Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Endocrinology

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/en.2012-1954PMID 23254197
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiology of the Adult Gonadotropin-Releasing Hormone Neuronal Network

  2015cited by this paper
• Review: Fetal Programming of Polycystic Ovary Syndrome by Androgen Excess — Evidence from Experimental, Clinical and Genetic Association Studies

  2014cited by this paper
• Disordered follicle development.

  2013cited by this paper
• Neuroendocrine dysfunction in polycystic ovary syndrome.

  2012cited by this paper
• Animal models of polycystic ovary syndrome: a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk.

  2012cited by this paper
• Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice.

  2012cited by this paper
• The Role of cAMP Response Element-Binding Protein in Estrogen Negative Feedback Control of Gonadotropin-Releasing Hormone Neurons

  2012cited by this paper
• Reproductive and metabolic phenotype of a mouse model of PCOS.

  2012cited by this paper
• Depolarising and Hyperpolarising Actions of GABAA Receptor Activation on Gonadotrophin‐Releasing Hormone Neurones: Towards an Emerging Consensus

  2011cited by this paper
• Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.

  2011influential reference
• Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge.

  2011cited by this paper
• Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels

  2010cited by this paper
• Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling

  2010cited by this paper
• Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats.

  2010cited by this paper
• Knockdown of GABA(A) receptor signaling in GnRH neurons has minimal effects upon fertility.

  2010cited by this paper
• Prenatal androgen exposure programs metabolic dysfunction in female mice.

  2010cited by this paper
• Polycystic ovary syndrome--"A riddle wrapped in a mystery inside an enigma".

  2009cited by this paper
• Differential Regulation of Gonadotropin-Releasing Hormone Neuron Activity and Membrane Properties by Acutely Applied Estradiol: Dependence on Dose and Estrogen Receptor Subtype

  2009cited by this paper
• Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome.

  2009cited by this paper
• Acute effects of testosterone infusion on the serum luteinizing hormone profile in eumenorrheic and polycystic ovary syndrome adolescents.

  2009cited by this paper
• Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome.

  2009cited by this paper
• Developmental Programming: Differential Effects of Prenatal Testosterone and Dihydrotestosterone on Follicular Recruitment, Depletion of Follicular Reserve, and Ovarian Morphology in Sheep1

  2009cited by this paper
• The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report.

  2009cited by this paper
• Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome.

  2008cited by this paper
• The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation.

  2008cited by this paper
• A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.

  2007cited by this paper
• Defining the Gonadotrophin‐Releasing Hormone Neuronal Network: Transgenic Approaches to Understanding Neurocircuitry

  2007cited by this paper
• Androgens increase gonadotropin-releasing hormone neuron firing activity in females and interfere with progesterone negative feedback.

  2006cited by this paper
• Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies.

  2006cited by this paper
• CHAPTER 28 – Physiology of the Gonadotropin-Releasing Hormone Neuronal Network

  2006cited by this paper
• Postnatal remodeling of dendritic structure and spine density in gonadotropin-releasing hormone neurons.

  2006cited by this paper
• Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls.

  2005cited by this paper
• GABAergic Integration of Progesterone and Androgen Feedback to Gonadotropin-Releasing Hormone Neurons1

  2005cited by this paper
• Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span.

  2005influential reference
• Biocytin filling of adult gonadotropin-releasing hormone neurons in situ reveals extensive, spiny, dendritic processes.

  2005cited by this paper
• Neuroendocrine Consequences of Prenatal Androgen Exposure in the Female Rat: Absence of Luteinizing Hormone Surges, Suppression of Progesterone Receptor Gene Expression, and Acceleration of the Gonadotropin-Releasing Hormone Pulse Generator1

  2005cited by this paper
• Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?

  2005cited by this paper
• Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).

  2004cited by this paper
• Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder.

  2004influential reference
• Ultrasound assessment of the polycystic ovary: international consensus definitions.

  2003cited by this paper
• Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess.

  2002cited by this paper
• Regulation of Gonadotropin Secretion: Implications for Polycystic Ovary Syndrome

  2002cited by this paper
• Intra-follicular activin availability is altered in prenatally-androgenized lambs.

