Inflammation and Immunity: From an Adipocyte's Perspective

Comprehension of adipocyte function has evolved beyond a long-held belief of their inert nature, as simple energy storing and releasing cells. Adipocytes, including white, brown, and beige, are capable mediators of global metabolic health, but their intersection with inflammation is a budding field of exploration. Evidence hints at a reciprocal relationship adipocytes share with immune cells. Adipocyte's capacity to behave in an “immune-like” manner and ability to sense inflammatory cues that subsequently alter core adipocyte function might play an important role in shaping immune responses. Clarifying this intricate relationship could uncover previously underappreciated contribution of adipocytes to inflammation-driven human health and disease. In this review, we highlight the potential of largely underappreciated adipocyte “immune-like” function and how it may contribute to inflammation, immunity, and pathology of various diseases.

• Publication year

  2019

• Venue

  Journal of Interferon and Cytokine Research

• Publication date

  2019-07-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/jir.2019.0014PMID 30920343PMCID PMC6660836
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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