Estradiol Reduces Activity of the Blood–Brain Barrier Na–K–Cl Cotransporter and Decreases Edema Formation in Permanent Middle Cerebral Artery Occlusion

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2006-01-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.jcbfm.9600278PMID 16421506
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

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  2005cited by this paper
• Moderate-to-severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na+-K+-Cl- cotransporter.

  2005influential reference
• Differences in Ischemic Lesion Evolution in Different Rat Strains Using Diffusion and Perfusion Imaging

  2005influential reference
• Nuclear magnetic resonance (NMR) measurement of the apparent diffusion coefficient (ADC) of tissue water and its relationship to cell volume changes in pathological states.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• The neurobiology of glia in the context of water and ion homeostasis.

  2004cited by this paper
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  2004cited by this paper
• Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium.

  2004cited by this paper
• Protective Effects of Estrogen and Selective Estrogen Receptor Modulators in the Brain1

  2002cited by this paper
• Estrogen blocks 3-nitropropionic acid-induced Ca2+i increase and cell damage in cultured rat cerebral endothelial cells.

  2002cited by this paper
• Contribution of Na(+)-K(+)-Cl(-) cotransporter to high-[K(+)](o)- induced swelling and EAA release in astrocytes.

  2002cited by this paper
• Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications.

  2001cited by this paper
• The sites of interaction of triphenyltetrazolium chloride with mitochondrial respiratory chains.

  2001cited by this paper
• Estrogens Decrease Reperfusion-Associated Cortical Ischemic Damage: An MRI Analysis in a Transient Focal Ischemia Model

  2001influential reference
• Estrogenic actions in the brain: estrogen, phytoestrogens, and rapid intracellular signaling mechanisms.

  2001cited by this paper
• Estrogen Induces the Akt-dependent Activation of Endothelial Nitric-oxide Synthase in Vascular Endothelial Cells*

  2001cited by this paper
• Na+-K+-Cl− Cotransporter in Rat Focal Cerebral Ischemia

  2001cited by this paper
• Regional Variations in the Apparent Diffusion Coefficient and the Intracellular Distribution of Water in Rat Brain During Acute Focal Ischemia

  2001influential reference
• Mitochondria and neuronal survival.

  2000cited by this paper
• Estrogen Receptor Antagonist ICI182,780 Exacerbates Ischemic Injury in Female Mouse

  2000cited by this paper
• Estradiol exerts neuroprotective effects when administered after ischemic insult.

  2000cited by this paper
• Estrogen as a Neuroprotectant in Stroke

  2000influential reference
• ICI 182,780 (Faslodex™)

  2000cited by this paper
• Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase via the PI3-Kinase–Akt Pathway in Human Endothelial Cells

  2000cited by this paper
• The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection

  2000cited by this paper
• 17beta-estradiol reduces stroke injury in estrogen-deficient female animals.

  1999cited by this paper
• Cell Swelling in Cerebral Ischemia

  1999cited by this paper
• Mechanisms of Cerebral Ischemic Damage

  1999cited by this paper
• Effects of gender and estradiol treatment on focal brain ischemia.

  1998influential reference
• Estrogen Increases cGMP in Selected Brain Regions and in Cerebral Microvessels

  1998cited by this paper
• Estrogen-mediated neuroprotection after experimental stroke in male rats.

  1998cited by this paper
• Effects of Arginine Vasopressin and Atriopeptin on Chloride Uptake in Cultured Astroglia

  1998cited by this paper
• Extracellular space structure revealed by diffusion analysis.

  1998influential reference
• Estradiol Protects against Ischemic Injury

  1998influential reference
• Molecular characterization of the Na-K-Cl cotransporter of bovine aortic endothelial cells.

  1997cited by this paper
• Effects of 17beta-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats.

  1997cited by this paper
• Effects of 17β-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats

  1997cited by this paper
• Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging.

  1996influential reference
• Effect of Hypoxia on Na+‐K+‐Cl− Cotransport in Cultured Brain Capillary Endothelial Cells of the Rat

  1996cited by this paper
• Current concepts of brain edema

  1996influential reference
• Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies.

  1995cited by this paper
• Astroglial cell-induced expression of Na-K-Cl cotransporter in brain microvascular endothelial cells.