  2001cited by this paper
• Subsets of gonadotropin-releasing hormone (GnRH) neurons are activated during a steroid-induced luteinizing hormone surge and mating in mice: a combined retrograde tracing double immunohistochemical study.

  2001cited by this paper
• Pathogenesis of polycystic ovary syndrome: Evidence for a genetically determined disorder of ovarian androgen production

  2000cited by this paper
• GABA- and Glutamate-Activated Channels in Green Fluorescent Protein-Tagged Gonadotropin-Releasing Hormone Neurons in Transgenic Mice

  1999cited by this paper
• Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons.

  1998cited by this paper
• Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone.

  1998influential reference
• Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome.

  1997cited by this paper
• Resistance of gonadotropin releasing hormone drive to sex steroid-induced suppression in hyperandrogenic anovulation.

  1997cited by this paper
• Increased GnRH mRNA in the GnRH neurons expressing cFos during the proestrous LH surge.

  1995cited by this paper
• Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women.

  1994cited by this paper
• THE PREVALENCE OF POLYCYSTIC OVARIES IN PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA AND THEIR CLOSE RELATIVES

  1990cited by this paper
• Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey.

  1981cited by this paper
• The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro.

  1979cited by this paper

• ∂Voltage-gated calcium channel activity of gonadotropin-releasing hormone (GnRH) neurons is altered by age and by prenatal androgen exposure in female mice

  2026cites this paper
• Transcriptome analysis of early embryonic development in a mouse model of polycystic ovary syndrome

  2025cites this paper
• Ovarian-Specific Cyp17A1 Overexpression in Female Mice: A Novel Model of Endogenous Testosterone Excess.

  2025cites this paper
• Modulatory impact of Bifidobacterium longum subsp. longum BL21 on the gut–brain–ovary axis in polycystic ovary syndrome: insights into metabolic regulation, inflammation mitigation, and neuroprotection

  2025influential citation
• The Hypothalamus and Pituitary Gland Regulate Reproduction and Are Involved in the Development of Polycystic Ovary Syndrome

  2025cites this paper
• POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons

  2025cites this paper
• Polycystic Ovary Syndrome (PCOS): Anti-Müllerian Hormone (AMH) and its role in the pathophysiology of the syndrome.

  2025cites this paper
• Forebrain AR Deletion Restores PR Expression but not Reproduction in Prenatally Androgenized Female Mice

  2025cites this paper
• Prenatally androgenized PCOS mice have ovary-independent uterine dysfunction and placental inflammation aggravated by high-fat diet

  2025cites this paper
• The androgen clock is an epigenetic predictor of long-term male hormone exposure

  2025cites this paper
• Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders.

  2025cites this paper
• Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome.

  2024cites this paper
• Altered GnRH neuron-glia networks close to interface of polycystic ovary syndrome: Molecular mechanism and clinical perspectives.

  2024cites this paper
• Rodent models in polycystic ovarian Syndrome: Dissecting reproductive and metabolic phenotypes for therapeutic Advancements.

  2024cites this paper
• GnRH pulse generator activity in mouse models of polycystic ovary syndrome

  2024influential citation
• Investigating GABA Neuron–Specific Androgen Receptor Knockout in two Hyperandrogenic Models of PCOS

  2024cites this paper
• Effects of the prenatal and postnatal nurturing environment on the phenotype and gut microbiota of mice with polycystic ovary syndrome induced by prenatal androgen exposure: a cross-fostering study

  2024cites this paper
• POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons

  2024cites this paper
• Androgen receptor actions on AgRP neurons are not a major cause of reproductive and metabolic impairments in peripubertally androgenized mice

  2024cites this paper
• High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures

  2024cites this paper
• A review on critical appraisal and pathogenesis of polycystic ovarian syndrome

  2024cites this paper
• Unkeito promotes follicle development by restoring reduced follicle-stimulating hormone responsiveness in rats with polycystic ovary syndrome

  2023cites this paper
• Microglia: Sculptors of the polycystic ovary syndrome (PCOS)-like brain?

