The Centenary of Immune Thrombocytopenia – Part 1: Revising Nomenclature and Pathogenesis

The natural history of the immune thrombocytopenia (ITP) is interesting and intriguing because it traces different steps underlying autoimmune diseases. The review points out the main steps that have accompanied the stages of its history and the consequential changes related to its terminology. ITP is an autoimmune disease resulting from platelet antibody-mediated destruction and impaired megakaryocyte and platelet production. However, research advances highlight that a complex dysregulation of the immune system is involved in the pathogenesis of this condition. The review examines the role of the multiple immune components involved in the autoimmunity process, focusing on the more recent mechanisms, which could be new promising therapeutic targets for ITP patients.

• Publication year

  2016

• Venue

  Frontiers in Pediatrics

• Publication date

  2016-10-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.3389/fped.2016.00102PMID 27807534PMCID 5069646
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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