Human adipose tissue as a reservoir for memory CD4+ T cells and HIV

No abstract is available for this paper.

• Publication year

  2015

• Venue

  AIDS (London)

• Publication date

  2015-03-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/QAD.0000000000000599PMID 25849830PMCID PMC4389783
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
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  2013cited by this paper
• HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy.

  2012cited by this paper
• Adipose tissue biology and HIV-infection.

  2011cited by this paper
• Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages

  2011cited by this paper
• HIV latency.

  2011cited by this paper
• Disruption of Intestinal CD4+ T Cell Homeostasis Is a Key Marker of Systemic CD4+ T Cell Activation in HIV-Infected Individuals

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• The function of adipocytes in the bone marrow stroma: an update.

  1996cited by this paper
• HIV Latency

  1993influential reference
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-�, in Vivo*

  year unknowncited by this paper

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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• HIV Persistence in Adipose Tissue Reservoirs

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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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