Treatment effects of high‐dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Thrombosis and Haemostasis

• Publication date

  2006-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1538-7836.2005.01697.xPMID 16409457
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dynamic evolution of coagulopathy in the first day of severe sepsis: Relationship with mortality and organ failure*

  2005cited by this paper
• Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation

  2005cited by this paper
• Disseminated intravascular coagulation in sepsis.

  2005cited by this paper
• Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation*

  2004cited by this paper
• Hemostatic markers and the sepsis‐related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit

  2004cited by this paper
• Coagulopathy of sepsis

  2004cited by this paper
• Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation 1

  2004cited by this paper
• Sepsis and Disseminated Intravascular Coagulation

  2003cited by this paper
• [Disseminated intravascular coagulation].

  2003cited by this paper
• Antithrombin, heparin, and heparan sulfate

  2002cited by this paper
• Adverse Effect of Heparin on Antithrombin Action during Endotoxemia: Microhemodynamic and Cellular Mechanisms

  2002cited by this paper
• Disseminated Intravascular Coagulation in Sepsis

  2001cited by this paper
• High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial

  2001cited by this paper
• Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial.

  2001cited by this paper
• Towards Definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation

  2001cited by this paper
• Disseminated Intravascular Coagulation

  1999cited by this paper
• Review: infectious diseases and coagulation disorders.

  1999cited by this paper
• Antithrombin III (ATIII) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study.

  1998cited by this paper
• Antithrombin III in patients with severe sepsis. A randomized, placebo-controlled, double-blind multicenter trial plus a meta-analysis on all randomized, placebo-controlled, double-blind trials with antithrombin III in severe sepsis.

  1998cited by this paper
• ANTITHROMBIN III SUPPLEMENTATION IN SEVERE SEPSIS: BENEFICIAL EFFECTS ON ORGAN DYSFUNCTION

  1997cited by this paper
• A pseudogene for the human ribosomal protein L5 (RPL5P1) maps within an intron of the SNRPN transcription unit on human chromosome 15.

  1996cited by this paper
• Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients.

  1996cited by this paper
• Disseminated Intravascular Coagulation Is a Frequent Complication of Systemic Inflammatory Response Syndrome

  1996cited by this paper
• Customized probability models for early severe sepsis in adult intensive care patients. Intensive Care Unit Scoring Group.

  1995cited by this paper
• Double-blind, placebo-controlled trial of antithrombin III concentrates in septic shock with disseminated intravascular coagulation.

  1993cited by this paper
• Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies.

  1992cited by this paper
• Substitution of antithrombin III in shock and DIC: a randomized study.

  1985cited by this paper
• Epidemiologic Research: Principles and Quantitative Methods.

  1983cited by this paper
• Antithrombin-III transfusion in disseminated intravascular coagulation.

  1978cited by this paper
• Clinical and Laboratory Aspects of Disseminated Intravascular Coagulation (DIC): A Study of 118 Cases

  1978cited by this paper
• Heparin therapy in bacterial septicemia.

  1977cited by this paper
• A Case against Heparin Therapy of Intravascular Coagulation

  1975cited by this paper
• Heparin therapy in septicemia with disseminated intravascular coagulation.

  1970cited by this paper

• Efficacy and safety of anticoagulant therapy in sepsis: A systematic review and meta-analysis

  2026cites this paper
• A Critical Role for MALAT1 in Gram-negative Bacteria-induced Coagulation via Regulation of Caspase-11 signaling.

  2025cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

  2025cites this paper
• Combination of antithrombin and soluble thrombomodulin for early prediction of sepsis-Induced disseminated intravascular coagulation

  2025cites this paper
• Anticoagulation in venovenous extracorporeal membrane oxygenation

  2025cites this paper
• The diagnostic and prognostic value of antithrombin III activity for sepsis-induced coagulopathy in septic patients: a prospective observational study

  2025cites this paper
• Early prediction of sepsis-induced coagulopathy in the ICU using interpretable machine learning: a multi-center retrospective cohort study

  2025cites this paper
• Damage-associated Molecular Patterns, Immunothrombosis, and Intravascular Inflammation in Sepsis: A Narrative Integrative Review

  2025cites this paper
• The modified Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria in sepsis is useful for an indicator of initiating treatment for disseminated intravascular coagulation.

  2025cites this paper
• Factors influencing antithrombin activity following supplementation in sepsis-associated disseminated intravascular coagulation

  2025cites this paper
• Infection at the Vascular Front: A Delicate Balance Between Defense and Pathology.

  2025cites this paper
• Natural products in treatment and management of sepsis-induced coagulopathy: Pharmacological basis and mechanisms.

  2025cites this paper
• The fibrinolytic system in disease: From molecular pathways to clinical outcomes.

  2025cites this paper
• Efficacy and safety of antithrombin or recombinant human thrombomodulin in the treatment of disseminated intravascular coagulation: A systematic review and meta-analysis.

