Interaction of zwitterionic penicillins with the OmpF channel facilitates their translocation.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Biophysical Journal

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1529/BIOPHYSJ.105.075192PMID 16339889PMCID PMC1367313
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efflux-Mediated Drug Resistance in Bacteria

  2012cited by this paper
• Antibiotic resistance: an ecological imbalance.

  2007cited by this paper
• Optimizing transport of metabolites through large channels: molecular sieves with and without binding.

  2005cited by this paper
• Salting out the ionic selectivity of a wide channel: the asymmetry of OmpF.

  2004cited by this paper
• Microscopic Mechanism of Antibiotics Translocation through a Porin.

  2004influential reference
• Ionization states of residues in OmpF and mutants: effects of dielectric constant and interactions between residues.

  2004cited by this paper
• Simulation and modeling of the Rhodobacter sphaeroides bacterial reaction center: Structure and interactions

  2003cited by this paper
• Channel-facilitated membrane transport: Average lifetimes in the channel

  2003cited by this paper
• Molecular Basis of Bacterial Outer Membrane Permeability Revisited

  2003cited by this paper
• Probing the Orientation of Reconstituted Maltoporin Channels at the Single-protein Level*

  2003cited by this paper
• Residue ionization and ion transport through OmpF channels.

  2003cited by this paper
• Solute uptake through general porins.

  2003cited by this paper
• Molecular origin of the cation selectivity in OmpF porin: single channel conductances vs. free energy calculation.

  2003cited by this paper
• Binding and Hydrolysis of Ampicillin in the Active Site of a Zinc Lactamase

  2003cited by this paper
• Escaping free-energy minima

  2002cited by this paper
• A fast in silico simulation of ion flux through the large-pore channel proteins.

  2002cited by this paper
• Transport of maltodextrins through maltoporin: a single-channel study.

  2002cited by this paper
• Ion permeation and selectivity of OmpF porin: a theoretical study based on molecular dynamics, Brownian dynamics, and continuum electrodiffusion theory.

  2002cited by this paper
• Designed to penetrate: Time-resolved interaction of single antibiotic molecules with bacterial pores

  2002influential reference
• Channel-facilitated membrane transport: Transit probability and interaction with the channel

  2002cited by this paper
• Orientation and interactions of dipolar molecules during transport through OmpF porin

  2002cited by this paper
• Evolution and spread of antibiotic resistance

  2002cited by this paper
• Energetics of glycerol conduction through aquaglyceroporin GlpF

  2002cited by this paper
• Molecular basis of voltage gating of OmpF porin.

  2002cited by this paper
• Ions and counterions in a biological channel: a molecular dynamics simulation of OmpF porin from Escherichia coli in an explicit membrane with 1 M KCl aqueous salt solution.

  2002cited by this paper
• Partitioning of differently sized poly(ethylene glycol)s into OmpF porin.

  2002cited by this paper
• Role of charged residues at the OmpF porin channel constriction probed by mutagenesis and simulation.

  2001cited by this paper
• Steered molecular dynamics and mechanical functions of proteins.

  2001cited by this paper
• Substitutions in the Eyelet Region Disrupt Cefepime Diffusion through the Escherichia coli OmpF Channel

  2000cited by this paper
• Comparative aspects of the diffusion of norfloxacin, cefepime and spermine through the F porin channel of Enterobacter cloacae.

  2000cited by this paper
• Ion Channels as Molecular Coulter Counters to Probe Metabolite Transport

  2000cited by this paper
• Probing sugar translocation through maltoporin at the single channel level

  2000cited by this paper
• Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).

  2000cited by this paper
• Membrane permeability modifications are involved in antibiotic resistance in Klebsiella pneumoniae.

  2000cited by this paper
• When drug inactivation renders the target irrelevant to antibiotic resistance: a case story with β‐lactams

  1999cited by this paper
• In vivo modification of porin activity conferring antibiotic resistance to Enterobacter aerogenes.

  1999cited by this paper
• Computational Observation of an Ion Permeation Through a Channel Protein

  1998cited by this paper
• A molecular dynamics study of the pores formed by Escherichia coli OmpF porin in a fully hydrated palmitoyloleoylphosphatidylcholine bilayer.

  1998cited by this paper
• Computer simulations of the OmpF porin from the outer membrane of Escherichia coli.

  1997cited by this paper
• ORAC: A Molecular dynamics program to simulate complex molecular systems with realistic electrostatic interactions

  1997cited by this paper
• VMD: visual molecular dynamics.

