Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cellular and Molecular Life Sciences

• Publication date

  2009-08-04

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00018-009-0111-6PMID 19652915PMCID PMC11115879
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate

  2009cited by this paper
• Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids

  2009cited by this paper
• Odor Coding by a Mammalian Receptor Repertoire

  2009cited by this paper
• ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

  2009cited by this paper
• Olfactory receptors: G protein‐coupled receptors and beyond

  2009cited by this paper
• Subsystem organization of the mammalian sense of smell.

  2009cited by this paper
• Sensing odorants and pheromones with chemosensory receptors.

  2009cited by this paper
• Genome analysis of the platypus reveals unique signatures of evolution

  2008cited by this paper
• The red flour beetle's large nose: an expanded odorant receptor gene family in Tribolium castaneum.

  2008cited by this paper
• Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

  2008cited by this paper
• Insect olfactory receptors are heteromeric ligand-gated ion channels

  2008cited by this paper
• Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

  2008cited by this paper
• The importance of odorant conformation to the binding and activation of a representative olfactory receptor.

  2008cited by this paper
• Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

  2008cited by this paper
• The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity

  2008cited by this paper
• Grueneberg Ganglion Cells Mediate Alarm Pheromone Detection in Mice

  2008cited by this paper
• Olfactory CNG channel desensitization by Ca2+/CaM via the B1b subunit affects response termination but not sensitivity to recurring stimulation.

  2008cited by this paper
• Grueneberg ganglion neurons respond to cool ambient temperatures

  2008cited by this paper
• Amino acids involved in conformational dynamics and G protein coupling of an odorant receptor: targeting gain‐of‐function mutation

  2008influential reference
• Myr-Ric-8A enhances G(alpha15)-mediated Ca2+ response of vertebrate olfactory receptors.

  2008cited by this paper
• Exploring the Odorant Binding Site of a G-Protein-Coupled Olfactory Receptor

  2008cited by this paper
• TMEM16A confers receptor-activated calcium-dependent chloride conductance

  2008cited by this paper
• A Family of Chemoreceptors in Tribolium castaneum (Tenebrionidae: Coleoptera)

  2007cited by this paper
• Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium

  2007cited by this paper
• Extensive Gains and Losses of Olfactory Receptor Genes in Mammalian Evolution

  2007cited by this paper
• Regulation of G proteins by human 5-HT1a receptor TM3/i2 and TM5/i3 loop peptides.

  2007cited by this paper
• Expression of trace amine-associated receptors in the Grueneberg ganglion.

  2007cited by this paper
• Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray

  2007cited by this paper
• Deorphanizing vertebrate olfactory receptors: recent advances in odorant-response assays.

  2007cited by this paper
• Modeling of the complex between transducin and photoactivated rhodopsin, a prototypical G-protein-coupled receptor.

  2007cited by this paper
• The Molecular Basis for Ligand Specificity in a Mouse Olfactory Receptor

  2007influential reference
• Detection of Near-Atmospheric Concentrations of CO2 by an Olfactory Subsystem in the Mouse

  2007influential reference
• Genetic variation in a human odorant receptor alters odour perception

  2007cited by this paper
• Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals

  2007influential reference
• Signaling in the Chemosensory Systems

  2006cited by this paper
• Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo

  2006cited by this paper
• Functional analysis of a mammalian odorant receptor subfamily

  2006cited by this paper
• Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

  2006cited by this paper
• Cells in the vomeronasal organ express odorant receptors but project to the accessory olfactory bulb

  2006cited by this paper
• A second class of chemosensory receptors in the olfactory epithelium

  2006influential reference
• The chemoreceptor superfamily in the honey bee, Apis mellifera: expansion of the odorant, but not gustatory, receptor family.

  2006cited by this paper
• β-Arrestin2-Mediated Internalization of Mammalian Odorant Receptors

  2006cited by this paper
• Olfactory receptors and signalling elements in the Grueneberg ganglion

  2006cited by this paper
• Characterization of the Residues in Helix 8 of the Human β1-Adrenergic Receptor That Are Involved in Coupling the Receptor to G Proteins*

  2006influential reference
• Novel function of β-arrestin2 in the nucleus of mature spermatozoa

  2006cited by this paper
• Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli.

  2006cited by this paper
• Trace amine‐associated receptors and their ligands

  2006cited by this paper
• Phosphatidyl‐inositide signalling proteins in a novel class of sensory cells in the mammalian olfactory epithelium

  2005cited by this paper
• The odorant receptor repertoire of teleost fish

  2005cited by this paper
• Mechanism of the excitatory Cl- response in mouse olfactory receptor neurons.

