Cell-Based Therapy for Silicosis

Silicosis is the most common pneumoconiosis globally, with higher prevalence and incidence in developing countries. To date, there is no effective treatment to halt or reverse the disease progression caused by silica-induced lung injury. Significant advances have to be made in order to reduce morbidity and mortality related to silicosis. In this review, we have highlighted the main mechanisms of action that cause lung damage by silica particles and summarized the data concerning the therapeutic promise of cell-based therapy for silicosis.

• Publication year

  2016

• Venue

  Stem Cells International

• Publication date

  2016-03-15

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2016/5091838PMID 27066079PMCID 4811211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice

  2016cited by this paper
• Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis

  2016cited by this paper
• Blocking the Wnt/β-Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting β-Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice

  2015cited by this paper
• Treating pulmonary silicosis by blocking interleukin 1.

  2015cited by this paper
• Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth

  2015cited by this paper
• The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis

  2015cited by this paper
• Pilot safety study of intrabronchial instillation of bone marrow-derived mononuclear cells in patients with silicosis

  2015cited by this paper
• Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure

  2015cited by this paper
• Treatment of silicosis with hepatocyte growth factor-modified autologous bone marrow stromal cells: a non-randomized study with follow-up.

  2015cited by this paper
• Systemic Administration of Human Bone Marrow‐Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract‐Induced Allergic Airway Inflammation in Immunocompetent Mice

  2015cited by this paper
• Infusion of Bone Marrow Mononuclear Cells Reduces Lung Fibrosis but Not Inflammation in the Late Stages of Murine Silicosis

  2014cited by this paper
• Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO

  2014influential reference
• Effects of bone marrow mononuclear cells from healthy or ovalbumin-induced lung inflammation donors on recipient allergic asthma mice

  2014cited by this paper
• Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice

  2014cited by this paper
• Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice.

  2014cited by this paper
• Outbreak of silicosis in Spanish quartz conglomerate workers

  2014cited by this paper
• Therapeutic Use of Stem Cell Transplantation for Cell Replacement or Cytoprotective Effect of Microvesicle Released from Mesenchymal Stem Cell

  2014cited by this paper
• Antifibrotic and Anti-inflammatory Activity of the Tyrosine Kinase Inhibitor Nintedanib in Experimental Models of Lung Fibrosis

  2014cited by this paper
• Current Status of Stem Cells and Regenerative Medicine in Lung Biology and Diseases

  2014cited by this paper
• Uncoupling between Inflammatory and Fibrotic Responses to Silica: Evidence from MyD88 Knockout Mice

  2014cited by this paper
• Lung transplantation: a treatment option in end-stage lung disease.

  2014cited by this paper
• N-acetylcysteine alleviated silica-induced lung fibrosis in rats by down-regulation of ROS and mitochondrial apoptosis signaling

  2014cited by this paper
• Particle transport and deposition: basic physics of particle kinetics.

  2013cited by this paper
• Treatment of Acute Silicoproteinosis by Whole-Lung Lavage

  2013cited by this paper
• Relaxin attenuates silica-induced pulmonary fibrosis by regulating collagen type I and MMP-2.

  2013cited by this paper
• IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice

  2013cited by this paper
• Therapeutic effect of exogenous bone marrow‑derived mesenchymal stem cell transplantation on silicosis via paracrine mechanisms in rats.

  2013cited by this paper
• Silica induces NLRP3 inflammasome activation in human lung epithelial cells

  2013influential reference
• Silica phagocytosis causes apoptosis and necrosis by different temporal and molecular pathways in alveolar macrophages

  2013cited by this paper
• Stem cells, cell therapies, and bioengineering in lung biology and diseases. Comprehensive review of the recent literature 2010-2012.

  2013cited by this paper
• Bone marrow-derived mononuclear cells vs. mesenchymal stromal cells in experimental allergic asthma.

