Na+-K+-Cl− Cotransporter in Rat Focal Cerebral Ischemia

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2001-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/00004647-200106000-00009PMID 11488540
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stimulation of Na-K-2Cl cotransporter in neurons by activation of Non-NMDA ionotropic receptor and group-I mGluRs.

  2001influential reference
• Abnormal GABAA Receptor-Mediated Currents in Dorsal Root Ganglion Neurons Isolated from Na–K–2Cl Cotransporter Null Mice

  2000cited by this paper
• Sodium-potassium-chloride cotransport.

  2000influential reference
• Regulation of Na(+)-K(+)-Cl(-) cotransporter in primary astrocytes by dibutyryl cAMP and high [K(+)](o).

  2000cited by this paper
• Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.

  1999cited by this paper
• Transient Inhibition of Glutamate Uptake In Vivo Induces Neurodegeneration when Energy Metabolism Is Impaired

  1999cited by this paper
• Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.

  1999influential reference
• Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain.

  1999cited by this paper
• Na+-K+-2Cl- cotransporter in immature cortical neurons: A role in intracellular Cl- regulation.

  1999influential reference
• Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate.

  1998cited by this paper
• The Na-K-Cl Cotransporters

  1998cited by this paper
• Optical Imaging of Hippocampal Neurons with a Chloride‐Sensitive Dye: Early Effects of In Vitro Ischemia

  1998cited by this paper
• Stimulation of Na+-K+-2Cl-cotransporter in neuronal cells by excitatory neurotransmitter glutamate.

  1998cited by this paper
• Ontogeny of cation-Cl- cotransporter expression in rat neocortex.

  1998cited by this paper
• Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain.

  1997influential reference
• Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]oregulation.

  1997influential reference
• Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation.

  1997influential reference
• Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system.

  1997influential reference
• Effect of Hypoxia on Na+‐K+‐Cl− Cotransport in Cultured Brain Capillary Endothelial Cells of the Rat

  1996cited by this paper
• Mechanisms of Sodium Transport at the Blood‐Brain Barrier Studied with In Situ Perfusion of Rat Brain

  1996cited by this paper
• Molecular Cloning and Functional Expression of the K-Cl Cotransporter from Rabbit, Rat, and Human

  1996influential reference
• Reduction of NaCl increases survival of mammalian spinal neurons subjected to dendrite transection injury.

  1996cited by this paper
• Delayed progression of cytotoxic oedema in focal cerebral ischemia after treatment with a torasemide derivative: a diffusion-weighted magnetic resonance imaging study.

  1996cited by this paper
• Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies.

  1995cited by this paper
• Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney.

  1994cited by this paper
• The Na-K-Cl cotransporters.

  1994cited by this paper
• Treatment of Vasogenic Brain Edema with the Novel Cl− Transport Inhibitor Torasemide

  1994cited by this paper
• Therapeutical efficacy of a novel chloride transport blocker and an IP3-analogue in vasogenic brain edema.

  1994cited by this paper
• Swelling-induced K+ influx in cultured primary astrocytes.

  1994cited by this paper
• The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.

  1990cited by this paper
• Microdialysis--theory and application.

  1990cited by this paper
• A Semiautomated Method for Measuring Brain Infarct Volume

  1990cited by this paper
• Intracellular chloride regulation in amphibian dorsal root ganglion neurones studied with ion‐selective microelectrodes.

  1988cited by this paper
• Effect on intracranial pressure of furosemide combined with varying doses and administration rates of mannitol.

  1987cited by this paper
• Anisotonic media and glutamate-induced ion transport and volume responses in primary astrocyte cultures.

  1987cited by this paper
• Anisotonic media and glutamate-induced ion transport and volume responses in primary astrocyte cultures

  1987cited by this paper
• The role of chloride transport in postsynaptic inhibition of hippocampal neurons.

  1986cited by this paper
• Measurement of protein using bicinchoninic acid.

  1985cited by this paper
• The neurotoxicity of excitatory amino acids is produced by passive chloride influx

  1985influential reference
• Intense Furosemide-Sensitive Potassium Accumulation in Astrocytes in the Presence of Pathologically High Extracellular Potassium Levels

  1984influential reference
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Nephrology Dialysis Transplantation the Na-(k)-cl Cotransporter Family in the Mammalian Kidney: Molecular Identification and Function (s)

  year unknowncited by this paper

• Modulation of GABAergic System in a Chicken Retinal Ischemic Model: The Role of Chloride Cotransporters

  2025cites this paper
• Zolpidem suppresses cortical spreading depolarization and protects against ischemia/reperfusion injury and resulting neurological dysfunctions.

  2025cites this paper
• Efficacy of bumetanide in animal models of ischemic stroke: a systematic review and meta-analysis

  2024cites this paper
• Alterations in brain fluid physiology during the early stages of development of ischaemic oedema

  2024cites this paper
• Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex

  2023cites this paper
• Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

  2023cites this paper
• How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders

  2022cites this paper
• Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

  2022cites this paper
• Role of 5-HT in Cerebral Edema after Traumatic Brain Injury

  2021cites this paper
• Is the awakening produced by benzodiazepines due to excitatory actions of GABA?