  1996cited by this paper
• Electrostatic properties of two porin channels from Escherichia coli.

  1994cited by this paper
• Noise analysis of ion current through the open and the sugar-induced closed state of the LamB channel of Escherichia coli outer membrane: evaluation of the sugar binding kinetics to the channel interior.

  1994cited by this paper
• Counting polymers moving through a single ion channel

  1994cited by this paper
• Resistance to Antimicrobial DrugsA Worldwide Calamity

  1993cited by this paper
• Probing alamethicin channels with water-soluble polymers. Effect on conductance of channel states.

  1993cited by this paper
• Probing alamethicin channels with water-soluble polymers. Size-modulated osmotic action.

  1993cited by this paper
• Crystal structures explain functional properties of two E. coli porins

  1992cited by this paper
• Hydrophobicity of β-lactam antibiotics: Explanation and prediction of their behaviour in various partitioning solvent systems and reversed-phase chromatography

  1991influential reference
• Hydrophobicity of beta-lactam antibiotics. Explanation and prediction of their behaviour in various partitioning solvent systems and reversed-phase chromatography.

  1991cited by this paper
• Outer membrane barrier as a mechanism of antimicrobial resistance

  1989cited by this paper
• Sensitivity of Escherichia coli to various β‐lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic β‐lactamases: a quantitative predictive treatment

  1987cited by this paper
• Diffusion of beta-lactam antibiotics through the porin channels of Escherichia coli K-12

  1985cited by this paper
• Porin channels in Escherichia coli: studies with beta-lactams in intact cells

  1983cited by this paper
• Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins

  1983cited by this paper
• Introduction to membrane noise

  1981cited by this paper
• Fluctuation spectroscopy: determination of chemical reaction kinetics from the frequency spectrum of fluctuations.

  1973cited by this paper
• Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties.

  1972cited by this paper
• The amino acid nature of ampicillin and related penicillins.

  1969cited by this paper
• Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.

  1965cited by this paper
• Microbiological Studies on a New Broad-spectrum Penicillin, “Penbritin”*

  1961influential reference

• Improved Free-Energy Estimates for the Permeation of Bulky Antibiotic Molecules through Porin Channels Using Temperature-Accelerated Sliced Sampling

  2025cites this paper
• Viroporins: discovery, methods of study, and mechanisms of host-membrane permeabilization

  2025cites this paper
• Components of Bacterial Cell Walls as Targets for Searching for New Antibacterial Compounds: Methods of Study

  2025cites this paper
• Molecular Mechanism of Ciprofloxacin Translocation Through the Major Diffusion Channels of the ESKAPE Pathogens Klebsiella pneumoniae and Enterobacter cloacae

  2024cites this paper
• Molecular Model of Norfloxacin Translocation Through the Yersinia pseudotuberculosis OmpF Porin Channel

  2024cites this paper
• Conformational flexibility driving charge-selective substrate translocation across a bacterial transporter

  2024cites this paper
• Revealing the single-channel characteristics of OprD (OccAB1) porins from hospital strains of Acinetobacter baumannii

  2023cites this paper
• Outer Membrane Porins Contribute to Antimicrobial Resistance in Gram-Negative Bacteria

  2023cites this paper
• Emergence of the Dickeya genus involved duplication of the OmpF porin and the adaptation of the EnvZ-OmpR signaling network

  2023cites this paper
• The influence of pH and dissolved organic carbon on the ecotoxicity of ampicillin and clarithromycin.

  2023cites this paper
• A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance

  2023cites this paper
• Converging PMF calculations of antibiotic permeation across an outer membrane porin with sub-kilocalorie per mole accuracy

  2023cites this paper
• Molecular Model of Norfloxacin Translocation through Yersinia pseudotuberculosis Porin OmpF Channel: Electrophysiological and Molecular Modeling Study

  2023cites this paper
• Antibiotic Charge Profile Determines the Extent of L3 Dynamics in OmpF: An Expedited Passage for Molecules with a Positive Charge.

  2023cites this paper
• The mechanism of an electrostatic nanofilter: overcoming entropy with electrostatics.

  2023cites this paper
• Thermodynamic and transport properties of amoxicillin

  2022cites this paper
• Emergence and spread of antibiotic-resistant foodborne pathogens from farm to table

  2022cites this paper
• In silico and in vitro evaluation of extract derived from Dunaliella salina, a halotolerant microalga for its antifungal and antibacterial activity

  2022cites this paper
• Biopolymers as intermediate layers for amoxicillin grafting on antibacterial surface

  2022cites this paper
• Reconstruction of the Gram-Negative Bacterial Outer-Membrane Bilayer.