  2013cited by this paper
• Protective effects of methyl palmitate against silica-induced pulmonary fibrosis in rats.

  2013cited by this paper
• Silicosis in India: past and present

  2013cited by this paper
• Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice

  2013cited by this paper
• Repeated Administration of Bone Marrow-Derived Cells Prevents Disease Progression in Experimental Silicosis

  2013cited by this paper
• Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model.

  2012cited by this paper
• Silicosis.

  2012cited by this paper
• Stem cells and regenerative medicine in lung biology and diseases.

  2012cited by this paper
• Mechanisms of fibrosis: therapeutic translation for fibrotic disease

  2012cited by this paper
• Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study

  2012cited by this paper
• Rescue of murine silica-induced lung injury and fibrosis by human embryonic stem cells

  2011cited by this paper
• Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis

  2011cited by this paper
• Bone marrow cells obtained from cirrhotic rats do not improve function or reduce fibrosis in a chronic liver disease model

  2011cited by this paper
• Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis

  2010cited by this paper
• Systemic Inhibition of NF-κB Activation Protects from Silicosis

  2009cited by this paper
• Silica exposure, smoking, silicosis and lung cancer--complex interactions.

  2009cited by this paper
• Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury.

  2009cited by this paper
• Mechanisms involved in the therapeutic properties of mesenchymal stem cells.

  2009cited by this paper
• Intratracheal instillation of bone marrow-derived cell in an experimental model of silicosis.

  2009cited by this paper
• Protection of bleomycin-induced fibrosis and inflammation by taurine.

  2009cited by this paper
• Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation

  2008cited by this paper
• Phenotypic and functional characterization of hematopoietic stem cells.

  2008cited by this paper
• Silica binding and toxicity in alveolar macrophages.

  2008cited by this paper
• Exposição ocupacional à sílica no Brasil no ano de 2001

  2008cited by this paper
• Bone marrow-derived cells and stem cells in lung repair.

  2008cited by this paper
• Silicosis: a review.

  2007cited by this paper
• Cell- and Isoform-Specific Increases in Arginase Expression in Acute Silica-Induced Pulmonary Inflammation

  2007cited by this paper
• New developments in the understanding of immunology in silicosis

  2007cited by this paper
• [Silicosis].

  2006cited by this paper
• Mesenchymal stem cells reside in virtually all post-natal organs and tissues

  2006cited by this paper
• [Trials of casual treatment of silicosis].

  2006cited by this paper
• Continued exposure to silica after diagnosis of silicosis in Brazilian gold miners.

  2006cited by this paper
• Antifibrotic effect of interferon gamma in silicosis model of rat.

  2005cited by this paper
• Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation.

  2005cited by this paper
• Role of Inducible Nitric Oxide Synthase-Derived Nitric Oxide in Silica-Induced Pulmonary Inflammation and Fibrosis

  2004cited by this paper
• Markers of macrophage differentiation in experimental silicosis

  2004cited by this paper
• Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects

  2003cited by this paper
• Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence

  2003cited by this paper
• Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis.

  2003cited by this paper
• Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica.

  2002cited by this paper
• Crucial role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in mice.

  2002cited by this paper
• Pharmacological actions of tetrandrine in inflammatory pulmonary diseases.

  2002cited by this paper
• Apoptosis underlies immunopathogenic mechanisms in acute silicosis.

  2002influential reference
• Diseases caused by silica: mechanisms of injury and disease development.

  2002influential reference
• Mesenchymal Stem Cells

  2002cited by this paper
• Polymorphisms of the IL-1 gene complex in coal miners with silicosis.

  2001cited by this paper
• FAS Ligand Triggers Pulmonary Silicosis

  2001influential reference
• Silicosis and coal workers' pneumoconiosis.

