The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cell

• Publication date

  2007-04-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CELL.2007.03.017PMID 17448999
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

  2006cited by this paper
• Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

  2005cited by this paper
• A role for proapoptotic BID in the DNA-damage response.

  2005cited by this paper
• Proapoptotic BID is an ATM effector in the DNA-damage response.

  2005cited by this paper
• Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM

  2005cited by this paper
• Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

  2005cited by this paper
• BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.

  2005cited by this paper
• Bim is a suppressor of Myc-induced mouse B cell leukemia.

  2004cited by this paper
• Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

  2004cited by this paper
• Proapoptotic BID is required for myeloid homeostasis and tumor suppression.

  2003cited by this paper
• Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

  2003cited by this paper
• Integral role of Noxa in p53-mediated apoptotic response.

  2003cited by this paper
• Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.

  2003cited by this paper
• p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

  2003cited by this paper
• Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

  2003cited by this paper
• Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

  2002cited by this paper
• BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

  2002cited by this paper
• Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

  2002cited by this paper
• Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

  2002cited by this paper
• BID regulation by p53 contributes to chemosensitivity

  2002cited by this paper
• Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis.

  2000cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.

  1999cited by this paper
• Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

  1999cited by this paper
• Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

  1998cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• The Bcl-2 protein family: arbiters of cell survival.

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• BID: a novel BH3 domain-only death agonist.

  1996cited by this paper
• A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.

  1995cited by this paper
• Targeted disruption within the CD3 zeta/eta/phi/Oct‐1 locus in mouse.

  1994cited by this paper
• bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship.

  1991cited by this paper
• Tumorigenesis and Neoplastic Progression Deletion of Bid Impedes Cell Proliferation and Hepatic Carcinogenesis

  year unknowncited by this paper

• Mitotic MTH1 inhibitor karonudib kills epithelial ovarian cancer independent of platinum sensitivity

  2025cites this paper
• Dysregulation of BCL-2 family proteins in blood neoplasm: therapeutic relevance of antineoplastic agent venetoclax

  2024cites this paper
• Caspase-2 kills cells with extra centrosomes

  2024cites this paper
• Apoptotic cell death in disease—Current understanding of the NCCD 2023

  2023cites this paper
• Photodynamic therapy induced cell cycle arrest and cancer cell synchronization: review

  2023cites this paper
• Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency

  2023cites this paper
• Expanding roles of BCL-2 proteins in apoptosis execution and beyond.

  2023cites this paper
• Regulation of Oocyte Apoptosis: A View from Gene Knockout Mice

  2023cites this paper
• Therapeutics targeting BCL2 family proteins

  2022cites this paper
• Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia

  2022cites this paper
• Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice

  2022cites this paper
• The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK

  2022influential citation
• Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak

  2022cites this paper
• Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

  2022influential citation
• Macrophage and neutrophil death programs differentially confer resistance to tuberculosis.

  2021cites this paper
• HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis

  2021cites this paper
• Mitochondrial Carrier Homolog 2 Functionally Co-operates With BH3 Interacting-Domain Death Agonist in Promoting Ca2+-Induced Neuronal Injury

  2021cites this paper
• Mitomycin C-induced cell cycle arrest enhances 5-aminolevulinic acid-based photodynamic therapy for bladder cancer.

  2020cites this paper
• Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.

  2020cites this paper
• The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils

  2020cites this paper
• Role of Bcl-2 Family Proteins in Photodynamic Therapy Mediated Cell Survival and Regulation

  2020cites this paper
• EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

  2019cites this paper
• The Role of miRNAs in Zearalenone-Promotion of TM3 Cell Proliferation

  2019cites this paper
• Investigation of the molecular mechanism of paclitaxel-induced apoptosis in cultured-human cells

  2019cites this paper
• Regulation of Cell Death and Immunity by XIAP.

  2019cites this paper
• Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells.

  2019cites this paper
• Investigating apoptosis regulation in mitosis through proximity labelling techniques

  2019cites this paper
• Increased A 20E 3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR 3-and TLR 4-induced inflammation

  2019cites this paper
• Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss

  2018cites this paper
• Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins

  2018cites this paper
• Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation

  2018cites this paper
• Regulation of oncogenes and gap junction intercellular communication during the proliferative response of zearalenone in TM3 cells

  2017cites this paper
• NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

  2017cites this paper
• Cell death and thymic tolerance

  2017cites this paper
• BH3-Only Proteins in Health and Disease.

  2017cites this paper
• Innovative targeted therapies for chemorefractory B-cell non-Hodgkin lymphomas

  2017cites this paper
• JCB_201608095 1795..1810

  2017cites this paper
• Bcl‐2 proteins in development, health, and disease of the hematopoietic system

  2016cites this paper
• Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia

  2016cites this paper
• BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume

  2016influential citation
• BCL-2 family proteins as regulators of mitochondria metabolism.

  2016cites this paper
• The effect of oleuropein from olive leaf (Olea europaea) extract on Ca²⁺ homeostasis, cytotoxicity, cell cycle distribution and ROS signaling in HepG2 human hepatoma cells.