  2022cites this paper
• Green’s function for two absorbing boundaries in the reaction–diffusion system: Beyond Oster-Nishijima Model in barrierless reaction

  2022cites this paper
• Separation of ampicillin on polar-endcapped phase: Development of the HPLC method to achieve its correct dosage in cardiac surgery

  2022cites this paper
• Rationalizing generation of broad spectrum antibiotics with the addition of a primary amine

  2021cites this paper
• Current noise of a protein‐selective biological nanopore

  2021cites this paper
• Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge †

  2021cites this paper
• Localized potential well vs binding site: Mapping solute dynamics in a membrane channel onto one-dimensional description.

  2021cites this paper
• LJMU Research Online

  2021cites this paper
• How to Enter a Bacterium: Bacterial Porins and the Permeation of Antibiotics.

  2021cites this paper
• The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux.

  2021cites this paper
• Improved Sampling and Free Energy Estimates for Antibiotic Permeation through Bacterial Porins.

  2021cites this paper
• Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model.

  2021cites this paper
• Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge

  2021cites this paper
• Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.

  2021cites this paper
• The Influence of Permeability through Bacterial Porins in Whole-Cell Compound Accumulation

  2021cites this paper
• The Effect of Rotating Magnetic Field on Susceptibility Profile of Methicillin-Resistant Staphylococcus aureus Strains Exposed to Activity of Different Groups of Antibiotics

  2021cites this paper
• Dynamic interaction of fluoroquinolones with magnesium ions monitored using bacterial outer membrane nanopores†

  2020cites this paper
• An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding

  2020cites this paper
• Permeation of β-Lactamase Inhibitors through the General Porins of Gram-Negative Bacteria

  2020cites this paper
• Protein Ligand-Induced Amplification in the 1/f Noise of a Protein-Selective Nanopore.

  2020cites this paper
• Permeability Through Bacterial Porins Dictates Whole Cell Compound Accumulation

  2020cites this paper
• Different time scales in dynamic systems with multiple outcomes.

  2020cites this paper
• Elektrophysiologische Charakterisierung des Transports von Antibiotika durch äußere Membrankanäle in Gram‐negativen Bakterien in Gegenwart von Lipopolysacchariden

  2020cites this paper
• Electrophysiological Characterization of Transport Across Outer‐Membrane Channels from Gram‐Negative Bacteria in Presence of Lipopolysaccharides

  2020cites this paper
• Outer Membrane Porins.

  2019cites this paper
• Autonomously Assembled Synthetic Transmembrane Peptide Pore.

  2019cites this paper
• Electrophysiological Characterization of Transport Across Outer Membrane Channels from Gram-Negative Bacteria in Their Native Environment

  2019cites this paper
• Metadynamics

  2019cites this paper
• Electrochemical synthesis of a new phosphonium betaine. Kinetic evaluation and antibacterial susceptibility

  2019cites this paper
• Assay Setup for High Throughput Screening to Identify Novel Efflux Pump Inhibitors against Escherichia coli

  2019cites this paper
• Determination of antimicrobial effect of protamine by transmission electron microscopy and SDS PAGE on Pseudomonas aeruginosa isolates from diabetic foot infection

  2019cites this paper
• University of Dundee High-resolution experimental and computational electrophysiology reveals weak-lactam binding events in the porin

  2019cites this paper
• High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB

  2018influential citation
• Ampicillin permeation across OmpF, the major outer-membrane channel in Escherichia coli

  2018cites this paper
• Influence of point mutations on the electrophysiological properties of a bacterial porin and its interaction with a β-lactam antibiotic

  2018influential citation
• Maximum likelihood estimation in hidden Markov models with inhomogeneous noise

  2018cites this paper
• Antibiotic Therapy for Neonatal Sepsis - Studies on epidemiology, gentamicin safety, and early adverse effects ofantibiotics

  2018cites this paper
• Detection of Antibiotics Sensitivity at Different PH Levels for Proteus Mirabilis Isolated from Patients with Urinary Tract Infections

  2018cites this paper
• Heterogeneous Multiscale Change-Point Inference and its Application to Ion Channel Recordings

  2018cites this paper
• Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics

  2017cites this paper
• Quantifying the Flux of Charged Molecules through Bacterial Membrane Proteins