  2005cited by this paper
• Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods

  2005cited by this paper
• Identification of Specific Ligands for Orphan Olfactory Receptors

  2005cited by this paper
• The Grueneberg ganglion projects to the olfactory bulb

  2005cited by this paper
• Structural Basis for a Broad But Selective Ligand Spectrum of a Mouse Olfactory Receptor: Mapping the Odorant-Binding Site

  2005influential reference
• The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb

  2005cited by this paper
• Calmodulin permanently associates with rat olfactory CNG channels under native conditions

  2004cited by this paper
• One neuron-one receptor rule in the mouse olfactory system.

  2004cited by this paper
• The mouse olfactory receptor gene family

  2004cited by this paper
• Odorant and vomeronasal receptor genes in two mouse genome assemblies.

  2004cited by this paper
• Molecular Organization of the Olfactory Septal Organ

  2004cited by this paper
• Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels.

  2004cited by this paper
• An odorant derivative as an antagonist for an olfactory receptor.

  2004cited by this paper
• Prediction of the odorant binding site of olfactory receptor proteins by human–mouse comparisons

  2004cited by this paper
• Genes and ligands for odorant, vomeronasal and taste receptors

  2004cited by this paper
• The human olfactory receptor gene family.

  2004cited by this paper
• Olfactory receptor antagonism between odorants

  2004cited by this paper
• Olfactory receptors in the mouse septal organ

  2004cited by this paper
• Odors Detected by Mice Deficient in Cyclic Nucleotide-Gated Channel Subunit A2 Stimulate the Main Olfactory System

  2004cited by this paper
• Non-visual GRKs: are we seeing the whole picture?

  2003cited by this paper
• Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster

  2003cited by this paper
• Identification of a Testicular Odorant Receptor Mediating Human Sperm Chemotaxis

  2003cited by this paper
• Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling.

  2002cited by this paper
• Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System

  2002cited by this paper
• The olfactory receptor gene superfamily of the mouse

  2002cited by this paper
• Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor

  2002cited by this paper
• G Protein-Coupled Receptors in Anopheles gambiae

  2002cited by this paper
• A single olfactory receptor specifically binds a set of odorant molecules

  2002cited by this paper
• Facilitation of Calmodulin-Mediated Odor Adaptation by cAMP-Gated Channel Subunits

  2001cited by this paper
• Molecular Bases of Odor Discrimination: Reconstitution of Olfactory Receptors that Recognize Overlapping Sets of Odorants

  2001cited by this paper
• Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

  2001cited by this paper
• Central Role of the CNGA4 Channel Subunit in Ca2+-Calmodulin-Dependent Odor Adaptation

  2001cited by this paper
• Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6*

  2001cited by this paper
• A cGMP-signaling pathway in a subset of olfactory sensory neurons.

  2000influential reference
• Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.

  2000influential reference
• Crystal structure of rhodopsin: A G protein-coupled receptor.

  2000cited by this paper
• The cellular and molecular basis of odor adaptation.

  2000cited by this paper
• The Amino Terminus of the Fourth Cytoplasmic Loop of Rhodopsin Modulates Rhodopsin-Transducin Interaction*

  2000cited by this paper
• The molecular receptive range of an odorant receptor

  2000cited by this paper
• A spatial map of olfactory receptor expression in the Drosophila antenna.

  1999cited by this paper
• Identification of candidate Drosophila olfactory receptors from genomic DNA sequence.

  1999cited by this paper
• Specificity and Sensitivity of a Human Olfactory Receptor Functionally Expressed in Human Embryonic Kidney 293 Cells andXenopus Laevis Oocytes

  1999cited by this paper
• Functional identification and reconstitution of an odorant receptor in single olfactory neurons.

  1999cited by this paper
• A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila.

  1999cited by this paper
• Mice deficient in G(olf) are anosmic.

  1998cited by this paper
• Functional expression of a mammalian odorant receptor.

  1998cited by this paper
• Identification of ligands for olfactory receptors by functional expression of a receptor library.

  1998cited by this paper
• Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals.

  1998cited by this paper
• G protein-coupled receptor kinases.

  1998cited by this paper
• Neurobiology of the Caenorhabditis elegans genome.

  1998cited by this paper
• G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization*

  1997cited by this paper

• The Emerging Role of Olfactory Receptors: From Genomics to Precision Medicine.

  2026cites this paper
• Physiological and perceptual characteristics of olfactory adaptation to pleasant and unpleasant odors

  2026cites this paper
• Computational modelling of olfactory receptors.