  2021cites this paper
• Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke

  2021cites this paper
• Cerebral Edema Formation After Stroke: Emphasis on Blood–Brain Barrier and the Lymphatic Drainage System of the Brain

  2021cites this paper
• Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage

  2021cites this paper
• Drug development in targeting ion channels for brain edema

  2020cites this paper
• Role of chloride cotransporters in the development of spasticity and neuropathic pain after spinal cord injury

  2020cites this paper
• WNK-SPAK/OSR1-CCC signaling in ischemic brain damage

  2020cites this paper
• The blood brain barrier in cerebral ischemic injury – Disruption and repair

  2020cites this paper
• Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro

  2020cites this paper
• Acorus tatarinowii Schott extract reduces cerebral edema caused by ischemia–reperfusion injury in rats: involvement in regulation of astrocytic NKCC1/AQP4 and JNK/iNOS-mediated signaling

  2020cites this paper
• TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

  2020cites this paper
• Intracellular Cl− dysregulation causing and caused by pathogenic neuronal activity

  2020cites this paper
• Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

  2020cites this paper
• Rehabilitation Decreases Spasticity by Restoring Chloride Homeostasis through the Brain-Derived Neurotrophic Factor–KCC2 Pathway after Spinal Cord Injury

  2019cites this paper
• Discovery and Characterization of Novel Selective NKCC1 Inhibitors for Down Syndrome and Brain Disorders withDepolarizing GABAergic Transmission

  2019cites this paper
• Bumetanide: A review of its neuroplasticity and behavioral effects after stroke

  2019cites this paper
• Off-Label Use of Bumetanide for Brain Disorders: An Overview

  2019cites this paper
• Bursting at the Seams: Molecular Mechanisms Mediating Astrocyte Swelling

  2019cites this paper
• The Developing Brain—Relevance to Pediatric Neurotechnology

  2019cites this paper
• Neurovascular unit transport responses to ischemia and common coexisting conditions: smoking and diabetes.

  2019cites this paper
• Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after MCAO in rats.

  2018cites this paper
• Analysis of subcellular structural tension in axonal growth of neurons

  2018influential citation
• Select hyperacute complications of ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema secondary to intravenous Alteplase

  2018cites this paper
• Cell Volume Control in Healthy Brain and Neuropathologies.

  2018cites this paper
• NKCC1 Inhibition Attenuates Chronic Cerebral Hypoperfusion-Induced White Matter Lesions by Enhancing Progenitor Cells of Oligodendrocyte Proliferation

  2018cites this paper
• Effects of Neuroprotectants Before and After Stroke: Statins and Anti-hypertensives

  2017cites this paper
• Blood-Brain Barrier Mechanisms of Edema Formation

  2017cites this paper
• NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders.

  2017cites this paper
• Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-κB signaling pathway

  2017cites this paper
• Brain Edema in Developing Brain Diseases

  2017cites this paper
• WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats

  2017cites this paper
• Glial Na+‐dependent ion transporters in pathophysiological conditions

  2016cites this paper
• LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats

  2016cites this paper
• Volume-regulated anion channel—a frenemy within the brain

  2016cites this paper
• Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases

  2015cites this paper
• Bumetanide-induced NKCC1 inhibition attenuates oxygen-glucose deprivation-induced decrease in proliferative activity and cell cycle progression arrest in cultured OPCs via p-38 MAPKs.

  2015cites this paper
• Molecular pathophysiology of cerebral edema

  2015cites this paper
• Effects of terlipressin as early treatment for protection of brain in a model of haemorrhagic shock

  2015cites this paper
• Mechanisms of astrocytic K+ clearance and swelling under high extracellular K+ concentrations

  2015cites this paper
• Comparação dos efeitos da ressuscitação com Ringer lactato, solução salina hipertônica e terlipressina sobre a perfusão e oxigenação cerebral em modelo experimental de choque hemorrágico

  2015cites this paper
• Expression of Aquaporins in Mouse Choroid Plexus and Ependymal Cells

  2015cites this paper
• Bumetanide protects focal cerebral ischemia-reperfusion injury in rat.

  2014cites this paper
• Ammonia, Like K+, Stimulates the Na+, K+, 2 Cl− Cotransporter NKCC1 and the Na+,K+-ATPase and Interacts with Endogenous Ouabain in Astrocytes

  2014cites this paper
• Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation

  2014cites this paper
• The role of blood-brain barrier transporters in pathophysiology and pharmacotherapy of stroke.