  2025cites this paper
• Disseminated Intravascular Coagulopathy and Persistent Inflammation, Immunosuppression, and Catabolism Syndrome: Pathophysiology, shared pathways, and clinical implications.

  2025cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

  2025cites this paper
• Therapie mit Blutprodukten auf der Intensivstation

  2025cites this paper
• Sepsis-Induced Coagulopathy: A Comprehensive Narrative Review of Pathophysiology, Clinical Presentation, Diagnosis, and Management Strategies

  2024cites this paper
• RỐI LOẠN ĐÔNG MÁU TRONG NHIỄM KHUẨN HUYẾT

  2024cites this paper
• Coagulation intravasculaire disséminée : mise au point

  2024cites this paper
• Rotational Thromboelastometry and Clot Waveform Analysis as Point-of-Care Tests for Diagnosis of Disseminated Intravascular Coagulation in Critically Ill Children in Thailand*

  2024cites this paper
• PROGNOSTIC MARKERS FOR THROMBOTIC EVENTS IN PATIENTS WITH GASTRIC OR COLORECTAL ADENOCARCINOMAS

  2024cites this paper
• The transition of the criteria for disseminated intravascular coagulation and the targeted patients in randomized controlled trials over the decades: a scoping review

  2024cites this paper
• A machine learning model for early and accurate prediction of overt disseminated intravascular coagulation before its progression to an overt stage

  2024cites this paper
• Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis

  2024cites this paper
• Anticoagulant therapy without bleeding: A novel molybdenum‐based nanodots alleviate lethal coagulation in bacterial sepsis by inhibiting ROS‐facilitated caspase‐11 activation

  2024cites this paper
• The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid

  2024cites this paper
• Deranged Balance of Hemostasis and Fibrinolysis in Disseminated Intravascular Coagulation: Assessment and Relevance in Different Clinical Settings

  2024cites this paper
• Practical approach to thrombocytopenia in patients with sepsis: a narrative review

  2024cites this paper
• Efficacy of antithrombin administration for patients with sepsis: A systematic review, meta‐analysis, and meta‐regression

  2024cites this paper
• Management Strategies in Septic Coagulopathy: A Review of the Current Literature

  2023cites this paper
• Symmetrical peripheral gangrene: potential mechanisms and therapeutic approaches in severe COVID-19

  2023cites this paper
• Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines

  2023cites this paper
• The antithrombin activity recovery after substitution therapy is associated with improved 28-day mortality in patients with sepsis-associated disseminated intravascular coagulation

  2023cites this paper
• Mechanisms and management of the coagulopathy of trauma and sepsis: TIC, SIC, and DIC.

  2023cites this paper
• Thromboinflammation in acute injury: infections, heatstroke, and trauma.

  2023cites this paper
• Sepsis - associated disseminated intravascular coagulation - a constant problem of the present

  2023cites this paper
• Anticoagulant therapies against sepsis‐induced disseminated intravascular coagulation

  2023cites this paper
• Pathogenesis and Therapy of Coagulation Disorders in Severe Acute Pancreatitis

  2023cites this paper
• The pathophysiology, diagnosis, and management of sepsis-associated disseminated intravascular coagulation

  2023cites this paper
• Effects of Antithrombin on Persistent Inflammation, Immunosuppression, and Catabolism Syndrome among Patients with Sepsis-Induced Disseminated Intravascular Coagulation

  2023cites this paper
• Hemostatic disorders associated with extracorporeal membrane oxygenation.

  2023cites this paper
• Antithrombin Replacement in Cardiac Surgery: Was Too Much of a Good Thing Bad?

  2023cites this paper
• Endothelial dysfunction and immunothrombosis in sepsis

  2023cites this paper
• Sepsis‐induced disseminated intravascular coagulation: an international estrangement of disease concept

  2023cites this paper
• Global trends in research on endothelial cells and sepsis between 2002 and 2022: A systematic bibliometric analysis

  2023cites this paper
• Prognostic Impact of the International Society on Thrombosis and Hemostasis Disseminated Intravascular Coagulation Score in Sepsis: A Systematic Review

  2023cites this paper
• Effect of Anticoagulant Versus Non-Anticoagulant Therapy on Mortality of Sepsis-Induced Disseminated Intravascular Coagulation: A Systematic Review and Meta-Analysis

  2023cites this paper
• Low-molecular-weight heparin therapy reduces 28-day mortality in patients with sepsis-3 by improving inflammation and coagulopathy

  2023cites this paper
• Antithrombin Therapy: Current State and Future Outlook

  2023cites this paper
• Association of Blood Glucose Variability with Sepsis-Related Disseminated Intravascular Coagulation Morbidity and Mortality

  2022cites this paper
• Impact of Antithrombin Activity Levels Following Recombinant Antithrombin Gamma Therapy in Patients with Sepsis-Induced Disseminated Intravascular Coagulation

  2022cites this paper
• Risk factors for mechanical ventilation and ECMO in COVID-19 patients admitted to the ICU: A multicenter retrospective observational study

  2022influential citation
• Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin

  2022cites this paper
• The pathogenesis and the treatment strategy of DIC complicated with hematological malignancy