  2000cited by this paper
• Physiologic role of interleukin-1 receptor antagonist

  2000influential reference
• From Coal Mine Dust To Quartz: Mechanisms of Pulmonary Pathogenicity

  2000cited by this paper
• Occupational exposure to carcinogens in the European Union

  2000cited by this paper
• Matrix metalloproteinases 2, 9, and 13, and tissue inhibitors of metalloproteinases 1 and 2 in experimental lung silicosis.

  1999cited by this paper
• Freshly Fractured Crystalline Silica Induces Activator Protein-1 Activation through ERKs and p38 MAPK*

  1999cited by this paper
• Surveillance of respirable crystalline silica dust using OSHA compliance data (1979-1995).

  1998cited by this paper
• Risk of pulmonary tuberculosis relative to silicosis and exposure to silica dust in South African gold miners.

  1998cited by this paper
• Transforming growth factor-beta (TGF-beta) in silicosis.

  1996cited by this paper
• Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis.

  1995cited by this paper
• Silicosis in Brazilian pit diggers: relationship between dust exposure and radiologic findings.

  1995cited by this paper
• Increased elastin production in experimental granulomatous lung disease.

  1995cited by this paper
• Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils.

  1994cited by this paper
• Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica.

  1993cited by this paper
• Acute silicosis responding to corticosteroid therapy.

  1992cited by this paper
• Mesenchymal Stem Cells

  1991cited by this paper
• Effect of prednisolone treatment in chronic silicosis.

  1991cited by this paper
• Aluminum inhalation reduces silicosis in a sheep model.

  1988cited by this paper
• Long-term follow-up observations of the therapeutic effect of PVNO on human silicosis.

  1983cited by this paper
• Long-term follow-up observations of the therapeutic effect of PVNO on human silicosis.

  1983cited by this paper
• Treatment of mixed-dust pneumoconiosis with whole lung lavage.

  1982cited by this paper
• Establishment in culture of pluripotential cells from mouse embryos

  1981cited by this paper
• Bronchoalveolar lavage in silicosis

  1979cited by this paper

• Respirable α-Quartz Silica Triggers Immune-Inflammatory-Fibrotic Initiation in Zebrafish Embryos via Hindbrain Ventricle Microinjection: Implications for Silicosis Early Risk Assessment.

  2026cites this paper
• BI 1015550 Improves Silica-Induced Silicosis and LPS-Induced Acute Lung Injury in Mice

  2025cites this paper
• Fermented Cordyceps Powder Alleviates Silica-induced Inflammation and Fibrosis by Inhibiting M1 Macrophage Polarization via the HMGB1-TLR4-NF-κB Pathway.

  2025cites this paper
• Submicron silica particles drives prostate cancer aggressiveness via lipid-metabolic reprogramming.

  2025cites this paper
• Diosgenin ameliorates silica‐induced tuberculosis in rats

  2025cites this paper
• Insights into the mechanism of METTL3-mediated m6A methylation in silicon dust-induced epithelial-mesenchymal transition

  2025cites this paper
• A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica

  2025cites this paper
• Interleukin-11 drives fibroblast metabolic reprogramming in crystalline silica-induced lung fibrosis.

  2024cites this paper
• Tripartite motif-containing 32 regulated by miR-6236-p5 inhibited silica-induced apoptosis of alveolar macrophages.

  2024cites this paper
• Incidence, mortality, and disability-adjusted life years due to silicosis worldwide, 1990–2019: evidence from the global burden of disease study 2019

  2024cites this paper
• Integration of apaQTL and eQTL analysis reveals novel SNPs associated with occupational pulmonary fibrosis risk

  2024cites this paper
• Systemic sclerosis, silica exposure and cellular therapies: The sand in the gears?

