Calpain as a therapeutic target in traumatic brain injury

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neurotherapeutics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.nurt.2009.11.002PMID 20129495PMCID PMC2842949
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antioxidant therapies for traumatic brain injury

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• Mechanistic Role of Calpains in Postischemic Neurodegeneration

  2008cited by this paper
• Neuroprotective Effects of Tempol, a Catalytic Scavenger of Peroxynitrite-Derived Free Radicals, in a Mouse Traumatic Brain Injury Model

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• Classification of Traumatic Brain Injury for Targeted Therapies

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• Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

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• Temporal Profiles of Cytoskeletal Protein Loss following Traumatic Axonal Injury in Mice

  2007cited by this paper
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  2007cited by this paper
• Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury.

  2007cited by this paper
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  2007cited by this paper
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• Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial.

  2007cited by this paper
• Calpain Inhibitor MDL-28170 Reduces the Functional and Structural Deterioration of Corpus Callosum following Fluid Percussion Injury

  2007cited by this paper
• Clinical Significance of αII-Spectrin Breakdown Products in Cerebrospinal Fluid after Severe Traumatic Brain Injury

  2007cited by this paper
• Therapeutic hypothermia: neuroprotective mechanisms.

  2007cited by this paper
• Alpha-II-Spectrin after Controlled Cortical Impact in the Immature Rat Brain

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  2006cited by this paper
• Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury

  2006cited by this paper
• Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice.

  2006cited by this paper
• Regionally Distinct Patterns of Calpain Activation and Traumatic Axonal Injury following Contusive Brain Injury in Immature Rats

  2006cited by this paper
• Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.

  2006cited by this paper
• Detection of alphaII-spectrin and breakdown products in humans after severe traumatic brain injury.

  2006cited by this paper
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  2005cited by this paper
• Spectrin breakdown products in the cerebrospinal fluid in severe head injury – preliminary observations

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  2005cited by this paper
• Moderate hypothermia, but not calpain inhibitor 2, attenuates the proteolysis of microtubule‐associated protein 2 in the hippocampus following traumatic brain injury in rats

  2005cited by this paper
• Mitochondrial localization of mu-calpain.

  2005cited by this paper
• Lack of a Gender Difference in Post-Traumatic Neurodegeneration in the Mouse Controlled Cortical Impact Injury Model

  2005cited by this paper
• A Novel Marker for Traumatic Brain Injury: CSF αII-Spectrin Breakdown Product Levels

  2004cited by this paper
• Effects of Injury Severity on Regional and Temporal mRNA Expression Levels of Calpains and Caspases after Traumatic Brain Injury in Rats

  2004cited by this paper
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  2004cited by this paper
• Cell Death Mechanisms Following Traumatic Brain Injury

  2004cited by this paper
• Detection of -II Spectrin and Breakdown Products in Humans after Severe Traumatic Brain Injury

  2004cited by this paper
• Traumatic Axonal Injury Results in Biphasic Calpain Activation and Retrograde Transport Impairment in Mice

  2003cited by this paper
• The calpain system.

  2003cited by this paper
• Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors.

  2003cited by this paper
• Association of the calpain/calpastatin network with subcellular organelles.

  2003cited by this paper
• Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.

  2003cited by this paper
• Preinjury Administration of the Calpain Inhibitor MDL-28170 Attenuates Traumatically Induced Axonal Injury

  2003cited by this paper
• Cytoskeletal protein degradation and neurodegeneration evolves differently in males and females following experimental head injury.

  2003cited by this paper
• Neuroimmunophilin Ligand V-10,367 is Neuroprotective after 24-Hour Delayed Administration in a Mouse Model of Diffuse Traumatic Brain Injury

  2002cited by this paper
• Temporal and Spatial Profile of Bid Cleavage after Experimental Traumatic Brain Injury

  2002cited by this paper
• Rapid loss and partial recovery of neurofilament immunostaining following focal brain injury in mice.

  2002cited by this paper
• Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats.

  2001cited by this paper
• Acute Cytoskeletal Alterations and Cell Death Induced by Experimental Brain Injury Are Attenuated by Magnesium Treatment and Exacerbated by Magnesium Deficiency

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• Basic Science

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• Accumulation of non‐erythroid αII‐spectrin and calpain‐cleaved αII‐spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats

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• Specific proteolysis of the NR2 subunit at multiple sites by calpain

  2001cited by this paper
• Lack of effect of induction of hypothermia after acute brain injury.

  2001cited by this paper
• The Novel Calpain Inhibitor SJA6017 Improves Functional Outcome after Delayed Administration in a Mouse Model of Diffuse Brain Injury

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• Stretch Injury Causes Calpain and Caspase-3 Activation and Necrotic and Apoptotic Cell Death in Septo-Hippocampal Cell Cultures

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• Calpain and caspase: can you tell the difference?, by kevin K.W. WangVol. 23, pp. 20-26

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• Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats

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• Calpain and caspase: can you tell the difference?, by Kevin K.W. Wang

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  1999cited by this paper
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  1999cited by this paper
• Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury.

  1999cited by this paper
• Altered Calpastatin Protein Levels Following Traumatic Brain Injury in Rat

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• The Neuronal Cytoskeleton Is at Risk After Mild and Moderate Brain Injury

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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• Mild Experimental Brain Injury in the Rat Induces Cognitive Deficits Associated with Regional Neuronal Loss in the Hippocampus

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