  2022cites this paper
• A current view of sepsis-induced disseminated intravascular coagulation

  2022cites this paper
• Antithrombin as Therapeutic Intervention against Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation: Lessons Learned from COVID-19-Associated Coagulopathy

  2022cites this paper
• Temporal Trends, Predictors, and Outcomes of Disseminated Intravascular Coagulation in Hospitalizations With Sepsis

  2022cites this paper
• Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

  2022cites this paper
• Prognostic value of serum high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

  2022cites this paper
• Concerns regarding meta-analysis and RCT selection about anticoagulants to treat sepsis-associated disseminated intravascular coagulation in the Japanese Surviving Sepsis Campaign Guidelines 2020

  2022cites this paper
• Incidence, Outcome, and Risk Factors of Cardiovascular Surgery-Associated Disseminated Intravascular Coagulation: A Single-Center Retrospective Study

  2022cites this paper
• Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling

  2022cites this paper
• Disseminated intravascular coagulation and its immune mechanisms

  2021cites this paper
• A Machine-Learning Approach for Dynamic Prediction of Sepsis-Induced Coagulopathy in Critically Ill Patients With Sepsis

  2021cites this paper
• Fibrinolytic Alterations in Sepsis: Biomarkers and Future Treatment Targets

  2021cites this paper
• Clinical Outcomes of Early Endoscopic Transpapillary Biliary Drainage for Acute Cholangitis Associated with Disseminated Intravascular Coagulation

  2021cites this paper
• Disseminated intravascular coagulation: epidemiology, biomarkers, and management

  2021cites this paper
• Antithrombin and Its Role in Host Defense and Inflammation

  2021cites this paper
• The Roles of Coagulation Disorder and Microthrombosis in Sepsis: Pathophysiology, Diagnosis, and Treatment.

  2021cites this paper
• Cytokine storm associated coagulation complications in COVID-19 patients: Pathogenesis and Management

  2021cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)

  2021cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020)

  2021cites this paper
• Influence of recombinant human-soluble thrombomodulin on extracorporeal circuit clotting in septic patients undergoing blood purification: a propensity-matched cohort study

  2021cites this paper
• Coagulation and fibrinolysis balance in disseminated intravascular coagulation

  2021cites this paper
• Age is Associated with the E cacy of Anticoagulant Therapies Against Sepsis-Induced Disseminated Intravascular Coagulation

  2021cites this paper
• Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation

  2021cites this paper
• A new SOFA score calculation to improve the predictive performance for mortality in sepsis-associated disseminated intravascular coagulopathy patients.

  2021cites this paper
• Limb ischemia in patients with COVID-19

  2021cites this paper
• Querschnitts-Leitlinien zur Therapie mit Blutkomponenten und Plasmaderivaten

  2021cites this paper
• Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment.

  2021cites this paper
• Letter from the Editor

  2021cites this paper
• Age Is Associated With the Efficacy of Anticoagulant Therapies Against Sepsis-Induced Disseminated Intravascular Coagulation

  2021cites this paper
• IMPACT OF COVID-19 ON COAGULATION

  2021cites this paper
• Signaling pathways and intervention therapies in sepsis

  2021cites this paper
• An evaluation of the Japanese Society on Thrombosis and Hemostasis criteria for disseminated intravascular coagulation as a predictor of prognosis in patients with infection

  2021cites this paper
• Disseminated intravascular coagulation following femoral nailing in a metastatic prostate carcinoma patient – A case report

  2021cites this paper
• Endothelial dysfunction: a therapeutic target in bacterial sepsis?

  2021cites this paper
• Therapeutic strategies in patients with coagulopathy and disseminated intravascular coagulation: awareness of the phase-dependent characteristics.

  2021cites this paper
• Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells

  2021cites this paper
• Management of Vascular Thrombosis in Patients with Thrombocytopenia

  2021cites this paper
• Early coagulation tests predict risk stratification and prognosis of COVID-19

  2020cites this paper
• Antithrombin use and mortality in patients with stage IV solid tumor-associated disseminated intravascular coagulation: a nationwide observational study in Japan

  2020cites this paper
• Understanding the andromeda strain – The role of cytokine release, coagulopathy and antithrombin III in SARS-CoV2 critical illness

  2020cites this paper
• COVID-19 and its implications for thrombosis and anticoagulation

  2020cites this paper
• Clinical characteristics of patients with severe sepsis and septic shock in relation to bacterial virulence of beta‐hemolytic Streptococcus and Streptococcus pneumoniae

  2020cites this paper
• 血栓性微小血管症（TMA）と播種性血管内凝固（DIC）の早期鑑別診断

  2020cites this paper
• The effects of sepsis on endothelium and clinical implications.

  2020cites this paper
• Complement C1q Enhances Primary Hemostasis

  2020cites this paper
• Recombinant thrombomodulin alleviates oxidative stress without compromising host resistance to infection in rats infected with methicillin-resistant Staphylococcus aureus

  2020cites this paper