  2016cites this paper
• Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis

  2016cites this paper
• Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo.

  2016cites this paper
• BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells

  2016cites this paper
• Molecular mechanisms controlling neuronal Bak expression

  2016cites this paper
• Caspase-2-mediated cell death is required for deleting aneuploid cells

  2016cites this paper
• MicroRNA-128-3p regulates mitomycin C-induced DNA damage response in lung cancer cells through repressing SPTAN1

  2016cites this paper
• Bcl-2 family proteins: master regulators of cell survival

  2016cites this paper
• Control of Cell Survival and Apoptosis

  2016cites this paper
• Human islet cells are killed by BID-independent mechanisms in response to FAS ligand

  2016cites this paper
• BH3‐Only Proteins

  2016cites this paper
• BCL2 Family, Mitochondrial Apoptosis, and Beyond

  2016cites this paper
• 5-4-2010 AMP kinase-mediated activation of the BH 3-only protein Bim couples energy depletion to stress-induced apoptosis

  2015cites this paper
• The ATM–BID pathway plays a critical role in the DNA damage response by regulating mitochondria metabolism

  2015cites this paper
• The BH3‐only protein BID impairs the p38‐mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

  2015cites this paper
• BH3‐only proteins: a 20‐year stock‐take

  2015cites this paper
• The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes Running title : Bid and NF-κ B activation

  2015influential citation
• Commutation ou extinction de l'expression du BCR et impact sur la cellule B

  2015cites this paper
• The Role of Bid as a positive regulator of mutant SOD1 - induced TLR4 - NF-ҡB signalling in microglia

  2015cites this paper
• XIAP acts as a switch between type I and type II FAS-induced apoptosis signalling

  2014cites this paper
• Confers Immunity Against Intracel lular Bacteria

  2014influential citation
• Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice.

  2014cites this paper
• A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage

  2014cites this paper
• Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling.

  2014cites this paper
• Regulation of DNA Double Strand Break Response

  2014cites this paper
• BID‐dependent release of mitochondrial SMAC dampens XIAP‐mediated immunity against Shigella

  2014cites this paper
• Inhibition of death receptor signaling by bacterial gut pathogens.

  2014cites this paper
• The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes.

  2014influential citation
• Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis

  2014cites this paper
• Gli1 Protein Regulates the S-phase Checkpoint in Tumor Cells via Bid Protein, and Its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors*

  2014cites this paper
• BID is a potential link between DNA damage and inflammatory responses in tumorigenesis

  2013cites this paper
• Bid-ding for mercy: twisted killer in action

  2013cites this paper
• Cell death, dysglycemia and myocardial infarction.

  2013cites this paper
• A type III effector antagonises death receptor signalling during bacterial gut infection

  2013cites this paper
• Cell death , dysglycemia and myocardial infarction ( Review )

  2013cites this paper
• Rejuvenating Bi(d)ology

  2013cites this paper
• Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

  2013cites this paper
• BH3-Only Proteins in Cancer and Apoptosis

  2013cites this paper
• Emerging roles of lipids in BCL-2 family-regulated apoptosis.

  2013cites this paper
• Bid-ding for mercy: twisted killer in action

  2013cites this paper
• Activation of survival pathways triggered by death receptors in the nervous system

  2013cites this paper
• Systems Biology of Apoptosis

  2013cites this paper
• Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells

  2013cites this paper
• Regulation of Fas-deficient Lymphoproliferative Double Negative T Cells by Interferon Gamma and the Fc Receptor Gamma Chain

  2013cites this paper
• A Role for Bclaf1 in mRNA Processing and Skeletal Muscle Differentiation

  2013cites this paper
• Is BID required for NOD signalling?

  2012cites this paper
• The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.

  2012cites this paper
• New insights into the mechanisms for photodynamic therapy-induced cancer cell death.

  2012cites this paper
• BH3-only proteins in apoptosis at a glance

  2012cites this paper
• Role of Bcl‐2 in tumour cell survival and implications for pharmacotherapy

  2012cites this paper
• Caspase-2 at a glance

  2012cites this paper
• Bid signal pathway components are identified in the temporal cortex with Parkinson disease

  2012cites this paper
• Characterisation of calpain activation in response to excitotoxic events in primary neurons

  2012cites this paper
• Non‐apoptotic functions of apoptosis‐regulatory proteins

  2012cites this paper
• The secret life of Bcl-2: apoptosis-independent inhibition of DNA repair by Bcl-2 family members.

  2012cites this paper
• Molecular mechanisms conferring resistance/sensitivity to glucocorticoid-induced apoptosis

  2012cites this paper
• Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis

  2012cites this paper
• Systems Level Characterizations of Single and Combination Drug Mechanisms of Action in vitro and in vivo

  2012cites this paper
• DNA-damage-mediated remodeling of normal and tumor microenvironments modulates cell survival

  2012cites this paper