper
• Intestinal barrier restoration in UC: dietary protein/peptide mediate microbiota-Trp-AhR axis and food processing implications.

  2025cites this paper
• Hypoxia and the cytoskeleton.

  2025cites this paper
• In vitro activity, structural characterization and modulation of DSS-induced intestinal inflammation in zebrafish by Pseudognaphalium affine (D.Don) Anderb polysaccharides.

  2025cites this paper
• Mechanisms and potential of mesenchymal stem cell-derived exosomes for treating radiation-induced intestinal injury

  2025cites this paper
• Challenges of concurrent HIV infection in the course and management of Crohn’s disease

  2025cites this paper
• S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function

  2025cites this paper
• Per- and polyfluoroalkyl substances (PFAS): immunotoxicity at the primary sites of exposure

  2025cites this paper
• Emerging Lipid-based Carriers for Systematic Utilization in the Pharmaceutical and Biomedical Sciences: A Review.

  2024cites this paper
• Recent Insight into Herbal Bioactives-Based Novel Approaches for Chronic Intestinal Inflammatory Disorders Therapy.

  2024cites this paper
• Procyanidin C1 Modulates the Microbiome to Increase FOXO1 Signaling and Valeric Acid Levels to Protect the Mucosal Barrier in Inflammatory Bowel Disease

  2024cites this paper
• Age-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates

  2024cites this paper
• Holothuria leucospilota polysaccharides (HLP) ameliorate colitis rats via regulation of the metabolic profiling and TLR4/NLRP3 signaling pathways

  2024cites this paper
• Heat-killed Lacticaseibacillus paracasei 6235 is more effective than live on DSS-induced colitis via modulation of intestinal microbiota and MAPK/NF-κB signaling pathways.

  2024cites this paper
• Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy

  2024cites this paper
• Capilliposide A alleviates DSS-induced colitis by regulating the intestinal flora and its metabolites of origin.

  2024cites this paper
• Evaluation of intestinal biopsy tissue preservation methods to facilitate large-scale mucosal microbiota research

  2024cites this paper
• Iron oxide nanoparticles for inflammatory bowel disease: Recent advances in diagnosis and targeted drug therapy

  2024cites this paper
• Wheat Bran Polyphenols Ameliorate DSS-Induced Ulcerative Colitis in Mice by Suppressing MAPK/NF-κB Inflammasome Pathways and Regulating Intestinal Microbiota

  2024cites this paper
• Advances in carbohydrate-based nanoparticles for targeted therapy of inflammatory bowel diseases: A review.

  2024cites this paper
• Navigating new horizons in inflammatory bowel disease: Integrative approaches and innovations

  2024cites this paper
• Goat Milk Exosomes Ameliorate Ulcerative Colitis in Mice through Modulation of the Intestinal Barrier, Gut Microbiota, and Metabolites.

  2024cites this paper
• Oral administration of LfcinB alleviates DSS-induced colitis by improving the intestinal barrier and microbiota.

  2024cites this paper
• Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction

  2024cites this paper
• Therapeutic Potential of Foodborne Indole Derived from Chinese Stinky Tofu in Reducing Intestinal Inflammation and Enhancing Barrier Function to Mitigate Alcoholic Liver Injury.

  2024cites this paper
• Obeticholic acid ameliorates sepsis-induced renal mitochondrial damage by inhibiting the NF-κb signaling pathway

  2024cites this paper
• Negatively Charged Thermosensitive Hydrogel Loaded with Pectin Microspheres to Recover the Mucosal Barrier for Ulcerative Colitis Therapy.

  2024cites this paper
• Disease clearance in ulcerative colitis: A new therapeutic target for the future

  2024cites this paper
• Association of Crohn’s disease and ulcerative colitis with the risk of neurological diseases: a large-scale Mendelian randomization study

  2024cites this paper
• Lactitol Alleviates Loperamide-Induced Constipation in Sprague Dawley Rats by Regulating Serotonin, Short-Chain Fatty Acids, and Gut Microbiota

  2024cites this paper
• Inhibiting the activation of enteric glial cells alleviates intestinal inflammation and comorbid anxiety- and depressive-like behaviors in the ulcerative colitis mice.

