Peptide alarmone signalling triggers an auto‐active bacteriocin necessary for genetic competence

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular Microbiology

• Publication date

  2009-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2958.2009.06693.xPMID 19400789PMCID PMC2771663
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Individuality in bacteria.

  2008cited by this paper
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  2008cited by this paper
• Involvement of Streptococcus mutans regulator RR11 in oxidative stress response during biofilm growth and in the development of genetic competence

  2008cited by this paper
• Common mechanisms of target cell recognition and immunity for class II bacteriocins

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  2007cited by this paper
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  2007cited by this paper
• The response regulator ComE in Streptococcus mutans functions both as a transcription activator of mutacin production and repressor of CSP biosynthesis.

  2007influential reference
• Antibiotic Stress Induces Genetic Transformability in the Human Pathogen Streptococcus pneumoniae

  2006cited by this paper
• Communication in bacteria: an ecological and evolutionary perspective

  2006cited by this paper
• Multilevel Control of Competence Development and Stress Tolerance in Streptococcus mutans UA159

  2006influential reference
• Bacteriocin Diversity in Streptococcus and Enterococcus

  2006cited by this paper
• Bacterially speaking.

  2006cited by this paper
• The Streptococcus mutans vicX Gene Product Modulates gtfB/C Expression, Biofilm Formation, Genetic Competence, and Oxidative Stress Tolerance

  2006cited by this paper
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  2006cited by this paper
• Bistability in bacteria

  2006cited by this paper
• Cell density- and ComE-dependent expression of a group of mutacin and mutacin-like genes in Streptococcus mutans.

  2006cited by this paper
• Induction of competence regulons as a general response to stress in gram-positive bacteria.

  2006influential reference
• Independent evolution of competence regulatory cascades in streptococci?

  2006cited by this paper
• Stripping Bacillus: ComK auto‐stimulation is responsible for the bistable response in competence development

  2005cited by this paper
• Regulation of Bacteriocin Production in Streptococcus mutans by the Quorum-Sensing System Required for Development of Genetic Competence

  2005cited by this paper
• Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements.

  2005cited by this paper
• Bacteriocin (Mutacin) Production by Streptococcus mutans Genome Sequence Reference Strain UA159: Elucidation of the Antimicrobial Repertoire by Genetic Dissection

  2005influential reference
• Co‐ordinated bacteriocin production and competence development: a possible mechanism for taking up DNA from neighbouring species

  2005influential reference
• Trigger Factor in Streptococcus mutans Is Involved in Stress Tolerance, Competence Development, and Biofilm Formation

  2005cited by this paper
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  2005influential reference
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  2005influential reference
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001influential reference
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  2001influential reference
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  2000cited by this paper
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  2000cited by this paper
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  1998cited by this paper
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  1996cited by this paper
• The multiple-sugar metabolism (msm) gene cluster of Streptococcus mutans is transcribed as a single operon.

  1996cited by this paper
• An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae.

  1995cited by this paper
• Pore-forming bacteriocins of gram-positive bacteria and self-protection mechanisms of producer organisms.

  1995cited by this paper
• Molecular, genetic, and functional analysis of the basic replicon of pVA380-1, a plasmid of oral streptococcal origin.

  1992cited by this paper
• Induction of autolysis in Enterococcus faecalis S-47 by peptide AS-48.

  1990cited by this paper
• Biological role of the pneumococcal amidase. Cloning of the lytA gene in Streptococcus pneumoniae.

  1987cited by this paper

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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2015cites this paper
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