  2024cites this paper
• High-fat Western diet alters crystalline silica-induced airway epithelium ion transport but not airway smooth muscle reactivity

  2024cites this paper
• Contemporary Concise Review 2023: Environmental and occupational lung diseases

  2024cites this paper
• The aryl hydrocarbon receptor pathway is a marker of lung cell activation but does not play a central pathologic role in engineered stone‐associated silicosis

  2024cites this paper
• Trigonelline hydrochloride attenuates silica-induced pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation

  2024cites this paper
• Framework for implementing collaborative TB-silicosis activities in India: insights from an expert panel

  2024cites this paper
• From Basic Research to Clinical Practice: Considerations for Treatment Drugs for Silicosis

  2023cites this paper
• Silica-exposed macrophages-secreted exosomal miR125a-5p induces Th1/Th2 and Treg/Th17 cell imbalance and promotes fibroblast transdifferentiation.

  2023cites this paper
• Apelin Prevents and Alleviates Crystalline Silica-induced Pulmonary Fibrosis via Inhibiting Transforming Growth Factor Beta 1-triggered Fibroblast Activation

  2023cites this paper
• Yangqing Chenfei formula alleviates silica-induced pulmonary inflammation in rats by inhibiting macrophage M1 polarization

  2023cites this paper
• Human embryonic stem cell‐derived mesenchymal stem cell secretome reverts silica‐induced airway epithelial cell injury by regulating Bmi1 signaling

  2023cites this paper
• Silicosis: New Challenges from an Old Inflammatory and Fibrotic Disease.

  2023influential citation
• Functional enhancement strategies to potentiate the therapeutic properties of mesenchymal stromal cells for respiratory diseases

  2023cites this paper
• SILICOSIS: A CURSE THAT NEEDS IDENTIFICATION

  2023cites this paper
• A mixed-methods study on impact of silicosis on tuberculosis treatment outcomes and need for TB-silicosis collaborative activities in India

  2023cites this paper
• The importance of tomographic findings for the diagnosis of silicotuberculosis: case report

  2023cites this paper
• Bmi1 signaling maintains the plasticity of airway epithelial progenitors in response to persistent silica exposures.

  2022cites this paper
• Insights into the mechanism underlying crystalline silica-induced pulmonary fibrosis via transcriptome-wide m6A methylation profile.

  2022cites this paper
• Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil

  2022influential citation
• Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis

  2022cites this paper
• Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish.

  2022cites this paper
• Respiratory symptoms, spirometric, and radiological status of stone‐cutting workers in Bangladesh: A cross‐sectional study

  2022cites this paper
• High-fat Western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis

  2022cites this paper
• Toxicological impact of nanoparticles on human health: A review

  2022cites this paper
• A toxicological profile of silica nanoparticles.

  2022cites this paper
• Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration

  2022cites this paper
• Combination therapy targeting inflammasome and fibrogenesis alleviates inflammation and fibrosis in a zebrafish model of silicosis

  2022influential citation
• Small airway dysfunction in pneumoconiosis: a cross-sectional study

  2022cites this paper
• Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo.

  2022cites this paper
• PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.

  2021cites this paper
• Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2

  2021cites this paper
• Krill oil and low-dose aspirin combination mitigates experimentally induced silicosis in rats: role of NF-κB/TGF-β1/MMP-9 pathway

  2021cites this paper
• Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives

  2021cites this paper
• The role of macrophage-derived TGF-β1 on SiO2-induced pulmonary fibrosis: A review

  2021cites this paper
• Hesperetin attenuates silica-induced lung injury by reducing oxidative damage and inflammatory response

  2021cites this paper
• Airborne respirable dust in fully mechanised underground metalliferous mines – Generation, health impacts and control measures for cleaner production

  2021cites this paper
• Association between Crystalline Silica Dust Exposure and Silicosis Development in Artificial Stone Workers

  2021cites this paper
• Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis Treatment

  2021influential citation
• Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies

  2021cites this paper
• Pirfenidone ameliorates silica-induced lung inflammation and fibrosis in mice by inhibiting the secretion of interleukin-17A

  2021cites this paper
• Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

  2021cites this paper
• A review on current strategies and emerging treatments in management of silicosis: An ayurveda perspective

  2021cites this paper
• Silicosis and methylated arginines/L-arginines: case-control adapted a cross-sectional design

  2021cites this paper
• Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial

  2021cites this paper
• High-fat western diet-consumption alters crystalline silica-induced serum adipokines, inflammatory cytokines and arterial blood flow in the F344 rat

  2021cites this paper
• Caveolin‐1 negatively regulates inflammation and fibrosis in silicosis

  2021cites this paper
• Herbal compounds in the treatment of pulmonary silicosis.