  2024cites this paper
• The microRNA Expression in Crypt-Top and Crypt-Bottom Colonic Epithelial Cell Populations Demonstrates Cell-Type Specificity and Correlates with Endoscopic Activity in Ulcerative Colitis

  2024cites this paper
• Mapping Crohn’s Disease Pathogenesis with Mycobacterium paratuberculosis: A Hijacking by a Stealth Pathogen

  2024cites this paper
• Alleviation of Alcoholic Liver Injury through Composite Postbiotics Regulation of Intestinal Flora and Promotion of Bile Acid Metabolism

  2024cites this paper
• Magnolin inhibits intestinal epithelial cell apoptosis alleviating Crohn's disease-like colitis by suppressing the PI3K/AKT signalling pathway.

  2024cites this paper
• Insights into the effects of chronic combined chromium-nickel exposure on colon damage in mice through transcriptomic analysis and in vitro gastrointestinal digestion assay.

  2024cites this paper
• Colonic epithelial cell-specific TFEB activation: a key mechanism promoting anti-bacterial defense in response to Salmonella infection

  2024cites this paper
• Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

  2024influential citation
• The immune interactions of gut glycans and microbiota in health and disease

  2024cites this paper
• Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation

  2024cites this paper
• Dysbiosis in inflammatory bowel diseases: egg, not chicken

  2024cites this paper
• Diosmin alleviates ulcerative colitis in mice by increasing Akkermansia muciniphila abundance, improving intestinal barrier function, and modulating the NF-κB and Nrf2 pathways

  2024cites this paper
• Krill Oil and Its Bioactive Components as a Potential Therapy for Inflammatory Bowel Disease: Insights from In Vivo and In Vitro Studies

  2024cites this paper
• Bioinspired and biomimetic strategies for inflammatory bowel disease therapy.

  2024cites this paper
• Ginsenosides from Panax ginseng as potential therapeutic candidates for the treatment of inflammatory bowel disease.

  2024cites this paper
• Exploring the potential use of Caenorhabditis elegans as an animal model for evaluating chemical-induced intestinal dysfunction.

  2024cites this paper
• Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment

  2024cites this paper
• Current Research on the Role of Isomaltooligosaccharides in Gastrointestinal Health and Metabolic Diseases

  2024influential citation
• Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease.

  2024cites this paper
• Changes in the Expression of Genes Regulating the Response to Hypoxia, Inflammation, Cell Cycle, Apoptosis, and Epithelial Barrier Functioning during Colitis-Associated Colorectal Cancer Depend on Individual Hypoxia Tolerance

  2024cites this paper
• Roseburia intestinalis‐derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses

  2024cites this paper
• Editor-in-Chief articles of choice and comments at the year-end of 2023

  2024cites this paper
• Endoplasmic reticulum stress: A possible connection between intestinal inflammation and neurodegenerative disorders

  2024cites this paper
• The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease

  2024cites this paper
• Worldwide research trends in Crohn’s disease treatment over the past 2 decades: a bibliometric analysis

  2024cites this paper
• Recognizing the biological barriers and pathophysiological characteristics of the gastrointestinal tract for the design and application of nanotherapeutics

  2024cites this paper
• Disturbance of intestinal permeability and its role in the development of cardiovascular complications in persons with inflammatory bowel diseases

  2023cites this paper
• The significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease

  2023cites this paper
• Intestinal Membrane Function in Inflammatory Bowel Disease

  2023cites this paper
• Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality

  2023cites this paper
• Ileal inflammation is reduced due to treatment with a metalloprotease from BmooMP-α-I snake venom in an experimental model of Toxoplasma gondii infection

  2023cites this paper
• The Role of the Microbiome in the Pathogenesis and Treatment of Ulcerative Colitis—A Literature Review

  2023cites this paper