AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

C. Concannon,L. P. Tuffy,Petronela Weisová,H. Bonner,D. Dávila,C. Bonner,M. Devocelle,A. Strasser,M. Ward,J. Prehn

Published 2010 in Journal of Cell Biology

ABSTRACT

Disturbances in cellular ion gradients by excitotoxicity promote apoptosis through activation of the Bcl-2 family member Bim.

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