  2014cites this paper
• Branchial Na+:K+:2Cl− cotransporter 1 and Na+/K+-ATPase α-subunit in a brackish water-type ionocyte of the euryhaline freshwater white-rimmed stingray, Himantura signifer

  2013influential citation
• High Brain Ammonia Tolerance and Down-Regulation of Na+:K+:2Cl- Cotransporter 1b mRNA and Protein Expression in the Brain of the Swamp Eel, Monopterus albus, Exposed to Environmental Ammonia or Terrestrial Conditions

  2013cites this paper
• Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema

  2013cites this paper
• Aquaporins in drug discovery and pharmacotherapy.

  2012cites this paper
• Calcium dependence of damage to mouse motor nerve terminals following oxygen/glucose deprivation.

  2012cites this paper
• The Role of Na+/Ca2+ Countertransport and Other Na+-Entry Routes in the Pathophysiology of Stroke

  2012cites this paper
• Maintenance and regulation of extracellular volume and the ion environment in Drosophila larval nerves

  2011cites this paper
• Novel Treatment Targets for Cerebral Edema

  2011cites this paper
• Emerging role of WNK1 in pathologic central nervous system signaling

  2011cites this paper
• Na‐K‐Cl cotransporter‐1 in the mechanism of cell swelling in cultured astrocytes after fluid percussion injury

  2011cites this paper
• Diuretics and epilepsy: Will the past and present meet?

  2011cites this paper
• Opioid receptor agonists reduce brain edema in stroke.

  2011cites this paper
• Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer

  2010cites this paper
• Systemic injection of recombinant human erythropoietin after focal cerebral ischemia enhances oligodendroglial and endothelial progenitor cells in rat brain

  2010cites this paper
• The Na–K–Cl Co-transporter in astrocyte swelling

  2010cites this paper
• Expression of Na-K-Cl cotransporter and edema formation are age dependent after ischemic stroke.

  2010cites this paper
• Na+–K+–2Cl− Cotransport Inhibitor Attenuates Cerebral Edema Following Experimental Stroke via the Perivascular Pool of Aquaporin-4

  2010cites this paper
• Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes.

  2009cites this paper
• of Electroneutral Ion Transport Molecular Mechanisms of Ischemic Cerebral Edema : Role

  2009cites this paper
• The Role of Cation-Chloride Transporters in Brain Ischemia

  2009cites this paper
• Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport.

  2009cites this paper
• The “Loop” Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia

  2009cites this paper
• Cation-chloride cotransporters and neuronal function.

  2009cites this paper
• A Concerted Role of Na+—K+—Cl− Cotransporter and Na+/Ca2+ Exchanger in Ischemic Damage

  2008cites this paper
• Cerebral Blood Flow and Cerebral Edema in Rats With Diabetic Ketoacidosis

  2008cites this paper
• Altered expression of sodium transporters in ischemic penumbra after focal cerebral ischemia in rats.

  2007cites this paper
• A review of progress in understanding the pathophysiology and treatment of brain edema.

  2007cites this paper
• Cell specificity of altered cation-chloride cotransporter expression and GABAergic innervation in the epileptic cerebral cortex

  2007cites this paper
• Role of membrane ion transport proteins in cerebral ischemic damage.

  2007cites this paper
• NKCC1 activity modulates formation of functional inhibitory synapses in cultured neocortical neurons

  2007cites this paper
• Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm.

  2007cites this paper
• Cytotoxic edema: mechanisms of pathological cell swelling.

  2007cites this paper
• Monocyte Chemoattractant Protein-1 Plays a Critical Role in Neuroblast Migration after Focal Cerebral Ischemia

  2007cites this paper
• Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood.

  2006cites this paper
• ROLE OF AQUAPORIN-4 WATER CHANNELS IN CEREBRAL EDEMA AFTER ISCHEMIC STROKE

  2006cites this paper
• Therapeutische Hypothermie nach Asphyxie aus neonatologischer Sicht

  2006cites this paper
• Chapter 10 - Physiology of Cation‐Chloride Cotransporters

  2006cites this paper
• Insulin‐like growth factor‐1 is an endogenous mediator of focal ischemia‐induced neural progenitor proliferation

  2006cites this paper
• Depressed Responses to Applied and Synaptically-Released GABA in CA1 Pyramidal Cells, but not in CA1 Interneurons, after Transient Forebrain Ischemia

  2006cites this paper
• Effects of chloride flux modulators in an in vitro model of brain edema formation.

  2006cites this paper
• The Chloride Transporter Na+-K+-Cl− Cotransporter Isoform-1 Contributes to Intracellular Chloride Increases after In Vitro Ischemia

  2006cites this paper
• Estradiol Reduces Activity of the Blood–Brain Barrier Na–K–Cl Cotransporter and Decreases Edema Formation in Permanent Middle Cerebral Artery Occlusion

  2006cites this paper
• Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy

  2005cites this paper
• Potassium homeostasis in the ischemic brain

  2005cites this paper
• Role of Cl- in cerebral vascular tone and expression of Na+-K+-2Cl- co-transporter after neonatal hypoxia-ischemia.

  2005cites this paper
• The role of Na–K–Cl co–transporter in cerebral ischemia

  2005cites this paper