  2017influential citation
• Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson-Nernst-Planck Study

  2017cites this paper
• The binding of free and copper-complexed fluoroquinolones to OmpF porins: an experimental and molecular docking study

  2017cites this paper
• How beta lactam antibiotics enter bacteria : a dialogue with the porins

  2017influential citation
• Nanomaterials and molecular transporters to overcome the bacterial 1 envelope barrier : towards advanced delivery of antibiotics 2 3

  2017cites this paper
• Erratum: Unusual marine unicellular symbiosis with the nitrogen-fixing cyanobacterium UCYN-A

  2017cites this paper
• Rationalizing the permeation of polar antibiotics into Gram-negative bacteria

  2017influential citation
• Bacterial Outer Membrane Porins as Electrostatic Nanosieves: Exploring Transport Rules of Small Polar Molecules.

  2017cites this paper
• Exploring bacterial outer membrane barrier to combat bad bugs

  2017cites this paper
• Orientation of the OmpF Porin in Planar Lipid Bilayers

  2017cites this paper
• OmpF, a nucleotide-sensing nanoprobe, computational evaluation of single channel activities

  2016cites this paper
• Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope.

  2016cites this paper
• Role of Electroosmosis in the Permeation of Neutral Molecules: CymA and Cyclodextrin as an Example.

  2016cites this paper
• Simulations of outer membrane channels and their permeability.

  2016cites this paper
• Exploiting the porin pathway for polar compound delivery into Gram-negative bacteria.

  2016cites this paper
• Etude théorique de la translocation de biomolécules à travers une membrane fine

  2016cites this paper
• Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development.

  2016cites this paper
• Discovery of an Escherichia coli channel with High voltage Dependence and Cooperativity

  2015cites this paper
• Enhanced sampling of chemical and biochemical reactions with metadynamics

  2015cites this paper
• Analysis of fast channel blockage: revealing substrate binding in the microsecond range.

  2015cites this paper
• Theoretical analysis of ion conductance and gating transitions in the OpdK (OccK1) channel.

  2015cites this paper
• Molecular basis of substrate translocation through the outer membrane channel OprD of Pseudomonas aeruginosa.

  2015cites this paper
• Filtering with Electric Field: The Case of E. coli Porins.

  2015cites this paper
• Neonatal sepsis and the adverse effect of antibiotic treatment - a systematic review

  2015cites this paper
• Amelioration of the Fitness Costs of Antibiotic Resistance Due To Reduced Outer Membrane Permeability by Upregulation of Alternative Porins.

  2015cites this paper
• Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms.

  2015cites this paper
• Transport across the outer membrane porin of mycolic acid containing actinomycetales: Nocardia farcinica.

  2015cites this paper
• Pharmacokinetics and Pharmacodynamics of Antibacterials, Antifungals, and Antivirals Used Most Frequently in Neonates and Infants

  2014cites this paper
• Real-time molecular uptake and membrane-specific transport in living cells by optical microscopy and nonlinear light scattering

  2014cites this paper
• Application of OmpF nanochannel forming protein in polynucleotide sequence recognition

  2014cites this paper
• Crystal structure of phosphonium carboxylate complexes. The role of the metal coordination geometry, ligand conformation and hydrogen bonding

  2014cites this paper
• Porin Involvement in Cephalosporin and Carbapenem Resistance of Burkholderia pseudomallei

  2014cites this paper
• Pharmacokinetics and Pharmacodynamics of Antibacterials, Antifungals, and Antivirals Used Most Frequently in Neonates and Infants Jessica K. RobertsChris StockmannJonathan E. Constance • Justin StiersMichael G. SpigarelliRobert M. Ward •

  2014cites this paper
• Molecular mechanisms of DNA translocation through a biological nanopore alpha-hemolysin

  2014cites this paper
• Structure‐kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin

  2014cites this paper
• Interaction of protamine with gram‐negative bacteria membranes: possible alternative mechanisms of internalization in Escherichia coli, Salmonella typhimurium and Pseudomonas aeruginosa

  2014cites this paper
• Electrophysiology of bacteria.

  2013cites this paper
• Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels

  2013cites this paper
• Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors.

  2013cites this paper
• Improved detection of antibiotic compounds by bacterial reporter strains achieved by manipulations of membrane permeability and efflux capacity

  2013cites this paper
• Structure, Function and Regulation of Outer Membrane Proteins Involved in Drug Transport in Enterobactericeae: the OmpF/C – TolC Case

  2013cites this paper