  2025cites this paper
• Docking process of 2-phenylethanethiol on human olfactory receptor OR2T11: Deep interpretation of the effect of silver ions via a new statistical physics mono-layer model

  2025cites this paper
• Ligand Differentiation Ability of Insect Odorant Receptors in Heterologously Expressed Cells as Potential Biosensor Elements

  2025cites this paper
• Thermal Cycling Stimulation via Nasal Inhalation Attenuates Aβ25–35-Induced Cognitive Deficits in C57BL/6 Mice

  2025cites this paper
• Competitive Bidirectional Response in Bi‐Polymeric Mechanochromic Cantilevers Toward Color Imaging‐Based VOC Discrimination

  2025cites this paper
• Propionate suppresses colitis-associated colorectal cancer in mice by Or51e2.

  2025cites this paper
• Psychophysiological influence of olfactory stimuli on human sexual behavior

  2025cites this paper
• Roles of sensory receptors in non-sensory organs: the kidney and beyond

  2025cites this paper
• MOR23 deficiency exacerbates hepatic steatosis in mice

  2024cites this paper
• A status report on human odorant Receptors and their allocated agonists.

  2024cites this paper
• Sensory Nutrition and Bitterness and Astringency of Polyphenols

  2024cites this paper
• Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig

  2024cites this paper
• Theoretical assessment of the adsorption mechanism of carvone enantiomers on cow btOR1A1: New microscopic interpretations.

  2024cites this paper
• High-throughput ligand profile characterization in novel cell lines expressing seven heterologous insect olfactory receptors for the detection of volatile plant biomarkers

  2023cites this paper
• Functions of human olfactory mucus and age-dependent changes

  2023cites this paper
• High-throughput ligand profile characterization in novel biosensor cell lines expressing seven heterologous olfactory receptors for the detection of volatile plant biomarkers

  2023cites this paper
• Differential sensing with arrays of de novo designed peptide assemblies

  2023cites this paper
• RNAi verifications on olfactory defects of an essential biocontrol agent Agasicles hygrophila (Coleoptera: Chrysomelidae) regarding mating and host allocation

  2023cites this paper
• Data-driven design of a multiplexed, peptide-sensitized transistor to detect breath VOC markers of COVID-19

  2023cites this paper
• Olfactory dysfunction in chronic rhinosinusitis: insights into the underlying mechanisms and treatments

  2023cites this paper
• Modeling by statistical physics and interpretation of the olfactory process of the two enantiomers 3-mercapto-2-methylbutan-1-ol and 3-mercapto-2-methylpentan-1-ol on the OR2M3 human olfactory receptor.

  2023cites this paper
• Targeting trafficking as a therapeutic avenue for misfolded GPCRs leading to endocrine diseases

  2022cites this paper
• Time-Dependent Odorant Sensitivity Modulation in Insects

  2022cites this paper
• Acute Myeloid Leukemia Expresses a Specific Group of Olfactory Receptors

  2022cites this paper
• Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli

  2022cites this paper
• Data-Driven Design of Protein-Derived Peptide Multiplexes for Biomimetic Detection of Exhaled Breath VOC Profiles

  2022cites this paper
• Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency

  2021cites this paper
• PKC98E Regulates Odorant Responses in Drosophila melanogaster

  2021cites this paper
• Antennal Enriched Odorant Binding Proteins Are Required for Odor Communication in Glossina f. fuscipes

  2021cites this paper
• G protein-coupled receptors as candidates for modulation and activation of the chemical senses in decapod crustaceans

  2021cites this paper
• The role of the odorant receptors in the formation of the sensory map

  2021cites this paper
• OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant–receptor interactions

  2021cites this paper
• Decoding the olfactory map: targeted transcriptomics link olfactory sensory neurons to glomeruli

  2021cites this paper
• The diversity of lipocalin receptors.

  2021cites this paper
• Olfactory receptor 5B21 drives breast cancer metastasis

  2021cites this paper
• Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors

  2021cites this paper
• odorants, olfactory receptors and odorant–receptor interactions

  2021cites this paper
• Interpretations of key food odorant dose-olfactory response curves using statistical physics method

  2020cites this paper
• PAN‐selective inhibition of cAMP‐phosphodiesterase 4 (PDE4) induces gastroparesis in mice

  2020cites this paper
• Cellular and Molecular Targets of Waterbuck Repellent Blend Odors in Antennae of Glossina fuscipes fuscipes Newstead, 1910

  2020cites this paper
• Quantitative analysis of the spontaneous activity and response profiles of odorant receptor neurons in larval Xenopus laevis using the cell-attached patch-clamp technique

  2020cites this paper
• Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3

  2019cites this paper
• Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research

  2019cites this paper
• Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization.

  2019cites this paper
• Strength in diversity: functional diversity among olfactory neurons of the same type

  2019cites this paper
• Ocean Acidification Impairs Foraging Behavior by Interfering With Olfactory Neural Signal Transduction in Black Sea Bream, Acanthopagrus schlegelii

  2018cites this paper
• Conducting Nanomaterial Sensor Using Natural Receptors.