  2021cites this paper
• Herbal Compounds in the Treatment of Pulmonary Silicosis

  2021cites this paper
• Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages

  2020cites this paper
• Perspective: The Lung, Particles, Fibers, Nanomaterials, and Autoimmunity

  2020cites this paper
• Biological effects of inhaled hydraulic fracturing sand dust. III. Cytotoxicity and pro-inflammatory responses in cultured murine macrophage cells.

  2020cites this paper
• A novel lung alveolar cell model for exploring volatile biomarkers of particle-induced lung injury

  2020cites this paper
• Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis

  2020cites this paper
• Artificial stone silicosis.

  2020cites this paper
• FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy.

  2020cites this paper
• Tanshinone IIA attenuates silica-induced pulmonary fibrosis via Nrf2-mediated inhibition of EMT and TGF-β1/Smad signaling.

  2020cites this paper
• CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis.

  2020cites this paper
• Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen.

  2020cites this paper
• Can treatment outcomes of latent TB infection and TB in silicosis be improved?

  2019cites this paper
• Asbestosis and silicosis hospitalizations in Italy (2001-2015): results from the National Hospital Discharge Registry.

  2019cites this paper
• Silica‐associated lung disease: An old‐world exposure in modern industries

  2019cites this paper
• Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology

  2019cites this paper
• N-acetylcysteine tiherapeutically protects against pulmonary fibrosis in a mouse model of silicosis

  2019cites this paper
• M10 peptide attenuates silica-induced pulmonary fibrosis by inhibiting Smad2 phosphorylation.

  2019cites this paper
• Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy

  2019cites this paper
• Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis.

  2019cites this paper
• Artificial Stone Associated Silicosis: A Systematic Review

  2019cites this paper
• Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c.

  2018cites this paper
• Silica dust and tobacco smoking : association in lung damage

  2018cites this paper
• Silicosis and lung cancer: current perspectives

  2018cites this paper
• Inflammatory and oxidative stress biomarkers at protein and molecular levels in workers occupationally exposed to crystalline silica

  2018cites this paper
• Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis

  2018cites this paper
• Pathologies dues à l’inhalation de poussières de silice

  2018cites this paper
• N‐acetyl‐seryl‐aspartyl‐lysyl‐proline (Ac‐SDKP) attenuates silicotic fibrosis by suppressing apoptosis of alveolar type II epithelial cells via mediation of endoplasmic reticulum stress

  2018cites this paper
• Erasmus syndrome: systemic sclerosis and silicosis co‐occurrence

  2018cites this paper
• Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica–Induced Sterile Inflammation

  2018cites this paper
• IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro

  2017cites this paper
• Papel do receptor atípico de quimiocinas ACKR2 na inflamação crônica pulmonar induzida por sílica em camundongos

  2017cites this paper
• Introductory Chapter: Therapies Based on Kidney Essence and Qi in Chinese Medicine

  2017cites this paper
• IL-10-Producing CD1dhiCD5+ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients

  2017influential citation
• Therapeutic effects of bone marrow-derived mononuclear cells from healthy or silicotic donors on recipient silicosis mice

  2017influential citation
• Stem-cell extracellular vesicles and lung repair.

  2017cites this paper
• New perspectives in nanotherapeutics for chronic respiratory diseases

  2017cites this paper
• Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice

  2016cites this paper