  1995influential reference
• Current concepts of brain edema. Review of laboratory investigations.

  1995influential reference
• Cerebral microvascular endothelial cell Na-K-Cl cotransport: regulation by astrocyte-conditioned medium.

  1995cited by this paper
• Magnetic Resonance Imaging Assessment of Evolving Focal Cerebral Ischemia Comparison With Histopathology in Rats

  1994cited by this paper
• MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia

  1994cited by this paper
• Blood—Brain Barrier Permeability and Brain Concentration of Sodium, Potassium, and Chloride during Focal Ischemia

  1994influential reference
• MAGNETIC-RESONANCE-IMAGING ASSESSMENT OF EVOLVING FOCAL CEREBRAL-ISCHEMIA - COMPARISON WITH HISTOPATHOLOGY IN RATS (VOL 25, PG 1252, 1994)

  1994cited by this paper
• Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat.

  1993cited by this paper
• Potassium transport at the blood-brain and blood-CSF barriers.

  1993cited by this paper
• Role of Na-K-Cl cotransport in vascular endothelial cell volume regulation.

  1993cited by this paper
• Contributions of ions and albumin to the formation and resolution of ischemic brain edema.

  1993cited by this paper
• Chapter 6: Central release of vasopressin: stimuli, dynamics, consequences

  1992cited by this paper
• Role of Na/K/Cl cotransport in astrocytes.

  1992cited by this paper
• Central release of vasopressin: stimuli, dynamics, consequences.

  1992cited by this paper
• Blood to Brain Sodium Transport and Interstitial Fluid Potassium Concentration during Early Focal Ischemia in the Rat

  1991influential reference
• Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury

  1991cited by this paper
• Early detection of regional cerebral ischemia in cats: Comparison of diffusion‐ and T2‐weighted MRI and spectroscopy

  1990cited by this paper
• A Semiautomated Method for Measuring Brain Infarct Volume

  1990cited by this paper
• Regulation of Na-K-Cl cotransport in endothelial cells by atrial natriuretic factor.

  1989cited by this paper
• Greater disturbance of water and ion homeostasis in the periphery of experimental focal cerebral ischemia.

  1987influential reference
• Convection of Cerebral Interstitial Fluid and Its Role in Brain Volume Regulation

  1986cited by this paper
• Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

  1986cited by this paper
• Immunoelectronhistochemical evidence for innervation of brain microvessels by vasopressin-immunoreactive neurons in the rat.

  1984cited by this paper
• Sodium Transport in Capillaries Isolated from Rat Brain

  1983cited by this paper
• Sodium Transport from Blood to Brain: Inhibition by Furosemide and Amiloride

  1983cited by this paper
• Biology of glial swelling in experimental brain edema.

  1980cited by this paper
• Follicular function in the domestic cat as determined by estradiol-17 beta concentrations in plasma: relation to estrous behavior and cornification of exfoliated vaginal epithelium.

  1979cited by this paper
• Partial resolution of the enzymes catalyzing oxidative phosphorylation. XXXIX. Reconstitution of the third segment of oxidative phosphorylation.

  1973cited by this paper
• Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation XXV. RECONSTITUTION OF VESICLES CATALYZING 32Pi—ADENOSINE TRIPHOSPHATE EXCHANGE

  1971cited by this paper
• Partial resolution of the enzymes catalyzing oxidative phosphorylation. XXI. Resolution of submitochondrial particles from bovine heart mitochondria with silicotungstate.

  1969cited by this paper
• Partial resolution of the enzymes catalyzing oxidative phosphorylation. 8. Properties of a factor conferring oligomycin sensitivity on mitochondrial adenosine triphosphatase.

  1966cited by this paper
• in male rats

  year unknowncited by this paper

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  2025cites this paper
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  2024cites this paper
• Identification of blood exosomal metabolomic profiling for high-altitude cerebral edema

  2024cites this paper
• ATR-FTIR spectroscopy to evaluate serum protein expression in a murine cerebral ischemia model.

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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Sex differences in risk factors for vascular contributions to cognitive impairment & dementia.

  2019cites this paper
• Blood-Brain Barrier: From Physiology to Disease and Back.

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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