  2018cites this paper
• Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1

  2017cites this paper
• Recovery of glomerular morphology in the olfactory bulb of young mice after disruption caused by continuous odorant exposure.

  2017cites this paper
• Two single-point mutations shift the ligand selectivity of a pheromone receptor between two closely related moth species

  2017influential citation
• Multisensory neural integration of chemical and mechanical signals

  2017cites this paper
• Odour perception: A review of an intricate signalling pathway

  2016cites this paper
• Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease

  2016cites this paper
• Vertebrate Odorant Receptors

  2016cites this paper
• Olfactory receptor signaling.

  2016cites this paper
• Co-expression of anoctamins in cilia of olfactory sensory neurons.

  2015cites this paper
• Towards an understanding of the structural basis for insect olfaction by odorant receptors.

  2015cites this paper
• G protein‐coupled odorant receptors: From sequence to structure

  2015cites this paper
• Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo

  2015cites this paper
• Olfactory Receptor Function

  2015cites this paper
• Haloferax volcanii, as a Novel Tool for Producing Mammalian Olfactory Receptors Embedded in Archaeal Lipid Bilayer

  2015cites this paper
• The structural organization in the Olfactory System of the Teleosts and Garfishes

  2015cites this paper
• Differential Gene Expression Profile in the Rat Caudal Vestibular Nucleus is Associated with Individual Differences in Motion Sickness Susceptibility

  2015cites this paper
• Unravelling the Olfactory Sense: From the Gene to Odor Perception.

  2015cites this paper
• Preferential binding of an odor within olfactory receptors: a precursor to receptor activation.

  2014cites this paper
• In Vivo Identification of Eugenol-Responsive and Muscone-Responsive Mouse Odorant Receptors

  2014cites this paper
• Honeybees (Apis mellifera) learn to discriminate the smell of organic compounds from their respective deuterated isotopomers

  2014cites this paper
• Extrasensory perception: odorant and taste receptors beyond the nose and mouth.

  2014cites this paper
• Diverse Cell Type-Specific Mechanisms Localize G Protein-Coupled Receptors to Caenorhabditis elegans Sensory Cilia

  2014cites this paper
• Evaluation of the role of g protein-coupled receptor kinase 3 in desensitization of mouse odorant receptors in a Mammalian cell line and in olfactory sensory neurons.

  2014cites this paper
• Three structurally similar odorants trigger distinct signaling pathways in a mouse olfactory neuron.

  2014cites this paper
• A computational microscope focused on the sense of smell.

  2014cites this paper
• Odor and Pheromone Molecules, Receptors, and Behavioral Responses

  2014cites this paper
• InVivoIdentificationofEugenol-ResponsiveandMuscone- ResponsiveMouseOdorantReceptors

  2014cites this paper
• The role of GPCR localization and putative tau-tubulin kinases in the transduction of environmental stimuli in Caenorhabditis elegans

  2014cites this paper
• Introduction to Chemical Signaling in Vertebrates and Invertebrates

  2014cites this paper
• isotopomerscompounds from their respective deuterated ) learn to discriminate the smell of Apis mellifera Honeybees (

  2014cites this paper
• Quantum Calculation for Musk Molecules Infrared Spectra towards the Understanding of Odor

  2014cites this paper
• Usaimena, zentzumen ahaztu hori

  2014cites this paper
• An Overview of Synergistic Data Tools for Biological Scrutiny

  2013cites this paper
• Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.

  2013cites this paper
• The sea lamprey has a primordial accessory olfactory system

  2013cites this paper
• The fundamental unit of pain is the cell.

  2013cites this paper
• Computational studies on seven helix transmembrane receptors

  2013cites this paper
• Functional and evolutionary aspects of chemoreceptors

  2012cites this paper
• Loss of the V-ATPase B1 Subunit Isoform Expressed in Non-Neuronal Cells of the Mouse Olfactory Epithelium Impairs Olfactory Function

  2012cites this paper
• Personal receptor repertoires: olfaction as a model

  2012cites this paper
• Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity.

  2012cites this paper
• The Swipe Card Model of Odorant Recognition

  2012cites this paper
• Evolutionary grass roots for odor recognition.

  2012cites this paper
• Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target.

  2012cites this paper
• Amino Acid- vs. Peptide-Odorants: Responses of Individual Olfactory Receptor Neurons in an Aquatic Species

  2012cites this paper
• Recetas para obtener una señalización específica y una transducción eficiente: Compartimentalización de la señalización

  2011cites this paper
• Making Sense of It All: A Review of Olfactory Biosensing

  2011cites this paper
• Autonomic Modulation of Olfactory Signaling

  2011cites this paper
• Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors.

  2011cites this paper
• The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket.

  2011cites this paper
• Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors.

  2011cites this paper