  2023cites this paper
• Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model

  2023cites this paper
• Molecular Mechanisms in the Etiology of Polycystic Ovary Syndrome (PCOS): A Multifaceted Hypothesis Towards the Disease with Potential Therapeutics

  2023cites this paper
• Maternal androgen excess significantly impairs sexual behavior in male and female mouse offspring: Perspective for a biological origin of sexual dysfunction in PCOS

  2023influential citation
• Deletion of Androgen Receptor in LepRb Cells Improves Estrous Cycles in Prenatally Androgenized Mice.

  2023cites this paper
• Suppression of neurotransmission on gonadotropin-releasing hormone neurons in letrozole-induced polycystic ovary syndrome: A mouse model

  2023cites this paper
• The effect of letrozole treatment on the fertility and embryos parameters in female mice: Histological and hormonal study

  2023cites this paper
• The role of gonadotropin‐releasing hormone neurons in polycystic ovary syndrome

  2022cites this paper
• A review of the hormones involved in the endocrine dysfunctions of polycystic ovary syndrome and their interactions

  2022cites this paper
• Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome

  2022cites this paper
• Association between Glucose Consumption and Oocyte Maturation Competence in Mice with Polycystic Ovarian Syndrome

  2022cites this paper
• Update on Animal Models of Polycystic Ovary Syndrome

  2022cites this paper
• A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)

  2022cites this paper
• Daughters of polycystic ovary syndrome pregnancies and androgen levels in puberty: a Meta-analysis

  2022cites this paper
• Prenatal androgen treatment impairs the suprachiasmatic nucleus arginine-vasopressin to kisspeptin neuron circuit in female mice

  2022influential citation
• Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway

  2022cites this paper
• Long-term role of neonatal microglia and monocytes in ovarian health.

  2022cites this paper
• The pathogenic role of androgen excess in PCOS

  2022cites this paper
• Developmental origins of polycystic ovary syndrome: Everything starts in utero

  2022cites this paper
• Polycystic Ovary Syndrome and the Neuroendocrine Consequences of Androgen Excess.

  2022cites this paper
• Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

  2022cites this paper
• Highlights of neuroanatomical discoveries of the mammalian gonadotropin‐releasing hormone system

  2022cites this paper
• Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons

  2022cites this paper
• Pathology of Hyperandrogenemia in the Oocyte of Polycystic Ovary Syndrome.

  2022cites this paper
• Early initiation of anti-androgen treatment is associated with increased probability of spontaneous conception leading to childbirth in women with polycystic ovary syndrome: a population-based multiregistry cohort study in Sweden

  2021cites this paper
• Gonadotrophin‐releasing hormone receptor autoantibodies induce polycystic ovary syndrome‐like features in a rat model

  2021cites this paper
• Animal Models of PCOS: A Comprehensive Review on Current Advancement, Diet-Microbiota Interactions and Future Trend on Developing PCOS Induced Rodent Models

  2021cites this paper
• Prenatal androgenization causes expression changes of progesterone and androgen receptor mRNAs in the arcuate nucleus of female mice across development

  2021cites this paper
• Temporal relationship between alterations in the gut microbiome and the development of polycystic ovary syndrome‐like phenotypes in prenatally androgenized female mice

  2021cites this paper
• Reproductive Deficits Induced by Prenatal Anti-Mullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells.

  2021cites this paper
• Polycystic ovary syndrome mouse model by prenatal exposure to high anti-Müllerian hormone

  2021cites this paper
• Ovarian follicles are resistant to monocyte perturbations—implications for ovarian health with immune disruption†

  2021cites this paper
• Inhibiting Kiss1 Neurons with Kappa Opioid Receptor Agonists to Treat Polycystic Ovary Syndrome and Vasomotor Symptoms.

  2021cites this paper
• Prenatal androgen exposure alters KNDy neurons and their afferent network in a model of polycystic ovarian syndrome.

  2021cites this paper
• Morphological evidence indicates a role for microglia in shaping the PCOS‐like brain

  2021cites this paper
• Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice.

  2021cites this paper
• Fetal Programming of Polycystic Ovary Syndrome: Effects of Androgen Exposure on Prenatal Ovarian Development.

