Strategies and methods for research on sex differences in brain and behavior.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Endocrinology

• Publication date

  2005-04-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1210/EN.2004-1142PMID 15618360
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sexual differentiation of the brain and behavior.

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  2002influential reference
• Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats.

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  1999cited by this paper
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  1999cited by this paper
• Severe rheumatoid arthritis prohibits the pregnancy-induced decrease in α3-fucosylation of α1-acid glycoprotein

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Mechanisms of Stress on Reproduction: Evidence for a Complex Intra‐Hypothalamic Circuit

  1998cited by this paper
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  1998cited by this paper
• Estrogen receptors are essential for female sexual receptivity.

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Reliability and validity of a daily diary for premenstrual syndrome.

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Induction of CCK mRNA levels in the limbic-hypothalamic circuit: time course and site-specific effects of estrogen.

  1996cited by this paper
• The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat.

  1995cited by this paper
• Ageing of the hypothalamo-pituitary-testicular axis in men.

  1995cited by this paper
• Human behavioral sex differences: a role for gonadal hormones during early development?

  1995cited by this paper
• Spatial cognition in humans: possible modulation by androgens and estrogens.

  1995cited by this paper
• Insights from the study of animals lacking functional estrogen receptor.

  1994cited by this paper
• Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior.

  1994cited by this paper
• Testosterone influences spatial cognition in older men.

  1994cited by this paper
• SRY and sex determination in mammals.

  1993influential reference
• Measurements of Salivary Progesterone a

  1993cited by this paper
• Tricyclic dose requirements across pregnancy.

  1993cited by this paper
• A Y-chromosomal effect on blastocyst cell number in mice.

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Social recognition in ovariectomized and estradiol-treated female rats.

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  1992cited by this paper
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  1992cited by this paper
• Neuroendocrinology fo sexual behavior in the female

  1991influential reference
• Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat.

  1991cited by this paper
• Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms.

  1991cited by this paper
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• Sexual differentiation of monoaminergic neurons--genetic or epigenetic?

  1991cited by this paper
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  1989cited by this paper
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  1989cited by this paper

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