  2021cites this paper
• Maternal adiponectin prevents visceral adiposity and adipocyte hypertrophy in prenatal androgenized female mice

  2021cites this paper
• The central role of ovulatory disturbances in the etiology of androgenic polycystic ovary syndrome (PCOS)—Evidence for treatment with cyclic progesterone

  2020cites this paper
• Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring.

  2020cites this paper
• Hyperactive LH pulses and elevated kisspeptin and NKB gene expression in the arcuate nucleus of a PCOS mouse model.

  2020cites this paper
• Relevance of KISS1 gene polymorphisms in susceptibility to polycystic ovary syndrome and its associated endocrine and metabolic disturbances

  2020cites this paper
• Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes

  2020cites this paper
• Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

  2020cites this paper
• Abnormal GnRH Pulsatility in Polycystic Ovary Syndrome: Recent Insights.

  2020cites this paper
• New insights into anti-Müllerian hormone role in the hypothalamic–pituitary–gonadal axis and neuroendocrine development

  2020cites this paper
• Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health

  2020cites this paper
• Investigating the NPY/AgRP/GABA to GnRH Neuron Circuit in Prenatally Androgenized PCOS-Like Mice

  2020influential citation
• History of Estrogen: Its Purification, Structure, Synthesis, Biologic Actions, and Clinical Implications.

  2019cites this paper
• Ovarian androgens maintain high GnRH neuron firing rate in adult prenatally androgenized female mice.

  2019cites this paper
• The influence of maternal androgen excess on the male reproductive axis

  2019cites this paper
• UNIVERSITY OF CALIFORNIA SAN DIEGO SAN DIEGO STATE UNIVERSITY Role of the Gut Microbiome in Polycystic Ovary Syndrome A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy

  2019influential citation
• Physiological and Pathological Androgen Actions in the Ovary.

  2019cites this paper
• Activation of a Classic Hunger Circuit Slows Luteinizing Hormone Pulsatility

  2019cites this paper
• Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome

  2019cites this paper
• Neuroendocrine impairments of PCOS.

  2019cites this paper
• The Mechanism of Androgen Actions in PCOS Etiology

  2019cites this paper
• Pathological pulses in PCOS.

  2019cites this paper
• Prenatal Testosterone Exposure Alters GABAergic Synaptic Inputs to GnRH and KNDy Neurons in a Sheep Model of Polycystic Ovarian Syndrome.

  2019cites this paper
• The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS)

  2019influential citation
• Role of the Gut Microbiome in Polycystic Ovary Syndrome

  2019influential citation
• Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndrome

  2019influential citation
• Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

  2019cites this paper
• Androgens and ovarian function: translation from basic discovery research to clinical impact.

  2019cites this paper
• Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?

  2019cites this paper
• Pregnancy and neonatal complications in women with polycystic ovary syndrome in relation to second-trimester anti-Müllerian hormone levels.

  2019cites this paper
• Pregnancy and neonatal complications in women with PCOS in relation to second trimester anti-M¨ullerian hormone levels

  2019cites this paper
• Prenatal exposures and birth indices, and subsequent risk of polycystic ovary syndrome: a national registry‐based cohort study

  2018cites this paper
• Prepubertal Development of GABAergic Transmission to Gonadotropin-Releasing Hormone (GnRH) Neurons and Postsynaptic Response Are Altered by Prenatal Androgenization

  2018cites this paper
• Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS

  2018cites this paper
• Animal models of polycystic ovary syndrome: A review of hormone‐induced rodent models focused on hypothalamus‐pituitary‐ovary axis and neuropeptides

  2018cites this paper
• Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS.

  2018influential citation
• How to choose the suitable animal model of polycystic ovary syndrome?

  2018cites this paper
• Dissecting the ontogeny and functional relevance of altered GABAergic circuitry in Polycystic Ovary Syndrome (PCOS)

  2018cites this paper
• Mapping GABA and glutamate inputs to gonadotrophin‐releasing hormone neurones in male and female mice

  2018cites this paper
• The effect of cinnamon on polycystic ovary syndrome in a mouse model

  2018cites this paper
• Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons.

  2018cites this paper
• New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins.

  2018cites this paper